Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)

From WikiPathways

Jump to: navigation, search
4, 12492, 12941, 8216, 70, 90, 100, 11320, 23, 80, 108229512, 1715, 69, 78, 114, 116...59103221, 39331821, 2719, 26, 31, 105, 13991264030, 106, 13260, 64, 72, 77, 81...30, 13296, 104, 12811710335, 43, 63, 1193, 33, 69, 9436, 74, 8757, 68, 916, 28, 50, 736238, 47, 61, 98127398532, 13684, 1458946, 102, 112, 14251, 71, 110, 123, 14149, 1425522, 621211317, 27, 1307, 82, 1254816, 70, 90, 100, 11310329, 43, 80, 13858398, 60, 64, 81103, 1432512212, 44, 742, 54, 7614447, 52, 99, 10912779, 11813334, 65, 67, 101, 135cytoplasmendoplasmic reticulum lumenfactor Xa heavy chain factor XI8xCbxE-3D-PROC(43-197) factor XIII A chainactivation peptideSERPING1factor VIIIa A2 polypeptide factor VIIIa A2 polypeptide 8xCbxE-3D-PROC(43-197) Ca2+ thrombin light chain Ca2+ factor XIIa light chain GP1BA factor VPF4(32-101) factor Viintermediate formKLKB1(20-390) F12 T328K(20-328) PROCR FGB(31-44)F8(392-759) R717L Activated protein Cfactor VIIIa A2 polypeptide FibrinogenPRCP Factor IIainhibitors(peptide):IIaF2R C1QBP F8(392-759) A2domain variantfactor X heavy chain A2M activated thrombin(factor IIa)A2M 12xCbxE-3D-F9(47-191) fibrin multimer,crosslinkedF8(392-759) R550C 11xCbxE-3D-F10(41-179) factor VIIa heavy chain KLKB1(20-390) factor XIIa heavy chain 11xCbxE-3D-F10(41-179) factor VIIIaFGG 12xCbxE-3D-F9(47-191) thrombin light chain factor Xa heavy chain factor IXaFactor IIainhibitors:IIaF8(392-759) R550H factor VIIIathrombin heavy chain Plasma kallikreinfactor XIIIafactor IXa heavy chain thrombin light chain Ca2+ Inactivated factorVIII11xCbxE-PROS1F8(582-640)factor VIIIa A2 polypeptide F8(392-759) N713I PalmC-F3Activated proteinC:Protein SCa2+ factor VIIIa withdefective A1 domainZn2+PROCR(18-?) Bradykininfactor XIIa light chain factor Va light chain CD177 factor XIII cleavedtetramerGP1BB Ca2+Ca2+ GP9 Ca2+ KNG1(19-644) sequestered tissuefactorprolylcarboxypeptidase dimerfactor XI:GPIb-IX-Vcomplex10xCbxE-F2(44-327)FVIIIa:FIXa R384LF8(392-759) R550G Va:Xa:Factor XainhibitorsF12 T328K (329-615) FGA(20-35)PROCR(18-?)8xCbxE-3D-PROC(43-197) SERPINA5:Activatedprotein CPROC(200-211)PROCRGPIb-IX-V12xCbxE-3D-F9(47-191) FGB 8xCbxE-3D-PROC(43-197) factor XIIa heavy chain F12 variant(373-615)factor VIIIa A1 polypeptide Ca2+ 11xCbxE-3D-F10(41-179) factor Va light chain factor VIIaPROCR:Protein CCa2+F8(20-391) S308L factor VIII:vonWillebrand factormultimer11xCbxE-3D-F10(41-179) F8(356-372)factor XIII A chain CD177 KNG1(390-644) FGA Plasma kallikreinthrombin light chain factor Va heavy chain Ca2+ factor VIIIa A2 polypeptide F8(373-581) factor Xa:Factor Xainhibitorsthrombin heavy chain F12 variant (20-328)Va:Xafactor Xa heavy chain factor XIIfactor Xa heavy chain factor XIa heavy chain Ca2+ factor VIIIa A3 C1 C2 polypeptide F12 T328K Ca2+ GAG kallikrein:C1Inhfactor IXa heavy chain SERPINC1 PalmC-F3 factor IX activationpeptidefactor VIIIactivatedthrombin:thrombomodulinCa2+ thrombin light chain F12 T328R factor VIIIa A1 polypeptide 10xCbxE-F7(61-212) GP1BB factor Va light chain factor VIIIa A3 C1 C2 polypeptide F5(535-737)thrombin heavy chain SERPINC1(426-464) Ca2+ factor Va heavy chain FGA THBD SERPINA5 activated thrombin(factor IIa)factorXIa:GPIb:GPIX:GPVcomplexfactor VIIIa A1 polypeptide factor ViKLKB1(20-638)TF:F7aFGB F12 variant(329-615)11xCbxE-PROS1 GP1BA thrombin light chain ExtracellularthrombininactivatingcomplexesF13B factor VIIIaA1:A3-C1-C2Ca2+ activatedkininogen:C1qbinding proteintetramerCa2+ factor XIIa:C1Inhfactor VIIIa A2 polypeptide 10xCbxE-F7(61-212) Factor IIainhibitors(peptide)PROCR(18-?) Ca2+ factor Xfactor XI monomer thrombin:SERPINC1:SERPINC1 activatorsthrombin heavy chain F2RGAG Ca2+ F8(20-391) S308L SERPINC1(33-425) 8xCbxE-3D-PROC(43-197) factor Xa heavy chain SERPIND1GP9 factor VIIIa A1variant:A3-C1-C2thrombin heavy chain KNG:C1q bindingprotein tetramerF8(392-759) R550C A2M tetramerF8(392-759) R717W PROC(212-461) F8(392-759) R550G factor X activationpeptideGP9 PROC(212-461) NH4+factor VIIIa A1 polypeptide factor VIIIa A1 polypeptide 11xCbxE-3D-F10(41-179) SERPINC1(426-464) FGB(31-491) PROC(212-461) F8(392-759) R717L KNG1(19-644) fibrin multimerCa2+ GP1BA factor IXa heavy chain Factor IIainhibitors:IIa12xCbxE-3D-F9(47-191) FGG factor VIII light chain kallikrein:kininogen:C1q binding protein tetramerPROC(212-461) factor VIIIa A1 polypeptide Ca2+ GP5 8xCbxE-3D-PROC(43-197) C1QBP F8(20-391) A303E factor VIIIa A3 C1 C2 polypeptide 10xCbxE-F7(61-212) SERPINC1(33-425) factor VIII heavy chain Ca2+ factor VIIIa A3 C1 C2 polypeptide thrombin:cleavedSERPINC1:SERPINC1activatorsPROC(212-461) SERPINC1(426-464) F8(20-391) A303E Ca2+ Ca2+ Ca2+ SERPINE2:GAG:activated thrombin (factor IIa)C1QBP factor XIa light chain F8(20-355) PROCR(18-?):Activated protein C11xCbxE-PROS1 PROCR:Activatedprotein C:F2Rfactor VIII light chain PF4V1(31-104) KNG1(19-644) factor Xa heavy chain 11xCbxE-3D-F10(41-179) VWF(764-2813) factor IXa heavy chain 10xCbxE-F7(61-466) C1QBP KNG1(19-644)F5(29-534) PRTN3 PRTN3 thrombin heavy chain F8(392-759) N713I Ca2+ FGG F8(392-759) R717W Protein CF9(227-461) R384L KLKB1(391-638) thrombin heavy chain PROCR:Activatedprotein Cfibrin monomerCa2+SERPINC1 KLKB1(20-638) KLKB1(391-638) SERPINC1thrombin:cleavedSERPINC1thrombin light chain thrombin light chain SERPINE2 10xCbxE-F7(61-466) F13BGP5 factor VIIIa A3 C1 C2 polypeptide factor VIIIa A3 C1 C2 polypeptide C1q binding proteintetramerF9(29-461)SERPING1 thrombin heavy chain SERPIND1 KLKB1(391-638) GP1BB factor Va heavy chain F12 T328K (373-615) factor Va light chain Ca2+ thrombin light chain factor VIIa heavy chain factor VIIa heavy chain factor XaSERPINE2 Ca2+ Ca2+ KLKB1(391-638) Factor IIainhibitors(compounds):IIafactor VIIIa withdefective A2 domainfactor Xafactor VIIIa A2polypeptide12xCbxE-3D-F9(47-191) SERPIND1 thrombin light chain F12 variantFactor IIainhibitors(compounds)PROC(200-461) Platelet Factor 4KNG1(19-380) thrombin heavy chain factor VIIIa A3 C1 C2 polypeptide factor VIIIa A3 C1 C2 polypeptide SERPING1 factor XIIIa A chain thrombin heavy chain SERPINA5 FVIIIa:FIXa:PROS1THBDfactor Vathrombin light chain F5(29-334) KLKB1(20-390) 10xCbxE-F2(44-622)Ca2+SERPINC1:SERPINC1activatorsSERPINE2:GAGfactor XI monomer F13B kallikrein:alpha2-macroglobulin8xCbxE-3D-PROC(43-197) factor VIIIa B A3acidic polypeptidefactor VIII heavy chain 8xCbxE-3D-PROC(43-197) factor IXafactor VIIIa A1 polypeptide Ca2+ factor V activationpeptideF12 T328R (373-615) F5(335-534)thrombin heavy chain PROCR FGA(20-866) PROC(212-461) TFPI factor VIIIa A3 C1 C2 polypeptide 12xCbxE-3D-F9(47-461)thrombin light chain TFPIFactor Xa inhibitorsTFPI:TF:F7a:factorXaKNG1(19-644)factor VIIIa A3 C1 C2 polypeptide von Willibrandfactor multimerSERPINA511xCbxE-3D-F10(41-179) KLKB1(20-390) PalmC-F3 factor XIIIfactor XIIIa A chain F12 T328R (329-615) VWF(764-2813) thrombin heavy chain 8xCbxE-3D-PROC(43-197) Ca2+ 10xCbxE-F7(61-466):Ca2+KLKB1(391-638) thrombin heavy chain factor XIIaPROC(200-461) PalmC-F3 PROCR(18-?):PRTN3:CD177GAGF12 T328R(20-328) Ca2+ C1QBP prekallikrein:kininogen:C1q binding protein tetramerTF:F7thrombin light chain GP5 factor Va light chain SERPINC1 activatorsCa2+ SERPINC1(33-425) PROC(212-461) Ca2+PROCR activated thrombin(factorIIa):SERPIND1factor VIIIa:factorIXaKLKB1(20-390) SERPING1Factor VIIIprecursorF8(392-759) R550H PRTN3:CD177Ca2+ 5, 1113, 3313, 2442, 14045, 6613, 24, 975, 11145, 663742, 14086111, 13, 2413, 24, 9742, 14014, 9742, 14093, 134378845, 661145, 6642, 755, 11153, 83, 1073714, 971, 13, 2413, 24, 97485, 11153, 83, 1078853, 83, 10713, 24, 971, 13, 2453, 83, 10713, 24, 9714, 9714863, 3313, 24, 9742, 14014, 97621, 13, 241, 13, 2442, 14042, 14053, 83, 10762, 9313, 24, 9730, 13242, 1405, 11193, 1343, 33869393, 13414, 9742, 1401273945, 6642, 1401413, 2442, 1401, 13, 241345, 11114, 9753, 83, 1071, 13, 2453, 83, 1075630, 106, 13293, 1341, 13, 2493, 13413, 24, 9742, 14030, 13210105, 1111271145, 66145, 111933, 3393, 13442, 14013, 24, 9742, 75, 1403, 3342, 14062, 9313, 2442, 1401442, 1405, 11153, 83, 10714, 9745, 661, 13, 24