Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)

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20, 10910, 13, 525872, 1018918, 44, 62, 65, 7337, 74, 9921, 23, 31, 57, 685680282, 22, 32, 485679254259, 10252, 55, 8243, 1064180910814, 19, 9710471823511219, 6391801, 24, 106, 116304629, 40, 97813, 506, 645, 51, 66, 703, 71101542, 17, 22, 48, 53...2677, 78, 88, 114361, 83, 86, 9221, 23, 31, 57, 6838069, 85, 87, 96, 9810188, 92, 110, 1154, 39, 45, 47, 90...11, 34, 66, 10549cytoplasm(2R,4R)-1-GAGPlasma kallikreinCa2+ Ca2+Ca2+ PROC(212-461) factor Va light chain Factor IIainhibitors:IIafactor XIActivated protein CTF:F7afactor XI:GPIb-IX-VcomplexFGA(20-866) 11xCbxE-3D-F10(41-179) bivalirudin PROCR:Activatedprotein CPalmC-F3factor VIIaSERPINE2:GAG:activated thrombin (factor IIa)factor Va light chain PROC(200-211)PalmC-F3 factor XIa light chain factor VIIIa A2 polypeptide factor VIIIa B A3acidic polypeptidefactor VIII heavy chain thrombin light chain factor VaCa2+ Ca2+ factor VIIIa A2 polypeptide KNG1(390-644) SERPINC1(426-464) C1QBP melagatran thrombin heavy chain FGG factor Xa heavy chain factor XI monomer KLKB1(391-638) FGB thrombin light chain betrixaban (2R,4R)-1-Platelet Factor 4Heparin FGA Factor IIainhibitors(compounds)11xCbxE-3D-F10(41-179) factor X heavy chain factor Xa heavy chain factor XIIIa A chain SERPIND1KLKB1(20-638) SERPINE2 FibrinogenDUP-714 Va:Xa:Factor Xainhibitors11xCbxE-3D-F10(41-179) factor V activationpeptideGP5 thrombin heavy chain F5(535-737)SERPINA58xCbxE-3D-PROC(43-197) F13Bdesirudin KNG1(19-644) Ca2+ thrombin:antithrombin III:heparinfactor VIIIthrombin heavy chain KLKB1(20-638)GAG 11xCbxE-3D-F10(41-179) (2R,4R)-1-A2M Ca2+ KNG1(19-644)factor XIII A chain factor Xa heavy chain (2R,4R)-1-A2M tetramerProtein Capixaban factor VIII:vonWillebrand factormultimerfactor XIII cleavedtetramerPROCR(18-?)KNG1(19-644) DUP-714 Ca2+thrombin light chain factor VIIa heavy chain apixaban desirudin F8(356-372)GP9 Ca2+edoxaban melagatran PRTN3:CD177NH4+Ca2+ factor Xa heavy chain Ca2+ factor V11xCbxE-PROS1 F5(335-534)antithrombinIII:heparinFGG KLKB1(20-390) CD177 12xCbxE-3D-F9(47-461)lepirudin SERPIND1 factor XIIa light chain rivaroxaban PROCR:Protein CPROC(212-461) lepirudin KLKB1(20-390) factor VIIIa A2 polypeptide factor XCa2+ SERPINC1(33-425) apixaban Heparinmelagatran KNG1(19-380) THBD CD177 factor Viactivatedkininogen:C1qbinding proteintetramerfactor Va heavy chain Inactivated factorVIIIactivatedthrombin:thrombomodulin10xCbxE-F7(61-212) thrombin heavy chain 8xCbxE-3D-PROC(43-197) Factor IIainhibitors:IIaCa2+thrombin light chain Heparin PROCR SERPINA5 PalmC-F3 activated thrombin(factorIIa):SERPIND1FGB(31-44)10xCbxE-F7(61-466) betrixaban factor VIIIa12xCbxE-3D-F9(47-191) KLKB1(20-390) SERPINA5 factor VIIa heavy chain PROC(212-461) Ca2+ Ca2+ VWF(764-2813) thrombin light chain Ca2+ PF4V1(31-104) F2R GPIb-IX-VCa2+ Ca2+ PROC(212-461) rivaroxaban KNG1(19-644) Ca2+ factor VIIa heavy chain 11xCbxE-3D-F10(41-179) KNG1(19-644)dabigatran factor Va light chain thrombin heavy chain GAG PROCRFGG 8xCbxE-3D-PROC(43-197) PROCR:Activatedprotein C:F2RCa2+ factor XIIa heavy chain PF4(32-101) SERPING1Zn2+Ca2+ thrombin heavy chain PROCR GP1BB SERPINC1(33-425) 12xCbxE-3D-F9(47-191) PRTN3 FGA(20-35)8xCbxE-3D-PROC(43-197) 8xCbxE-3D-PROC(43-197) thrombin heavy chain PROCR(18-?):PRTN3:CD17711xCbxE-3D-F10(41-179) PalmC-F3 thrombin heavy chain C1QBP bivalirudin Activated proteinC:Protein Sfactor VIIIa A1 polypeptide C1QBP factor Xa heavy chain factor VIIIa A3 C1 C2 polypeptide SERPINC1 GP1BB factor Viintermediate formfactor VIIIa A3 C1 C2 polypeptide Ca2+ factor VIIIaF2Rfactor VIIIa A3 C1 C2 polypeptide TFPI factor Xa heavy chain factor XIIa heavy chain GP9 fibrin multimer8xCbxE-3D-PROC(43-197) factor XIIafactor VIII heavy chain Ca2+ Factor Xa inhibitorsF13B 11xCbxE-PROS1Ca2+ lepirudin Ca2+ SERPINC1(426-464) PROC(200-461) activated thrombin(factor IIa)10xCbxE-F7(61-466) 12xCbxE-3D-F9(47-191) Factor IIainhibitors(compounds):IIaprekallikrein:kininogen:C1q binding protein tetramer8xCbxE-3D-PROC(43-197) factor XIa heavy chain factor VIIIa A1 polypeptide GP5 Factor IIainhibitors(peptide)VWF(764-2813) DUP-714 factor IXa heavy chain BradykininCa2+ Ca2+ PROC(212-461) lepirudin GP1BA thrombin light chain 10xCbxE-F7(61-212) factor Xafactor Va light chain SERPINE2:GAGfactor Va light chain SERPINC1(33-425) factor VIIIa A3 C1 C2 polypeptide activated thrombin(factor IIa)SERPINC1 C1q binding proteintetramerrivaroxaban factor X activationpeptideeribaxaban Heparin fibrin monomerF13B thrombin heavy chain eribaxaban TFPIFGB(31-491) kallikrein:alpha2-macroglobulinGP1BB thrombin light chain factor XIIa:C1InhKNG:C1q bindingprotein tetramerprolylcarboxypeptidase dimerSERPINA5:Activatedprotein CTHBD10xCbxE-F2(44-327)thrombin light chain ExtracellularthrombininactivatingcomplexesC1QBP factor IXa heavy chain bivalirudin edoxaban Ca2+ KLKB1(20-390) bivalirudin thrombin heavy chain PROCR dabigatran factor Va heavy chain factor XIIthrombin light chain PRTN3 8xCbxE-3D-PROC(43-197) thrombin:cleavedantithrombinIII:heparinthrombin light chain PROC(212-461) C1QBP factor VIII light chain SERPIND1 Ca2+ PROC(200-461) betrixaban kallikrein:kininogen:C1q binding protein tetramerCa2+ GP9 factor XI monomer factor VIIIa A1 polypeptide factor VIIIa:factorIXaGP1BA factor IXaVa:Xafactor XIIIa A chain 10xCbxE-F7(61-212) SERPING1 factor XIIIthrombin:cleavedantithrombin IIIA2M thrombin light chain 10xCbxE-F7(61-466):Ca2+sequestered tissuefactorfactor IX activationpeptidethrombin heavy chain F8(20-355) PROCR(18-?):Activated protein Cthrombin light chain 11xCbxE-3D-F10(41-179) TFPI:TF:F7a:factorXafactor XIII A chainactivation peptidedesirudin GP1BA factorXIa:GPIb:GPIX:GPVcomplexfibrin multimer,crosslinkedPRCP thrombin heavy chain dabigatran PROCR(18-?) SERPINC1(426-464) factor XaKLKB1(391-638) F5(29-334) DUP-714 10xCbxE-F2(44-622)SERPING1 F8(373-581) Ca2+ factor XIIa light chain eribaxaban dabigatran FGA factor IXaSERPINC1SERPINE2 F8(582-640)thrombin heavy chain Ca2+ F5(29-534) melagatran Ca2+ Ca2+ GP5 factor Va heavy chain TF:F7FGB PROCR(18-?) factor VIII light chain kallikrein:C1InhPROC(212-461) KLKB1(391-638) von Willibrandfactor multimer8xCbxE-3D-PROC(43-197) desirudin Ca2+ factor Xa:Factor Xainhibitorsfactor XIIIathrombin light chain factor IXa heavy chain edoxaban Factor IIainhibitors(peptide):IIaKLKB1(391-638) 33, 11827, 75, 9512, 845638, 67, 7210193, 117763638, 67, 7212, 38, 6727, 75, 9512, 38, 677, 163627, 75, 9560, 11393, 11738, 67, 7233, 11893, 11793, 11793, 1177, 1633, 11893, 11738, 67, 7293, 11760, 11312, 38, 6760, 11327, 75, 9538, 6727, 75, 9593, 11727, 75, 9512, 8438, 67, 7212, 38, 6738, 67738, 67, 729412, 8493, 11710060, 11312, 38, 6793, 11760, 11338, 67, 7215, 9393, 1171038493, 11793, 11793, 11738, 6733, 118165627, 75, 9571100847, 7133, 11877, 1638, 67, 728415, 93, 1177, 1660, 11312, 38, 6712, 38, 677, 717, 1612, 38, 679460, 11310360, 1137, 16849433, 11812, 8410060, 11393, 11712, 38, 6733, 11893, 11738, 67, 7227, 75, 95