Complement cascade (Homo sapiens)

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6, 31, 44, 88, 102634016, 5835, 45, 53, 77, 81...10215, 11242, 85, 100, 11128, 90, 9189985250, 91, 1105710037, 9622, 114578, 41, 7618, 101, 1159552, 1092119, 27, 29, 33, 45...75265518, 101, 11510249, 5664, 78105932832, 579712, 955249, 10311, 462595345910251, 99, 11373210210249, 71, 10424713, 14, 10052, 1094, 22, 1146814, 17, 89, 1051149, 20, 66399, 1028074, 1091035, 36, 53, 62, 65...2, 60, 72, 73, 1073915, 1129, 102Target CellInnocent bystander cellcytosolcytosolC3a C4BPA FCN1 ligands:FCN1dodecamer:MASP1dimer:MASP2-1dimer:4xCa2+C3 beta chain C4B(1454-1744) Ig heavy chain V-II region MCE Ig lambda chain V region 4A C3 beta chain IGLV8-61(1-?) Ig lambda chain V-II region NEI IGHG3 IGLV2-33(1-?) C3 beta chain C1S N-terminal fragment Cell surface CFI:CFH,FHR3:C3bC7 IGLV3-27(1-?) IGLV11-55(1-?) Antigen MASP2-1 IGLV2-11(1-?) C3 beta chain FCN1 IGLV2-18(1-?) C3b alpha' C1QB IGKC Cell surface Ig lambda chain V-IV region Bau Ig heavy chain V-III region CAM COLEC10 C3b alpha' Ig heavy chain V-III region WEA CFB(260-764)MASP2-1(445-686) C8B CFB(260-764) Ig heavy chain V-I region EU IGLV4-3(1-?) IGLV5-37(1-?) C3 beta chain IGLC1 dNQ-C4B(757-1446) IGHG1 IGLV3-22(1-?) C2a MBL2 Ig heavy chain V-II region NEWM C2a MASP1(20-699) Lipoteichoic acid C4A(20-675) C3 beta chain C9(22-559)CFH C1QA Ig kappa chain V-III region VG Sialic acid C3a-desArg IGLV4-60(1-?) IGLV1-36(1-?) C4B(20-675) MASP1(20-699) CR1 C5b alpha' C8G IgH heavy chain V-III region VH26 precursor dNQ-C4B(757-1446) Complement factor DLipoteichoic acid Ig kappa chain V-II region RPMI 6410 Ig lambda chain V-II region TOG Ig heavy chain V-III region DOB IGLV4-3(1-?) IGKV2D-30 Cell surface:C4bComplement factor 3IGLV2-23(1-?) IGLV4-69(1-?) IGHG4 C1QC C3dgIGKV4-1(21-?) Ca2+IGLV3-25(1-?) IGLV3-27(1-?) Ig lambda chain V-II region MGC FCN2 ligands:FCN2dodecamer:MASP1dimer:MASP2-1dimer:4xCa2+Ig kappa chain V region EV15 C4bC2a, C3bBbIg kappa chain V-III region VG IGHG2 Ig heavy chain V-II region NEWM S-(L-isoglutamyl)-L-cysteine-C4B(757-1446) C2a FCN1 IGKV1-5(23-?) Ig lambda chain V-II region BOH IGLV5-45(1-?) CFHR3 CR1:C4bC4BPB C4B(20-675) MASP2-1 C3b alpha' CD55 Ig lambda chain V-I region NEW Ig kappa chain V region EV15 dNQ-C3(672-1663) IGKV2D-30 Ig lambda chain V-II region NEI IGLV8-61(1-?) IGKVA18(21-?) MASP1(20-699) IGLC7 MASP1(20-699) C4A(1454-1744) Ig heavy chain V-III region BRO CR1:iC3bIg kappa chain V region EV15 Ig lambda chain V-VI region AR Cell surface Ig heavy chain V-II region NEWM C6 IGLV3-16(1-?) C5 beta chain S-(L-isoglutamyl)-L-cysteine-C4B(757-1446) C3d IGLV10-54(1-?) IGHV7-81(1-?) Cell surface C9(22-559)Ig kappa chain V-II region Cum C4B(20-675) IGHG1 IGLC7 Ig kappa chain V-I region BAN IGLV2-33(1-?) IGKV1-5(23-?) IGKC Ig heavy chain V-II region WAH Ig kappa chain V-II region Cum Ig lambda chain V-I region NEWM C4A(20-675) C3b alpha' Ig lambda chain V-I region HA Ig kappa chain V-I region Gal IGLV7-46(1-?) Ig lambda chain V-I region VOR C7 MBL2 C3 beta chain IGLC7 IGLV8-61(1-?) IGKC C4B(1454-1744) C4A(1454-1744) C3b alpha' C4A(20-675) C5 beta chain Ig lambda chain V-VI region AR IgH heavy chain V-III region VH26 precursor CFB(260-764) dNQ-C4B(757-1446) C3 beta chain C3 beta chain N-acetylgalactosamine Ig lambda chain V-IV region Hil CD55 IGLV4-69(1-?) C6 C5 convertasesCell surfaceVTNC5AR1 Ig lambda chain V-III region LOI IGLV8-61(1-?) IGKVA18(21-?) Ig lambda chain V-I region NEWM Ig lambda chain V-IV region Bau Ig heavy chain V-II region WAH C4A(1454-1744) IGHV1-2 Cell surface:C4bC3 beta chain C3 beta chain CLU:C5b:C6:C7, C8,C9FCN2 IGLC6 C3aCFHR dimersIg heavy chain V-III region BUT MBL2 dodecamer:MASP1dimer:MASP2-1 dimerIg kappa chain V-I region Gal Cell surface Ig kappa chain V-III region B6 IGKV3D-20 SERPING1 IGKV1-12 C3 beta chain Ig heavy chain V-III region DOB Cell surface:C4b:C2aIGHG1 Ig heavy chain V-I region EU IGLV11-55(1-?) Ig lambda chain V-II region BOH Ig kappa chain V-I region AU C4B(20-675) Ig kappa chain V-II region RPMI 6410 C3cCFHR1 C8A Ig kappa chain V-I region Daudi C3a-desArg IGKC C4A(1454-1744) Ig kappa chain V-I region HK101 CFHR2 Ig lambda chain V-III region SH C4A(1454-1744) CFI:CFH:C3bN-acetylgalactosamine Ig kappa chain V-III region B6 Ig heavy chain V-III region KOL IGLV3-12(1-?) Ig heavy chain V-III region TRO CR1 CFHR3 C3 beta chain C4A(20-675) Ig kappa chain V-I region Gal Ig heavy chain V-III region BUT CLUIg kappa chain V-I region Wes C9(22-559) C3(H2O):BbIGLV2-11(1-?) Properdin oligomer C4B(20-675) CFB(260-764) IGKV2-28 Ig heavy chain V-III region DOB Sialic acid MASP1(20-448) C3 beta chain C5b alpha' CFB(260-764) C3b alpha' Ig lambda chain V-I region VOR IGKV3D-20 C6 IGKV2D-30 N-acetyl-D-glucosamine Antigen C4B-derived C4a Ig kappa chain V region EV15 IGLC1 Ig lambda chain V-I region NEWM 1,3-beta-D-glucan Ig kappa chain V-I region Gal C3 beta chain C3a, C5aC3b alpha' Cell surface Ig heavy chain V-III region WEA CFB(260-764) IGLV1-36(1-?) C3 beta chain IGLV1-40(1-?) C1QA C4A(20-675) C4c, C3fN-acetyl-D-glucosamine C9(22-559) Ig heavy chain V-I region EU C3c alpha' chain fragment 2 FCN2 dodecamer:MASP1dimer:MASP2-1 dimerIGLV1-44(1-?) IGLV3-12(1-?) CRP(19-224) C3 beta chain C3(H2O):CFBIg heavy chain V-III region BRO FCN2 C4BPA Ig kappa chain V-III region POM C4A(20-675) CR1 Cell surface IGLC7 C3 beta chain IGLV2-33(1-?) C5AR2IGLV1-36(1-?) C9(22-559) C5b alpha' IGLV1-36(1-?) IGKV4-1(21-?) dNQ-C4A(757-1446) C3b alpha' C5a-desArg C4B(1454-1744) Ca2+ MBL2,FCN:activatedMASPs:carbohydratepatternsCellsurface:C3b:Bb:ProperdinAntigen:IgG:C1Q:2xActivated C1R:2xActivated C1SIg lambda chain V-III region SH CFI(340-583) CLU(228-449) CD55:C3bIg heavy chain V-II region ARH-77 IGLV3-22(1-?) Ig kappa chain V-I region Daudi IGLV2-33(1-?) Ig lambda chain V-IV region Hil Ig kappa chain V-I region Daudi IGLV7-43(1-?) IGHV(1-?) C3 beta chain C2a IGLC6 C1R C-terminal fragment C8B C3 beta chain CFI(19-335)IGKVA18(21-?) Ig lambda chain V-III region SH C3bIGLV5-37(1-?) C4A(20-675) IGLV7-43(1-?) CFHR3 CFI(19-335) Bacterial mannose surface pattern Ig heavy chain V-III region CAM IGLC3 IGHV1-2 Ca2+IGLV1-36(1-?) IGLV1-40(1-?) Ig heavy chain V-III region BRO Cell surface:C4bIg lambda chain V-VI region AR C8B dNQ-C4B(757-1446) C3b alpha' C8G C7 IGLV3-27(1-?) C4A(1454-1744) C3(H2O)Ig lambda chain V-IV region Kern IGHV1-2 Ig lambda chain V-VI region AR Ig lambda chain V-II region NEI CD46 C3fC4BPA IGLV10-54(1-?) C8A C2bCell surface CFI(19-335) IgH heavy chain V-III region VH26 precursor C3aC3 beta chain dNQ-C4A(757-1446) C7 MASP1(20-699) IGLV11-55(1-?) N-acetyl-D-glucosamine Ig heavy chain V-II region ARH-77 Ig kappa chain V-I region DEE C3AR1Ig heavy chain V-III region WEA C4 bindingprotein:C4bC2aCFI(340-583)C5b alpha' C1QIg lambda chain V-IV region Kern Ig heavy chain V-I region EU C4B(1454-1744) C8A IGLV2-23(1-?) CD59IGLV(23-?) IGLC3 C4A alpha3 FCN3 Ig lambda chain V-II region BOH Ig lambda chain V-I region VOR C1R C-terminal fragment C6 CPN, CBP2C6 IGLV2-18(1-?) CFI(19-335) dNQ-C4A(757-1446) IGLC7 IGLV8-61(1-?) dNQ-C3(672-1663) IGHG2 Ig heavy chain V-III region CAM MASP2-1 Ig heavy chain V-II region WAH Ig lambda chain V-VI region AR Ca2+dNQ-C4B(757-1446) C5 beta chain C4A(20-675) C4A(20-675) C4B(20-675) MASP2-1 Heparins C3bIg lambda chain V-I region NEWM Ig heavy chain V-III region JON MASP1(20-699) MASP1(20-699) Ig heavy chain V-II region NEWM Properdin oligomerdNQ-C3(672-1663) C1QC Ig kappa chain V-I region BAN Ig kappa chain V-I region Wes C6 Cell surface FCN1 dodecamer:MASP1dimer:MASP2-1 dimerCell surface IGHG1 C4A(1454-1744) Ig heavy chain V-III region BUT C1S(16-688) Ig kappa chain V-I region HK101 dNQ-C4A(757-1446) IGLV(23-?) Ca2+ IGLC1 Ig kappa chain V-I region DEE dNQ-C3(672-1663) Ig heavy chain V-II region ARH-77 C4B(20-675) CD19 N-acetyl-D-glucosamine C4b:C2a:C3bC4A(20-675) IGHV7-81(1-?) Cell surface C5b alpha' IGHV7-81(1-?) Ig heavy chain V-I region HG3 IGLV11-55(1-?) Ig kappa chain V-I region BAN CFH:Host cellsurfaceCell surface C3b alpha' C7 IGLV1-40(1-?) C4A(1454-1744) MASP2-1 FCN3 IGLV3-12(1-?) CFI(340-583) Ig kappa chain V-II region FR C2aIg kappa chain V-II region Cum IGLC6 CD46IGLV1-44(1-?) IGHG3 C3c alpha' chain fragment 1 precursor C5 beta chain IGLV10-54(1-?) C4A(20-675) C4A(1454-1744) CFH Ig heavy chain V-III region KOL Ig heavy chain V-III region TRO C3a ActivatedC1R:SERPING1IGHV1-2 C4B(1454-1744) IGLV10-54(1-?) C5a-desArg IGKVA18(21-?) IGHG4 Ig heavy chain V-II region ARH-77 MBL2,FCN:MASPs:carbohydrate patterns1,3-beta-D-glucan C4B(1454-1744) C4B(20-675) IGLV3-22(1-?) Host cell surfaceC1QC Ig kappa chain V-III region VG C4B alpha3 C9(22-559) C4-bindingprotein:C4bC3 alpha chain CFI(340-583) Ig kappa chain V-I region Gal C4B(1454-1744) Ig lambda chain V-IV region Kern Ig kappa chain V-I region AG C4A(1454-1744) C3 beta chain C3b alpha' Ig kappa chain V-I region DEE IGKV2-28 IGLV1-40(1-?) C4A(1454-1744) VTN C8G dNQ-C3(672-1663) N-acetylgalactosamine IGKV1-5(23-?) IGHV1-2 IGLV2-11(1-?) C1R N-terminal fragment IGLV3-27(1-?) C3b alpha' CFH dNQ-C4A(757-1446) C3f Ig lambda chain V-II region NEI Ig heavy chain V-II region OU C5 beta chain Cell surface IGLV7-43(1-?) CD55 C3a IGLV3-25(1-?) dNQ-C4A(757-1446) Ig kappa chain V-I region AU C4B(956-1336) Ig heavy chain V-II region ARH-77 Ig kappa chain V-I region AU C2aC4A(20-675) C4B(20-675) IGLV2-18(1-?) Ig lambda chain V-I region NEWM CPN2 Sialic acid Ig lambda chain V-I region HA C2a IGLV2-11(1-?) dNQ-C4B(757-1446) IGLV3-25(1-?) Ig kappa chain V-III region VG C1QA Ig heavy chain V-III region WEA C5b alpha' Bacterial mannose surface pattern IGLV4-3(1-?) IGLV3-27(1-?) Ig heavy chain V-II region WAH Antigen:IgG:C1Q:2xC1R:2xC1SIg kappa chain V-I region AG Ig lambda chain V-IV region Hil IGLV3-16(1-?) dNQ-C4A(757-1446) C4 activatorsCL-LK:MASP1dimer:MASP2 dimerC7 dNQ-C4B(757-1446) IGLV1-44(1-?) IGLV7-46(1-?) IGHG2 IGLV4-69(1-?) CR2dNQ-C4B(757-1446) C4B(1454-1744) MBL2,FCN:activated MASPs:carbohydrate patterns CD46 MASP2-1 IGHV1-2 CR1 C4B(20-675) IGLV5-45(1-?) C3b alpha' C2aD-fucose C3d, C3dg, iC3bdNQ-C4A(757-1446) C4A(1454-1744) Ig lambda chain V region 4A Ig lambda chain V region 4A Ig kappa chain V-III region B6 C3 beta chain Ig lambda chain V-IV region Hil Ig lambda chain V-IV region Hil C4B(1454-1744) C4B(1454-1744) Ig lambda chain V-II region MGC Ig kappa chain V-I region Daudi IGLC3 Ig heavy chain V-II region WAH C3c alpha' chain fragment 1 precursor IGLV5-37(1-?) C1S N-terminal fragment Ig kappa chain V-I region Daudi Ig lambda chain V-I region NEW Ig lambda chain V-IV region Kern IGLV3-25(1-?) IGKV2-28 C5aTCD19 C1QA Ig lambda chain V-I region NEW Ig kappa chain V-I region DEE Cell surface IGLV4-3(1-?) IGLC6 C8A Ig kappa chain V-I region Daudi C2a IGLV11-55(1-?) FCN1 Ig kappa chain V-II region RPMI 6410 C5a IGLV2-18(1-?) IGKV2D-30 Ig kappa chain V-I region DEE C3b alpha' Ig heavy chain V-III region CAM C4A(20-675) Ig lambda chain V-II region TOG IGLV7-43(1-?) Ig lambda chain V-II region NEI Ig kappa chain V-II region FR D-fucose C7 C1R C-terminal fragment C1QB IGLV4-69(1-?) Cell surface CFB(26-764) C4d C4B alpha Ig heavy chain V-III region BUT MASP2-1(16-444) CFH C1QB D-fucose CFHR5 MBL2 C4B(20-675) CFH Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1C1R N-terminal fragment C3 beta chain FCN3 Ig lambda chain V-I region HA IGHG4 IGLV4-60(1-?) CR1 IGLV4-3(1-?) C4B(20-675) CFI:CD46, CR1:C4b,C3b complexesC3b alpha' C3 beta chain C4B(20-675) IGHG4 FCN1 ligandsIg kappa chain V-I region HK101 C1QB C7 IGLC1 dNQ-C4B(757-1446) Ig kappa chain V-III region POM thrombin heavy chain IGLV3-16(1-?) IGLC2 Cell surface:C3bIGKV2D-30 Cell surface C5IGLV1-44(1-?) IGHG2 Ig lambda chain V-I region HA IGHG4 Ig heavy chain V-III region BRO IGKV3D-20 N-acetylgalactosamine C3 beta chain C3 beta chain C2a FCN2 C1R N-terminal fragment IGLV7-43(1-?) IgH heavy chain V-III region VH26 precursor C1QC Ig lambda chain V-VI region AR SERPING1C3 convertasesCell surface Cell surface Ig lambda chain V-I region VOR Ig kappa chain V-III region VG Ig kappa chain V-I region HK101 IGLC1 VTN:C5b:C6:C7:C8:C9IGLV4-60(1-?) CFI(340-583) C3dg Ig lambda chain V-IV region Bau C4b-bindingprotein:Factor IC3 beta chain IGLV3-22(1-?) Ig lambda chain V-II region MGC CFB(260-764) C3b alpha' Ig kappa chain V-I region BAN IGLV7-46(1-?) IGLV3-22(1-?) Ig kappa chain V-I region DEE C6 C4B(1454-1744) C1QC IGLV3-25(1-?) C3 beta chain 1,3-beta-D-glucan IgH heavy chain V-III region VH26 precursor C2a IGHV(1-?) Ig kappa chain V-I region Gal IGLV3-22(1-?) Sialic acid IGLV2-18(1-?) C3c alpha' chain fragment 2 C4B(1454-1744) IGKV4-1(21-?) CR2 C4A(1454-1744) dNQ-C4A(757-1446) C4B(20-675) Ig lambda chain V-III region LOI IGLC3 Ig lambda chain V-II region MGC C2a D-fucose 11xCbxE-PROS1 IGKV4-1(21-?) Ig kappa chain V-I region AU Ig heavy chain V-III region DOB C3dg C8Antigen C1QA Ig lambda chain V-III region LOI Ig kappa chain V-III region B6 IGLV3-16(1-?) C1R C-terminal fragment Ig lambda chain V-II region BOH Ig lambda chain V region 4A Ig kappa chain V-I region AG IGKV1-5(23-?) IGKV1-5(23-?) C5b:C6:C7, C8, C9C3a C3c alpha' chain fragment 2 C5b:C6:C7Ig kappa chain V-II region FR IGLC3 C1QA C3 beta chain Cell surface C3c alpha' chain fragment 2 Cell surface IGLV4-3(1-?) Ca2+ Antigen:IgGIGLC2 CFHR4 Ig heavy chain V-III region KOL MASP2-1 CFHR3 Ig lambda chain V-I region NEW Ig heavy chain V-III region JON IGKV3D-20 CFB(260-764) C4A(1454-1744) C3c alpha' chain fragment 2 C1R N-terminal fragment C4BPB C3b alpha' Ig heavy chain V-II region MCE Ig kappa chain V-III region B6 C4B(1454-1744) Ig kappa chain V-II region RPMI 6410 IGLV4-60(1-?) dNQ-C4B(757-1446) C3c alpha' chain fragment 1 precursor C4BPA IGLV4-60(1-?) Ig heavy chain V-III region CAM IGLV7-46(1-?) Ig kappa chain V-I region BAN CR1:C3bCFI(340-583) C3 beta chain Cell surface:C3bIg kappa chain V-I region Daudi Heparins CR1 Ig heavy chain V-II region MCE IGHG4 C4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446),C4B(1454-1744):C4B(20-675):S-(L-isoglutamyl)-L-cysteine-C4B(757-1446)C4B(1454-1744) IGKVA18(21-?) IGKV3D-20 IGLV7-46(1-?) C4A(20-675) C4A(20-675) C7 C5aC4A(20-675):C4A(1454-1744):S-(L-isoglutamyl)-L-cysteine-C4A(757-1446),C4B(1454-1744):C4B(20-675):S-(L-isoglutamyl)-L-cysteine-C4B(757-1446)IGLV2-23(1-?) C3 beta chain Cell surface:CFH,CFHR3:C3bBbCa2+ IGKVA18(21-?) CD55:C4bCFI(19-335) IGHV7-81(1-?) C5 beta chain IGLV4-60(1-?) C5bTIGHG2 Ig kappa chain V-I region Wes Bacterial mannose surface pattern CFI(19-335) C5AR2 C1R C-terminal fragment Cell surface Ig kappa chain V-I region Wes Ig lambda chain V-II region TOG IGLV5-45(1-?) IGHV(1-?) C4A(20-675) C5b alpha' MASP2-1 Ig kappa chain V-II region Cum IGHG3 Ig heavy chain V-III region JON IGHG3 CFB(260-764) dNQ-C4A(757-1446) CFB(260-764) Ig kappa chain V-I region AU IGLV2-23(1-?) IGKV2-28 CR2 Ig lambda chain V-II region TOG C5a dNQ-C4B(757-1446) Lipoteichoic acid C8A Ig lambda chain V-I region NEW S-(L-isoglutamyl)-L-cysteine-C4A(757-1446) C4B alpha4 fragment dNQ-C3(672-1663) CFH Cell surface:C3b:BbC1S N-terminal fragment Cell surface:C3bC1QC Ig kappa chain V-I region AU Ig heavy chain V-II region MCE IGLV1-36(1-?) C1R N-terminal fragment IGKV1-12 IGLV3-12(1-?) C4A(1454-1744) IGLV2-11(1-?) IGLV2-23(1-?) C5b alpha' C4A(1454-1744) GZMM Ig heavy chain V-II region ARH-77 C4B(20-675) Ig heavy chain V-III region JON MASP2-1 CLU(23-227) Ig kappa chain V region EV15 C5AR1:C5aS-(L-isoglutamyl)-L-cysteine-C4B(757-1446) C6 C8G Ig lambda chain V-IV region Bau Cellsurface:FH,FHR3:C3bIg lambda chain V-IV region Bau COLEC11 CR2:C3d,C3dg,iC3bCD46:Cellsurface:C4bIg heavy chain V-II region MCE IGLC2 Ig lambda chain V-IV region Hil CD55:C3 convertasecomplexesC4A(20-675) iC3bIg lambda chain V-IV region Kern C3b alpha' Ig heavy chain V-II region MCE C4A(20-675) IGKV1-12 Antigen Cell surface Ig lambda chain V-IV region Kern CR1:C3bBb, C4bC2acomplexesC3b alpha' CFB(26-259)C3c alpha' chain fragment 1 precursor C7 Ig heavy chain V-I region EU C4b-binding proteindNQ-C4A(757-1446) IGLV3-12(1-?) C3b alpha' ActivatedC1S:SERPING1Ig lambda chain V-VI region AR dNQ-C4B(757-1446) C3dg C4BPB MASP1(20-699) IGLV5-37(1-?) C3b alpha' Bacterial mannose surface pattern C3b alpha' C8G IGHG1 Properdin oligomerC4A(20-675) IGHG2 Ca2+ Ig heavy chain V-III region DOB C3b alpha' C4B(1454-1744) Ig heavy chain V-II region OU CFHR2 C8B MASP1(20-699) Ig lambda chain V-III region LOI Cell surface Cell surfaceIGKV3D-20 Ig lambda chain V-I region HA Lipoteichoic acid IGLV1-44(1-?) C3 beta chain C3 beta chain CD55C-reactiveproteinpentamer:phosphocholine:C1QC4B(20-675) Cell surface CFIC1QA Ig kappa chain V-I region AG C3d MASP1(20-699) Ig heavy chain V-III region DOB MBL2 dodecamer:MASP1dimer:MASP2-1dimer:Bacterialmannose surfacepattern:4xCa2+C4 alpha Ig heavy chain V-III region TRO C4d, iC3bIGKV4-1(21-?) MASP1(20-699) C3c alpha' chain fragment 1 C3 beta chain C5 beta chain IGHV7-81(1-?) C5 alpha chain IGHG1 Ig heavy chain V-III region KOL C4B(20-675)