Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA (Homo sapiens)

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1, 2, 5, 12, 13, 151, 2, 5, 6, 12...1-5, 7, 9...1, 2, 5, 12, 15cytosolMYC mRNA isoform 201 CD44 mRNA isoform 201 IGF2BP3 CD44 mRNA isoform 202 CD44 mRNA isoform 205 IGF2-001 mRNA IGF2BP2:RNAH19 noncoding RNA CD44 mRNA isoform 202 CD44 mRNA isoform 202 Beta-actin mRNA isoform 001 IGF2-002 mRNA IGF2-002 mRNA CD44 mRNA isoform 202 IGF2BP1:RNAIGF2BP2IGF2BP1 IGF2-001 mRNA H19 noncoding RNA RNAs bound byIGF2BP3CD44 mRNA isoform 201 CD44 mRNA isoform 203 CD44 mRNA isoform 203 CD44 mRNA isoform 204 IGF2BP2 RNAs bound byIGF2BP2IGF2BP3:RNAIGF2-002 mRNA IGF2-001 mRNA RNAs bound byIGF2BP1IGF2-001 mRNA IGF2-002 mRNA IGF2BP1CD44 mRNA isoform 203 CD44 mRNA isoform 201 CD44 mRNA isoform 203 CD44 mRNA isoform 204 MYC mRNA isoform 201 IGF2BP3IGF2-001 mRNA CD44 mRNA isoform 201 CD44 mRNA isoform 204 IGF2-001 mRNA IGF2-002 mRNA CD44 mRNA isoform 204 IGF2-002 mRNA CD44 mRNA isoform 205 CD44 mRNA isoform 205 Beta-actin mRNA isoform 001 CD44 mRNA isoform 205 1, 3, 5, 7-10, 13...1, 51, 3, 5, 7-10, 13...1, 5


Description

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs) bind specific sets of RNA and regulate their translation, stability, and subcellular localization. IGF2BP1, IGF2BP2, and IGF2BP3 bind about 8400 protein-coding transcripts. The target RNAs contain the sequence motif CAUH (where H is A, U, or, C) and binding of IGFBPs increases the stability of the target RNAs. View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 428359
Reactome-version 
Reactome version: 66
Reactome Author 
Reactome Author: May, Bruce

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Ontology Terms

 

Bibliography

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  1. Yisraeli JK.; ''VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins.''; PubMed Europe PMC
  2. Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC.; ''A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.''; PubMed Europe PMC
  3. Ioannidis P, Mahaira L, Papadopoulou A, Teixeira MR, Heim S, Andersen JA, Evangelou E, Dafni U, Pandis N, Trangas T.; ''CRD-BP: a c-Myc mRNA stabilizing protein with an oncofetal pattern of expression.''; PubMed Europe PMC
  4. Runge S, Nielsen FC, Nielsen J, Lykke-Andersen J, Wewer UM, Christiansen J.; ''H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein.''; PubMed Europe PMC
  5. Nielsen FC, Nielsen J, Christiansen J.; ''A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking.''; PubMed Europe PMC
  6. Groenewoud MJ, Dekker JM, Fritsche A, Reiling E, Nijpels G, Heine RJ, Maassen JA, Machicao F, Schäfer SA, Häring HU, 't Hart LM, van Haeften TW.; ''Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps.''; PubMed Europe PMC
  7. Noubissi FK, Elcheva I, Bhatia N, Shakoori A, Ougolkov A, Liu J, Minamoto T, Ross J, Fuchs SY, Spiegelman VS.; ''CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling.''; PubMed Europe PMC
  8. Hüttelmaier S, Zenklusen D, Lederer M, Dictenberg J, Lorenz M, Meng X, Bassell GJ, Condeelis J, Singer RH.; ''Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1.''; PubMed Europe PMC
  9. Lemm I, Ross J.; ''Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant.''; PubMed Europe PMC
  10. Weidensdorfer D, Stöhr N, Baude A, Lederer M, Köhn M, Schierhorn A, Buchmeier S, Wahle E, Hüttelmaier S.; ''Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.''; PubMed Europe PMC
  11. Chao JA, Patskovsky Y, Patel V, Levy M, Almo SC, Singer RH.; ''ZBP1 recognition of beta-actin zipcode induces RNA looping.''; PubMed Europe PMC
  12. Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T.; ''Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.''; PubMed Europe PMC
  13. Oberman F, Rand K, Maizels Y, Rubinstein AM, Yisraeli JK.; ''VICKZ proteins mediate cell migration via their RNA binding activity.''; PubMed Europe PMC
  14. Christiansen J, Kolte AM, Hansen Tv, Nielsen FC.; ''IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes.''; PubMed Europe PMC
  15. Vikesaa J, Hansen TV, Jønson L, Borup R, Wewer UM, Christiansen J, Nielsen FC.; ''RNA-binding IMPs promote cell adhesion and invadopodia formation.''; PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
101390view11:27, 1 November 2018ReactomeTeamreactome version 66
100928view21:03, 31 October 2018ReactomeTeamreactome version 65
100467view19:37, 31 October 2018ReactomeTeamreactome version 64
100013view16:21, 31 October 2018ReactomeTeamreactome version 63
99566view14:54, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99190view12:42, 31 October 2018ReactomeTeamreactome version 62
93763view13:34, 16 August 2017ReactomeTeamreactome version 61
93287view11:19, 9 August 2017ReactomeTeamreactome version 61
86371view09:16, 11 July 2016ReactomeTeamreactome version 56
83361view10:58, 18 November 2015ReactomeTeamVersion54
81774view10:26, 26 August 2015ReactomeTeamVersion53
77054view08:35, 17 July 2014ReactomeTeamFixed remaining interactions
76759view12:12, 16 July 2014ReactomeTeamFixed remaining interactions
76085view10:14, 11 June 2014ReactomeTeamRe-fixing comment source
75795view11:32, 10 June 2014ReactomeTeamReactome 48 Update
75145view14:09, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74792view08:52, 30 April 2014ReactomeTeamReactome46
44977view14:24, 6 October 2011MartijnVanIerselOntology Term : 'insulin-like growth factor signaling pathway' added !
42012view21:50, 4 March 2011MaintBotAutomatic update
39815view05:51, 21 January 2011MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Beta-actin mRNA isoform 001 ProteinENST00000331789 (Ensembl)
CD44 mRNA isoform 201 ProteinENST00000263398 (Ensembl)
CD44 mRNA isoform 202 ProteinENST00000278385 (Ensembl)
CD44 mRNA isoform 203 ProteinENST00000278386 (Ensembl)
CD44 mRNA isoform 204 ProteinENST00000279452 (Ensembl)
CD44 mRNA isoform 205 ProteinENST00000352818 (Ensembl)
H19 noncoding RNA ProteinENST00000252900 (Ensembl)
IGF2-001 mRNA ProteinENST00000381406 (Ensembl)
IGF2-002 mRNA ProteinENST00000337883 (Ensembl)
IGF2BP1 ProteinQ9NZI8 (Uniprot-TrEMBL)
IGF2BP1:RNAComplexR-HSA-428327 (Reactome)
IGF2BP1ProteinQ9NZI8 (Uniprot-TrEMBL)
IGF2BP2 ProteinQ9Y6M1 (Uniprot-TrEMBL)
IGF2BP2:RNAComplexR-HSA-428335 (Reactome)
IGF2BP2ProteinQ9Y6M1 (Uniprot-TrEMBL)
IGF2BP3 ProteinO00425 (Uniprot-TrEMBL)
IGF2BP3:RNAComplexR-HSA-428310 (Reactome)
IGF2BP3ProteinO00425 (Uniprot-TrEMBL)
MYC mRNA isoform 201 ProteinENST00000613283 (Ensembl)
RNAs bound by IGF2BP1ComplexR-HSA-428308 (Reactome)
RNAs bound by IGF2BP2ComplexR-HSA-428328 (Reactome)
RNAs bound by IGF2BP3ComplexR-HSA-428384 (Reactome)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
IGF2BP1:RNAArrowR-HSA-428296 (Reactome)
IGF2BP1R-HSA-428296 (Reactome)
IGF2BP2:RNAArrowR-HSA-428293 (Reactome)
IGF2BP2R-HSA-428293 (Reactome)
IGF2BP3:RNAArrowR-HSA-428287 (Reactome)
IGF2BP3R-HSA-428287 (Reactome)
R-HSA-428287 (Reactome) Insulin-like Growth Factor mRNA Binding Factor-3 (IGF2BP3, also known as IMP3 and VICKZ3) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA.
Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP3 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive).
R-HSA-428293 (Reactome) Insulin-like Growth Factor mRNA Binding Factor-2 (IGF2BP2, also known as IMP2 and VICKZ2) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA.
Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP2 at the 5' UTR, repressing translation (Other isoforms of IGF2 are constitutive).
IGF2BP2 may be a causal factor in type 2 diabetes.
R-HSA-428296 (Reactome) Insulin-like Growth Factor mRNA Binding Factor-1 (IGF2BP1, also known as ZBP1, CRD-BP, IMP1, and VICKZ1) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA.
Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP1 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive).
ZBP1 (IGF2BP1) uses its third and fourth KH domains to recognize the first 28 nts of the 3' UTR of Beta actin mRNA. The KH domains are arranged as an anti-parallel pseudo-dimer that specifically recognize a bipartite element located in this RNA sequence.
MYC (c-MYC) and Beta-TRCP1 mRNAs are bound at sites termed Coding Region Determinants (CDRs) in the open reading frame of the message. Binding of the MYC mRNA shields it from degradation and increases its half-life
The CD44 mRNA is bound at the 3' UTR.
IGF2BP1 also binds the non-coding, imprinted H19 RNA.
RNAs bound by IGF2BP1R-HSA-428296 (Reactome)
RNAs bound by IGF2BP2R-HSA-428293 (Reactome)
RNAs bound by IGF2BP3R-HSA-428287 (Reactome)
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