Bile acid and bile salt metabolism (Homo sapiens)
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19, 41, 49, 60
58
12, 39
40, 53
3
24, 40, 53
19
18, 28, 55
30, 54
32
57
7
19
57
59
19
40, 53
16, 56, 65
3
64
11, 50, 52
24, 40, 53
5
19
6, 15, 23, 31, 37...
33, 38
11, 50, 52
34, 42
10
22, 46
64
13
19
29
41, 49, 61
64
19
11, 50, 52
57
19
18, 28, 55
64
19
53
26, 47
9, 45
3
12, 39
8, 21, 63
3
40, 53
30, 54
19
25, 51
11, 50, 52
1, 2
25, 51
52
11, 50, 52
30, 54
18, 28, 55
57
24, 40, 53
59
11, 50, 52
40, 53
19
40, 53
29
19
40, 53
40, 53
1, 2
11, 50, 52
17, 20, 59
19
4, 14, 27, 35, 36, 43...
24, 40, 53
65
11, 50, 52
22, 46
4, 27, 35, 36, 43...
40, 53
19
64
19
64
19
3
19
22, 46
18, 28, 55
1, 2
3
nucleoplasm
endoplasmic reticulum lumen
mitochondrial matrix
Golgi lumen
nucleoplasm
cytosol
cytosol
cytosol
endoplasmic reticulum lumen
endoplasmic reticulum lumen
cytosol
endoplasmic reticulum lumen
mitochondrial matrix
endoplasmic reticulum lumen
nucleoplasm
endoplasmic reticulum lumen
peroxisomal matrix
H+
NADPH
SLCO1B1
H2O
SLCO1A2
bile salts and acids
PTGIS
CYP7A1
NADP+
CH25H
TCCA
TCDCA
AKR1D1
(24R,
25R)
3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
NCOA2
RXRA
glycine; taurine
taurocholate
NADP+
DHCA
NADP+
O2
CDCA
AKR1C2
ABCB11
O2
NAD+
TCCA
TCDCA
albumin:bile salt
and acid (OATP-A)
complex
NADPH
BAAT
H+
GCDCA
H2O
NADP+
3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
PTGIS
PPi
NCOA2
Cytochrome P450
(CYP7B1 based)
NADP+
NCOA1
NADP+
DCA
CCA
NR1H4
OSBPL6
Na+
Cytochrome P450
(CYP8B1 based)
3,7,24THCA-CoA
ATP
Aldo-keto reductase
family
O2
H+
CCA
O2
25OH-CHOL
Gly
H2O
NCOA2
NADP+
H2O
ATP
H+
DHCA
24OH-CHOL
H+
25(R) DHCA-CoA
TCCA
CDCA
CH25H (Fe2+
cofactor)
TCCA
GCCA
H2O
NADP+
CYP7B1
CDCA
25(S)
3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA
ALB
CYP8B1
OSBPL1A
H2O
LCHA
H+
CYP39A1
CoA-SH
O2
NADPH
GCDCA
TCCA
PPi
ABCC3
GCDCA
CoA-SH
NADP+
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol
4CHOL7a,27DONE
Na+
DCA
NADPH
AKR1C4
H+
taurochenodeoxycholate
AKR1C2
CYP27A1
bile salts and acids
(OATP-A)
DCA
O2
CYP27A1
TCCA
25OH-CHOL
chenodeoxycholoyl-CoA
FAD
Na+
H+
H+
NADP+
H+
NR1H4:DCA,CDCA,LCHA
H2O
H+
GCDCA
NADPH
NADPH
3,7,24THCA-CoA
THCA-CoA
SCP2-1
LCA
H2O
TCCA
GCCA
GCCA
O2
GCCA
THCA
25(R) DHCA-CoA
GCCA, TCCA
GCCA
ALB
5beta-cholestan-7alpha,24(S)-diol-3-one
CHOL7a,24(S)DIOL
5beta-cholestan-3alpha, 7alpha-diol
Pi
H2O
CCA
SLC10A1
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA
OSBPs
5β-CHOL3α,7α,24(s)-triol
TCDCA
NAD+
GCDCA
CDCA
Cytochrome P450
(CYP7A1 based)
NADPH
H+
CYP27A1
GCCA
ACOT8
5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol
NADPH
CYP7A1
BAAT
NADPH
CHOL3b,7a,25TRIOL
bile salts
ALB
CDCA
25(R) THCA-CoA
H+
H+
24OH-CHOL
Cytochrome P450
(CYP7B1 based)
5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol
DCA
glycine; taurine
chenodeoxycholoyl-CoA
H2O
H2O
NADH
ATP
CHOL
CYP7A1
SLC27A2
NR1H4
CHOL
RXRA
CCA
SLC10A2
NADPH
TCCA
cholate
NAD+
bile salts
FABP6
Cytochrome P450
(CYP8B1 based)
AKR1C3
5beta-cholestan-3alpha,7alpha,12alpha-triol
25(S) DHCA-CoA
CCA
CYP8B1
H2O
3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA
choloyl-CoA
NADPH
AMP
NADPH
glycocholate
NADP+
H+
ACOX2
O2
H2O
24OH-CHOL
3,7,24THCA-CoA
ADP
PTGIS
AKR1D1
H+
NADH
27OH-CHOL
RXRA
CDCA
CDCA
NADP+
GCCA
CYP27A1
H+
NADPH
ATP
OSBPL3
HSD17B4 dimer
NADPH
CYP7B1
SLCO1B3
AMP
NADP+
3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al
TCCA
7
alpha-hydroxycholesterol
AKR1D1
CYP8B1
NADP+
27HCHOL
25(R) THCA-CoA
GCDCA
TetraHCA
taurocholate
STARD5:DCA,LCA
propionyl CoA
O2
25OH-CHOL
CDCA
TetraHCA
4CHOL7a,12aDONE
STARD5
bile salts and
acids:FABP6
TAU
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol
TCDCA
GCCA
NADP+
H2O
NCOA2
PPi
TCDCA
ALB:(GCCA, TCCA)
NADP+
AMP
H+
H2O
CDCA
4CHOL7a,12a,27TONE
GCCA
glycocholate
NADP+
TCCA
H2O
Aldo-keto reductase
family
SLC27A2
25OH-CHOL
Gly
5bCHOL3a,7a,12a,27-tetrol
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA
3,7,24THCA
5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one
bile salts
AKR1C1
THCA
HSD3B7
5beta-cholesten-7alpha, 12alpha-diol-3-one
O2
LCHA
Aldo-keto reductase
family
cholate bile salts
NADP+
27OH-CHOL
DCA
3,7,24THCA
NADPH
CoA-SH
O2
O2
ALB
5bCHOL3a,7a,12a-triol
choloyl-CoA
5bCHOL3a,7a,24(s),27-tetrol
NADPH
CoA-SH
NCOA1
NAD+
H2O
CCA
RXRA
5beta-cholestan-3alpha,7alpha,24(S)-triol
SLC27A5
5beta-cholestan-3alpha,7alpha-diol
CYP27A1
H2O2
TCDCA
albumin:bile salt
complex
5beta-cholestan-7alpha,27-diol-3-one
HSD17B4(1-736)
NADPH
Cholest-5-ene-3beta,7alpha,27-triol
O2
AMACR
25(R) TetraHCA-CoA
H+
TAU
glycochenodeoxycholate
NADP+
TCDCA
NADP+
NADH
NR1H4
NADPH
NADPH
taurochenodeoxycholate
TCDCA
AKR1C4
AKR1C2
H+
H+
CYP27A1
25(S) THCA-CoA
ADP
CYP27A1
GCCA
H+
TCCA
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA
25(R) TetraHCA-CoA
O2
OSBP
O2
NADPH
glycochenodeoxycholate
Na+
bile salts and acids
complexed with
albumin
ATP
NADH
OSBPL9
5beta-cholestan-3alpha,7alpha,26-triol
AKR1C3
SLC27A5
CDCA
CDCA
H+
ACOX2:FAD
choloyl-CoA;
chenodeoxycholoyl-CoA
H+
CoA-SH
CoA-SH
H+
CHOL
NCOA1
Cytochrome P450
(CYP8B1 based)
cholate;
chenodeoxycholate
5beta-cholestan-7alpha-ol-3-one
LCHA
5beta-cholestan-3alpha,7alpha,26-triol
SLC27A5
4CHOL7a,24(S)DONE
3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al
PI4P
5beta-cholestan-7alpha,12alpha,27-triol-3-one
chenodeoxycholate
bile salts
DCA
4CHOL7a,12a,24(S)TONE
ALB
AKR1C1
OSBPL2
CHOL
H2O
OSBPL7
H+
NADP+
LCHA
AKR1C4
H2O
H2O
NADPH
LCHA
STARD5
CCA
NR1H4
NCOA1
CoA-SH
4CHOL7aOLONE
HSD3B7
LCA
Fe2+
bile salts
NADP+
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
O2
CYP46A1
Pi
HSD3B7
NADPH
PI4P
FABP6
NR1H4
AKR1C1
GCDCA
CYP7B1
GCCA
AKR1C3
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA
TCDCA
DCA
DCA,CDCA,LCHA