Bile acid and bile salt metabolism (Homo sapiens)

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19, 41, 49, 605812, 3940, 53324, 40, 531918, 28, 5530, 54325771957591940, 5316, 56, 6536411, 50, 5224, 40, 535196, 15, 23, 31, 37...33, 3811, 50, 5234, 421022, 466413192941, 49, 61641911, 50, 52571918, 28, 5564195326, 479, 45312, 398, 21, 63340, 5330, 541925, 5111, 50, 521, 225, 515211, 50, 5230, 5418, 28, 555724, 40, 535911, 50, 5240, 531940, 53291940, 5340, 531, 211, 50, 5217, 20, 59194, 14, 27, 35, 36, 43...24, 40, 536511, 50, 5222, 464, 27, 35, 36, 43...40, 53196419641931922, 4618, 28, 551, 23nucleoplasmendoplasmic reticulum lumenmitochondrial matrixGolgi lumennucleoplasmcytosolcytosolcytosolendoplasmic reticulum lumenendoplasmic reticulum lumencytosolendoplasmic reticulum lumenmitochondrial matrixendoplasmic reticulum lumennucleoplasmendoplasmic reticulum lumenperoxisomal matrixH+NADPHSLCO1B1H2OSLCO1A2bile salts and acidsPTGIS CYP7A1 NADP+CH25H TCCA TCDCA AKR1D1(24R,25R)3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoANCOA2 RXRA glycine; taurinetaurocholate NADP+DHCANADP+O2CDCA AKR1C2 ABCB11O2NAD+TCCA TCDCA albumin:bile saltand acid (OATP-A)complexNADPHBAATH+GCDCA H2ONADP+3alpha,7alpha-dihydroxy-5beta-cholestan-26-alPTGIS PPiNCOA2 Cytochrome P450(CYP7B1 based)NADP+NCOA1 NADP+DCA CCA NR1H4 OSBPL6 Na+Cytochrome P450(CYP8B1 based)3,7,24THCA-CoAATPAldo-keto reductasefamilyO2H+CCA O225OH-CHOLGly H2ONCOA2NADP+H2OATPH+DHCA24OH-CHOLH+25(R) DHCA-CoATCCA CDCA CH25H (Fe2+cofactor)TCCA GCCA H2ONADP+CYP7B1 CDCA 25(S)3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoAALB CYP8B1 OSBPL1A H2OLCHA H+CYP39A1CoA-SHO2NADPHGCDCA TCCA PPiABCC3GCDCA CoA-SHNADP+5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol4CHOL7a,27DONENa+DCA NADPHAKR1C4 H+taurochenodeoxycholate AKR1C2 CYP27A1bile salts and acids(OATP-A)DCAO2CYP27A1TCCA 25OH-CHOLchenodeoxycholoyl-CoA FAD Na+H+H+NADP+H+NR1H4:DCA,CDCA,LCHAH2OH+GCDCA NADPHNADPH3,7,24THCA-CoATHCA-CoASCP2-1LCAH2OTCCA GCCA GCCA O2GCCA THCA25(R) DHCA-CoAGCCA, TCCAGCCA ALB5beta-cholestan-7alpha,24(S)-diol-3-oneCHOL7a,24(S)DIOL5beta-cholestan-3alpha, 7alpha-diolPiH2OCCASLC10A13alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoAOSBPs5β-CHOL3α,7α,24(s)-triolTCDCA NAD+GCDCA CDCA Cytochrome P450(CYP7A1 based)NADPHH+CYP27A1GCCA ACOT85beta-cholestan-3alpha,7alpha,12alpha,27-tetrolNADPHCYP7A1 BAATNADPHCHOL3b,7a,25TRIOLbile saltsALB CDCA 25(R) THCA-CoAH+H+24OH-CHOLCytochrome P450(CYP7B1 based)5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentolDCA glycine; taurinechenodeoxycholoyl-CoAH2OH2ONADHATPCHOLCYP7A1 SLC27A2NR1H4 CHOLRXRACCA SLC10A2NADPHTCCA cholateNAD+bile saltsFABP6 Cytochrome P450(CYP8B1 based)AKR1C3 5beta-cholestan-3alpha,7alpha,12alpha-triol25(S) DHCA-CoACCA CYP8B1 H2O3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoAcholoyl-CoANADPHAMPNADPHglycocholate NADP+H+ACOX2 O2H2O24OH-CHOL3,7,24THCA-CoAADPPTGIS AKR1D1H+NADH27OH-CHOLRXRA CDCA CDCA NADP+GCCA CYP27A1H+NADPHATPOSBPL3 HSD17B4 dimerNADPHCYP7B1 SLCO1B3AMPNADP+3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-alTCCA 7alpha-hydroxycholesterolAKR1D1CYP8B1 NADP+27HCHOL25(R) THCA-CoAGCDCA TetraHCAtaurocholate STARD5:DCA,LCApropionyl CoAO225OH-CHOLCDCA TetraHCA4CHOL7a,12aDONESTARD5 bile salts andacids:FABP6TAU 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrolTCDCA GCCA NADP+H2ONCOA2 PPiTCDCA ALB:(GCCA, TCCA)NADP+AMPH+H2OCDCA 4CHOL7a,12a,27TONEGCCA glycocholate NADP+TCCA H2OAldo-keto reductasefamilySLC27A225OH-CHOLGly 5bCHOL3a,7a,12a,27-tetrolNCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA3,7,24THCA5beta-cholestan-7alpha,12alpha,24(S)-triol-3-onebile saltsAKR1C1 THCAHSD3B75beta-cholesten-7alpha, 12alpha-diol-3-oneO2LCHA Aldo-keto reductasefamilycholate bile saltsNADP+27OH-CHOLDCA 3,7,24THCANADPHCoA-SHO2O2ALB 5bCHOL3a,7a,12a-triolcholoyl-CoA 5bCHOL3a,7a,24(s),27-tetrolNADPHCoA-SHNCOA1 NAD+H2OCCA RXRA 5beta-cholestan-3alpha,7alpha,24(S)-triolSLC27A55beta-cholestan-3alpha,7alpha-diolCYP27A1H2O2TCDCA albumin:bile saltcomplex5beta-cholestan-7alpha,27-diol-3-oneHSD17B4(1-736) NADPHCholest-5-ene-3beta,7alpha,27-triolO2AMACR25(R) TetraHCA-CoAH+TAU glycochenodeoxycholate NADP+TCDCA NADP+NADHNR1H4NADPHNADPHtaurochenodeoxycholate TCDCA AKR1C4 AKR1C2 H+H+CYP27A125(S) THCA-CoAADPCYP27A1GCCA H+TCCA NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA25(R) TetraHCA-CoAO2OSBPO2NADPHglycochenodeoxycholate Na+bile salts and acidscomplexed withalbuminATPNADHOSBPL9 5beta-cholestan-3alpha,7alpha,26-triolAKR1C3 SLC27A5CDCA CDCA H+ACOX2:FADcholoyl-CoA;chenodeoxycholoyl-CoAH+CoA-SHCoA-SHH+CHOLNCOA1Cytochrome P450(CYP8B1 based)cholate;chenodeoxycholate5beta-cholestan-7alpha-ol-3-oneLCHA 5beta-cholestan-3alpha,7alpha,26-triolSLC27A54CHOL7a,24(S)DONE3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-alPI4P5beta-cholestan-7alpha,12alpha,27-triol-3-onechenodeoxycholatebile saltsDCA 4CHOL7a,12a,24(S)TONEALB AKR1C1 OSBPL2 CHOLH2OOSBPL7 H+NADP+LCHA AKR1C4 H2OH2ONADPHLCHA STARD5CCA NR1H4 NCOA1 CoA-SH4CHOL7aOLONEHSD3B7LCA Fe2+ bile saltsNADP+3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-alO2CYP46A1PiHSD3B7NADPHPI4PFABP6NR1H4 AKR1C1 GCDCA CYP7B1 GCCA AKR1C3 NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHATCDCA DCA DCA,CDCA,LCHA