Bile acid and bile salt metabolism (Homo sapiens)

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6, 11, 18, 529, 26, 475712, 613626, 474, 14, 4919, 35364, 14, 49361821, 54261426, 4718364, 14, 494, 14, 4921, 543619, 3548, 651818184, 14, 496, 13, 529, 26, 4720, 622426, 476439423, 30, 32, 43, 55...19, 355337, 5018412418247, 25, 2826, 4718249, 26, 472739181, 151822, 53, 5826, 471820, 625, 5116461, 15537, 25, 289, 26, 4721, 5426, 4710, 23, 33, 34, 38...4, 14, 4917, 29, 592416, 31, 602, 818394, 14, 491, 15572, 826, 4739244, 14, 491826, 471810, 23, 33, 34, 38...7, 25, 284518187, 25, 2836cytosolnucleoplasmmitochondrial matrixmitochondrial matrixendoplasmic reticulum lumenendoplasmic reticulum lumenendoplasmic reticulum lumenendoplasmic reticulum lumenendoplasmic reticulum lumencytosolnucleoplasmcytosolnucleoplasmperoxisomal matrixGolgi lumencytosolendoplasmic reticulum lumenNADP+NADPHAKR1C2 NCOA1 H2OGCCA O2NAD+NADPHAKR1C1 CoA-SHGCCA NADP+glycochenodeoxycholate H2O5beta-cholesten-7alpha, 12alpha-diol-3-oneAMP4CHOL7a,12a,27TONEAKR1D1CDCA NADP+Gly TCDCA DCA ATPNADPH27HCHOL5beta-cholestan-7alpha,27-diol-3-oneSLC27A5LCHA Na+DHCAOSBPL9 NADP+SLCO1B1OSBP3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoATCCA GCCA H+CYP8B1 7alpha-hydroxycholesterolTCDCA choloyl-CoA 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one25(S) THCA-CoA25(S) DHCA-CoASCP2-1NADPHCYP27A1STARD5 25OH-CHOLNADPHNADP+5beta-cholestan-3alpha,7alpha,12alpha,27-tetrolCDCA GCCA AMACRRXRANR1H4H2OCytochrome P450(CYP7A1 based)RXRA NCOA1 AKR1C4 NADP+NADPHNAD+25(R) THCA-CoAO2H+TCDCA THCAGCCA, TCCA5beta-cholestan-3alpha,7alpha,26-triolAldo-keto reductasefamilyO2PPiH+5beta-cholestan-3alpha,7alpha-diolTCCA 5bCHOL3a,7a,12a-triolNADP+O2DCA LCA H2Otaurocholate H+O2bile salts andacids:FABP6H+H2OPI4P25(R) DHCA-CoANADPHOSBPL3 ACOX2 ATP25OH-CHOLAKR1C2 H+NCOA2 NR1H4:DCA,CDCA,LCHA3,7,24THCAH2OALBCCA H2OACOT8CYP8B1 CoA-SHH+H2O2bile saltsLCHA NADP+LCANR1H4 NADP+DCA CDCA cholate;chenodeoxycholateNADPHNADPHTCDCA NADPHGCDCA DHCA3,7,24THCAH2OH2OGCCA NADP+Cytochrome P450(CYP8B1 based)25(R) DHCA-CoAO225(S)3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoAH+TCDCA CDCA TCCA chenodeoxycholoyl-CoA NADPH3,7,24THCA-CoAtaurochenodeoxycholate TCDCA H2OH2Otaurochenodeoxycholate NR1H4 CDCA FABP6 H+ALB:(GCCA, TCCA)Cytochrome P450(CYP8B1 based)NCOA14CHOL7a,27DONEcholate bile salts3alpha,7alpha-dihydroxy-5beta-cholestan-26-alGCCA NCOA1 TCCA RXRA CYP7B1 24OH-CHOL3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-alCCA NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHATCCA Cholest-5-ene-3beta,7alpha,27-triolALB TCCA O2CYP39A1STARD5Pi24OH-CHOLSLC27A5CYP46A1H+H+Cytochrome P450(CYP8B1 based)H2OH+SLC10A2NADP+NADPHNAD+CYP27A1Aldo-keto reductasefamilySLC27A5PPiATPTetraHCACH25H CCA NADP+ADPGCDCA NADPHH+27OH-CHOLH+CHOL7a,24(S)DIOLCoA-SHGCDCA 5bCHOL3a,7a,12a,27-tetrolH+ALB 5beta-cholestan-3alpha, 7alpha-diolSLC10A1H+TCCA HSD17B4 dimerCYP7B1 LCHA NCOA2 OSBPL1A H+bile saltscholoyl-CoA;chenodeoxycholoyl-CoAH2OHSD17B4(1-736) AKR1C4 4CHOL7aOLONE5beta-cholestan-7alpha,12alpha,27-triol-3-oneOSBPL2 NR1H4 3,7,24THCA-CoAAKR1C1 NR1H4 NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHAH+AKR1C3 NADPHDCAglycine; taurinealbumin:bile saltcomplexPI4PCHOL3b,7a,25TRIOL3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-alHSD3B7CCACoA-SHBAATCYP27A1NADPH25(R) TetraHCA-CoAAKR1C4 NADHNADPHAMPTCCA TCCA NADP+H+SLCO1A2bile saltsATPH2ONa+O2NADPH3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoASLC27A2TAU Cytochrome P450(CYP7B1 based)TCCA PTGIS OSBPL7 NADPHH2OCYP7A1 CCA NADPHNADHBAATFe2+ O2NADHH+25OH-CHOLNADP+STARD5:DCA,LCAglycocholate CYP27A1O2CCA 5beta-cholestan-3alpha,7alpha,12alpha-triolACOX2:FADH2Obile salts and acidsNADP+Pibile salts and acids(OATP-A)CYP27A1THCA-CoACYP7A1 O2TCDCA LCHA ADPTCDCA GCDCA Gly 5beta-cholestan-7alpha-ol-3-oneH2O25(R) THCA-CoADCA,CDCA,LCHAAKR1C3 CHOLHSD3B7H+GCCA GCDCA SLCO1B3CoA-SHcholateTHCA3,7,24THCA-CoACoA-SHH2OCDCA NADP+NAD+TAU albumin:bile saltand acid (OATP-A)complexAKR1C1 choloyl-CoA3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-alLCHA GCDCA AKR1D1TCCA GCCA PTGIS chenodeoxycholatebile saltsCYP8B1 H2O25(R) TetraHCA-CoA4CHOL7a,12aDONEDCA CDCA glycochenodeoxycholate ALB ALB CoA-SH27OH-CHOLH+(24R,25R)3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoAH+NADPHNADP+24OH-CHOLAldo-keto reductasefamilypropionyl CoAGCDCA chenodeoxycholoyl-CoACHOLAKR1C3 O25beta-cholestan-7alpha,24(S)-diol-3-oneCDCA 4CHOL7a,12a,24(S)TONE5bCHOL3a,7a,24(s),27-tetrolNADP+25OH-CHOLtaurocholate CDCA NADP+O25beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrolTetraHCACYP27A15beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentolCCA NADP+DCA AMPCYP27A15beta-cholestan-3alpha,7alpha,26-triolO2AKR1D1NCOA2 CDCA NADPHH2ONCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHANADHH+glycine; taurineH+OSBPsNCOA2GCCA CH25H (Fe2+cofactor)HSD3B7bile salts5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrolH+CYP7A1 FAD CHOLCHOLO2SLC27A2GCCA Na+DCA NADPHCDCA PPi4CHOL7a,24(S)DONERXRA Na+glycocholate O2ABCC35β-CHOL3α,7α,24(s)-triolCYP7B1 OSBPL6 ATPNADP+5beta-cholestan-3alpha,7alpha,24(S)-triolGCCA NADP+ABCB11TCDCA bile salts and acidscomplexed withalbuminAKR1C2 Cytochrome P450(CYP7B1 based)FABP6PTGIS