Bile acid and bile salt metabolism (Homo sapiens)
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19, 41, 49, 60
25, 51
1, 2
64
24, 40, 53
57
7
11, 50, 52
4, 27, 35, 36, 43...
19
59
11, 50, 52
19
3
10
64
64
3
18, 28, 55
64
17, 20, 59
13
19
18, 28, 55
57
25, 51
30, 54
18, 28, 55
24, 40, 53
16, 56, 65
57
22, 46
11, 50, 52
58
40, 53
4, 14, 27, 35, 36, 43...
40, 53
33, 38
40, 53
19
19
19
11, 50, 52
40, 53
57
59
19
3
22, 46
19
3
34, 42
52
53
26, 47
40, 53
3
24, 40, 53
19
11, 50, 52
19
11, 50, 52
40, 53
19
29
22, 46
12, 39
11, 50, 52
1, 2
41, 49, 61
19
19
3
64
24, 40, 53
30, 54
29
65
19
40, 53
5
19
1, 2
30, 54
12, 39
6, 15, 23, 31, 37...
18, 28, 55
9, 45
11, 50, 52
40, 53
8, 21, 63
19
32
64
mitochondrial matrix
endoplasmic reticulum lumen
endoplasmic reticulum lumen
nucleoplasm
endoplasmic reticulum lumen
endoplasmic reticulum lumen
cytosol
Golgi lumen
cytosol
nucleoplasm
peroxisomal matrix
mitochondrial matrix
nucleoplasm
endoplasmic reticulum lumen
cytosol
endoplasmic reticulum lumen
cytosol
H+
glycochenodeoxycholate
O2
NCOA2
TCCA
GCCA
TAU
NADP+
NADPH
O2
DCA,CDCA,LCHA
CHOL3b,7a,25TRIOL
CHOL
H+
5beta-cholestan-3alpha,7alpha,12alpha-triol
GCDCA
Cytochrome P450
(CYP8B1 based)
NADPH
DCA
3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA
TCDCA
NADP+
AKR1C3
CDCA
DCA
CCA
NCOA2
TCCA
NADPH
CCA
3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
O2
AKR1D1
ATP
STARD5
Gly
CDCA
PI4P
OSBPL2
NADPH
H+
NADPH
NADP+
TCCA
CYP8B1
NADP+
SLCO1A2
5beta-cholestan-7alpha,12alpha,27-triol-3-one
O2
25(R) TetraHCA-CoA
NR1H4:DCA,CDCA,LCHA
Pi
bile salts and acids
complexed with
albumin
CoA-SH
NADPH
DCA
NR1H4
AKR1C1
4CHOL7a,12aDONE
CCA
25OH-CHOL
FABP6
NADP+
H+
Fe2+
ALB:(GCCA, TCCA)
AKR1D1
H2O
THCA
NADPH
H+
3,7,24THCA
DHCA
CYP7B1
OSBPL1A
AKR1C4
GCCA
ADP
SLC27A5
GCDCA
5bCHOL3a,7a,24(s),27-tetrol
ADP
O2
PPi
GCCA, TCCA
H2O
GCDCA
CHOL
chenodeoxycholoyl-CoA
CoA-SH
taurocholate
SLCO1B3
HSD3B7
5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol
DCA
NADPH
GCDCA
ABCC3
NAD+
ALB
4CHOL7a,12a,24(S)TONE
CYP27A1
TCDCA
TCDCA
NR1H4
CHOL
albumin:bile salt
and acid (OATP-A)
complex
AMP
CDCA
H+
CYP39A1
LCA
H2O
choloyl-CoA;
chenodeoxycholoyl-CoA
24OH-CHOL
NAD+
NR1H4
24OH-CHOL
H2O
CoA-SH
NADP+
DCA
NADP+
SLC27A2
O2
H+
27OH-CHOL
ATP
LCHA
H+
H+
PTGIS
H+
HSD3B7
25OH-CHOL
5beta-cholestan-3alpha,7alpha,26-triol
27OH-CHOL
5beta-cholestan-7alpha-ol-3-one
DCA
HSD17B4 dimer
cholate
GCCA
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA
NADPH
CYP8B1
AMACR
PPi
bile salts
OSBPL7
NADPH
5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one
CDCA
NADP+
GCDCA
LCA
ACOT8
O2
CYP27A1
H+
SLC27A5
FAD
TCDCA
STARD5
Cholest-5-ene-3beta,7alpha,27-triol
NADH
AKR1C2
GCCA
TCDCA
ACOX2:FAD
TCDCA
Gly
Cytochrome P450
(CYP7B1 based)
H+
5beta-cholestan-3alpha,7alpha,26-triol
NADPH
3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al
CCA
CYP27A1
O2
5beta-cholesten-7alpha, 12alpha-diol-3-one
TCCA
bile salts and acids
(OATP-A)
5beta-cholestan-3alpha,7alpha,24(S)-triol
Cytochrome P450
(CYP8B1 based)
CHOL7a,24(S)DIOL
NADPH
O2
choloyl-CoA
Cytochrome P450
(CYP7B1 based)
NADPH
CDCA
25(S) DHCA-CoA
FABP6
BAAT
H2O
AKR1C4
NADPH
NADPH
3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al
25(R) DHCA-CoA
NCOA2
ATP
TCDCA
Cytochrome P450
(CYP8B1 based)
CYP7A1
5beta-cholestan-7alpha,24(S)-diol-3-one
CoA-SH
CYP7A1
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
TCCA
5bCHOL3a,7a,12a,27-tetrol
RXRA
Na+
chenodeoxycholoyl-CoA
choloyl-CoA
taurochenodeoxycholate
GCDCA
H+
CHOL
25OH-CHOL
H+
NADP+
O2
cholate;
chenodeoxycholate
Aldo-keto reductase
family
O2
NADPH
TCCA
3,7,24THCA-CoA
3,7,24THCA-CoA
H2O
glycochenodeoxycholate
CCA
Aldo-keto reductase
family
H+
H2O
Pi
LCHA
SLC27A5
NADH
PTGIS
GCCA
TCDCA
THCA
bile salts
NADH
(24R,
25R)
3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
O2
bile salts and acids
NADP+
NCOA1
ABCB11
TetraHCA
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA
NADP+
taurochenodeoxycholate
propionyl CoA
AMP
CDCA
glycocholate
3,7,24THCA-CoA
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol
H+
bile salts and
acids:FABP6
SLC10A1
NAD+
5β-CHOL3α,7α,24(s)-triol
CDCA
NCOA2
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol
5beta-cholestan-3alpha,7alpha-diol
AKR1C3
NADP+
chenodeoxycholate
bile salts
O2
DCA
O2
CYP7A1
RXRA
7
alpha-hydroxycholesterol
NADP+
H2O
glycine; taurine
ALB
25(S)
3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA
GCCA
GCCA
AKR1C1
SLC27A2
3,7,24THCA
H2O
5beta-cholestan-3alpha, 7alpha-diol
AMP
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA
OSBPL9
AKR1D1
CCA
H2O
NADH
GCCA
H+
SLCO1B1
HSD17B4(1-736)
NADP+
NR1H4
H2O
CDCA
CYP46A1
4CHOL7a,24(S)DONE
5bCHOL3a,7a,12a-triol
OSBP
CH25H (Fe2+
cofactor)
PTGIS
GCDCA
4CHOL7aOLONE
NADPH
ACOX2
5beta-cholestan-7alpha,27-diol-3-one
PI4P
ALB
CDCA
NCOA1
glycocholate
NADP+
5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol
LCHA
OSBPL6
NCOA1
Na+
ALB
NADP+
CYP7B1
25OH-CHOL
NADP+
H+
25(R) DHCA-CoA
NAD+
GCCA
TCCA
25(R) THCA-CoA
O2
NADP+
LCHA
AKR1C1
STARD5:DCA,LCA
NR1H4
AKR1C2
NADPH
H2O
H2O2
H2O
taurocholate
Na+
NADP+
O2
CoA-SH
SLC10A2
CYP27A1
H+
cholate bile salts
24OH-CHOL
H2O
Na+
25(S) THCA-CoA
PPi
TetraHCA
CYP7B1
H2O
RXRA
TCCA
H+
NADPH
H2O
4CHOL7a,12a,27TONE
H2O
ATP
TAU
25(R) THCA-CoA
DHCA
ALB
OSBPs
TCDCA
CH25H
NCOA1
NADP+
GCCA
CYP27A1
CDCA
AKR1C2
OSBPL3
H+
CCA
H2O
glycine; taurine
H+
ATP
bile salts
NADPH
H2O
GCCA
TCCA
NADPH
H2O
NADP+
AKR1C3
Cytochrome P450
(CYP7A1 based)
CoA-SH
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA
bile salts
Aldo-keto reductase
family
CoA-SH
LCHA
CYP27A1
NADPH
THCA-CoA
27HCHOL
H+
HSD3B7
H+
25(R) TetraHCA-CoA
CDCA
H+
H+
AKR1C4
TCCA
CYP27A1
TCCA
CYP8B1
BAAT
NADP+
SCP2-1
RXRA
albumin:bile salt
complex
4CHOL7a,27DONE