Bile acid and bile salt metabolism (Homo sapiens)
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6, 11, 18, 52
9, 26, 47
57
12, 61
36
26, 47
4, 14, 49
19, 35
36
4, 14, 49
36
18
21, 54
26
14
26, 47
18
36
4, 14, 49
4, 14, 49
21, 54
36
19, 35
48, 65
18
18
18
4, 14, 49
6, 13, 52
9, 26, 47
20, 62
24
26, 47
64
39
42
3, 30, 32, 43, 55...
19, 35
53
37, 50
18
41
24
18
24
7, 25, 28
26, 47
18
24
9, 26, 47
27
39
18
1, 15
18
22, 53, 58
26, 47
18
20, 62
5, 51
16
46
1, 15
53
7, 25, 28
9, 26, 47
21, 54
26, 47
10, 23, 33, 34, 38...
4, 14, 49
17, 29, 59
24
16, 31, 60
2, 8
18
39
4, 14, 49
1, 15
57
2, 8
26, 47
39
24
4, 14, 49
18
26, 47
18
10, 23, 33, 34, 38...
7, 25, 28
45
18
18
7, 25, 28
36
cytosol
nucleoplasm
mitochondrial matrix
mitochondrial matrix
endoplasmic reticulum lumen
endoplasmic reticulum lumen
endoplasmic reticulum lumen
endoplasmic reticulum lumen
endoplasmic reticulum lumen
cytosol
nucleoplasm
cytosol
nucleoplasm
peroxisomal matrix
Golgi lumen
cytosol
endoplasmic reticulum lumen
NADP+
NADPH
AKR1C2
NCOA1
H2O
GCCA
O2
NAD+
NADPH
AKR1C1
CoA-SH
GCCA
NADP+
glycochenodeoxycholate
H2O
5beta-cholesten-7alpha, 12alpha-diol-3-one
AMP
4CHOL7a,12a,27TONE
AKR1D1
CDCA
NADP+
Gly
TCDCA
DCA
ATP
NADPH
27HCHOL
5beta-cholestan-7alpha,27-diol-3-one
SLC27A5
LCHA
Na+
DHCA
OSBPL9
NADP+
SLCO1B1
OSBP
3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA
TCCA
GCCA
H+
CYP8B1
7
alpha-hydroxycholesterol
TCDCA
choloyl-CoA
5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one
25(S) THCA-CoA
25(S) DHCA-CoA
SCP2-1
NADPH
CYP27A1
STARD5
25OH-CHOL
NADPH
NADP+
5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol
CDCA
GCCA
AMACR
RXRA
NR1H4
H2O
Cytochrome P450
(CYP7A1 based)
RXRA
NCOA1
AKR1C4
NADP+
NADPH
NAD+
25(R) THCA-CoA
O2
H+
TCDCA
THCA
GCCA, TCCA
5beta-cholestan-3alpha,7alpha,26-triol
Aldo-keto reductase
family
O2
PPi
H+
5beta-cholestan-3alpha,7alpha-diol
TCCA
5bCHOL3a,7a,12a-triol
NADP+
O2
DCA
LCA
H2O
taurocholate
H+
O2
bile salts and
acids:FABP6
H+
H2O
PI4P
25(R) DHCA-CoA
NADPH
OSBPL3
ACOX2
ATP
25OH-CHOL
AKR1C2
H+
NCOA2
NR1H4:DCA,CDCA,LCHA
3,7,24THCA
H2O
ALB
CCA
H2O
ACOT8
CYP8B1
CoA-SH
H+
H2O2
bile salts
LCHA
NADP+
LCA
NR1H4
NADP+
DCA
CDCA
cholate;
chenodeoxycholate
NADPH
NADPH
TCDCA
NADPH
GCDCA
DHCA
3,7,24THCA
H2O
H2O
GCCA
NADP+
Cytochrome P450
(CYP8B1 based)
25(R) DHCA-CoA
O2
25(S)
3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA
H+
TCDCA
CDCA
TCCA
chenodeoxycholoyl-CoA
NADPH
3,7,24THCA-CoA
taurochenodeoxycholate
TCDCA
H2O
H2O
taurochenodeoxycholate
NR1H4
CDCA
FABP6
H+
ALB:(GCCA, TCCA)
Cytochrome P450
(CYP8B1 based)
NCOA1
4CHOL7a,27DONE
cholate bile salts
3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
GCCA
NCOA1
TCCA
RXRA
CYP7B1
24OH-CHOL
3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al
CCA
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA
TCCA
Cholest-5-ene-3beta,7alpha,27-triol
ALB
TCCA
O2
CYP39A1
STARD5
Pi
24OH-CHOL
SLC27A5
CYP46A1
H+
H+
Cytochrome P450
(CYP8B1 based)
H2O
H+
SLC10A2
NADP+
NADPH
NAD+
CYP27A1
Aldo-keto reductase
family
SLC27A5
PPi
ATP
TetraHCA
CH25H
CCA
NADP+
ADP
GCDCA
NADPH
H+
27OH-CHOL
H+
CHOL7a,24(S)DIOL
CoA-SH
GCDCA
5bCHOL3a,7a,12a,27-tetrol
H+
ALB
5beta-cholestan-3alpha, 7alpha-diol
SLC10A1
H+
TCCA
HSD17B4 dimer
CYP7B1
LCHA
NCOA2
OSBPL1A
H+
bile salts
choloyl-CoA;
chenodeoxycholoyl-CoA
H2O
HSD17B4(1-736)
AKR1C4
4CHOL7aOLONE
5beta-cholestan-7alpha,12alpha,27-triol-3-one
OSBPL2
NR1H4
3,7,24THCA-CoA
AKR1C1
NR1H4
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA
H+
AKR1C3
NADPH
DCA
glycine; taurine
albumin:bile salt
complex
PI4P
CHOL3b,7a,25TRIOL
3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al
HSD3B7
CCA
CoA-SH
BAAT
CYP27A1
NADPH
25(R) TetraHCA-CoA
AKR1C4
NADH
NADPH
AMP
TCCA
TCCA
NADP+
H+
SLCO1A2
bile salts
ATP
H2O
Na+
O2
NADPH
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA
SLC27A2
TAU
Cytochrome P450
(CYP7B1 based)
TCCA
PTGIS
OSBPL7
NADPH
H2O
CYP7A1
CCA
NADPH
NADH
BAAT
Fe2+
O2
NADH
H+
25OH-CHOL
NADP+
STARD5:DCA,LCA
glycocholate
CYP27A1
O2
CCA
5beta-cholestan-3alpha,7alpha,12alpha-triol
ACOX2:FAD
H2O
bile salts and acids
NADP+
Pi
bile salts and acids
(OATP-A)
CYP27A1
THCA-CoA
CYP7A1
O2
TCDCA
LCHA
ADP
TCDCA
GCDCA
Gly
5beta-cholestan-7alpha-ol-3-one
H2O
25(R) THCA-CoA
DCA,CDCA,LCHA
AKR1C3
CHOL
HSD3B7
H+
GCCA
GCDCA
SLCO1B3
CoA-SH
cholate
THCA
3,7,24THCA-CoA
CoA-SH
H2O
CDCA
NADP+
NAD+
TAU
albumin:bile salt
and acid (OATP-A)
complex
AKR1C1
choloyl-CoA
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
LCHA
GCDCA
AKR1D1
TCCA
GCCA
PTGIS
chenodeoxycholate
bile salts
CYP8B1
H2O
25(R) TetraHCA-CoA
4CHOL7a,12aDONE
DCA
CDCA
glycochenodeoxycholate
ALB
ALB
CoA-SH
27OH-CHOL
H+
(24R,
25R)
3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
H+
NADPH
NADP+
24OH-CHOL
Aldo-keto reductase
family
propionyl CoA
GCDCA
chenodeoxycholoyl-CoA
CHOL
AKR1C3
O2
5beta-cholestan-7alpha,24(S)-diol-3-one
CDCA
4CHOL7a,12a,24(S)TONE
5bCHOL3a,7a,24(s),27-tetrol
NADP+
25OH-CHOL
taurocholate
CDCA
NADP+
O2
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol
TetraHCA
CYP27A1
5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol
CCA
NADP+
DCA
AMP
CYP27A1
5beta-cholestan-3alpha,7alpha,26-triol
O2
AKR1D1
NCOA2
CDCA
NADPH
H2O
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA
NADH
H+
glycine; taurine
H+
OSBPs
NCOA2
GCCA
CH25H (Fe2+
cofactor)
HSD3B7
bile salts
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol
H+
CYP7A1
FAD
CHOL
CHOL
O2
SLC27A2
GCCA
Na+
DCA
NADPH
CDCA
PPi
4CHOL7a,24(S)DONE
RXRA
Na+
glycocholate
O2
ABCC3
5β-CHOL3α,7α,24(s)-triol
CYP7B1
OSBPL6
ATP
NADP+
5beta-cholestan-3alpha,7alpha,24(S)-triol
GCCA
NADP+
ABCB11
TCDCA
bile salts and acids
complexed with
albumin
AKR1C2
Cytochrome P450
(CYP7B1 based)
FABP6
PTGIS