Bile acid and bile salt metabolism (Homo sapiens)

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19, 41, 49, 6025, 511, 26424, 40, 5357711, 50, 524, 27, 35, 36, 43...195911, 50, 52193106464318, 28, 556417, 20, 59131918, 28, 555725, 5130, 5418, 28, 5524, 40, 5316, 56, 655722, 4611, 50, 525840, 534, 14, 27, 35, 36, 43...40, 5333, 3840, 5319191911, 50, 5240, 53575919322, 4619334, 42525326, 4740, 53324, 40, 531911, 50, 521911, 50, 5240, 53192922, 4612, 3911, 50, 521, 241, 49, 61191936424, 40, 5330, 5429651940, 535191, 230, 5412, 396, 15, 23, 31, 37...18, 28, 559, 4511, 50, 5240, 538, 21, 63193264mitochondrial matrixendoplasmic reticulum lumenendoplasmic reticulum lumennucleoplasmendoplasmic reticulum lumenendoplasmic reticulum lumencytosolGolgi lumencytosolnucleoplasmperoxisomal matrixmitochondrial matrixnucleoplasmendoplasmic reticulum lumencytosolendoplasmic reticulum lumencytosolH+glycochenodeoxycholate O2NCOA2 TCCA GCCA TAU NADP+NADPHO2DCA,CDCA,LCHACHOL3b,7a,25TRIOLCHOLH+5beta-cholestan-3alpha,7alpha,12alpha-triolGCDCA Cytochrome P450(CYP8B1 based)NADPHDCA 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoATCDCA NADP+AKR1C3 CDCA DCA CCA NCOA2TCCA NADPHCCA 3alpha,7alpha-dihydroxy-5beta-cholestan-26-alO2AKR1D1ATPSTARD5Gly CDCA PI4POSBPL2 NADPHH+NADPHNADP+TCCA CYP8B1 NADP+SLCO1A25beta-cholestan-7alpha,12alpha,27-triol-3-oneO225(R) TetraHCA-CoANR1H4:DCA,CDCA,LCHAPibile salts and acidscomplexed withalbuminCoA-SHNADPHDCA NR1H4 AKR1C1 4CHOL7a,12aDONECCA 25OH-CHOLFABP6 NADP+H+Fe2+ ALB:(GCCA, TCCA)AKR1D1H2OTHCANADPHH+3,7,24THCADHCACYP7B1 OSBPL1A AKR1C4 GCCA ADPSLC27A5GCDCA 5bCHOL3a,7a,24(s),27-tetrolADPO2PPiGCCA, TCCAH2OGCDCA CHOLchenodeoxycholoyl-CoACoA-SHtaurocholate SLCO1B3HSD3B75beta-cholestan-3alpha,7alpha,12alpha,27-tetrolDCA NADPHGCDCA ABCC3NAD+ALB 4CHOL7a,12a,24(S)TONECYP27A1TCDCA TCDCA NR1H4 CHOLalbumin:bile saltand acid (OATP-A)complexAMPCDCA H+CYP39A1LCAH2Ocholoyl-CoA;chenodeoxycholoyl-CoA24OH-CHOLNAD+NR1H4 24OH-CHOLH2OCoA-SHNADP+DCANADP+SLC27A2O2H+27OH-CHOLATPLCHA H+H+PTGIS H+HSD3B725OH-CHOL5beta-cholestan-3alpha,7alpha,26-triol27OH-CHOL5beta-cholestan-7alpha-ol-3-oneDCA HSD17B4 dimercholateGCCA NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHANADPHCYP8B1 AMACRPPibile saltsOSBPL7 NADPH5beta-cholestan-7alpha,12alpha,24(S)-triol-3-oneCDCA NADP+GCDCA LCA ACOT8O2CYP27A1H+SLC27A5FAD TCDCA STARD5 Cholest-5-ene-3beta,7alpha,27-triolNADHAKR1C2 GCCA TCDCA ACOX2:FADTCDCA Gly Cytochrome P450(CYP7B1 based)H+5beta-cholestan-3alpha,7alpha,26-triolNADPH3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-alCCA CYP27A1O25beta-cholesten-7alpha, 12alpha-diol-3-oneTCCA bile salts and acids(OATP-A)5beta-cholestan-3alpha,7alpha,24(S)-triolCytochrome P450(CYP8B1 based)CHOL7a,24(S)DIOLNADPHO2choloyl-CoA Cytochrome P450(CYP7B1 based)NADPHCDCA 25(S) DHCA-CoAFABP6BAATH2OAKR1C4 NADPHNADPH3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al25(R) DHCA-CoANCOA2 ATPTCDCA Cytochrome P450(CYP8B1 based)CYP7A1 5beta-cholestan-7alpha,24(S)-diol-3-oneCoA-SHCYP7A1 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-alTCCA 5bCHOL3a,7a,12a,27-tetrolRXRA Na+chenodeoxycholoyl-CoA choloyl-CoAtaurochenodeoxycholate GCDCA H+CHOL25OH-CHOLH+NADP+O2cholate;chenodeoxycholateAldo-keto reductasefamilyO2NADPHTCCA 3,7,24THCA-CoA3,7,24THCA-CoAH2Oglycochenodeoxycholate CCAAldo-keto reductasefamilyH+H2OPiLCHA SLC27A5NADHPTGIS GCCA TCDCA THCAbile saltsNADH(24R,25R)3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoAO2bile salts and acidsNADP+NCOA1ABCB11TetraHCA3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoANADP+taurochenodeoxycholate propionyl CoAAMPCDCA glycocholate 3,7,24THCA-CoA5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrolH+bile salts andacids:FABP6SLC10A1NAD+5β-CHOL3α,7α,24(s)-triolCDCA NCOA2 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol5beta-cholestan-3alpha,7alpha-diolAKR1C3 NADP+chenodeoxycholatebile saltsO2DCA O2CYP7A1 RXRA 7alpha-hydroxycholesterolNADP+H2Oglycine; taurineALB 25(S)3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoAGCCA GCCA AKR1C1 SLC27A23,7,24THCAH2O5beta-cholestan-3alpha, 7alpha-diolAMPNCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHAOSBPL9 AKR1D1CCA H2ONADHGCCA H+SLCO1B1HSD17B4(1-736) NADP+NR1H4 H2OCDCA CYP46A14CHOL7a,24(S)DONE5bCHOL3a,7a,12a-triolOSBPCH25H (Fe2+cofactor)PTGIS GCDCA 4CHOL7aOLONENADPHACOX2 5beta-cholestan-7alpha,27-diol-3-onePI4PALB CDCA NCOA1 glycocholate NADP+5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentolLCHA OSBPL6 NCOA1 Na+ALB NADP+CYP7B1 25OH-CHOLNADP+H+25(R) DHCA-CoANAD+GCCA TCCA 25(R) THCA-CoAO2NADP+LCHA AKR1C1 STARD5:DCA,LCANR1H4AKR1C2 NADPHH2OH2O2H2Otaurocholate Na+NADP+O2CoA-SHSLC10A2CYP27A1H+cholate bile salts24OH-CHOLH2ONa+25(S) THCA-CoAPPiTetraHCACYP7B1 H2ORXRA TCCA H+NADPHH2O4CHOL7a,12a,27TONEH2OATPTAU 25(R) THCA-CoADHCAALBOSBPsTCDCA CH25H NCOA1 NADP+GCCA CYP27A1CDCA AKR1C2 OSBPL3 H+CCA H2Oglycine; taurineH+ATPbile saltsNADPHH2OGCCA TCCA NADPHH2ONADP+AKR1C3 Cytochrome P450(CYP7A1 based)CoA-SHNCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHAbile saltsAldo-keto reductasefamilyCoA-SHLCHA CYP27A1NADPHTHCA-CoA27HCHOLH+HSD3B7H+25(R) TetraHCA-CoACDCA H+H+AKR1C4 TCCA CYP27A1TCCA CYP8B1 BAATNADP+SCP2-1RXRAalbumin:bile saltcomplex4CHOL7a,27DONE