ABC-family proteins mediated transport (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none mitochondrial matrixperoxisomal matrixcytosoltransport vesiclelysosomal lumenlamellar bodyendoplasmic reticulum lumenABCA7-dependentphospholipidsABCA7-dependentphospholipidsABCA7-1:ApoA1complexhemehemeLCFALCFACHOLCHOLABCA cholesteroltransportersPEX19:ABCD1/2/3PEX3HCO3-CFTRHCO3-H2OATPPiADPH2OATPADPPiATPH2OADPPiHeme transportersADPPiH2OATPADPPiorganic anionH2OATPorganic anionABCCsporphyrinH2OATPADPporphyrinMTABC3 dimerPisterolsH2OATPsterolsADPABCG5:ABCG8PiH2OATPADPABCG4 dimerPiCHOLCHOLCHOLH2OATPCHOLADPABCG1 dimerPiABCD1-3 dimersH2OATPa xenobioticABCA8/B1/B5atRALADPABCA4Pia xenobioticPEX19atRALATP23mer peptideH2O23mer peptideADPABCB9 dimerPiEIF2S1:EIF2S2:EIF2S3ABCF1:EIF2S1:EIF2S2:EIF2S3ABCF1PCATPH2OPCADPABCB4PiCl-ADPPiCFTR G551DIvacaftorIvacaftor:CFTR G551DCl-Cl-H2OATPADPPiH2OATPBMG,BDGADPBMG,BDGABCC2PiATPlipidsH2OADPlipidsABCA12PiABCA3PiH2OATPPC, PGADPPC, PGK+K+KCNJ11:ABCC9CHOLH2OATPADPABCA5PiUb-misfolded nascentCFTR:ERAD complexERAD complexmisfolded CFTR:ERADcomplexUbATPH2OUb-misfolded nascentCFTR26S proteasomeUbADPPiCFTRmisfolded CFTRSPHMPCPCSPHMABCA7APOA1(25-266)ABCA2ABCA6ABCA9ABCA10ABCD1ABCD2ABCD3PEX19ABCB7(23-752)ABCB10ABCB8ABCC1ABCC2ABCC3ABCC4ABCC5ABCC6CFTRABCC8ABCC9ABCC10ABCC11ABCB6CHOLphytosterolsCHOLphytosterolsABCG5ABCG8ABCG4ABCG1ABCD1ABCD2ABCD3ABCA8ABCB1ABCB5ABCB9EIF2S1EIF2S2EIF2S3EIF2S1EIF2S2EIF2S3ABCF1IvacaftorCFTR G551DBMGBDGBMGBDGPCPGPCPGABCC9KCNJ11RPS27A(1-76)UBA52(1-76)UBB(1-76)UBB(77-152)UBB(153-228)UBC(1-76)UBC(77-152)UBC(153-228)UBC(229-304)UBC(305-380)UBC(381-456)UBC(457-532)UBC(533-608)UBC(609-684)misfolded CFTRVCPDERL1DERL2DERL3SEL1LERLEC1OS9RNF185RNF5ERLIN1ERLIN2VCPDERL1DERL2DERL3SEL1LERLEC1OS9RNF185RNF5ERLIN1ERLIN2VCPDERL1DERL2DERL3SEL1LERLEC1OS9RNF185RNF5ERLIN1ERLIN2misfolded CFTRRPS27A(1-76)UBA52(1-76)UBB(1-76)UBB(77-152)UBB(153-228)UBC(1-76)UBC(77-152)UBC(153-228)UBC(229-304)UBC(305-380)UBC(381-456)UBC(457-532)UBC(533-608)UBC(609-684)RPS27A(1-76)UBA52(1-76)UBB(1-76)UBB(77-152)UBB(153-228)UBC(1-76)UBC(77-152)UBC(153-228)UBC(229-304)UBC(305-380)UBC(381-456)UBC(457-532)UBC(533-608)UBC(609-684)misfolded CFTRPSMD14PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB10PSMB2PSMB3PSMB4PSMB5PSMB6PSMB7PSMB8PSMB9PSMC1PSMC2PSMC3PSMC4PSMC5PSMC6PSMD1PSMD10PSMD11PSMD12PSMD13PSMD2PSMD3PSMD4PSMD5PSMD6PSMD7PSMD8PSMD9PSME1PSME2PSME3PSMF1PSME4PSMA8PSMB11SHFM1RPS27A(1-76)UBA52(1-76)UBB(1-76)UBB(77-152)UBB(153-228)UBC(1-76)UBC(77-152)UBC(153-228)UBC(229-304)UBC(305-380)UBC(381-456)UBC(457-532)UBC(533-608)UBC(609-684)Name: ABC-family proteins mediated transportOrganism: Homo sapiens