Cell Cycle Checkpoints (Homo sapiens)

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10046, 63, 66, 70, 81...932965, 9454, 59, 738, 24, 35, 44286856956019965, 27, 96651001838, 61, 779714, 16, 20, 26, 3386, 92456, 15, 22, 23, 80...187234, 971, 13, 56, 8437, 31, 39, 43, 53...49, 62, 6712, 19, 29, 6445281821, 30, 6085379, 55, 87, 9165, 66, 9411, 51, 76, 8610, 331827, 9615, 80, 881842, 69, 7934, 9736, 9949, 6732, 40857825, 41nucleoplasmcytosolDYNC1I1 PPP2R5C p-S327,T847,T859-RBBP8 PolyUb,p-S166,S188-MDM2 RAD17 p-S435-GTSE1 DYNC1LI2 HIST1H2BH CENPP ANAPC15 MLF1IP CCNE2 PPP2R5E HIST1H2BL CENPH CLIP1 UIMC1 RFC4 RFC3 DBF4 PPP2R5D SGOL1 KinetochoreNSL1 UBC(381-456) HUS1 ANAPC2 ADPp-S15,S20-TP53Tetramer:ZNF385ANDE1 CENPO HIST1H2BN UbRPA3 ATR p-S25,S1778-TP53BP1 PPP2R5B CENPC1 MDM4 RAD1 UBC(77-152) Zn2+ UBC(609-684) CDC20PSMD10 CDCA8 CENPT CDC20 HIST1H2BN ANAPC10 PHF20PSMA2 ANAPC2 ATPNDE1 ATR:ATRIPPSMB3 CyclinA:Cdk2:p21/p27complexNUF2 SPC25 UBA52(1-76) p-S166,S188-MDM2 UIMC1 DNA double-strand break ends NUP85 BLM Activated MAD2L1 UBC(457-532) NDE1 p-5T-MDC1 UBC(77-152) CENPQ p-S123-CDC25AZWILCH HIST3H3 CCNB1 DSN1 ZWINT CLASP1 SEH1L-1 TOPBP1 UBC(305-380) CENPC1 CENPM Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complexORC5 MLF1IP MCM10 SEH1L-1 INCENP CDK2 NSL1 CDKN1B B9D2 PPP1CC PPP2R5B CDKN1A ORC1 CENPN CENPQ SPC24 CLASP2 AURKB CHEK2UBB(1-76) PMF1 CASC5 ERCC6L HIST1H2BB Activated MAD2L1 ITGB3BP SPDL1 PSME2 RAD9B p-S15-TP53 Tetramer26S proteasomeCDC20 RAD50 NUP43 RPS27 NUP98-5 ADPUbMAPRE1 CENPO RPS27 MCM4 MAD2L1p-S123-CDC25A p-S,3T-CHEK2ORC1 DYNC1H1 ORC3 p-S346,S367,S403-MDM4 PPP2R1B MAD2L1 p-T14,Y15,T161-CDK1 MCM5 RFC5 DYNC1LI1 CENPO ERCC6L CDC6 UBC(609-684) YWHAG NUP43 DYNLL2 YWHAH TP53 TetramerUBE2D1 UBB(1-76) BUB1 NUF2 ATPPPP2R5D CDK2 CDKN1A gene MRE11A DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2ATPCCNB1:p-T14,T161-CDK1RMI1 UBC(609-684) ITGB3BP p-T714,T734-BARD1 NUP37 ANAPC16 BABAM1 CENPM ATPp-S166,S188-MDM2dimer,p-S166,S188-MDM2:MDM4Kinetochore:Mad1:MAD2* ComplexCDC45 UBE2V2 PolyUb-TP53 p-S343-NBN RFC5 p-S166,S188-MDM2,MDM4DYNLL1 CDC20 CDK2 p-S123-CDC25ACDC27 PSME3 CLASP1 CCNB2 CDC26 p14-ARF PolyUb-TP53 TetramerCCNB1 APITD1 CENPA YWHAB CKAP5 NUP107 UBC(533-608) CENPT CLASP1 p-T68-CHEK2 dimerPSMB11 p-S1387,S1423,S1524,S1547-BRCA1 ANAPC4 p-S166,S188-MDM2 RPA complexed tossDNACHEK2 CDCA8 DYNC1H1 PLK1 DSN1 PSMD9 ERCC6L p-T68-CHEK2 p-S343-NBN ADPUBC(153-228) p-S387-RFWD2 p-T714,T734-BARD1 DYNLL1 CENPQ Ubiquitin ligaseRPA heterotrimerMCM7 MCM2 APITD1 PPP2CA UBC(153-228) DYNC1LI1 RPS27A(1-76) HIST1H2BO UBC(77-152) UBA52(1-76) ATPPSMD11 SPC25 NUDC DYNC1I2 DYNC1LI2 UBB(153-228) ZNF385A RAD17 Ub-p-S123-CDC25AXPO1 Rad9-Hus1-Rad1 boundto DNARPA2 p-S1981,Ac-K3016-ATMp-T68-CHEK2ADPHIST1H2BC BUB3origin of replication PPP1CC MAPRE1 ORC1 ORC3 UBC(229-304) BUB1B MDM4 origin of replication Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complexPPP2R1B PPP2R5D CENPM SKA2 RPA1 RPA3 ADPUbUBC(305-380) RPS27A(1-76) CLASP1 PSMC6 ATR RANGAP1 HIST2H2BE PLK1 KIF2B CLASP2 RPA1 KIF18A PSMC4 HUS1 BABAM1 KNTC1 RFC5 MAD1L1 p-S317,S345-CHEK1XPO1 UBC(229-304) EXO1 KIF2B CDK2 NDEL1 PSMA6 RAD9A MAD2L1 NUP107 PSMD7 CENPQ DYNLL1 CKAP5 PSMA5 p-S216-CDC25CNUF2 NDC80 UBC(533-608) SKA1 DNA Double StrandBreak ResponseMe2K21-HIST1H4 CENPI RPA3 UBC(77-152) RCC2 CENPH ANAPC1 UBA52(1-76) MAD1L1 CENPK p-S166,S188-MDM2:p-S403-MDM4H2BFS CENPN CENPH ATR:ATRIP:RPA:3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1p-S15,S20-TP53 ZWILCH NSL1 SHFM1 INCENP HIST1H2BC UBC(609-684) CENPP Activated MAD2L1HIST1H2BK ZWINT CDC6 SEH1L-1 UBB(153-228) ORC2 Kinetochore:Mad1:MAD2 ComplexRAD9B ATRIP CDKN1A geneUBC(533-608) ATPCDKN1A,CDKN1BSKA2 cyclin RMI2 DYNC1LI2 p-S15,S20-TP53 CENPN NUP37 RPA1 HIST1H2BJ MCM2 MCM3 PPP2R5C CLASP2 CDC16 ATR BUB3 BUB3 PPP2R5E MCM6 ANAPC11 TP53 p-S216-CDC25C BIRC5 UBC(305-380) BUB1B APITD1 p-S15-TP53 NUDC CCNE2 CDC6 CENPF CDCA8 SKA1 PPP2CB SGOL1 CDK2 CDC25APPP2R5A p-T714,T734-BARD1 PSMB8 UBB(1-76) MCM5 AHCTF1 PAFAH1B1 ATPp-S343-NBN NUP133 MAD2L1 UBB(77-152) Persistent single-stranded DNA SEH1L-1 p-S990,Ac-K1249-BRIP1 CDKN1A mRNA AHCTF1 p-S387-RFWD2:p-S15-TP53ATRIP UBC(457-532) UBC(1-76) ADPPPP2R5C CENPT Zn2+ MRE11A MCM7 p-S15,S20-TP53 ATPp-S216-CDC25C:14-3-3protein complexSEC13 ADPNUP133 p-S102-WHSC1 DNA2 CDC26 PPP2R5A PolyUb-TP53 APITD1 p-S166,S188-MDM2 K63PolyUb-K14,K16,p-S140-H2AFX HERC2-SUMO1 PSMB1 CENPK CDC7 14-3-3 dimerBIRC5 SPDL1 DBF4 CDKN1AMCM8 p-S1387,S1423,S1524,S1547-BRCA1 SGOL2 ERCC6L RAD9A UBC(457-532) PCBP4ORC2 UBC(153-228) p-T14,T161-CDK1 NDC80 MCM10 MAD1L1 CDC27 p-T14-CDK1 RFC2 cyclin AURKB p-S25,S1778-TP53BP1 CENPP Persistent single-stranded DNA SFN ZNF385A BIRC5 Activated MAD2L1 PPP2R1A KIF18A UBC(229-304) CLIP1 UBA52(1-76) RFC5 PSMA4 SPC25 PCBP4 UBB(77-152) UBC(533-608) Persistent single-stranded DNA KIF2B PPP2R5C H2BFS UBA52(1-76) MCM8 TOP3A p-S166,S188-MDM2 SPC24 KIF2C p-S166,S188-MDM2:p-S346,S367,S403-MDM4KNTC1 UBC(229-304) PSMD8 HIST1H2BH p-S15,S20-TP53Tetramer:ZNF385A:CDKN1A GeneCENPE INCENP ADPCCNA:CDK2BUB1B MCM6 YWHAG MIS12 PAFAH1B1 DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complexATPUBC(1-76) B9D2 BRE UBE2N p-S1981,Ac-K3016-ATM p-S406-FAM175A DNA double-strand break ends RANBP2 PSMD5 MCM3 PAFAH1B1 DSN1 CASC5 PSMD2 DYNC1H1 HUS1 UBC(457-532) UBE2V2 NUP160 PPP2R5B TP53 CENPF CDKN1B PPP2R1B UBC(153-228) UBC(77-152) PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4SPDL1 KAT5 ORC2 KIF2C ANAPC7 DBF4 RPS27 NUP160 RAD17:RFCCCNE1 MCM6 PSMD13 PSME4 HIST1H2BO ATPRPS27 SPC24 NUP37 UBB(1-76) UBC(153-228) PPP2R5A TAOK1 p14-ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4DSN1 CDKN1B p-S1981,Ac-K3016-ATM RPA3 RANBP2 ADPPPP2R1A DYNC1I2 HIST3H3 ORC6 UBB(1-76) CENPL p-S166,S188-MDM2 BIRC5 ANAPC15 RFC3 BUB1 NSL1 K63PolyUb-K14,K16,p-S140-H2AFX ATPNUP98-5 CENPC1 RFC4 UBE2E1 CENPL UBB(77-152) PSMD6 NUP133 SEC13 BRCC3 UBB(153-228) CENPA PMF1 UBB(77-152) PPP2CB Me2K21-HIST1H4 SGOL2 ZW10 KIF2C UBB(1-76) ATPKIF2A SGOL2 RNF168 PSMB4 PSMD12 ATPCENPM CHEK1PPP1CC ATR:ATRIP:RPA:ssDNAsignaling complexSKA2 PPP2CA PMF1 CKAP5 BUB1B BUB3 CENPE CCNE1 MIS12 NDEL1 CCNA2 p-S435-GTSE1DYNC1I1 RPA3 MCC:APC/C complexPolyUb,p-S342,S367,S403-MDM4 PSMB6 p-S166,S188-MDM2dimer,p-S166,S188-MDM2,MDM4:TP53UBC(305-380) CLSPN HIST2H2BE MCM2 HIST3H2BB PMF1 NUP43 UBA52(1-76) PSME1 PPP2CB CDC45 ORC6 MAD1L1 CENPI CLSPNMCM7 YWHAQ ANAPC11 CENPF UBC(229-304) HIST1H2BM ADPp-S15-TP53 RAD17 CENPH PPP2R1B KIF2A ADPBUB1 MRE11A ITGB3BP HIST1H2BL PolyUb-TP53 TetramerTAOK1 PPP2R1A p-S15,S20-TP53TetramerBUB3 p-S435-GTSE1:PolyUb-TP53 TetramerBUB3 UBC(533-608) KIF2C SPDL1 KAT5 NUP160 NUP107 ANAPC4 PSMB5 AURKB PPP1CC RAD9B PSMD1 DYNC1I1 CENPN PPP2CA UbMDM4 CDKN1A mRNASKA1 RHNO1 PSMD3 HIST3H2BB p-S403-MDM4 Persistent single-stranded DNA ubiquitinatedphospho-COP1(ser-387)DYNC1LI1 PolyUb-TP53 PSMB10 p-S988,S1387,S1423,S1524,S1547-BRCA1 Mad1:kinetochorecomplexRPA2 ADPNUDC CENPE ORC5 HIST1H2BM KNTC1 PSMA3 phosphorylatedanaphase promotingcomplex (APC/C)p-T916,S945-CLSPN HIST1H2BA RNF8 PPP2R5E MCM4 XPO1 NUP98-5 p-S1981,Ac-K3016-ATM NUDC PPP2CA CASC5 RANBP2 DYNC1H1 RPS27A(1-76) AHCTF1 MAD2*CDC20 complexCDC20 CCNB2 PolyUb-TP53 ADPDYNLL2 AHCTF1 UBE2N UBC(305-380) DYNC1LI2 CCNE:CDK2CCNB1:p-T14,Y15,T161-CDK1RNF168 BUB1B RCC2 p-WEE1CASC5 ORC4 ADPSFN PPP2R5A PSMC5 UBC(381-456) CCNB:CDK1ZW10 NUP98-5 RPA1 RAD1 MCM10 ANAPC1 RPA2 PSMD14 PSMB7 YWHAH UBC(609-684) PAFAH1B1 DYNLL2 PSMC3 PPP2R1A PSMB9 PLK1 YWHAZ hBUBR1:hBUB3:MAD2*:CDC20 complexp-5T-MDC1 p-T4827,SUMO1-HERC2 ORC6 NUP85 PSMA7 CDC20 CENPL Activated MAD2L1 ANAPC16 origin of replication ADPUBC(381-456) ATPUBC(229-304) RAD50 RPA1 RPA2 MDM4 RPA2 B9D2 ZW10 ANAPC5 MCM5 NDE1 KIF2A WRN PCBP4:CDKN1A mRNAMIS12 ZWILCH TAOK1 DYNC1LI1 ADPp-S166,S188-MDM2UBB(153-228) CENPE BUB1BMCM8 HERC2-SUMO1 CDC25CMCM3 CDC20 CKAP5 ZNF385AUBE2C UBC(381-456) CENPK CCNA1 NUP85 RFC4 CDC7 CENPL UBC(457-532) ANAPC5 PSMA1 RFC4 UBC(1-76) BRE CDC16 RFC3 CENPO UBC(77-152) RAD9A ZWINT RANGAP1 RNF8 SKA2 INCENP DYNC1I2 p-S435-GTSE1:PolyUb-TP53 TetramerNUP37 p-5S,T-MDM2UBC(1-76) CCNB1 PKMYT1RANGAP1 HIST1H2BK CyclinE:CDK2:CDKN1A,CDKN1BMAD2L1 ADPNUF2 MAPRE1 RPS27A(1-76) p-S166,S188-MDM2 CCNB1 p-S102-WHSC1 CLIP1 RFC2 RPA1 MLF1IP CENPC1 YWHAQ DYNLL2 ANAPC7 CDC7 UBB(77-152) NDEL1 RFC2 CDK2 CCNA1 PIAS4 PIAS4 SKA1 HIST1H2BA CDKN1A KIF18A UBC(609-684) CDK2 UBC(381-456) YWHAB RAD50 PSMC2 UBE2E1 ORC3 HIST1H2BD BUB1 ATPSEC13 KNTC1 UBE2D1 NUP43 UBC(457-532) 3' overhanging DNA at resected DSB ends CCNB:p-T14-CDK1p-S216-CDC25CBRCC3 PSMF1 HIST1H2BD BUB1B p-S387-RFWD2 CDC20 p-T4827,SUMO1-HERC2 PSMA8 DYNLL1 CLIP1 MCM4 CDK:DDK:MCM10:activepre-replicativecomplex:CDC45ORC4 PPP2R5B MAPRE1 HIST1H2BB KIF2B UBC(1-76) CENPP BUB3 CENPI XPO1 UBC(305-380) NUP160 PSMD4 RFC3 cyclin MAD1L1PPP2R5E ADPCENPA TAOK1 p-S406-FAM175A PLK1 ZWILCH p-S435-GTSE1MIS12 NDC80 KIF18A KIF2A ITGB3BP MLF1IP DYNC1I2 CCNA2 NDEL1 ZW10 KAT5 RPS27A(1-76) CDK1 p-S387-RFWD2CENPK RAD1 YWHAE p-S166,S188-MDM2 UBB(77-152) ATPHIST1H2BJ RPA2 CENPI SGOL2 DYNC1I1 CDC45 B9D2 UBE2C NUP107 ZWINT RAD17 SGOL1 CENPF PSMC1 RFC2 WEE1ANAPC10 RCC2 p-S387-RFWD2RFWD2Rad17-RFC complexbound to DNASPC24 ATRIP UBB(153-228) MDM4 SEC13 RPS27A(1-76) RANBP2 NUP133 RAD9:HUS1:RAD1Persistentsingle-stranded DNAUBC(533-608) RPA3 UBB(153-228) ORC4 CDCA8 SPC25 SGOL1 ORC5 UBC(153-228) PPP2R5D NDC80 CDC23 CENPA p-S435-GTSE1 UBC(1-76) NUP85 YWHAZ RANGAP1 p-S166,S188-MDM2:MDM4RCC2 YWHAE ATPPSMB2 UBC(381-456) ATPPPP2CB AURKB CDC23 CDKN1A CLASP2 CENPT 52177410, 3326011, 76, 8647, 987511, 76574, 487446, 63, 70, 8197834787, 89, 91529771, 826544, 50, 58, 90459696