Cell cycle checkpoints (Homo sapiens)

From WikiPathways

Jump to: navigation, search
36, 39, 50, 6635, 975, 24, 45, 65, 83...2, 60, 9570539, 495, 15, 37, 62, 72...20, 489642019, 34, 575, 16, 818, 12, 25, 64, 67...75, 8496773622, 29, 826, 21, 30, 51, 9111, 4220, 48521678, 12, 86963132, 53, 55, 597726, 6871, 80, 994728961823, 38, 61, 8444, 58, 63, 899, 49, 88943, 41, 74, 859669, 76, 7916, 818046, 9160, 95925095944731nucleoplasmcytosolPPP2R5D NUP98-5 BUB1B CDKN1A,CDKN1BNUP85 PSMD6 SKA1 MCM4 CENPE ITGB3BP p-S123-CDC25A ADPRPA1 p-S988,S1387,S1423,S1524,S1547-BRCA1 CENPA CCNE1 CENPL SPC24 AURKB K63PolyUb-K14,K16,p-S140-H2AFX PPP2CA PSMC2 CDC45 PPP1CC ATPCASC5 p-WEE1CDC7 CDKN1A gene p-S15,S20-TP53Tetramer:ZNF385A:CDKN1A GeneCyclinE:CDK2:CDKN1A,CDKN1BSGOL1 SEC13 CENPM PPP2CA UBC(533-608) ATPK6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 RPA3 CENPT MCM8 SKA2 KIF2A UBC(533-608) TOP3A p-S15-TP53 PPP2R5E CDKN1A HIST1H2BK B9D2 ORC3 TAOK1 SEC13 UbCDC23 NUP107 UBC(1-76) CCNB:CDK1RFC3 p-S990,Ac-K1249-BRIP1 p-S346,S367,S403-MDM4 KIF2A KIF18A ATPMCM8 NUP43 NSL1 DYNC1H1 ATPp-S216-CDC25C:14-3-3protein complexZW10 BABAM1 ATPAPITD1 PPP2CB p-T916,S945-CLSPN ZWILCH UBE2D1 CLIP1 p-S435-GTSE1 CLASP1 SGOL1 DYNC1I2 p-S1387,S1423,S1524,S1547-BRCA1 ORC6 RPA1 p-T14,Y15,T161-CDK1 RANGAP1 UBC(381-456) RPA1 CENPF PSMA8 B9D2 CENPT PolyUb-TP53 KIF2B ATPRPS27A(1-76) RPA2 UBC(381-456) YWHAB CDC7 p-T68-CHEK2 dimerRPS27A(1-76) KNTC1 DYNC1I1 SPC24 KAT5 ANAPC10 HIST1H2BN ERCC6L PSMD5 ADPHIST1H2BO PMF1 PPP2R5E UBC(77-152) CENPC1 ADPUBC(381-456) SPC25 XPO1 NSL1 UBC(381-456) CDC20 UBE2S CENPI RPA2 MRE11A CCNB1 MAD1L1 CDK2 RAD50 cyclin MIS12 UBC(533-608) RPA1 NUDC DNA double-strand break ends H2BFS cyclin CDC6 DYNLL2 CENPH Ubiquitin ligaseCENPE PSMD10 PSMA1 BUB1B TAOK1 APITD1 PSME4 KIF2B ATPp-S25,S1778-TP53BP1 PSMD4 p14ARF K63PolyUb-K14,K16,p-S140-H2AFX CENPO NDE1 CENPE RPS27 PPP2R5D MCM2 NUP43 PSMD1 CKAP5 DYNC1I2 CENPH HUS1 CCNA2 HIST1H2BA PAFAH1B1 SPC25 INCENP ATRIP cyclin UBC(457-532) UBC(229-304) RANBP2 DSN1 HIST3H2BB UBC(229-304) RAD9A p-S403-MDM4 ZWINT p-S166,S188-MDM2:p-S346,S367,S403-MDM4Activated MAD2L1 CDK2 NDC80 PPP2R5A NUP37 UBE2C SGOL2 ATPPolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4HIST1H2BL UBA52(1-76) origin of replication CASC5 ATPATPBRE PPP2R1A p-S,3T-CHEK2CDC23 p-S166,S188-MDM2 ZNF385A ZNF385A PSMB3 RANGAP1 SEH1L-1 ORC2 MAD1L1DYNC1I1 UBC(153-228) BUB1 RPS27 UBC(457-532) MCM8 NDE1 CDK2 PSMB1 ADPCENPQ MCM7 3' overhanging DNA at resected DSB ends p-S435-GTSE1:PolyUb-TP53 TetramerRHNO1 p-S166,S188-MDM2dimer,p-S166,S188-MDM2,MDM4:TP53MDM4 ANAPC7 PAFAH1B1 DSN1 CDC20 ANAPC2 p-S1981,Ac-K3016-ATM BABAM1 PPP2R5B ADPPSMC5 PLK1 ANAPC1 HERC2-SUMO1 HIST1H2BL CDCA8 CENPM p-S166,S188-MDM2 NUDC ITGB3BP DYNC1LI1 RFC4 CLASP1 B9D2 CENPN CDKN1A ZWINT CENPP CENPP UBB(77-152) CENPI PPP2R5B p-S15,S20-TP53 UBC(1-76) UBC(305-380) CCNA:CDK2DYNLL1 PLK1 CDC45 DYNC1H1 CDKN1A mRNA PSMC3 SHFM1 RANBP2 RPS27A(1-76) SFN CLSPN SKA1 CENPA MRE11A UBC(305-380) MIS12 phosphorylatedanaphase promotingcomplex (APC/C)CKAP5 ANAPC1 MCM6 UBB(77-152) UbDYNC1LI1 MCM10 PPP2R5A p-S15,S20-TP53 MCM7 BUB1 MLF1IP UBC(457-532) p-S15,S20-TP53 p-T4827,SUMO1-HERC2 ANAPC10 ANAPC5 PSMB7 RPA heterotrimerCENPM UBB(1-76) BIRC5 p-S327,T847,T859-RBBP8 BUB1B ubiquitinatedphospho-COP1(ser-387)NUP43 ORC6 ATRIP p-S216-CDC25CRPA2 NUF2 ORC5 RMI1 p-T68-CHEK2 UBC(609-684) UBC(457-532) ATR UBE2C PMF1 p-S1981,Ac-K3016-ATMAHCTF1 PSMA3 RAD9:HUS1:RAD1CASC5 UBE2E1 MCM10 SPC25 UBC(457-532) MCM2 PPP1CC ANAPC11 PolyUb-TP53 Tetramerp-S216-CDC25CCDC6 RNF168 PSMA6 CDK2 UBC(77-152) HIST1H2BH NUDC HIST1H2BC PolyUb,p-S342,S367,S403-MDM4 PSMC1 MCM6 CENPT UBB(153-228) CENPK CKAP5 K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 NDE1 PSMB8 PCBP4:CDKN1A mRNAANAPC4 PHF20UBC(77-152) Persistent single-stranded DNA RPS27A(1-76) KIF2C CENPO CENPF CENPF PLK1 CENPK CCNB1:p-T14,T161-CDK1HIST1H2BM SEC13 UBC(229-304) MAD2L1 p-5T-MDC1 ADPAPITD1 HIST1H2BJ DYNC1I2 DBF4 Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complexPSMA4 Mad1:kinetochorecomplexp-S1981,Ac-K3016-ATM DYNC1I1 UBB(77-152) RPA3 Zn2+ ERCC6L PSME1 RCC2 DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2CDK2 UBC(609-684) TP53 BUB1 PolyUb,p-S166,S188-MDM2 ADPORC6 CCNB2 p-T14-CDK1 CDK2 p-S102-WHSC1 BUB1B SKA2 PolyUb-TP53 TetramerCENPQ UBE2V2 ATR:ATRIPADPNUP160 p-S166,S188-MDM2 CDC25AANAPC15 p-S435-GTSE1MAD1L1 CDKN1A ATR:ATRIP:RPA:3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1YWHAE UBB(77-152) CLASP1 PPP2R1B PSMF1 p-T14,T161-CDK1 Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complexUBB(153-228) K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 ATPMAPRE1 DYNC1LI2 NDE1 YWHAQ NSL1 p-S406-FAM175A PPP2R5B NDC80 RFC4 UBC(1-76) RANBP2 origin of replication RNF8 MAD2L1 DYNLL2 MCM4 CENPN p-S166,S188-MDM2,MDM4NUP37 EXO1 MAD2L1 Me2K21-HIST1H4 MCC:APC/C complexp-S15,S20-TP53Tetramerp-S216-CDC25C PSMD7 CENPI RPA2 RPA2 NDEL1 BUB3 DYNLL1 NDC80 ANAPC4 KNTC1 p-S1981,Ac-K3016-ATM RAD17:RFCUBC(609-684) UBB(77-152) UBB(1-76) KinetochoreMLF1IP HIST1H2BN DYNC1LI2 origin of replication H2BFS CLASP2 RAD17 TP53 TetramerDBF4 RPS27 UBB(153-228) CDC27 PKMYT1DYNC1I1 RFC3 Me2K21-HIST1H4 UBC(153-228) CCNA1 UBC(77-152) NDC80 MAD2L1 CLSPNDYNC1H1 AHCTF1 SKA2 CDC20 p-S15,S20-TP53Tetramer:ZNF385APolyUb-TP53 HIST2H2BE BUB3 p-S166,S188-MDM2:MDM4DNA Double StrandBreak ResponseNDEL1 PSMB6 BIRC5 UBB(1-76) UBB(153-228) CENPM HIST1H2BD WEE1NUP107 PSMB11 PMF1 ADPRAD1 ANAPC5 CCNE2 HIST1H2BB ADPCDC45 PMF1 DYNLL1 CDC20 ZW10 CDC20 PLK1 CCNA2 TAOK1 UBC(77-152) p-S387-RFWD2 UBA52(1-76) ORC4 p-S387-RFWD2 CDCA8 PPP2CA UBB(153-228) BUB3CLASP2 PSMB2 HIST1H2BH MCM7 ERCC6L ATR PolyUb-TP53 SPC24 RPS27A(1-76) PCBP4MLF1IP RNF8 CDC7 INCENP K6PolyUb,p-T714,T734-BARD1 UBC(77-152) HIST1H2BO BRCC3 Kinetochore:Mad1:MAD2* ComplexSPC25 SPDL1 CHEK1UBC(609-684) UIMC1 p-S1387,S1423,S1524,S1547-BRCA1 CENPK MRE11A PCBP4 p-S387-RFWD2NSL1 UBC(153-228) UBE2S ORC2 PPP2R5D p-S387-RFWD2:p-S15-TP53MCM5 YWHAH MDM4 RAD1 PPP2R1A PSMA5 PPP2R5C RPA complexed tossDNASGOL2 NUP107 CDCA8 KIF2A RPS27 PSMB5 p-5T-MDC1 p-S123-CDC25APPP2R5C PPP2R1A ZWILCH Persistent single-stranded DNA KIF18A RPA1 CCNB1 Rad17-RFC complexbound to DNASGOL2 CHEK2PIAS4 CENPP ANAPC15 p-S25,S1778-TP53BP1 SFN RPA3 NUP37 UBE2V2 Activated MAD2L1 p-S343-NBN PSMC6 PPP1CC DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complexBUB1BDBF4 Activated MAD2L1CENPK HUS1 CENPF ATPUBB(1-76) Activated MAD2L1 p-S343-NBN CDCA8 UBC(1-76) PPP2R1A ORC5 INCENP CENPH DYNLL2 KIF2C MCM3 CENPL 26S proteasomeYWHAH SGOL2 DYNLL1 PPP2R1B CDC16 RFC5 CDKN1A mRNAORC1 UIMC1 UBC(305-380) CLIP1 YWHAG INCENP RFC2 RPA1 KIF2C p-S166,S188-MDM2 RAD9B RAD50 CCNB2 DYNC1LI2 SKA2 UBB(1-76) DNA double-strand break ends CDC16 NUP37 RAD17 p-S123-CDC25AB9D2 CLASP2 MDM4 YWHAB RFC5 K6PolyUb,p-T714,T734-BARD1 PSME2 ADPp-S435-GTSE1 CDC6 p-S343-NBN PSMD9 KAT5 UBB(1-76) CDK:DDK:MCM10:activepre-replicativecomplex:CDC45UBC(533-608) ORC4 CENPL MCM2 SKA1 KIF2A ADPCDKN1B PPP1CC YWHAG RAD17 UBC(229-304) ADPZWILCH UBC(153-228) BUB1B DYNC1LI1 NUP43 ANAPC2 PSMD2 NUP160 CCNE1 ATPCHEK2 CCNA1 TOPBP1 DNA2 ATPUBC(381-456) ADPPersistentsingle-stranded DNASEC13 CENPC1 p-S435-GTSE1ZW10 SGOL1 UBA52(1-76) ANAPC7 p-S166,S188-MDM2 KNTC1 CDK2 CENPO UBC(609-684) CDC26 APITD1 UBC(305-380) PSMD11 ATPCCNB1 UbDYNC1I2 AURKB SEH1L-1 CENPC1 UBC(533-608) KIF2B UBE2N p-S406-FAM175A Activated MAD2L1 NUP107 PPP2R1B RPA2 NUP160 BRCC3 ADPp-S166,S188-MDM2 SKA1 PSMD14 PSMB4 ORC2 p-T714,T734-BARD1 UBB(153-228) BUB3 NUP98-5 HIST1H2BD HIST1H2BA RFC2 RMI2 p-S435-GTSE1:PolyUb-TP53 TetramerATR:ATRIP:RPA:ssDNAsignaling complexPAFAH1B1 BUB3 BRE HIST1H2BM ITGB3BP p-S15-TP53 TetramerATR CENPN RANGAP1 ORC3 YWHAE CLASP1 YWHAQ SPC24 NUP160 UBC(229-304) ZWINT K6PolyUb,p-T714,T734-BARD1 CENPE TP53 RCC2 RAD9A DYNC1LI2 CDC27 PPP2R5E ZWILCH UBC(609-684) HIST1H2BC BUB1 HIST3H3 RFC4 MDM4 ORC1 CENPH UBA52(1-76) PPP2R5E p-T714,T734-BARD1 KIF2C PSMD8 KAT5 MAPRE1 PSMD12 UBA52(1-76) SPDL1 CDC26 PPP2R5A RPA3 CDC20 RCC2 p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4RFC3 CENPQ UBE2D1 PSMA2 PPP2R5C HIST2H2BE XPO1 UBE2N ITGB3BP ZNF385AHERC2-SUMO1 p-S15-TP53 MCM4 hBUBR1:hBUB3:MAD2*:CDC20 complexERCC6L DSN1 CDC20 CCNB1 PPP2R1B ANAPC11 Rad9-Hus1-Rad1 boundto DNAKIF2B NUP98-5 MCM10 RFC2 CENPP CENPA CKAP5 p-S166,S188-MDM2NUP85 Ub-p-S123-CDC25AKNTC1 BUB1B BLM DYNLL2 RFC5 BIRC5 CDKN1APolyUb-TP53 PPP2R5C RAD9B Ubp-S166,S188-MDM2:p-S403-MDM4SGOL1 CyclinA:Cdk2:p21/p27complexKinetochore:Mad1:MAD2 ComplexPPP2CB Persistent single-stranded DNA CCNB:p-T14-CDK1CDK1 p-S166,S188-MDM2dimer,p-S166,S188-MDM2:MDM4CCNE:CDK2SPDL1 MAPRE1 SPDL1 NUP85 MCM6 PSMA7 Zn2+ RAD9B RANGAP1 PSMC4 PSMD3 CLIP1 PSMB9 CDKN1B RFC5 CASC5 RPA3 XPO1 UBC(381-456) PPP2CA p-S387-RFWD2p-S317,S345-CHEK1YWHAZ UBE2E1 BUB3 KIF18A 14-3-3 dimerZWINT ADPCDKN1A geneUBC(153-228) CENPN HIST3H3 RAD9A RCC2 WRN PPP2R5A ZW10 NUP133 CENPQ NUP133 DSN1 ATPCLASP2 HUS1 PAFAH1B1 RAD17 Persistent single-stranded DNA CCNB1:p-T14,Y15,T161-CDK1ANAPC16 NUP133 PPP2CB p-S102-WHSC1 MCM5 RNF168 UBC(229-304) ORC4 PPP2CB UBC(457-532) UBC(305-380) MAD2*CDC20 complexHIST1H2BB CENPO ANAPC16 RPA3 CDKN1B CDC20MLF1IP MCM3 MAD1L1 HIST1H2BJ RFC4 UBC(1-76) p-5S,T-MDM2NDEL1 RFC2 ADPADPRANBP2 PPP2R5B MIS12 UBC(305-380) MAPRE1 ORC5 TAOK1 MDM4 CENPI NDEL1 MCM5 MAD2L1NUF2 CENPC1 PSMD13 UBA52(1-76) HIST3H2BB DYNC1H1 p-S166,S188-MDM2 HIST1H2BK RFWD2AHCTF1 ATRIP NUF2 NUF2 NUP85 UBC(153-228) UBC(1-76) p-T714,T734-BARD1 BIRC5 XPO1 CDC25CMIS12 NUP98-5 AURKB UBB(77-152) NUDC ATPCCNE2 PPP2R5D BUB3 RPS27A(1-76) PIAS4 DYNC1LI1 p-T68-CHEK2AHCTF1 UBC(533-608) CENPA YWHAZ SEH1L-1 p-T4827,SUMO1-HERC2 PSME3 AURKB ORC3 PSMB10 RFC3 CENPT ATPKIF18A CLIP1 MCM3 MAD1L1 SEH1L-1 NUP133 ORC1 CENPL RAD1 RAD50 33204323, 38, 8495333, 74, 7846, 911040, 5613952723, 3877738054, 58, 87, 10010982073, 931, 141615, 37, 62, 7217