Cell Cycle Checkpoints (Homo sapiens)

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19, 34, 579622, 29, 82289, 49, 883123, 38, 61, 849, 49538, 12, 25, 64, 67...5216, 81779675, 8471, 80, 9946, 91708, 12, 865, 16, 81952, 60, 9596925, 15, 37, 62, 72...60, 9526, 685, 24, 45, 65, 83...94496779420, 4869, 76, 79476, 21, 30, 51, 9132, 53, 55, 598044, 58, 63, 8911, 4235, 97477365036, 39, 50, 6620, 483, 41, 74, 851820961631cytosolnucleoplasmRCC2 PSMF1 p-T714,T734-BARD1 CKAP5 KIF18A INCENP CENPM CLASP1 RAD17 PolyUb-TP53 TetramerBUB3 UBC(533-608) CENPK KNTC1 MAD2L1 YWHAZ RPA3 ANAPC7 CENPP CENPK PSMC2 ERCC6L PPP2CA DBF4 UBC(153-228) CENPL TOPBP1 RAD9B ATPANAPC16 B9D2 ZWILCH ITGB3BP p-S166,S188-MDM2NUP107 UBC(1-76) ADPDSN1 ZW10 ATR ATPCDC23 BUB3 ZNF385AUBC(609-684) origin of replication RPA2 DYNC1LI2 MCM5 MRE11A PPP2R5A INCENP UBC(609-684) CENPI CDKN1A PMF1 PSMC6 14-3-3 dimerPersistent single-stranded DNA TAOK1 CENPH p-S166,S188-MDM2 CDC20 KIF18A p-S15,S20-TP53TetramerPMF1 p-5T-MDC1 ANAPC5 CENPF MCM4 YWHAG ATPRPA1 MCM3 RANGAP1 PPP2R1B ATR:ATRIPATR RFC4 NUP160 CENPQ PIAS4 YWHAE K63PolyUb-K14,K16,p-S140-H2AFX RCC2 RANGAP1 Persistent single-stranded DNA CENPK p-S435-GTSE1PSMA7 UBC(1-76) UBB(77-152) MRE11A CCNB1:p-T14,Y15,T161-CDK1MCM6 BUB3 RAD9B CCNB2 RANGAP1 MAPRE1 p-S166,S188-MDM2 UBC(457-532) MCM5 KIF2B PSME4 ITGB3BP UBE2S CCNE:CDK2PPP1CC SKA1 PSMB1 ATRIP NUP107 PMF1 ANAPC7 TP53 NDE1 RPS27 p-S988,S1387,S1423,S1524,S1547-BRCA1 HIST3H3 RPS27A(1-76) ATPPolyUb,p-S166,S188-MDM2 p-S166,S188-MDM2:MDM4PolyUb-TP53 Tetramerp-S406-FAM175A BIRC5 RPS27A(1-76) CENPA RFC3 PSMD1 PAFAH1B1 CDC26 CENPK DYNC1I2 YWHAG PPP2R5A MAD2L1XPO1 MDM4 PolyUb-TP53 YWHAH PPP2R5C CHEK2 p-S403-MDM4 p-5S,T-MDM2NUP98-5 p-S166,S188-MDM2 PSMB5 NDEL1 PAFAH1B1 p-S102-WHSC1 RANBP2 UBC(533-608) ADPCENPE ANAPC15 PSMD10 p-S25,S1778-TP53BP1 DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complexRAD17 p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4Persistent single-stranded DNA CDK2 RPA1 DYNC1I1 MCM10 SPC24 RFC3 BUB1B p-T4827,SUMO1-HERC2 BUB1B CENPT NUP133 CENPO ADPNDE1 BUB1 BUB1 CLIP1 SEC13 UBC(305-380) RFC3 UBB(153-228) UBE2C MLF1IP HIST1H2BM TP53 TetramerPPP2CB CCNB1 UBC(305-380) KIF2B MAD1L1 UbXPO1 CDKN1B PPP2R5E PSMD11 p-S15,S20-TP53Tetramer:ZNF385A:CDKN1A GeneRPA3 ATPPPP2R1B NDC80 RPA1 BRCC3 Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complexSGOL1 Rad17-RFC complexbound to DNACDC16 cyclin PAFAH1B1 MLF1IP CDKN1A CCNA:CDK2BUB3MIS12 PPP2R5D p-S166,S188-MDM2 Activated MAD2L1 WEE1AHCTF1 HIST1H2BJ p-S15,S20-TP53Tetramer:ZNF385Ap-T4827,SUMO1-HERC2 PSMA1 UBB(1-76) phosphorylatedanaphase promotingcomplex (APC/C)UBC(1-76) CCNE2 NSL1 KNTC1 PPP2R1A UBC(229-304) RPA2 Ub-p-S123-CDC25AAURKB NUP85 p-5T-MDC1 APITD1 CDCA8 RANGAP1 CDKN1A mRNASGOL1 HIST1H2BC DYNC1I2 ANAPC4 CKAP5 PCBP4NDEL1 RFC5 ZWILCH CENPA ZWINT RNF8 HIST1H2BL p-S406-FAM175A CLASP2 CHEK1p-S15-TP53 XPO1 UBB(153-228) CKAP5 PSMB3 CASC5 CENPO DYNLL2 CDC7 UBC(229-304) PSMB11 p-S123-CDC25AYWHAE UBC(77-152) CLASP2 KIF2C RPA3 ANAPC10 ITGB3BP UbRAD9B SPDL1 CASC5 CDCA8 UBE2E1 CLSPN PSMB10 ATPCDK2 KIF2B RAD9A UBC(381-456) RPA1 Kinetochore:Mad1:MAD2* ComplexMAD2*CDC20 complexCENPC1 CDC25CCENPM CCNA1 MAPRE1 YWHAH CENPQ MCM6 HUS1 NDC80 SEH1L-1 p-S435-GTSE1 p-T916,S945-CLSPN NDC80 HIST1H2BL CDC25ARAD9:HUS1:RAD1PSMD14 CDKN1A AHCTF1 DYNC1LI2 KIF18A SPC25 UBB(153-228) p-S343-NBN DYNC1LI1 CDK2 NSL1 SPC25 CDK2 ERCC6L PPP2R5D 3' overhanging DNA at resected DSB ends AHCTF1 RAD9A DYNLL2 RFWD2KAT5 p-S343-NBN INCENP SPDL1 HIST1H2BN ADPCLSPNp-S387-RFWD2:p-S15-TP53RPS27A(1-76) MAPRE1 YWHAQ PPP2R5D RPA2 DYNC1LI2 SEC13 ATR ORC6 SKA2 CENPF MCM8 ZW10 p-S15,S20-TP53 BIRC5 ATPADPUBC(381-456) UBB(1-76) PPP2R1A ORC4 ORC1 CDC23 K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 RPS27 PLK1 UBE2E1 ATPRANBP2 CENPP CDC7 ORC5 MCM4 NUP43 ORC3 RAD1 UBC(533-608) KIF2C UBC(609-684) DYNC1I1 CENPL PSMA4 p-S,3T-CHEK2RAD1 RFC4 SKA1 ADPPAFAH1B1 CENPE SKA2 p-S216-CDC25CRANBP2 p-S166,S188-MDM2dimer,p-S166,S188-MDM2,MDM4:TP53p-S15-TP53 KAT5 BRE ERCC6L CDC6 BUB1 ZWILCH ANAPC4 DYNC1H1 MCM3 MCM5 p-T68-CHEK2CDKN1B CDCA8 ATPNUP133 NDE1 PSMB9 UBC(153-228) UBB(77-152) SEH1L-1 ZW10 CCNA2 PPP2R5A RPS27A(1-76) UbHIST1H2BA ATPCDC45 KIF2B DYNLL1 UBC(305-380) BUB1 HIST1H2BB ATPMAPRE1 CHEK2BUB3 ORC2 KIF2C ATPMLF1IP ADPZW10 SHFM1 CCNA1 PPP2R5C PSME3 SPC24 B9D2 p-S387-RFWD2MIS12 MAD1L1 CDK:DDK:MCM10:activepre-replicativecomplex:CDC45DSN1 Activated MAD2L1MCM4 PolyUb,p-S342,S367,S403-MDM4 CDKN1B MDM4 p-S343-NBN RAD17:RFCMCM10 NUP37 CENPE UIMC1 CENPT HIST2H2BE TP53 RAD9A PSMB4 UBC(381-456) MAD1L1 PSMB7 YWHAB Me2K21-HIST1H4 CDC45 NUP85 RAD1 NUDC CENPP UBA52(1-76) PPP2R1A PSMD9 SGOL1 CENPN ORC5 CENPL UBC(533-608) NUDC hBUBR1:hBUB3:MAD2*:CDC20 complexUBC(153-228) p-S1387,S1423,S1524,S1547-BRCA1 TAOK1 CDC20 PPP2R5A ADPUBC(381-456) UBC(305-380) HUS1 UBA52(1-76) RPA2 BUB1B RPA3 RNF8 DYNC1H1 BUB1B ORC6 HIST1H2BD HERC2-SUMO1 PSMA3 UBC(609-684) PSMA2 origin of replication p-T68-CHEK2 dimerZWINT PPP2CA NUF2 RMI2 RFC2 CDKN1A,CDKN1BANAPC10 CENPO ATRIP MCM2 DYNLL2 p-S166,S188-MDM2:p-S346,S367,S403-MDM4HIST3H3 ATPCDC20 SGOL2 BLM MAD2L1 PLK1 Zn2+ NUP43 CENPQ UBA52(1-76) CDCA8 NUP107 SEC13 RNF168 Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complexXPO1 CENPH PPP2CA DBF4 DYNC1H1 p-S387-RFWD2PPP2R5E MDM4 HIST1H2BH HIST1H2BH p-T14-CDK1 ZNF385A RPA1 CENPT p-S435-GTSE1:PolyUb-TP53 TetramerUBC(609-684) ATPRFC2 ITGB3BP EXO1 CyclinE:CDK2:CDKN1A,CDKN1BCENPI UBC(305-380) UBC(457-532) KIF2A AHCTF1 CENPN MCM2 NUP37 RANBP2 DYNC1LI1 MCM7 p-S123-CDC25A DNA double-strand break ends K6PolyUb,p-T714,T734-BARD1 PSME1 UBE2D1 ORC2 NSL1 DYNC1I1 H2BFS UBC(77-152) p-S1981,Ac-K3016-ATM origin of replication p-WEE1SFN PSMB8 CDC45 UBC(153-228) p-S216-CDC25C PPP1CC CDKN1A gene YWHAQ ANAPC11 MCM7 RPA heterotrimerRPA3 UBB(1-76) PPP2R1A ANAPC11 26S proteasomeUBA52(1-76) PSMC5 PSMC1 PolyUb-TP53 K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 UBB(153-228) Me2K21-HIST1H4 BABAM1 TAOK1 CENPC1 UBE2N MAD1L1CDK1 ATR:ATRIP:RPA:ssDNAsignaling complexHIST1H2BA PSME2 NUP37 DSN1 RFC5 DNADNADSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2CENPN Persistent single-stranded DNA UBC(1-76) UBC(77-152) SKA2 CASC5 p-S15-TP53 TetramerCLIP1 CENPA NUP160 p-S317,S345-CHEK1DYNC1LI2 PSMA8 PHF20PolyUb-TP53 PPP2R5B p-T68-CHEK2 UBE2N PPP2R5E UBB(77-152) SKA1 CDC16 SPC25 DNA2 DYNC1I2 CLASP1 CCNB1 CKAP5 ubiquitinatedphospho-COP1(ser-387)NDEL1 NUP85 HIST1H2BB RFC4 TOP3A RPA complexed tossDNAUbiquitin ligaseCyclinA:Cdk2:p21/p27complexSFN WRN PPP1CC MAD2L1 UBB(77-152) CDKN1A mRNA UBB(153-228) UBC(1-76) APITD1 DYNLL2 RAD50 RPS27 PSMB2 MCM8 RFC5 BUB3 PPP2CA CENPF UBC(153-228) NUP107 UBE2V2 PPP2R5C Activated MAD2L1 MCM3 NUP43 ATPp-S102-WHSC1 RFC3 YWHAZ ADPPSMA5 SKA1 Zn2+ UBC(381-456) UIMC1 PSMA6 MRE11A MCM2 CLASP2 ANAPC2 ZNF385A ATPSPC25 PPP2R5B K63PolyUb-K14,K16,p-S140-H2AFX B9D2 ORC4 BUB3 CCNE1 p14ARF HIST3H2BB SGOL2 ERCC6L p-S1981,Ac-K3016-ATM p-S166,S188-MDM2:p-S403-MDM4CDK2 RFC5 KIF2A Kinetochore:Mad1:MAD2 ComplexRCC2 AURKB UBC(1-76) RNF168 CENPT PIAS4 Rad9-Hus1-Rad1 boundto DNAUBC(305-380) RPA1 NUDC HIST1H2BC PSMD3 UBE2D1 p-S327,T847,T859-RBBP8 K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 MIS12 CCNE1 DSN1 RFC2 RMI1 RAD50 SKA2 MCC:APC/C complexRHNO1 BRCC3 CENPM ADPPSMD12 ADPPSMC4 BIRC5 SPDL1 cyclin ORC1 ATR:ATRIP:RPA:3'overhangingssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1DYNLL1 NSL1 UBB(77-152) HIST2H2BE CENPF PPP2R1B NDE1 KIF2A CENPP Activated MAD2L1 p-T714,T734-BARD1 UBB(1-76) HIST1H2BD PLK1 SPC24 PSMD2 RAD50 DYNC1LI1 ADPUBC(77-152) PPP1CC SEH1L-1 PSMD5 CDK2 HIST1H2BO CDC27 KAT5 UBB(1-76) PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4ANAPC16 UbNUP133 RFC4 CENPE HIST1H2BO RAD17 HIST3H2BB BUB1BATPp-S387-RFWD2 UBB(1-76) CENPH ORC1 CDC6 RCC2 RPS27A(1-76) NUP160 PCBP4 RAD17 p-S166,S188-MDM2 MCM7 UBC(381-456) HERC2-SUMO1 DYNC1I1 PPP2R5B SGOL1 MDM4 DBF4 SPDL1 NUP85 PSMD4 cyclin UBC(229-304) CDK2 AURKB p-T714,T734-BARD1 BIRC5 CCNB1 K6PolyUb,p-T714,T734-BARD1 CDC20 DNA Double StrandBreak ResponseMAD2L1 CLASP1 UBE2S p-S25,S1778-TP53BP1 p-S15,S20-TP53 NUF2 HIST1H2BN p-S166,S188-MDM2 SGOL2 PPP2CB MCM8 UBB(153-228) MAD1L1 RPS27A(1-76) CCNB:p-T14-CDK1p-S1981,Ac-K3016-ATMUBC(457-532) ADPUBC(77-152) HIST1H2BJ CDC6 RPA2 DYNC1LI1 ANAPC15 HIST1H2BK KNTC1 p-S123-CDC25APSMD13 KinetochoreORC3 B9D2 p-S15,S20-TP53 p-S166,S188-MDM2,MDM4NUP37 UBC(457-532) TAOK1 NUP160 UBC(609-684) UBC(229-304) RFC2 Persistentsingle-stranded DNACENPC1 CCNB1:p-T14,T161-CDK1UBC(153-228) NUDC PPP2R1B H2BFS CCNE2 KIF2C PPP2CB CLASP2 CDKN1ACLIP1 CDC20p-S1981,Ac-K3016-ATM PSMD6 UBA52(1-76) BUB1B ANAPC1 p-S435-GTSE1 BRE CLIP1 ADPPPP2CB CDC27 CDC7 NUP98-5 PSMC3 p-S435-GTSE1:PolyUb-TP53 TetramerSEC13 ATRIP DNA double-strand break ends ANAPC2 CDC20 UBC(457-532) ATPp-S216-CDC25CCDC26 NUP43 DYNC1H1 APITD1 MIS12 MCM10 CCNB2 p-S435-GTSE1YWHAB UBC(533-608) ADPUBC(533-608) p-S990,Ac-K1249-BRIP1 KNTC1 CCNA2 BABAM1 UBA52(1-76) PPP2R5C p-S346,S367,S403-MDM4 SEH1L-1 DYNC1I2 PSMB6 ADPPCBP4:CDKN1A mRNAPPP2R5D CASC5 HUS1 ZWINT KIF18A RPS27 PMF1 CENPL UBE2V2 DYNLL1 ORC4 ADPKIF2A ZWILCH RPA2 ZWINT ADPMad1:kinetochorecomplexUBC(457-532) CENPI DYNLL1 ORC5 CENPO CCNB1 NUP133 p-S1387,S1423,S1524,S1547-BRCA1 CENPH PPP2R5E PKMYT1p-S216-CDC25C:14-3-3protein complexUBC(229-304) PolyUb-TP53 ORC2 NUF2 CDC20 NDC80 ORC3 NUP98-5 CDC20 p-T14,T161-CDK1 p-S166,S188-MDM2 MCM6 CENPA SGOL2 AURKB MLF1IP CENPM NDEL1 PSMD8 PPP2R5B CDKN1A geneHIST1H2BM UBE2C CENPN PSMD7 ANAPC1 p-S166,S188-MDM2dimer,p-S166,S188-MDM2:MDM4p-S387-RFWD2 NUF2 HIST1H2BK UBB(77-152) K6PolyUb,p-T714,T734-BARD1 CCNB:CDK1CENPI CLASP1 ANAPC5 PLK1 BUB1B RPA3 CENPQ UBC(77-152) NUP98-5 ORC6 Activated MAD2L1 APITD1 CENPC1 SPC24 UBC(229-304) p-T14,Y15,T161-CDK1 INCENP MDM4 40, 5646, 91201073, 93777315, 37, 62, 72273, 74, 78981623, 38, 8420174323, 388054, 58, 87, 100953313331, 149510