Cell cycle checkpoints (Homo sapiens)
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36, 39, 50, 66
35, 97
5, 24, 45, 65, 83...
2, 60, 95
70
53
9, 49
5, 15, 37, 62, 72...
20, 48
96
4
20
19, 34, 57
5, 16, 81
8, 12, 25, 64, 67...
75, 84
96
77
36
22, 29, 82
6, 21, 30, 51, 91
11, 42
20, 48
52
16
7
8, 12, 86
96
31
32, 53, 55, 59
77
26, 68
71, 80, 99
47
28
96
18
23, 38, 61, 84
44, 58, 63, 89
9, 49, 88
94
3, 41, 74, 85
96
69, 76, 79
16, 81
80
46, 91
60, 95
92
50
95
94
47
31
nucleoplasm
cytosol
PPP2R5D
NUP98-5
BUB1B
CDKN1A,CDKN1B
NUP85
PSMD6
SKA1
MCM4
CENPE
ITGB3BP
p-S123-CDC25A
ADP
RPA1
p-S988,S1387,S1423,S1524,S1547-BRCA1
CENPA
CCNE1
CENPL
SPC24
AURKB
K63PolyUb-K14,K16,p-S140-H2AFX
PPP2CA
PSMC2
CDC45
PPP1CC
ATP
CASC5
p-WEE1
CDC7
CDKN1A gene
p-S15,S20-TP53
Tetramer:ZNF385A:CDKN1A Gene
Cyclin
E:CDK2:CDKN1A,CDKN1B
SGOL1
SEC13
CENPM
PPP2CA
UBC(533-608)
ATP
K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1
RPA3
CENPT
MCM8
SKA2
KIF2A
UBC(533-608)
TOP3A
p-S15-TP53
PPP2R5E
CDKN1A
HIST1H2BK
B9D2
ORC3
TAOK1
SEC13
Ub
CDC23
NUP107
UBC(1-76)
CCNB:CDK1
RFC3
p-S990,Ac-K1249-BRIP1
p-S346,S367,S403-MDM4
KIF2A
KIF18A
ATP
MCM8
NUP43
NSL1
DYNC1H1
ATP
p-S216-CDC25C:14-3-3
protein complex
ZW10
BABAM1
ATP
APITD1
PPP2CB
p-T916,S945-CLSPN
ZWILCH
UBE2D1
CLIP1
p-S435-GTSE1
CLASP1
SGOL1
DYNC1I2
p-S1387,S1423,S1524,S1547-BRCA1
ORC6
RPA1
p-T14,Y15,T161-CDK1
RANGAP1
UBC(381-456)
RPA1
CENPF
PSMA8
B9D2
CENPT
PolyUb-TP53
KIF2B
ATP
RPS27A(1-76)
RPA2
UBC(381-456)
YWHAB
CDC7
p-T68-CHEK2 dimer
RPS27A(1-76)
KNTC1
DYNC1I1
SPC24
KAT5
ANAPC10
HIST1H2BN
ERCC6L
PSMD5
ADP
HIST1H2BO
PMF1
PPP2R5E
UBC(77-152)
CENPC1
ADP
UBC(381-456)
SPC25
XPO1
NSL1
UBC(381-456)
CDC20
UBE2S
CENPI
RPA2
MRE11A
CCNB1
MAD1L1
CDK2
RAD50
cyclin
MIS12
UBC(533-608)
RPA1
NUDC
DNA double-strand break ends
H2BFS
cyclin
CDC6
DYNLL2
CENPH
Ubiquitin ligase
CENPE
PSMD10
PSMA1
BUB1B
TAOK1
APITD1
PSME4
KIF2B
ATP
p-S25,S1778-TP53BP1
PSMD4
p14ARF
K63PolyUb-K14,K16,p-S140-H2AFX
CENPO
NDE1
CENPE
RPS27
PPP2R5D
MCM2
NUP43
PSMD1
CKAP5
DYNC1I2
CENPH
HUS1
CCNA2
HIST1H2BA
PAFAH1B1
SPC25
INCENP
ATRIP
cyclin
UBC(457-532)
UBC(229-304)
RANBP2
DSN1
HIST3H2BB
UBC(229-304)
RAD9A
p-S403-MDM4
ZWINT
p-S166,S188-MDM2:p-S346,S367,S403-MDM4
Activated MAD2L1
CDK2
NDC80
PPP2R5A
NUP37
UBE2C
SGOL2
ATP
PolyUb,p-S166,S188-MDM2:PolyUb,p-S342,S367,S403-MDM4
HIST1H2BL
UBA52(1-76)
origin of replication
CASC5
ATP
ATP
BRE
PPP2R1A
p-S,3T-CHEK2
CDC23
p-S166,S188-MDM2
ZNF385A
ZNF385A
PSMB3
RANGAP1
SEH1L-1
ORC2
MAD1L1
DYNC1I1
UBC(153-228)
BUB1
RPS27
UBC(457-532)
MCM8
NDE1
CDK2
PSMB1
ADP
CENPQ
MCM7
3' overhanging DNA at resected DSB ends
p-S435-GTSE1:PolyUb-TP53 Tetramer
RHNO1
p-S166,S188-MDM2
dimer,
p-S166,S188-MDM2,MDM4:TP53
MDM4
ANAPC7
PAFAH1B1
DSN1
CDC20
ANAPC2
p-S1981,Ac-K3016-ATM
BABAM1
PPP2R5B
ADP
PSMC5
PLK1
ANAPC1
HERC2-SUMO1
HIST1H2BL
CDCA8
CENPM
p-S166,S188-MDM2
NUDC
ITGB3BP
DYNC1LI1
RFC4
CLASP1
B9D2
CENPN
CDKN1A
ZWINT
CENPP
CENPP
UBB(77-152)
CENPI
PPP2R5B
p-S15,S20-TP53
UBC(1-76)
UBC(305-380)
CCNA:CDK2
DYNLL1
PLK1
CDC45
DYNC1H1
CDKN1A mRNA
PSMC3
SHFM1
RANBP2
RPS27A(1-76)
SFN
CLSPN
SKA1
CENPA
MRE11A
UBC(305-380)
MIS12
phosphorylated
anaphase promoting
complex (APC/C)
CKAP5
ANAPC1
MCM6
UBB(77-152)
Ub
DYNC1LI1
MCM10
PPP2R5A
p-S15,S20-TP53
MCM7
BUB1
MLF1IP
UBC(457-532)
p-S15,S20-TP53
p-T4827,SUMO1-HERC2
ANAPC10
ANAPC5
PSMB7
RPA heterotrimer
CENPM
UBB(1-76)
BIRC5
p-S327,T847,T859-RBBP8
BUB1B
ubiquitinated
phospho-COP1(ser-387)
NUP43
ORC6
ATRIP
p-S216-CDC25C
RPA2
NUF2
ORC5
RMI1
p-T68-CHEK2
UBC(609-684)
UBC(457-532)
ATR
UBE2C
PMF1
p-S1981,Ac-K3016-ATM
AHCTF1
PSMA3
RAD9:HUS1:RAD1
CASC5
UBE2E1
MCM10
SPC25
UBC(457-532)
MCM2
PPP1CC
ANAPC11
PolyUb-TP53 Tetramer
p-S216-CDC25C
CDC6
RNF168
PSMA6
CDK2
UBC(77-152)
HIST1H2BH
NUDC
HIST1H2BC
PolyUb,p-S342,S367,S403-MDM4
PSMC1
MCM6
CENPT
UBB(153-228)
CENPK
CKAP5
K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1
NDE1
PSMB8
PCBP4:CDKN1A mRNA
ANAPC4
PHF20
UBC(77-152)
Persistent single-stranded DNA
RPS27A(1-76)
KIF2C
CENPO
CENPF
CENPF
PLK1
CENPK
CCNB1:p-T14,T161-CDK1
HIST1H2BM
SEC13
UBC(229-304)
MAD2L1
p-5T-MDC1
ADP
APITD1
HIST1H2BJ
DYNC1I2
DBF4
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex
PSMA4
Mad1:kinetochore
complex
p-S1981,Ac-K3016-ATM
DYNC1I1
UBB(77-152)
RPA3
Zn2+
ERCC6L
PSME1
RCC2
DNA
DNA
DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2
CDK2
UBC(609-684)
TP53
BUB1
PolyUb,p-S166,S188-MDM2
ADP
ORC6
CCNB2
p-T14-CDK1
CDK2
p-S102-WHSC1
BUB1B
SKA2
PolyUb-TP53 Tetramer
CENPQ
UBE2V2
ATR:ATRIP
ADP
NUP160
p-S166,S188-MDM2
CDC25A
ANAPC15
p-S435-GTSE1
MAD1L1
CDKN1A
ATR:ATRIP:RPA:3'
overhanging
ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1
YWHAE
UBB(77-152)
CLASP1
PPP2R1B
PSMF1
p-T14,T161-CDK1
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex
UBB(153-228)
K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1
ATP
MAPRE1
DYNC1LI2
NDE1
YWHAQ
NSL1
p-S406-FAM175A
PPP2R5B
NDC80
RFC4
UBC(1-76)
RANBP2
origin of replication
RNF8
MAD2L1
DYNLL2
MCM4
CENPN
p-S166,S188-MDM2,MDM4
NUP37
EXO1
MAD2L1
Me2K21-HIST1H4
MCC:APC/C complex
p-S15,S20-TP53
Tetramer
p-S216-CDC25C
PSMD7
CENPI
RPA2
RPA2
NDEL1
BUB3
DYNLL1
NDC80
ANAPC4
KNTC1
p-S1981,Ac-K3016-ATM
RAD17:RFC
UBC(609-684)
UBB(77-152)
UBB(1-76)
Kinetochore
MLF1IP
HIST1H2BN
DYNC1LI2
origin of replication
H2BFS
CLASP2
RAD17
TP53 Tetramer
DBF4
RPS27
UBB(153-228)
CDC27
PKMYT1
DYNC1I1
RFC3
Me2K21-HIST1H4
UBC(153-228)
CCNA1
UBC(77-152)
NDC80
MAD2L1
CLSPN
DYNC1H1
AHCTF1
SKA2
CDC20
p-S15,S20-TP53
Tetramer:ZNF385A
PolyUb-TP53
HIST2H2BE
BUB3
p-S166,S188-MDM2:MDM4
DNA Double Strand
Break Response
NDEL1
PSMB6
BIRC5
UBB(1-76)
UBB(153-228)
CENPM
HIST1H2BD
WEE1
NUP107
PSMB11
PMF1
ADP
RAD1
ANAPC5
CCNE2
HIST1H2BB
ADP
CDC45
PMF1
DYNLL1
CDC20
ZW10
CDC20
PLK1
CCNA2
TAOK1
UBC(77-152)
p-S387-RFWD2
UBA52(1-76)
ORC4
p-S387-RFWD2
CDCA8
PPP2CA
UBB(153-228)
BUB3
CLASP2
PSMB2
HIST1H2BH
MCM7
ERCC6L
ATR
PolyUb-TP53
SPC24
RPS27A(1-76)
PCBP4
MLF1IP
RNF8
CDC7
INCENP
K6PolyUb,p-T714,T734-BARD1
UBC(77-152)
HIST1H2BO
BRCC3
Kinetochore:Mad1:MAD2* Complex
SPC25
SPDL1
CHEK1
UBC(609-684)
UIMC1
p-S1387,S1423,S1524,S1547-BRCA1
CENPK
MRE11A
PCBP4
p-S387-RFWD2
NSL1
UBC(153-228)
UBE2S
ORC2
PPP2R5D
p-S387-RFWD2:p-S15-TP53
MCM5
YWHAH
MDM4
RAD1
PPP2R1A
PSMA5
PPP2R5C
RPA complexed to
ssDNA
SGOL2
NUP107
CDCA8
KIF2A
RPS27
PSMB5
p-5T-MDC1
p-S123-CDC25A
PPP2R5C
PPP2R1A
ZWILCH
Persistent single-stranded DNA
KIF18A
RPA1
CCNB1
Rad17-RFC complex
bound to DNA
SGOL2
CHEK2
PIAS4
CENPP
ANAPC15
p-S25,S1778-TP53BP1
SFN
RPA3
NUP37
UBE2V2
Activated MAD2L1
p-S343-NBN
PSMC6
PPP1CC
DNA
DNA
DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex
BUB1B
DBF4
Activated MAD2L1
CENPK
HUS1
CENPF
ATP
UBB(1-76)
Activated MAD2L1
p-S343-NBN
CDCA8
UBC(1-76)
PPP2R1A
ORC5
INCENP
CENPH
DYNLL2
KIF2C
MCM3
CENPL
26S proteasome
YWHAH
SGOL2
DYNLL1
PPP2R1B
CDC16
RFC5
CDKN1A mRNA
ORC1
UIMC1
UBC(305-380)
CLIP1
YWHAG
INCENP
RFC2
RPA1
KIF2C
p-S166,S188-MDM2
RAD9B
RAD50
CCNB2
DYNC1LI2
SKA2
UBB(1-76)
DNA double-strand break ends
CDC16
NUP37
RAD17
p-S123-CDC25A
B9D2
CLASP2
MDM4
YWHAB
RFC5
K6PolyUb,p-T714,T734-BARD1
PSME2
ADP
p-S435-GTSE1
CDC6
p-S343-NBN
PSMD9
KAT5
UBB(1-76)
CDK:DDK:MCM10:active
pre-replicative
complex:CDC45
UBC(533-608)
ORC4
CENPL
MCM2
SKA1
KIF2A
ADP
CDKN1B
PPP1CC
YWHAG
RAD17
UBC(229-304)
ADP
ZWILCH
UBC(153-228)
BUB1B
DYNC1LI1
NUP43
ANAPC2
PSMD2
NUP160
CCNE1
ATP
CHEK2
CCNA1
TOPBP1
DNA2
ATP
UBC(381-456)
ADP
Persistent
single-stranded DNA
SEC13
CENPC1
p-S435-GTSE1
ZW10
SGOL1
UBA52(1-76)
ANAPC7
p-S166,S188-MDM2
KNTC1
CDK2
CENPO
UBC(609-684)
CDC26
APITD1
UBC(305-380)
PSMD11
ATP
CCNB1
Ub
DYNC1I2
AURKB
SEH1L-1
CENPC1
UBC(533-608)
KIF2B
UBE2N
p-S406-FAM175A
Activated MAD2L1
NUP107
PPP2R1B
RPA2
NUP160
BRCC3
ADP
p-S166,S188-MDM2
SKA1
PSMD14
PSMB4
ORC2
p-T714,T734-BARD1
UBB(153-228)
BUB3
NUP98-5
HIST1H2BD
HIST1H2BA
RFC2
RMI2
p-S435-GTSE1:PolyUb-TP53 Tetramer
ATR:ATRIP:RPA:ssDNA
signaling complex
PAFAH1B1
BUB3
BRE
HIST1H2BM
ITGB3BP
p-S15-TP53 Tetramer
ATR
CENPN
RANGAP1
ORC3
YWHAE
CLASP1
YWHAQ
SPC24
NUP160
UBC(229-304)
ZWINT
K6PolyUb,p-T714,T734-BARD1
CENPE
TP53
RCC2
RAD9A
DYNC1LI2
CDC27
PPP2R5E
ZWILCH
UBC(609-684)
HIST1H2BC
BUB1
HIST3H3
RFC4
MDM4
ORC1
CENPH
UBA52(1-76)
PPP2R5E
p-T714,T734-BARD1
KIF2C
PSMD8
KAT5
MAPRE1
PSMD12
UBA52(1-76)
SPDL1
CDC26
PPP2R5A
RPA3
CDC20
RCC2
p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4
RFC3
CENPQ
UBE2D1
PSMA2
PPP2R5C
HIST2H2BE
XPO1
UBE2N
ITGB3BP
ZNF385A
HERC2-SUMO1
p-S15-TP53
MCM4
hBUBR1:hBUB3:MAD2*:CDC20 complex
ERCC6L
DSN1
CDC20
CCNB1
PPP2R1B
ANAPC11
Rad9-Hus1-Rad1 bound
to DNA
KIF2B
NUP98-5
MCM10
RFC2
CENPP
CENPA
CKAP5
p-S166,S188-MDM2
NUP85
Ub-p-S123-CDC25A
KNTC1
BUB1B
BLM
DYNLL2
RFC5
BIRC5
CDKN1A
PolyUb-TP53
PPP2R5C
RAD9B
Ub
p-S166,S188-MDM2:p-S403-MDM4
SGOL1
Cyclin
A:Cdk2:p21/p27
complex
Kinetochore:Mad1:MAD2 Complex
PPP2CB
Persistent single-stranded DNA
CCNB:p-T14-CDK1
CDK1
p-S166,S188-MDM2
dimer,
p-S166,S188-MDM2:MDM4
CCNE:CDK2
SPDL1
MAPRE1
SPDL1
NUP85
MCM6
PSMA7
Zn2+
RAD9B
RANGAP1
PSMC4
PSMD3
CLIP1
PSMB9
CDKN1B
RFC5
CASC5
RPA3
XPO1
UBC(381-456)
PPP2CA
p-S387-RFWD2
p-S317,S345-CHEK1
YWHAZ
UBE2E1
BUB3
KIF18A
14-3-3 dimer
ZWINT
ADP
CDKN1A gene
UBC(153-228)
CENPN
HIST3H3
RAD9A
RCC2
WRN
PPP2R5A
ZW10
NUP133
CENPQ
NUP133
DSN1
ATP
CLASP2
HUS1
PAFAH1B1
RAD17
Persistent single-stranded DNA
CCNB1:p-T14,Y15,T161-CDK1
ANAPC16
NUP133
PPP2CB
p-S102-WHSC1
MCM5
RNF168
UBC(229-304)
ORC4
PPP2CB
UBC(457-532)
UBC(305-380)
MAD2*CDC20 complex
HIST1H2BB
CENPO
ANAPC16
RPA3
CDKN1B
CDC20
MLF1IP
MCM3
MAD1L1
HIST1H2BJ
RFC4
UBC(1-76)
p-5S,T-MDM2
NDEL1
RFC2
ADP
ADP
RANBP2
PPP2R5B
MIS12
UBC(305-380)
MAPRE1
ORC5
TAOK1
MDM4
CENPI
NDEL1
MCM5
MAD2L1
NUF2
CENPC1
PSMD13
UBA52(1-76)
HIST3H2BB
DYNC1H1
p-S166,S188-MDM2
HIST1H2BK
RFWD2
AHCTF1
ATRIP
NUF2
NUF2
NUP85
UBC(153-228)
UBC(1-76)
p-T714,T734-BARD1
BIRC5
XPO1
CDC25C
MIS12
NUP98-5
AURKB
UBB(77-152)
NUDC
ATP
CCNE2
PPP2R5D
BUB3
RPS27A(1-76)
PIAS4
DYNC1LI1
p-T68-CHEK2
AHCTF1
UBC(533-608)
CENPA
YWHAZ
SEH1L-1
p-T4827,SUMO1-HERC2
PSME3
AURKB
ORC3
PSMB10
RFC3
CENPT
ATP
KIF18A
CLIP1
MCM3
MAD1L1
SEH1L-1
NUP133
ORC1
CENPL
RAD1
RAD50
33
20
43
23, 38, 84
95
33
3, 74, 78
46, 91
10
40, 56
13
95
27
23, 38
77
73
80
54, 58, 87, 100
10
98
20
73, 93
1, 14
16
15, 37, 62, 72
17