Oxidative Stress (Rattus norvegicus)

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Repression of ROS-producing systemsActivationStress-regulated MAP kinaseImmediate-earlygene inductionAdaptive responseInhibition of oxidasesInduction ofantioxidant genesTF activationRepressionReactive Oxygen SpeciesTF inhibitionFosHmox1Txnrd1Sp1Ugt1a6Mgst1Nqo1Txnrd2Cyp1a1Mapk14Gpx3JunbSod1Nrf2Sod3GclcCatGsrTxn2Mapk10MaoaNfixSod2CybaGSTT2Gpx1XdhNfkb1MT1X


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GenMAPP notes 
Adapted from Biochem J 1999 Sep 15;342 Pt 3:481-96 Morel Y, Barouki R. Repression of gene expression by oxidative stress. Biochem J 1999 Sep 15;342 Pt 3:481-96
GenMAPP remarks 
Adapted from rat by GenMAPP.org
This pathway was inferred from Homo sapiens pathway WP408(r21540) with a 89% conversion rate.

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71778view20:31, 17 October 2013MaintBotAutomated update of data sources
69354view18:53, 8 July 2013MaintBotUpdated to 2013 gpml schema
67563view11:26, 26 June 2013DdiglesOntology Term : 'oxidative stress response pathways' added !
41666view02:35, 2 March 2011MaintBotRemoved redundant pathway information and comments
34061view19:06, 9 December 2009MaintBotAutomatic update of empty xrefs
32355view13:39, 15 August 2009MaintBotFixed text labels
31985view13:12, 14 August 2009MaintBotFixed group labels
31404view20:50, 13 August 2009MaintBotFixed text labels
30993view00:57, 30 July 2009MaintBotConverted from Homo sapiens
21043view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Oxidative Stress]] moved to [[Pathway:WP173]]: Moved to stable identifier
8322view13:46, 7 January 2008MaintBot[[Pathway:Rat:Oxidative Stress]] moved to [[Pathway:Rattus norvegicus:Oxidative Stress]]: Renaming species
7779view16:17, 18 December 2007MaintBotfixed category names
7484view12:42, 4 November 2007MaintBotAdded categories to GPML
19533view22:20, 22 May 2007I.Reyesgpml file for [[Rat:Oxidative_Stress]]
6584view22:20, 22 May 2007N.Reyesgpml file for [[Rat:Oxidative_Stress]]

External references


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NameTypeDatabase referenceComment
CatGeneProduct24248 (Entrez Gene)
CybaGeneProduct79129 (Entrez Gene) Probe set ID: u18729
Cyp1a1GeneProduct24296 (Entrez Gene)
FosGeneProduct314322 (Entrez Gene)
GSTT2GeneProduct29487 (Entrez Gene)
GclcGeneProduct25283 (Entrez Gene)
Gpx1GeneProduct24404 (Entrez Gene)
Gpx3GeneProduct64317 (Entrez Gene)
GsrGeneProduct116686 (Entrez Gene)
Hmox1GeneProduct24451 (Entrez Gene)
JunbGeneProduct24517 (Entrez Gene)
MaoaGeneProduct29253 (Entrez Gene)
Mapk10GeneProduct25272 (Entrez Gene)
Mapk14GeneProduct81649 (Entrez Gene)
Mgst1GeneProduct171341 (Entrez Gene)
NfixGeneProduct81524 (Entrez Gene)
Nfkb1GeneProduct81736 (Entrez Gene)
Nqo1GeneProduct24314 (Entrez Gene)
Sod1GeneProduct24786 (Entrez Gene)
Sod2GeneProduct24787 (Entrez Gene)
Sod3GeneProduct25352 (Entrez Gene)
Sp1GeneProduct24790 (Entrez Gene)
Txn2GeneProduct79462 (Entrez Gene)
Txnrd1GeneProduct58819 (Entrez Gene)
Txnrd2GeneProduct50551 (Entrez Gene)
Ugt1a6GeneProduct113992 (Entrez Gene)
XdhGeneProduct497811 (Entrez Gene)

Annotated Interactions

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