Lipoic acid metabolism (Mycobacterium tuberculosis)

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1Glycene cleavage system (H protein)Oxo-acid dehydrogenaase complexes (E2 subunit)Protein N6-(octanoyl)lysineOctanoyl-[acp]Protein N6-(lipoyl)lysinelipAFatty acid biosynthesisLipoyl-[acp]lipB


Source: KEGG Pathways.

The lipoic acid metabolism is a subcategory of the "Metabolism of cofactors and vitamins".

The salvage pathway is not understood for Mycobacterium tuberculosis, and therefore only the biosynthesis is described here.

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Ontology Terms



  1. Zhao X, Miller JR, Jiang Y, Marletta MA, Cronan JE; ''Assembly of the covalent linkage between lipoic acid and its cognate enzymes.''; Chem Biol, 2003 PubMed Europe PMC Scholia


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95552view13:32, 27 December 2017DeSlRemoved licence number
95477view23:54, 17 December 2017Andrachecked connectivity of lines
95433view16:40, 14 December 2017DeSlOntology Term : 'fatty acid biosynthetic pathway' added !
95432view16:40, 14 December 2017DeSlOntology Term : 'fatty acid metabolic pathway' added !
95431view16:39, 14 December 2017DeSlAdded literature reference (general for PW).
95430view16:37, 14 December 2017DeSlModified description
95429view16:35, 14 December 2017DeSlRemoved KEGG ortholog IDs, added Enzyme nomenclature IDs where needed; changed layout; converted arrows to MIM conversion, connected all enzymes where needed.
71605view19:31, 17 October 2013MaintBotAutomated update of data sources
70858view11:52, 12 September 2013AndraPeriodical save, work in progress
70856view11:31, 12 September 2013AndraConnecting lines
69520view20:13, 8 July 2013MaintBotUpdated to 2013 gpml schema
67435view11:01, 26 June 2013DdiglesOntology Term : 'lipoic acid metabolic pathway' added !
41455view01:08, 2 March 2011MaintBotRemoved redundant pathway information and comments
38987view18:51, 25 September 2010AlexanderPicoModified categories
38977view18:37, 25 September 2010AlexanderPicoModified description
38976view18:36, 25 September 2010AlexanderPico
38975view18:36, 25 September 2010AlexanderPicomodified labels and Lipoic Acid database connection
38825view10:18, 24 September 2010AllanKuchinskyadded pathway ref, labels
38824view10:14, 24 September 2010AllanKuchinskyPeriodical save, work in progress
38820view10:09, 24 September 2010AllanKuchinskySpecify description
38818view09:52, 24 September 2010AllanKuchinskyPeriodical save, work in progress
38817view09:42, 24 September 2010AllanKuchinskyPeriodical save, work in progress
38793view06:41, 24 September 2010AllanKuchinskySpecify description
38792view04:24, 24 September 2010AllanKuchinskycleaning up labels
38791view04:22, 24 September 2010AllanKuchinskyPeriodical save, work in progress
38554view17:51, 21 September 2010MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
Fatty acid biosynthesisPathwayWP1647 (WikiPathways)
Lipoyl-[acp]MetaboliteC16239 (KEGG Compound)
Octanoyl-[acp]MetaboliteC05752 (KEGG Compound)
Protein N6-(lipoyl)lysineMetaboliteC16237 (KEGG Compound)
Protein N6-(octanoyl)lysineMetaboliteC16236 (KEGG Compound)
lipAGeneProductRv2218 (TubercuList) Original kegg element: gene;1;mtu:Rv2218
lipBGeneProduct2.3.1.181 (Enzyme Nomenclature) Original kegg element: gene;8;mtu:Rv2217

Annotated Interactions

No annotated interactions

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