Tryptophan Biosynthesis (Saccharomyces cerevisiae)

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1-31-(o-carboxyphenylamino)-1'-deoxyribulose-5'-phosphateN-(5'-Phosphoribosyl)anthranilatepyruvateIndole-3-glycerophosphateL-serineglyceraldehyde-3-phosphateTRP1TRP3waterTRP5L-glutaminePRPPcarbon dioxideTRP4L-glutamateTRP2pyrophosphateTRP3chorismateanthranilateL-tryptophanwater


Biosynthesis of the aromatic amino acids tryptophan, tyrosine, and phenylalanine proceeds via a common pathway to chorismate, at which point the pathway branches (CITS:[Jones][1943992]). One branch proceeds to tryptophan, and the other to tyrosine and phenylalanine (CITS:[Jones]). The series of reactions to chorismate, called the shikimate pathway, and the series of reactions from chorismate to tryptophan have been found to be common to all eukaryotes and prokaryotes studied thus far (as reported in (CITS:[1943992])). In contrast, there appears to be two separate routes from chorismate to tyrosine and phenylalanine, only one of which has been found in S. cerevisiae (CITS:[1943992]). Aromatic amino acid biosynthesis in S. cerevisiae is controlled by a combination of feedback inhibition, activation of enzyme activity, and regulation of enzyme synthesis (CITS:[Jones][1943992]). The first step in the tryptophan branch is feedback inhibited by tryptophan, and the first step in the phenylalanine-tyrosine branch is feedback inhibited by tyrosine and activated by tryptophan (CITS:[1943992]). The transcriptional activator GCN4 regulates most of the genes encoding for the aromatic amino acid biosynthetic enzymes; however, no GCN4 regulation was found for TRP1 of the tryptophan branch, TYR1 of the tyrosine branch or ARO7 of the tyrosine and phenylalanine branch (CITS:[1943992]).

SOURCE: SGD pathways,

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  1. Braus GH; ''Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway.''; Microbiol Rev, 1991 PubMed Europe PMC
  2. Toyn JH, Gunyuzlu PL, White WH, Thompson LA, Hollis GF; ''A counterselection for the tryptophan pathway in yeast: 5-fluoroanthranilic acid resistance.''; Yeast, 2000 PubMed Europe PMC
  3. Zalkin H, Paluh JL, van Cleemput M, Moye WS, Yanofsky C; ''Nucleotide sequence of Saccharomyces cerevisiae genes TRP2 and TRP3 encoding bifunctional anthranilate synthase: indole-3-glycerol phosphate synthase.''; J Biol Chem, 1984 PubMed Europe PMC


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107248view14:34, 17 September 2019MaintBotChEBI identifier normalization
92981view17:50, 21 July 2017Khanspersconverted labels to metabolites
92980view17:43, 21 July 2017KhanspersModified description
92979view17:43, 21 July 2017Khanspersremoved GenMAPP notes
92916view10:50, 17 July 2017DeSlChanged CAs to ChEBI ID (more stereospecific).
71899view10:51, 22 October 2013Mkutmonfixed unconnected lines
71898view10:37, 22 October 2013Mkutmonchanged unknown datanode to metabolite datanode
70273view21:51, 15 July 2013MaintBotupdated to 2013 schema
69766view11:20, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
67722view11:54, 26 June 2013DdiglesOntology Term : 'tryptophan biosynthetic pathway' added !
41818view04:49, 2 March 2011MaintBotRemoved redundant pathway information and comments
36638view22:36, 9 April 2010MaintBotDescription and bibliography added from SGD
21027view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Tryptophan Biosynthesis]] moved to [[Pathway:WP165]]: Moved to stable identifier
12881view08:06, 17 May 2008MaintBotautomated metabolite conversion
8981view14:13, 7 January 2008MaintBotAdded to category $category
8979view14:13, 7 January 2008M.BraymerUploaded new pathway

External references


View all...
NameTypeDatabase referenceComment
Indole-3-glycerophosphateMetaboliteCHEBI:18299 (ChEBI)
L-glutamateMetabolite56-86-0 (CAS)
L-glutamineMetabolite56-85-9 (CAS)
L-serineMetabolite56-45-1 (CAS)
L-tryptophanMetabolite73-22-3 (CAS)
N-(5'-Phosphoribosyl)anthranilateMetaboliteCHEBI:7091 (ChEBI)
PRPPMetabolite97-55-2 (CAS)
TRP1GeneProductS000002414 (SGD)
TRP2GeneProductS000000892 (SGD)
TRP3GeneProductS000001694 (SGD)
TRP4GeneProductS000002762 (SGD)
TRP5GeneProductS000002994 (SGD)
anthranilateMetaboliteCHEBI:16567 (ChEBI)
carbon dioxideMetaboliteCHEBI:16526 (ChEBI)
chorismateMetaboliteCHEBI:17333 (ChEBI)
glyceraldehyde-3-phosphateMetabolite591-57-1 (CAS)
pyrophosphateMetabolite2466-09-3 (CAS)
pyruvateMetaboliteCHEBI:15361 (ChEBI)
waterMetaboliteCHEBI:15377 (ChEBI)

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