Fatty Acid Elongation, Unsaturated (Saccharomyces cerevisiae)

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D-3-hydroxy-acyl-ACP2,3-decenoyl-ACP3,4-decenoyl-ACPbeta-ketoacyl-ACPtrans-delta2-enoyl-acyl-ACPacetoacetyl-ACPD-3-hydroxy-acyl-ACPOAR1CEM1beta-ketoacyl-ACPFAS2ACP-SHNADPHNADPOAR1NADPHH+FAS2NADPH+malonyl-ACPCO2FAS2acyl-ACP


Description

Sphingolipids are essential components of the plasma membrane in all eukaryotic cells. S. cerevisiae cells make three complex sphingolipids: inositol-phosphoceramide (IPC), mannose-inositol-phosphoceramide (MIPC), and mannose-(inositol phosphate)2-ceramide (M(IP)2C)(CITS: [12069845]). In the yeast plasma membrane sphingolipids concentrate with ergosterol to form lipid rafts, specialized membrane microdomains implicated in a variety of cellular processes, including sorting of membrane proteins and lipids, as well as organizing and regulating signaling cascades (CITS: [12452424]). Intermediates in sphingolipid biosynthesis have been shown to play important roles as signaling molecules and growth regulators. Sphingolipid long chain bases (LCBs), dihydrosphingosine (DHS) and phytosphingosine (PHS), have been implicated as secondary messengers in signaling pathways that regulate heat stress response (CITS: [9405471])(CITS: [11967828]). Other intermediates, phytoceramide and long-chain base phosphates (LCBPs), have been shown to be components of the tightly-controlled ceramide/LCBP rheostat, which regulates cell growth (CITS: [12684378]). Since phosphoinositol-containing sphingolipids are unique to fungi, the sphingolipid biosynthesis pathway is considered a target for antifungal drugs (CITS: [9092515])(CITS: [15578972]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
89650view16:16, 23 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
71346view18:02, 17 October 2013MaintBotAutomated update of data sources
70229view19:05, 15 July 2013MaintBotminor layout
69769view11:51, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69619view20:34, 8 July 2013MaintBotUpdated to 2013 gpml schema
67245view10:26, 26 June 2013Christine ChichesterOntology Term : 'fatty acid biosynthetic pathway' added !
53539view20:01, 8 November 2012EgonwConnected the dots.
53538view19:58, 8 November 2012EgonwConverted several labels into Metabolite DataNode's.
41853view04:51, 2 March 2011MaintBotRemoved redundant pathway information and comments
36655view22:40, 9 April 2010MaintBotDescription and bibliography added from SGD
20707view11:29, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Fatty Acid Elongation Unsaturated]] moved to [[Pathway:WP16]]: Moved to stable identifier
12702view07:58, 17 May 2008MaintBotautomated metabolite conversion
8711view14:07, 7 January 2008MaintBotAdded to category $category
8709view14:07, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2,3-decenoyl-ACPMetabolite
3,4-decenoyl-ACPMetabolite
ACP-SHMetabolite
CEM1GeneProductS000000863 (SGD)
CO2Metabolite
D-3-hydroxy-acyl-ACPMetabolite
FAS2GeneProductS000006152 (SGD)
H+Metabolite
NADPMetabolite
NADPHMetabolite53-57-6 (CAS)
OAR1GeneProductS000001538 (SGD)
acetoacetyl-ACPMetabolite
acyl-ACPMetabolite
beta-ketoacyl-ACPMetabolite
malonyl-ACPMetabolite
trans-delta2-enoyl-acyl-ACPMetabolite

Annotated Interactions

No annotated interactions
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