Folate-Alcohol and Cancer Pathway Hypotheses (Homo sapiens)

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1MethyltransferasesDNANON-COMPETITIVEINHIBITIONNUCLEUSMethylated DNACystathionineNucleotide SynthesisADH5ALDH1L1SAM5,10-Methylene-THF5-Methyl THFMethionineAcetateMTHFRAcetaldehydeHomocysteineALDH1A1CBSMTRALDH1A1CYP2E1ALDH1L1C/EBPBCREB1SAHEthanolTHFCYP2E1CysteineFolate


As described in Hwang, et al., "The interaction of folate and alcohol consumption has been shown to have an antagonistic effect on the risk of oral cancer. Studies have demonstrated that increased intake of folate decreases the risk of oral cancer, while greater alcohol consumption has an opposite effect." This pathway is a hypothetical model for a causal role for P450 2E1 (CYP2E1) and aldehyde dehydrogenase 1 (ALDH1) in oral cancers, implicating folate (via SAM) and alcohol.

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Ontology Terms



  1. Hwang PH, Lian L, Zavras AI; ''Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis.''; Med Hypotheses, 2012 PubMed


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96101view23:23, 15 February 2018AlexanderPicoOntology Term : 'oral cavity cancer' added !
96100view23:22, 15 February 2018AlexanderPicoModified description
96099view23:15, 15 February 2018AlexanderPicoModified title
96098view23:14, 15 February 2018AlexanderPicoclarified layout and interations; added MTR
92113view18:55, 28 April 2017EgonwRemoved a lone metabolite node.
87508view01:49, 25 July 2016AlexanderPicoOntology Term : 'cancer pathway' added !
87507view01:49, 25 July 2016AlexanderPicoOntology Term : 'disease pathway' added !
82223view03:26, 16 September 2015AlexanderPicofixed catalysis for biopax conversion
78797view13:00, 30 January 2015EgonwAdded missing metabolite identifiers.
78796view12:51, 30 January 2015EgonwConnected dots.
74018view13:36, 22 March 2014EgonwAdded a few metabolite identifiers.
62366view23:57, 27 April 2013AlexanderPicoFixed gene and metabolite annotations
45285view19:11, 7 October 2011AlexanderPicoadded nucleus
45284view19:10, 7 October 2011AlexanderPicofixed reactions
45282view19:08, 7 October 2011AlexanderPicofixed gene labels
41113view23:36, 1 March 2011MaintBotRemoved redundant pathway information and comments
38167view22:39, 20 August 2010KhanspersAdded xrefs
38166view22:24, 20 August 2010KhanspersAdded xrefs
38165view22:21, 20 August 2010KhanspersPeriodical save, work in progress
38164view22:11, 20 August 2010KhanspersPeriodical save, work in progress
38163view22:00, 20 August 2010KhanspersPeriodical save, work in progress
38147view19:01, 17 August 2010KhanspersModified categories
37896view19:18, 13 July 2010WhomNew pathway

External references


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NameTypeDatabase referenceComment
5,10-Methylene-THFMetaboliteHMDB01533 (HMDB)
5-Methyl THFMetaboliteCHEBI:15641 (ChEBI)
ADH5GeneProductENSG00000197894 (Ensembl)
ALDH1A1GeneProduct216 (Entrez Gene)
ALDH1L1GeneProduct10840 (Entrez Gene)
AcetaldehydeMetaboliteHMDB00990 (HMDB)
AcetateMetaboliteCHEBI:30089 (ChEBI)
C/EBPBGeneProduct1051 (Entrez Gene)
CBSGeneProduct875 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CYP2E1GeneProduct1571 (Entrez Gene)
CystathionineMetaboliteHMDB00099 (HMDB)
CysteineMetaboliteHMDB00574 (HMDB)
EthanolMetaboliteHMDB00108 (HMDB)
FolateMetaboliteCHEBI:62501 (ChEBI)
HomocysteineMetaboliteHMDB00742 (HMDB)
MTHFRGeneProduct4524 (Entrez Gene)
MTRGeneProductENSG00000116984 (Ensembl)
MethionineMetaboliteHMDB00696 (HMDB)
Nucleotide SynthesisPathwayWP404 (WikiPathways)
SAHMetaboliteCHEBI:16680 (ChEBI)
SAMMetabolite8041295 (Chemspider)
THFMetaboliteCHEBI:20506 (ChEBI)

Annotated Interactions

No annotated interactions

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