1-4Insulin signaling pathwayROSDNAPancreatic beta cellCa 2+ dependentGlucose ( hyperglycemia)transient hyperglycemia hyperinsulinismPrevention of membrane depolarization+py (tyrosine phosphorylation)ObesityK+Adipoctokine signaling pathway+ps (serine phosphorylation)Insulin ResistanceImpaired Insulin Secretionglycation, hexosamine pathway,respiratory chainFFAType II diabetes mellitusMaturity onsetdiabetes of the youngAdipotocyte, heptocyte, skeletal muscle cell Adipocytokine Signaling PathwayobesityINSIKKGlucoseJNKmTORVDCCMafASOCSJNKPyruvateIRSADIPOINSTNF alphaERKATPPDX-1P13KCa2+GLUT2GLUT4GKApoptosis PRKCDPYKKir6.2IRSPRKCZINSRSURF1