Proteasome Degradation (Saccharomyces cerevisiae)

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Alpha subunitsCytosolic ProteinsUbiquitin/ProteinOxidatively DamagedAMP Ubiquitin/E1 ComplexLid subunitsPresentation by MHC class 120S ComplexDegrades only PeptidesUbiquitin/E2 ComplexIntact ProteinsBeta subunitsCatalytic Core (p45)E3/ProteinProteasome 26 SProteins to be DegradedProteasome 20S(PA700) (ATP dependent)p45 ATPase SubunitUnfolds and DegradesActivators ofPRE9RPN2RPN12PRE10HLA-HRPN5NAS2UBE1LRPN9RPN1RPT1IFNGRPT5HLA-FUBC4RPN2HTZ1UBC5UBE2D1PSMB9RPN10PUP2PSMB3PRE3HLA-GRPN8HLA-ERPT3RPT2PRE4PSMB8PSMD5PRE8PSME3PSME1RPT6HLA-CPRE1NAS6HLA-BUBE2BUBA1PUP1PSME2PRE7HLA-ARPN3PSMD6HIST1H2ABRPN6SCL1PRE2RPT6HLA-JHTA2ATPPRE6RPN1NEDD4RPT4PRE5PSMB10UBI4


Description

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Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
77442view20:28, 8 September 2014MaintBotremoved old homology label
69763view11:15, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69657view20:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
67610view11:32, 26 June 2013DdiglesOntology Term : 'ubiquitin/proteasome degradation pathway' added !
41941view18:02, 2 March 2011MaintBotRemoved redundant pathway information and comments
41896view04:53, 2 March 2011MaintBotRemoved redundant pathway information and comments
21013view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Proteasome Degradation]] moved to [[Pathway:WP158]]: Moved to stable identifier
12824view08:04, 17 May 2008MaintBotautomated metabolite conversion
9029view14:15, 7 January 2008MaintBotAdded to category $category
9027view14:15, 7 January 2008NsalomonisUploaded new pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATPMetabolite1927-31-7 (CAS)
HIST1H2ABGeneProduct (Entrez Gene)
HLA-AGeneProduct (Entrez Gene)
HLA-BGeneProduct (Entrez Gene)
HLA-CGeneProduct (Entrez Gene)
HLA-EGeneProduct (Entrez Gene)
HLA-FGeneProduct (Entrez Gene)
HLA-GGeneProduct (Entrez Gene)
HLA-HGeneProduct (Entrez Gene)
HLA-JGeneProduct (Entrez Gene)
HTA2GeneProduct852283 (Entrez Gene)
HTZ1GeneProduct854150 (Entrez Gene)
IFNGGeneProduct (Entrez Gene)
NAS2GeneProduct854810 (Entrez Gene)
NAS6GeneProduct853147 (Entrez Gene)
NEDD4GeneProduct (Entrez Gene)
PRE10GeneProduct854544 (Entrez Gene)
PRE1GeneProduct856731 (Entrez Gene)
PRE2GeneProduct856218 (Entrez Gene)
PRE3GeneProduct853456 (Entrez Gene) U13393
PRE4GeneProduct850611 (Entrez Gene)
PRE5GeneProduct855362 (Entrez Gene)
PRE6GeneProduct854119 (Entrez Gene)
PRE7GeneProduct852239 (Entrez Gene)
PRE8GeneProduct854882 (Entrez Gene)
PRE9GeneProduct853036 (Entrez Gene)
PSMB10GeneProduct (Entrez Gene)
PSMB3GeneProduct (Entrez Gene)
PSMB8GeneProduct (Entrez Gene)
PSMB9GeneProduct (Entrez Gene)
PSMD5GeneProduct (Entrez Gene)
PSMD6GeneProduct (Entrez Gene)
PSME1GeneProduct (Entrez Gene)
PSME2GeneProduct (Entrez Gene)
PSME3GeneProduct (Entrez Gene)
PUP1GeneProduct854328 (Entrez Gene)
PUP2GeneProduct853168 (Entrez Gene)
RPN1GeneProduct (Entrez Gene)
RPN10GeneProduct856607 (Entrez Gene)
RPN12GeneProduct850613 (Entrez Gene)
RPN1GeneProduct856422 (Entrez Gene)
RPN2GeneProduct (Entrez Gene)
RPN2GeneProduct854735 (Entrez Gene)
RPN3GeneProduct856742 (Entrez Gene)
RPN5GeneProduct851408 (Entrez Gene)
RPN6GeneProduct851461 (Entrez Gene)
RPN8GeneProduct854435 (Entrez Gene)
RPN9GeneProduct852037 (Entrez Gene)
RPT1GeneProduct853712 (Entrez Gene)
RPT2GeneProduct851557 (Entrez Gene)
RPT3GeneProduct852003 (Entrez Gene) PRS6_HUMAN
RPT4GeneProduct854433 (Entrez Gene)
RPT5GeneProduct854284 (Entrez Gene)
RPT6GeneProduct852834 (Entrez Gene) PRS6_HUMAN
SCL1GeneProduct852873 (Entrez Gene)
UBA1GeneProduct853670 (Entrez Gene)
UBC4GeneProduct852376 (Entrez Gene)
UBC5GeneProduct851631 (Entrez Gene)
UBE1LGeneProduct (Entrez Gene)
UBE2BGeneProduct (Entrez Gene)
UBE2D1GeneProduct (Entrez Gene)
UBI4GeneProduct850620 (Entrez Gene)

Annotated Interactions

No annotated interactions

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