DNA damage response (Sus scrofa)

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783, 6, 10, 13, 171614, 18167814147161, 2, 4, 9-12, 155514, 181, 2, 4, 9-12, 15161, 2, 4, 9-12, 15141681, 2, 4, 9-12, 151614, 18161614, 18161, 2, 4, 9-12, 151, 2, 4, 9-12, 15581616161, 2, 4, 9-12, 15161814, 18Bulky DNA lesionGene productSpecialized:Somatic hypermutaionV(D)J recombinationClass switchingDouble-strand breaksBlocked transcriptionROSDifferent pathwayCellChange in the Cell conditionG1/S transitionMetaboliteEndogenous:Collapsed replication forksSingle stranded DNA replication breaksFree radicals (ROS)DNA damage sourceDNA adductInhibitionROSCaption:Chromatin alterationExtral cellularSpaceExogenous:Cigarette SmokeCaffeineRadiation (UV)ClastogenesHypoxiaGenotoxic drugsActivationBlocked replicationmitoch-ondrionMembraneG2/M transitionAlkylating agentsReplication stressEstradiolCell Cyle progressionGADD45GGADD45GCell survivalCHEK2CDKN1ATNFRSF10BDNA repair anddamage preventionFASRAD17CDK6ATMSenescenceGADD45AATRRB1DDB2c-MycDNA damage ATM dependentChromatinremodellingDNA repair7-hydroxystaurosporineTP53AIP1CHEK1G2/M checkpointCDC25ABAXCDKN1BABL1CCNB1ApoptosisRAD1PRKDCPMLCDK5RRM2BE2F1RB1RPA2Cell CycleCASP9GADD45BCCNE2CCND1CaffeineCYCSBIDPIDDCDC25CAPAF1FANCD2CCNE1RAD50G2/McheckpointNBNGADD45BE2F1TLK2RAD52BRCA1TP53CCNB3ATRIPMRE11HUS1PMAIP1CDK2CREBCCND3TLK1RAD9ACCND2CASP3CDK1GADD45ACDK4SMC1AH2AFXRAD51CASP8CCNB2SFNRFCSESN1BBC3


This is the first pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and ATR) which are connected to the sources of DNA damage (in blue). The two central genes can be divides furthermore into their most important genes. In the ATM pathway are the most important genes TP53 and CHEK2 and on the other hand in the ATR pathway is this CHEK1.

If it is not mentioned different, the processes take place in the cell cytoplasm.

The goal of this first pathway is to give an overview of the most important gene products, processes and changes in the cell condition through the DNA damage response pathway and at the same time to keep it clearly arranged


This pathway was inferred from Homo sapiens pathway WP707(r34441) with a 61% conversion rate.

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Ontology Terms



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  1. L��Ωbrich M, Jeggo PA; ''The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
  2. Harrison JC, Haber JE; ''Surviving the breakup: the DNA damage checkpoint.''; Annu Rev Genet, 2006 PubMed Europe PMC Scholia
  3. Sherr CJ, Roberts JM; ''Living with or without cyclins and cyclin-dependent kinases.''; Genes Dev, 2004 PubMed Europe PMC Scholia
  4. Sengupta S, Harris CC; ''p53: traffic cop at the crossroads of DNA repair and recombination.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
  5. Reshmi SC, Gollin SM; ''Chromosomal instability in oral cancer cells.''; J Dent Res, 2005 PubMed Europe PMC Scholia
  6. Sparmann A, van Lohuizen M; ''Polycomb silencers control cell fate, development and cancer.''; Nat Rev Cancer, 2006 PubMed Europe PMC Scholia
  7. Zhou BB, Bartek J; ''Targeting the checkpoint kinases: chemosensitization versus chemoprotection.''; Nat Rev Cancer, 2004 PubMed Europe PMC Scholia
  8. Ljungman M, Lane DP; ''Transcription - guarding the genome by sensing DNA damage.''; Nat Rev Cancer, 2004 PubMed Europe PMC Scholia
  9. Wang W; ''Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.''; Nat Rev Genet, 2007 PubMed Europe PMC Scholia
  10. Boutros R, Lobjois V, Ducommun B; ''CDC25 phosphatases in cancer cells: key players? Good targets?''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
  11. Toledo F, Wahl GM; ''Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.''; Nat Rev Cancer, 2006 PubMed Europe PMC Scholia
  12. Vousden KH, Lane DP; ''p53 in health and disease.''; Nat Rev Mol Cell Biol, 2007 PubMed Europe PMC Scholia
  13. Pagano M, Jackson PK; ''Wagging the dogma; tissue-specific cell cycle control in the mouse embryo.''; Cell, 2004 PubMed Europe PMC Scholia
  14. Strasser A; ''The role of BH3-only proteins in the immune system.''; Nat Rev Immunol, 2005 PubMed Europe PMC Scholia
  15. Antoni L, Sodha N, Collins I, Garrett MD; ''CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?''; Nat Rev Cancer, 2007 PubMed Europe PMC Scholia
  16. Chargari C, Toillon RA, Macdermed D, Castadot P, Magn��٠N; ''Concurrent hormone and radiation therapy in patients with breast cancer: what is the rationale?''; Lancet Oncol, 2009 PubMed Europe PMC Scholia
  17. Gil J, Peters G; ''Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC Scholia
  18. Cory S, Huang DC, Adams JM; ''The Bcl-2 family: roles in cell survival and oncogenesis.''; Oncogene, 2003 PubMed Europe PMC Scholia


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107274view14:36, 17 September 2019MaintBotChEBI identifier normalization
87238view09:50, 20 July 2016SusanOntology Term : 'DNA damage response pathway' added !
73852view00:52, 26 February 2014MaintBotupdated schema
58994view20:00, 21 February 2013MaintBotUpdated Ensembl data source
41922view05:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
38659view13:30, 23 September 2010Mkutmonadded pathway links
37717view20:26, 28 June 2010MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
7-hydroxystaurosporineMetabolite65225 (Chemspider)
ABL1GeneProductENSSSCG00000005706 (Ensembl)
APAF1GeneProductENSSSCG00000000884 (Ensembl)
ATMGeneProductENSSSCG00000015007 (Ensembl)
ATRGeneProductENSSSCG00000011679 (Ensembl)
BAXGeneProductENSSSCG00000003144 (Ensembl)
BIDGeneProductENSSSCG00000000769 (Ensembl)
CASP3GeneProductENSSSCG00000015783 (Ensembl)
CASP8GeneProductENSSSCG00000016106 (Ensembl)
CASP9GeneProductENSSSCG00000003460 (Ensembl)
CCNB2GeneProductENSSSCG00000004588 (Ensembl)
CCNB3GeneProductENSSSCG00000012307 (Ensembl)
CCND2GeneProductENSSSCG00000000727 (Ensembl)
CCND3GeneProductENSSSCG00000001632 (Ensembl)
CCNE1GeneProductENSSSCG00000002855 (Ensembl)
CCNE2GeneProductENSSSCG00000006095 (Ensembl)
CDC25CGeneProductENSSSCG00000014329 (Ensembl)
CDK1GeneProductENSSSCG00000010214 (Ensembl)
CDK2GeneProductENSSSCG00000000373 (Ensembl)
CDK4GeneProductENSSSCG00000000445 (Ensembl)
CDK6GeneProductENSSSCG00000015318 (Ensembl)
CDKN1AGeneProductENSSSCG00000001565 (Ensembl)
CaffeineMetabolite2424 (Chemspider)
Cell CyclePathway
Cell Cyle progressionPathway
Cell survivalPathway
Chromatin remodellingPathway
DDB2GeneProductENSSSCG00000013243 (Ensembl)
DNA damage ATM dependentPathway
DNA repairPathway
DNA repair and damage preventionPathway
E2F1GeneProductENSSSCG00000007268 (Ensembl)
EstradiolMetaboliteCHEBI:16469 (ChEBI)
FANCD2GeneProductENSSSCG00000011563 (Ensembl)
FASGeneProductENSSSCG00000010448 (Ensembl)
G2/M checkpointPathway
G2/M checkpointPathway
GADD45GGeneProductENSSSCG00000009585 (Ensembl)
PRKDCGeneProductENSSSCG00000006274 (Ensembl)
RAD17GeneProductENSSSCG00000016960 (Ensembl)
RAD1GeneProductENSSSCG00000016826 (Ensembl)
RAD50GeneProductENSSSCG00000014280 (Ensembl)
RAD52GeneProductENSSSCG00000000754 (Ensembl)
RAD9AGeneProductENSSSCG00000012914 (Ensembl)
RB1GeneProductENSSSCG00000009401 (Ensembl)
RPA2GeneProductENSSSCG00000003583 (Ensembl)
RRM2BGeneProductENSSSCG00000006058 (Ensembl)
SESN1GeneProductENSSSCG00000004390 (Ensembl)
SFNGeneProductENSSSCG00000003562 (Ensembl)
SMC1AGeneProductENSSSCG00000012325 (Ensembl)
TLK1GeneProductENSSSCG00000015944 (Ensembl)
TLK2GeneProductENSSSCG00000017301 (Ensembl)
TP53GeneProductENSSSCG00000017950 (Ensembl)

Annotated Interactions

No annotated interactions
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