Non-homologous end joining (Sus scrofa)

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XRCC5XRCC6PRKDCXRCC6XRCC6XRCC4XRCC6XRCC5MRE11AXRCC5RAD50NHEJ1Nbs1 ?XRCC5XRCC5Ligase VXRCC6XRCC6XRCC5XRCC6XRCC5PRKDCXRCC6PRKDCPRKDCXRCC5XRCC6Ligase VPRKDCXRCC5XRCC5PRKDCXRCC4XLFXRCC6PRKDCPRKDC


Description

(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP438(r35395) with a 89% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
87946view13:05, 25 July 2016ElisaOntology Term : 'DNA repair pathway' added !
87944view13:04, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
68429view18:54, 5 July 2013MaintBotUpdated to 2013 gpml schema
58999view20:01, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41927view05:03, 2 March 2011MaintBotRemoved redundant pathway information and comments
37708view19:26, 28 June 2010MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Ligase VGeneProduct
MRE11AGeneProductENSSSCG00000014955 (Ensembl)
NHEJ1GeneProductENSSSCG00000016205 (Ensembl)
Nbs1 ?GeneProduct
PRKDCGeneProductENSSSCG00000006274 (Ensembl)
RAD50GeneProductENSSSCG00000014280 (Ensembl)
XLFGeneProduct
XRCC4GeneProductENSSSCG00000014135 (Ensembl)
XRCC5GeneProductENSSSCG00000016177 (Ensembl)
XRCC6GeneProductENSSSCG00000000059 (Ensembl)

Annotated Interactions

No annotated interactions
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