Glycolysis and Gluconeogenesis (Mycobacterium tuberculosis)

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1pgiadhApdhAtpidehydrogenasePhosphoenolpyruvatepdhCadhE1Enzyme N6-(lipoyl)lysine[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine2-(alpha-Hydroxyethyl)thiamine diphosphateglpXppgKCitrate cycle (TCA cycle)OxaloacetatepdhBpckAAcetaldehydepfkAD-Glyceraldehyde 3-phosphatebeta-D-fructose-6Palpha-D-glucosepfkBpykAaldehyde dehydrogenase (EC:1.2.1.3)adhEthanolsugar kinase (EC:2.7.-.-)lpdaceEPyruvatelpdAaldehyde dehydrogenase (EC:1.2.1.-)AcetateppgKD-Glucose 1-phosphate3-Phospho-D-glycerateThiamin diphosphatepgkCarbon fixation in photosynthetic organismsbeta-D-fructose-(1,6)PPacspdhAGlycerone phosphate2-Phospho-D-glycerate(1,3)-diPhospho-D-glyceroyloxidoreductasealdCsugar kinase (EC:2.7.1.2)gapStarch and sucrose metabolismAcetyl-CoAadhBpgmAadhDphosphoglycerate mutase (phosphoglyceromutase) (EC:5.4.2.1)alpha-D-glucose-6PEnzyme N6-(dihydrolipoyl)lysinedehydrogenasePentose phosphate pathwaypdhBaldAfbaaceEBeta-D-Glucose 6-phosphateenobeta-D-glucose


Description

Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00679]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which often corresponds to operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003]. Source: KEGG (http://www.genome.jp/kegg-bin/show_pathway?map00010)

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Ontology Terms

 

Bibliography

  1. Ganapathy U, Marrero J, Calhoun S, Eoh H, de Carvalho LP, Rhee K, Ehrt S; ''Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.''; Nat Commun, 2015 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
95496view13:14, 18 December 2017DeSlRemoved licence number
95495view13:13, 18 December 2017DeSlAdded specific literature reference.
95494view13:09, 18 December 2017DeSlModified description
95493view13:09, 18 December 2017DeSlConnected last unconnected line
95491view13:06, 18 December 2017DeSlRemoved KEGHG orthologs which were not present for this species, changed layout, annotated nodes with Enzyme nomenclature/NCBI protein ID where needed, changed layout.
71589view19:30, 17 October 2013MaintBotAutomated update of data sources
69504view20:12, 8 July 2013MaintBotUpdated to 2013 gpml schema
67314view10:35, 26 June 2013Christine ChichesterOntology Term : 'glycolysis/gluconeogenesis pathway' added !
41440view01:07, 2 March 2011MaintBotRemoved redundant pathway information and comments
39002view20:03, 25 September 2010AlexanderPico
39001view20:02, 25 September 2010AlexanderPico
39000view20:01, 25 September 2010AlexanderPicofixed pathway nodes and lines
38214view23:29, 26 August 2010KhanspersChanged xrefs - TubercuList
37740view19:00, 30 June 2010KhanspersModified description
37729view23:35, 28 June 2010KhanspersChanged labels
37698view22:36, 25 June 2010KhanspersModified categories
37696view22:32, 25 June 2010KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(1,3)-diPhospho-D-glyceroylMetaboliteC00236 (KEGG Compound)
2-(alpha-Hydroxyethyl) thiamine diphosphateMetaboliteC05125 (KEGG Compound)
2-Phospho-D-glycerateMetaboliteC00631 (KEGG Compound)
3-Phospho-D-glycerateMetaboliteC00197 (KEGG Compound)
AcetaldehydeMetaboliteC00084 (KEGG Compound)
AcetateMetaboliteC00033 (KEGG Compound)
Acetyl-CoAMetaboliteC00024 (KEGG Compound)
Beta-D-Glucose 6-phosphateMetaboliteC01172 (KEGG Compound)
Carbon fixation in photosynthetic organismsPathway
Citrate cycle (TCA cycle)PathwayWP1566 (WikiPathways)
D-Glucose 1-phosphateMetaboliteC00103 (KEGG Compound)
D-Glyceraldehyde 3-phosphateMetaboliteC00118 (KEGG Compound)
Enzyme N6-(dihydrolipoyl)lysineMetaboliteC15973 (KEGG Compound)
Enzyme N6-(lipoyl)lysineMetaboliteC15972 (KEGG Compound)
EthanolMetaboliteC00469 (KEGG Compound)
Glycerone phosphateMetaboliteC00111 (KEGG Compound)
OxaloacetateMetaboliteC00036 (KEGG Compound)
Pentose phosphate pathwayPathwayWP1684 (WikiPathways)
PhosphoenolpyruvateMetaboliteC00074 (KEGG Compound)
PyruvateMetaboliteC00022 (KEGG Compound)
Starch and sucrose metabolismPathwayWP1701 (WikiPathways)
Thiamin diphosphateMetaboliteC00068 (KEGG Compound)
[Dihydrolipoyllysine-

residue acetyltransferase]

S-acetyldihydrolipoyllysine
MetaboliteC16255 (KEGG Compound)
aceEGeneProductRv2241 (TubercuList) Original kegg element: gene;12;mtu:Rv0843 mtu:Rv2241 mtu:Rv2496c mtu:Rv2497c
acsGeneProductRv3667 (TubercuList) Original kegg element: gene;91;mtu:Rv3667
adhAGeneProductRv1862 (TubercuList) Original kegg element: gene;10;mtu:Rv0162c mtu:Rv0761c mtu:Rv1530 mtu:Rv1862
adhBGeneProductRv0761c (TubercuList) Original kegg element: gene;10;mtu:Rv0162c mtu:Rv0761c mtu:Rv1530 mtu:Rv1862
adhDGeneProductNP_217602 (NCBI Protein) Original kegg element: gene;9;mtu:Rv3045
adhE1GeneProductRv0162c (TubercuList) Original kegg element: gene;10;mtu:Rv0162c mtu:Rv0761c mtu:Rv1530 mtu:Rv1862
adhGeneProductRv1530 (TubercuList) Original kegg element: gene;10;mtu:Rv0162c mtu:Rv0761c mtu:Rv1530 mtu:Rv1862
aldAGeneProductRv0768 (TubercuList) Original kegg element: gene;2;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
aldCGeneProductRv2858c (TubercuList) Original kegg element: gene;2;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
aldehyde dehydrogenase (EC:1.2.1.-)GeneProductRv0147 (TubercuList) Original kegg element: gene;2;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
aldehyde dehydrogenase (EC:1.2.1.3)GeneProductRv0458 (TubercuList) Original kegg element: gene;2;mtu:Rv0147 mtu:Rv0458 mtu:Rv0768 mtu:Rv2858c
alpha-D-glucose-6PMetaboliteC00668 (KEGG Compound)
alpha-D-glucoseMetaboliteC00267 (KEGG Compound)
beta-D-fructose-(1,6)PPMetaboliteC05378 (KEGG Compound)
beta-D-fructose-6PMetaboliteC05345 (KEGG Compound)
beta-D-glucoseMetaboliteC00221 (KEGG Compound)
dehydrogenaseGeneProductRv0843 (TubercuList) Original kegg element: gene;12;mtu:Rv0843 mtu:Rv2241 mtu:Rv2496c mtu:Rv2497c
enoGeneProduct4.2.1.11 (Enzyme Nomenclature) Original kegg element: gene;19;mtu:Rv1023
fbaGeneProduct4.1.2.13 (Enzyme Nomenclature) Original kegg element: gene;1;mtu:Rv0363c
gapGeneProduct1.2.1.12 (Enzyme Nomenclature) Original kegg element: gene;21;mtu:Rv1436
glpXGeneProduct3.1.3.11 (Enzyme Nomenclature) Original kegg element: gene;25;mtu:Rv1099c
lpdAGeneProductRv3303c (TubercuList) Original kegg element: gene;41;mtu:Rv0462 mtu:Rv0794c mtu:Rv3303c
lpdGeneProductRv0462 (TubercuList) Original kegg element: gene;41;mtu:Rv0462 mtu:Rv0794c mtu:Rv3303c
oxidoreductaseGeneProductRv0794c (TubercuList) Original kegg element: gene;41;mtu:Rv0462 mtu:Rv0794c mtu:Rv3303c
pckAGeneProductRv0211 (TubercuList) Original kegg element: gene;76;mtu:Rv0211
pdhAGeneProductRv2497c (TubercuList) Original kegg element: gene;13;mtu:Rv0843 mtu:Rv2241 mtu:Rv2496c mtu:Rv2497c
pdhBGeneProductRv2496c (TubercuList) Original kegg element: gene;12;mtu:Rv0843 mtu:Rv2241 mtu:Rv2496c mtu:Rv2497c
pdhCGeneProductRv2495c (TubercuList) Original kegg element: gene;14;mtu:Rv2495c
pfkAProteinNP_217526 (NCBI Protein) Original kegg element: gene;24;mtu:Rv2029c mtu:Rv3010c
pfkBProteinNP_216545 (NCBI Protein) Original kegg element: gene;24;mtu:Rv2029c mtu:Rv3010c
pgiGeneProductRv0946c (TubercuList) Original kegg element: gene;29;mtu:Rv0946c
pgkGeneProduct2.7.2.3 (Enzyme Nomenclature) Original kegg element: gene;42;mtu:Rv1437
pgmAGeneProduct5.4.2.2 (Enzyme Nomenclature) Original kegg element: gene;28;mtu:Rv3068c mtu:Rv3257c
phosphoglycerate mutase

(phosphoglyceromutase)

(EC:5.4.2.1)
GeneProduct5.4.2.1 (Enzyme Nomenclature) Original kegg element: gene;20;mtu:Rv0489 mtu:Rv2419c mtu:Rv3214
ppgKGeneProductRv2702 (TubercuList) Original kegg element: gene;44;mtu:Rv2702
pykAGeneProduct2.7.1.40 (Enzyme Nomenclature) Original kegg element: gene;17;mtu:Rv1617
sugar kinase (EC:2.7.-.-)GeneProductRv0650 (TubercuList) Original kegg element: gene;31;mtu:Rv0650
sugar kinase (EC:2.7.1.2)GeneProduct2.7.1.2 (Enzyme Nomenclature) Original kegg element: gene;35;mtu:Rv0650
tpiGeneProduct5.3.1.1 (Enzyme Nomenclature) Original kegg element: gene;23;mtu:Rv1438

Annotated Interactions

No annotated interactions

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