MicroRNAs in Cardiomyocyte Hypertrophy (Mus musculus)

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612161771764617316616171761716Pol IIRhoStressCatecholaminesStressRTKsGPCRCelmembranePI3KRCAN1 promotorTGFR/ActivinStretchTNFRGβγSarcomere organizationGC-AGαq/α11GPCRNucleusProtein SynthesisCellular ProteinsHypertrophic gene transcriptionRASTranscription FactorsPrkcbmmu-mir-15bmmu-mir-199a-2Rock2mmu-mir-199a-1mmu-mir-195Calciummmu-mir-199a-2mmu-mir-21mmu-mir-199a-2mmu-mir-133a-1Pik3r2mmu-mir-133a-1mmu-mir-199a-2Mapk14Lrp5mmu-mir-30emmu-mir-15bMapk1Map2k3IkbkgPpp3cammu-mir-15bMapk7mmu-mir-30eCdk7mmu-mir-103-1mmu-mir-140NppaCtf1mmu-mir-30emmu-mir-185mmu-mir-27bmmu-mir-199a-2mmu-let-7bmmu-mir-103-2mmu-mir-125b-2mmu-mir-23aPdpk1mmu-mir-15bmmu-mir-195mmu-mir-199a-1Hdac9Cdk9mmu-mir-195mmu-mir-125b-1mmu-let-7bmmu-mir-30emmu-mir-214Pik3cbIkbkbRcan1CaMmmu-mir-23ammu-mir-15bmmu-mir-195Nfatc4mmu-mir-195-1Map2k5Map2k4mmu-mir-125b-1mmu-mir-140Pik3r3Igf1Calciummmu-mir-195CishMtormmu-mir-23aNrg1Fzd2mmu-mir-103-1mmu-mir-15bmmu-let-7bHdac4Raf1mmu-mir-199a-2Map3k7ip1mmu-mir-30emmu-mir-130bmmu-mir-30eIgf1rmmu-mir-15bmmu-mir-21Il6stmmu-mir-21mmu-mir-140Camk2dmmu-mir-15bmmu-mir-133a-2Map2k1Calciummmu-let-7bIP3mmu-mir-21Tgfb1mmu-mir-195mmu-mir-27bmmu-mir-199a-1mmu-mir-103-2Gsk3bmmu-mir-27bmmu-mir-15bmmu-mir-125b-1mmu-mir-27bEdn1Wnt5aCalmodulinEif2b5Mapk8Map3k14mmu-let-7bPlcb2mmu-mir-23aChukHdac5Fgf2Pdpk1Mapk3Hdac7Nppbmmu-mir-185mmu-mir-199a-1mmu-mir-27bMapk4mmu-mir-199a-2mmu-mir-23aRhoammu-mir-125b-2Gata4Map2k6mmu-mir-208ammu-mir-208ammu-mir-125b-2Nfkb1Mapk3Lrp6Mapk3Ikbkemmu-mir-27bFzd1mmu-mir-199a-1Fgfr2Nfatc4sPla2-IIAmmu-mir-195Mapk8Wnt3ammu-mir-15bPik3r1Tnfmmu-mir-27bCyclic GMPmmu-mir-195mmu-mir-125b-2mmu-mir-195mmu-mir-27bAkt2Ppp3cbmmu-mir-15bmmu-mir-199a-1mmu-mir-130bmmu-mir-125b-1mmu-let-7bAgtStat3mmu-mir-27bHdac7mmu-mir-27bmmu-mir-133bLifPik3cgHdac4mmu-mir-15bMap2k7Gsk3bmmu-mir-195mmu-mir-30eMylkmmu-mir-30ePrkcbMapk3Prkg1Nfatc4mmu-mir-23aMapk1Stat3Mapk14mmu-mir-130bAgtmmu-mir-30eDAGHdac5Akt1mmu-mir-208ammu-mir-195mmu-mir-195mmu-mir-23ammu-mir-27bPik3cdDvl1Rac1Map2k2mmu-mir-199a-1Rock1mmu-mir-133bCtnnb1EgfPik3cammu-mir-15bmmu-mir-133a-2Mylk3mmu-mir-133bMyef2Nfkb1Mapk3mmu-mir-23aHdac9


This pathway shows the role of microRNAs in the process of cardiac hypertrophy.

Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red, dashed lines. MicroRNAs are shown as purple rounded rectangles.

It is not sure which WNT and frizzled proteins influence cardiac hypertrophy. Though there are strong indications that WNT3A, WNT5A, frizzled1 and frizzled2 play a role in cardiac hypertrophy. Thus these have been added to the pathway instead of all the WNT and frizzled proteins. Experiments which will shed light on this are still being done.


This pathway was inferred from Homo sapiens pathway WP1544(r37553) with a 96% conversion rate.

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Ontology Terms



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  1. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN; ''A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.''; Cell, 1998 PubMed
  2. Molkentin JD; ''Calcineurin and beyond: cardiac hypertrophic signaling.''; Circ Res, 2000 PubMed
  3. Lim HW, Molkentin JD; ''Calcineurin and human heart failure.''; Nat Med, 1999 PubMed
  4. Wang J, Xu R, Lin F, Zhang S, Zhang G, Hu S, Zheng Z; ''MicroRNA: novel regulators involved in the remodeling and reverse remodeling of the heart.''; Cardiology, 2009 PubMed
  5. Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, Hewett TE, Jones SP, Lefer DJ, Peng CF, Kitsis RN, Molkentin JD; ''The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice.''; EMBO J, 2000 PubMed
  6. Heineke J, Molkentin JD; ''Regulation of cardiac hypertrophy by intracellular signalling pathways.''; Nat Rev Mol Cell Biol, 2006 PubMed
  7. Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, Bang ML, Segnalini P, Gu Y, Dalton ND, Elia L, Latronico MV, Høydal M, Autore C, Russo MA, Dorn GW 2nd, Ellingsen O, Ruiz-Lozano P, Peterson KL, Croce CM, Peschle C, Condorelli G; ''MicroRNA-133 controls cardiac hypertrophy.''; Nat Med, 2007 PubMed
  8. Wollert KC, Taga T, Saito M, Narazaki M, Kishimoto T, Glembotski CC, Vernallis AB, Heath JK, Pennica D, Wood WI, Chien KR; ''Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways.''; J Biol Chem, 1996 PubMed
  9. Clerk A, Sugden PH; ''Small guanine nucleotide-binding proteins and myocardial hypertrophy.''; Circ Res, 2000 PubMed
  10. Wollert KC, Chien KR; ''Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development.''; J Mol Med, 1997 PubMed
  11. Olson EN, Molkentin JD; ''Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype?''; Circ Res, 1999 PubMed
  12. Vanhaesebroeck B, Alessi DR; ''The PI3K-PDK1 connection: more than just a road to PKB.''; Biochem J, 2000 PubMed
  13. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR; ''Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.''; J Biol Chem, 1998 PubMed
  14. Jalili T, Takeishi Y, Walsh RA; ''Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC.''; Cardiovasc Res, 1999 PubMed
  15. Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA; ''Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy.''; Circ Res, 2000 PubMed
  16. Haghikia A, Stapel B, Hoch M, Hilfiker-Kleiner D; ''STAT3 and cardiac remodeling.''; Heart Fail Rev, 2010 PubMed
  17. Blankesteijn WM, van de Schans VA, ter Horst P, Smits JF; ''The Wnt/frizzled/GSK-3 beta pathway: a novel therapeutic target for cardiac hypertrophy.''; Trends Pharmacol Sci, 2008 PubMed


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70037view02:02, 12 July 2013AlexanderPicoModified title
69898view19:27, 11 July 2013MaintBotupdating to 2013 schema
67464view11:05, 26 June 2013DdiglesOntology Term : 'hypertrophic cardimyopathy pathway' added !
41377view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
37650view09:39, 16 June 2010MLevelsEdited Line
37649view08:00, 16 June 2010MLevelsID
37634view14:40, 14 June 2010MLevelsMicroRNA IDs
37633view14:38, 14 June 2010MLevelsMicroRNA IDs
37632view14:33, 14 June 2010MLevelsIDs of microRNAs converted to mouse
37629view14:26, 14 June 2010MLevelsPeriodical save, work in progress
37628view14:16, 14 June 2010MLevelsPeriodical save, work in progress
37625view14:05, 14 June 2010MLevelsPeriodical save, work in progress
37623view13:55, 14 June 2010MLevelsPeriodical save, work in progress
37613view11:26, 14 June 2010MLevelsSpecify description
37612view11:24, 14 June 2010MLevelsPeriodical save, work in progress
37609view10:54, 14 June 2010MLevelsModified description
37608view10:53, 14 June 2010MLevelsChanged Lines, corrected IDs
37607view10:45, 14 June 2010MLevelsPeriodical save, work in progress
37606view10:34, 14 June 2010MLevelsPeriodical save, work in progress
37605view10:13, 14 June 2010MLevelsModified description
37568view18:09, 11 June 2010MaintBotNew pathway

External references


View all...
NameTypeDatabase referenceComment
AgtGeneProduct11606 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
Akt2GeneProduct11652 (Entrez Gene)
CaMProtein12313 (Entrez Gene)
CalciumMetaboliteHMDB00464 (HMDB)
Camk2dGeneProduct108058 (Entrez Gene)
Cdk7GeneProduct12572 (Entrez Gene)
Cdk9GeneProduct107951 (Entrez Gene)
ChukGeneProduct12675 (Entrez Gene)
CishGeneProduct12700 (Entrez Gene)
Ctf1GeneProduct13019 (Entrez Gene)
Ctnnb1GeneProduct12387 (Entrez Gene)
Cyclic GMPMetaboliteHMDB01314 (HMDB)
DAGMetaboliteHMDB07009 (HMDB)
Dvl1GeneProduct13542 (Entrez Gene)
Edn1GeneProduct13614 (Entrez Gene)
EgfGeneProduct13645 (Entrez Gene)
Eif2b5GeneProduct224045 (Entrez Gene)
Fgf2GeneProduct14173 (Entrez Gene)
Fgfr2GeneProduct14183 (Entrez Gene)
Fzd1GeneProduct14362 (Entrez Gene)
Fzd2GeneProduct57265 (Entrez Gene)
Gata4GeneProduct14463 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene)
Hdac4GeneProduct208727 (Entrez Gene)
Hdac5GeneProduct15184 (Entrez Gene)
Hdac7GeneProduct56233 (Entrez Gene)
Hdac9GeneProduct79221 (Entrez Gene)
IP3MetaboliteHMDB01498 (HMDB)
Igf1GeneProduct16000 (Entrez Gene)
Igf1rGeneProduct16001 (Entrez Gene)
IkbkbGeneProduct16150 (Entrez Gene)
IkbkeGeneProduct56489 (Entrez Gene)
IkbkgGeneProduct16151 (Entrez Gene)
Il6stGeneProduct16195 (Entrez Gene)
LifGeneProduct16878 (Entrez Gene)
Lrp5GeneProduct16973 (Entrez Gene)
Lrp6GeneProduct16974 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Map2k3GeneProduct26397 (Entrez Gene)
Map2k4GeneProduct26398 (Entrez Gene)
Map2k5GeneProduct23938 (Entrez Gene)
Map2k6GeneProduct26399 (Entrez Gene)
Map2k7GeneProduct26400 (Entrez Gene)
Map3k14GeneProduct53859 (Entrez Gene)
Map3k7ip1GeneProduct66513 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk14GeneProduct26416 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mapk4GeneProduct225724 (Entrez Gene)
Mapk7GeneProduct23939 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
MtorGeneProduct56717 (Entrez Gene)
Myef2GeneProduct17876 (Entrez Gene)
MylkGeneProduct107589 (Entrez Gene)
Mylk3GeneProduct213435 (Entrez Gene)
Nfatc4GeneProduct73181 (Entrez Gene)
Nfkb1GeneProduct18033 (Entrez Gene)
NppaGeneProduct230899 (Entrez Gene)
NppbGeneProduct18158 (Entrez Gene)
Nrg1GeneProduct211323 (Entrez Gene)
Pdpk1GeneProduct18607 (Entrez Gene)
Pik3caGeneProduct18706 (Entrez Gene)
Pik3cbGeneProduct74769 (Entrez Gene)
Pik3cdGeneProduct18707 (Entrez Gene)
Pik3cgGeneProduct30955 (Entrez Gene)
Pik3r1GeneProduct18708 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Pik3r3GeneProduct18710 (Entrez Gene)
Plcb2GeneProduct18796 (Entrez Gene)
Ppp3caGeneProduct19055 (Entrez Gene)
Ppp3cbGeneProduct19056 (Entrez Gene)
PrkcbGeneProduct18751 (Entrez Gene)
Prkg1GeneProduct19091 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
Rcan1GeneProduct54720 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
Rock1GeneProduct19877 (Entrez Gene)
Rock2GeneProduct19878 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Tgfb1GeneProduct21803 (Entrez Gene)
TnfGeneProduct21926 (Entrez Gene)
Wnt3aGeneProduct22416 (Entrez Gene)
Wnt5aGeneProduct22418 (Entrez Gene)
mmu-let-7bRnaMI0000558 (miRBase Sequence)
mmu-mir-103-1RnaMI0000587 (miRBase Sequence)
mmu-mir-103-2RnaMI0000588 (miRBase Sequence)
mmu-mir-125b-1RnaMI0000725 (miRBase Sequence)
mmu-mir-125b-2RnaMI0000152 (miRBase Sequence)
mmu-mir-130bRnaMI0000408 (miRBase Sequence)
mmu-mir-133a-1RnaMI0000159 (miRBase Sequence)
mmu-mir-133a-2RnaMI0000820 (miRBase Sequence)
mmu-mir-133bRnaMI0000821 (miRBase Sequence)
mmu-mir-140RnaMI0000165 (miRBase Sequence)
mmu-mir-15bRnaMI0000140 (miRBase Sequence)
mmu-mir-185RnaMI0000227 (miRBase Sequence)
mmu-mir-195-1RnaMI0000237 (miRBase Sequence)
mmu-mir-195RnaMI0000237 (miRBase Sequence)
mmu-mir-199a-1RnaMI0000241 (miRBase Sequence)
mmu-mir-199a-2RnaMI0000713 (miRBase Sequence)
mmu-mir-208aRnaMI0000555 (miRBase Sequence)
mmu-mir-214RnaMI0000698 (miRBase Sequence)
mmu-mir-21RnaMI0000569 (miRBase Sequence)
mmu-mir-23aRnaMI0000571 (miRBase Sequence)
mmu-mir-27bRnaMI0000142 (miRBase Sequence)
mmu-mir-30eRnaMI0000259 (miRBase Sequence)
sPla2-IIAGeneProduct18780 (Entrez Gene)

Annotated Interactions

No annotated interactions
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