miRNAs involved in DNA damage response (Homo sapiens)

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1024510101512, 21258, 1330, 3142363111112, 218303723917-1914113023, 2610112230296112833011620927inhibitionmicroRNA clustergene product used more than once in this pathwaygene productconsists ofmicroRNAactivationhsa-mir-100hsa-mir-21CDKN1Bhsa-mir-181ahsa-mir-503hsa-miR-195/497 clusterhsa-mir-15ac-Mychsa-mir-424CCNE1hsa-mir-29aCCND1hsa-miR-210 genehsa-mir-181a-2/181b-2 clusterhsa-mir-203RAD52hsa-let-7a-1/7d clusterhsa-mir-371/373 clusterhsa-let-7a-3/7b clusterCDKN1Ahsa-mir-20ahsa-miR-449c/449a clusterhsa-mir-23ahsa-let-7a-2/100 clusterhsa-mir-34b/34c clusterhsa-miR-29b-2/29c clusterhsa-mir-24hsa-mir-143/145 clusterhsa-miR-222/221 clusterhsa-mir-374bCDC25A2hsa-mir-145hsa-miR-223 genehsa-mir-181a-1/181b-1 clusterhsa-miR-21genehsa-let-7ahsa-mir-3074hsa-mir-374b/421 clusterhsa-mir-449ahsa-mir-372hsa-mir-106bhsa-mir-195hsa-mir-330hsa-mir-15bhsa-mir-27bhsa-mir-371hsa-miR-424/450b clusterhsa-mir-373hsa-mir-222H2AFXhsa-let-7bhsa-mir-34chsa-mir-19b-1 CCND3hsa-mir-17hsa-mir-25hsa-mir-16hsa-mir-450ahsa-let-7fE2F1hsa-mir-93hsa-miR-203 geneATMhsa-miR-330 geneCCND1hsa-mir-92a-1hsa-mir-23b/24-1 clusterhsa-mir-497hsa-mir-23bhsa-mir-210hsa-mir-221hsa-mir-450bhsa-mir-15a/16-1 clusterCREB1hsa-mir-223E2F1hsa-mir-15b/16-2 clusterhsa-mir-19ahsa-let-7dhsa-mir-23a/24-2 clusterhsa-mir-29b-1hsa-mir-181bhsa-mir-18aTP53c-MycABL1hsa-miR-17/92a-1 clusterhsa-mir-27ahsa-mir-449bhsa-mir-29chsa-mir-542hsa-mir-143hsa-mir-34bhsa-mir-421hsa-miR-106b/25 clusterhsa-miR-29b-1/29a clusterCDK6hsa-mir-449c


Description

MicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo sapiens)". More info can be found there.

Comments

 
This pathway show all microRNA gene cluster involed in the wikipathway pathway "DNA damage response (Homo sapiens)". More info can be found there.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Yu Z, Wang C, Wang M, Li Z, Casimiro MC, Liu M, Wu K, Whittle J, Ju X, Hyslop T, McCue P, Pestell RG; ''A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation.''; J Cell Biol, 2008 PubMed Europe PMC
  2. Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M; ''p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC
  3. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, Dessureault S, Moscinski LC, Rezania D, Dalton WS, Sotomayor E, Tao J, Cheng JQ; ''microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.''; Blood, 2010 PubMed Europe PMC
  4. Ivanovska I, Ball AS, Diaz RL, Magnus JF, Kibukawa M, Schelter JM, Kobayashi SV, Lim L, Burchard J, Jackson AL, Linsley PS, Cleary MA; ''MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.''; Mol Cell Biol, 2008 PubMed Europe PMC
  5. Wang P, Zou F, Zhang X, Li H, Dulak A, Tomko RJ Jr, Lazo JS, Wang Z, Zhang L, Yu J; ''microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.''; Cancer Res, 2009 PubMed Europe PMC
  6. Crosby ME, Kulshreshtha R, Ivan M, Glazer PM; ''MicroRNA regulation of DNA repair gene expression in hypoxic stress.''; Cancer Res, 2009 PubMed Europe PMC
  7. Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G; ''Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia.''; Blood, 2010 PubMed Europe PMC
  8. Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY; ''p53 represses c-Myc through induction of the tumor suppressor miR-145.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC
  9. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT; ''c-Myc-regulated microRNAs modulate E2F1 expression.''; Nature, 2005 PubMed Europe PMC
  10. Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M, Yu Q; ''miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.''; Genes Dev, 2009 PubMed Europe PMC
  11. Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT; ''Widespread microRNA repression by Myc contributes to tumorigenesis.''; Nat Genet, 2008 PubMed Europe PMC
  12. Fornari F, Gramantieri L, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Giovannini C, Croce CM, Bolondi L, Negrini M; ''MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.''; Oncogene, 2008 PubMed Europe PMC
  13. Quintavalle M, Elia L, Condorelli G, Courtneidge SA; ''MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro.''; J Cell Biol, 2010 PubMed Europe PMC
  14. Pigazzi M, Manara E, Baron E, Basso G; ''miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia.''; Cancer Res, 2009 PubMed Europe PMC
  15. Wong P, Iwasaki M, Somervaille TC, Ficara F, Carico C, Arnold C, Chen CZ, Cleary ML; ''The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression.''; Cancer Res, 2010 PubMed Europe PMC
  16. Woods K, Thomson JM, Hammond SM; ''Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors.''; J Biol Chem, 2007 PubMed Europe PMC
  17. Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, Zhai Y, Giordano TJ, Qin ZS, Moore BB, MacDougald OA, Cho KR, Fearon ER; ''p53-mediated activation of miRNA34 candidate tumor-suppressor genes.''; Curr Biol, 2007 PubMed Europe PMC
  18. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY; ''MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth.''; Cancer Res, 2007 PubMed Europe PMC
  19. Yamakuchi M, Lowenstein CJ; ''MiR-34, SIRT1 and p53: the feedback loop.''; Cell Cycle, 2009 PubMed Europe PMC
  20. Bueno MJ, Pérez de Castro I, Gómez de Cedrón M, Santos J, Calin GA, Cigudosa JC, Croce CM, Fernández-Piqueras J, Malumbres M; ''Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.''; Cancer Cell, 2008 PubMed Europe PMC
  21. Pineau P, Volinia S, McJunkin K, Marchio A, Battiston C, Terris B, Mazzaferro V, Lowe SW, Croce CM, Dejean A; ''miR-221 overexpression contributes to liver tumorigenesis.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC
  22. Lee KH, Chen YL, Yeh SD, Hsiao M, Lin JT, Goan YG, Lu PJ; ''MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation.''; Oncogene, 2009 PubMed Europe PMC
  23. Bueno MJ, Gómez de Cedrón M, Laresgoiti U, Fernández-Piqueras J, Zubiaga AM, Malumbres M; ''Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling.''; Mol Cell Biol, 2010 PubMed Europe PMC
  24. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, Ferbeyre G, Chartrand P; ''An E2F/miR-20a autoregulatory feedback loop.''; J Biol Chem, 2007 PubMed Europe PMC
  25. Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, Bentwich Z, Lieberman J, Chowdhury D; ''miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC
  26. Brosh R, Shalgi R, Liran A, Landan G, Korotayev K, Nguyen GH, Enerly E, Johnsen H, Buganim Y, Solomon H, Goldstein I, Madar S, Goldfinger N, Børresen-Dale AL, Ginsberg D, Harris CC, Pilpel Y, Oren M, Rotter V; ''p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.''; Mol Syst Biol, 2008 PubMed Europe PMC
  27. Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA; ''ATM is down-regulated by N-Myc-regulated microRNA-421.''; Proc Natl Acad Sci U S A, 2010 PubMed Europe PMC
  28. Cuesta R, Martínez-Sánchez A, Gebauer F; ''miR-181a regulates cap-dependent translation of p27(kip1) mRNA in myeloid cells.''; Mol Cell Biol, 2009 PubMed Europe PMC
  29. Lee SO, Masyuk T, Splinter P, Banales JM, Masyuk A, Stroope A, Larusso N; ''MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease.''; J Clin Invest, 2008 PubMed Europe PMC
  30. Liu Q, Fu H, Sun F, Zhang H, Tie Y, Zhu J, Xing R, Sun Z, Zheng X; ''miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes.''; Nucleic Acids Res, 2008 PubMed Europe PMC
  31. Pothof J, Verkaik NS, van IJcken W, Wiemer EA, Ta VT, van der Horst GT, Jaspers NG, van Gent DC, Hoeijmakers JH, Persengiev SP; ''MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response.''; EMBO J, 2009 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
102985view12:29, 31 January 2019SusanUpdated microRNA annotations
102984view11:59, 31 January 2019SusanAdapted annotation of microRNAs hsa-mir-497 and hsa-mir-20a
98356view05:43, 24 August 2018EgonwFixed weird chars in author names.
98338view13:28, 23 August 2018EgonwUpdated the MIR21 identifier.
94759view15:43, 5 October 2017Mkutmonlines in legend changed to graphical lines
84697view21:15, 15 March 2016KhanspersQuick edit to datanode annotation or property
78559view10:31, 7 January 2015MaintBotadded missing graphIds
70088view17:52, 12 July 2013MaintBotModified title
70087view17:52, 12 July 2013MaintBotupdating to 2013 schema
59082view21:58, 21 February 2013MaintBotUpdated Ensembl data source
53519view12:41, 8 November 2012Andra
53518view12:40, 8 November 2012Andra
45378view21:35, 7 October 2011KhanspersOntology Term : 'DNA repair pathway' added !
44909view10:27, 6 October 2011MartijnVanIerselOntology Term : 'miRNA pathway' added !
41207view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
37867view17:22, 13 July 2010KhanspersModified categories
37421view14:16, 1 June 2010J.krumeichSpecify description
37420view14:10, 1 June 2010J.krumeichPeriodical save, work in progress
37417view13:42, 1 June 2010J.krumeichModified description
37416view13:35, 1 June 2010J.krumeichSpecify description
37415view13:29, 1 June 2010J.krumeichSpecify description
37414view13:24, 1 June 2010J.krumeichSpecify description
37413view13:19, 1 June 2010J.krumeichPeriodical save, work in progress
37412view13:09, 1 June 2010J.krumeichPeriodical save, work in progress
37411view12:58, 1 June 2010J.krumeichPeriodical save, work in progress
37410view12:28, 1 June 2010J.krumeichPeriodical save, work in progress
37409view12:18, 1 June 2010J.krumeichPeriodical save, work in progress
37408view12:07, 1 June 2010J.krumeichPeriodical save, work in progress
37403view11:44, 1 June 2010J.krumeichSpecify description
37400view11:37, 1 June 2010J.krumeichPeriodical save, work in progress
37398view11:16, 1 June 2010J.krumeichPeriodical save, work in progress
37384view13:13, 31 May 2010J.krumeichSpecify description
37383view13:10, 31 May 2010J.krumeichSpecify description
37382view13:08, 31 May 2010J.krumeichPeriodical save, work in progress
37381view12:57, 31 May 2010J.krumeichPeriodical save, work in progress
37380view12:47, 31 May 2010J.krumeichPeriodical save, work in progress
37379view12:37, 31 May 2010J.krumeichPeriodical save, work in progress
37378view12:26, 31 May 2010J.krumeichPeriodical save, work in progress
37377view12:16, 31 May 2010J.krumeichPeriodical save, work in progress
37376view12:06, 31 May 2010J.krumeichPeriodical save, work in progress
37375view11:55, 31 May 2010J.krumeichPeriodical save, work in progress
37374view11:45, 31 May 2010J.krumeichPeriodical save, work in progress
37373view11:38, 31 May 2010J.krumeichSpecify description
37372view10:22, 31 May 2010J.krumeichPeriodical save, work in progress
37371view10:02, 31 May 2010J.krumeichSpecify description
37370view09:55, 31 May 2010J.krumeichSpecify description
37369view09:52, 31 May 2010J.krumeichPeriodical save, work in progress
37368view09:46, 31 May 2010J.krumeichalle mirs
37367view09:41, 31 May 2010J.krumeichPeriodical save, work in progress
37366view09:31, 31 May 2010J.krumeichPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
ATMGeneProduct472 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CDC25A2GeneProduct993 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
E2F1GeneProduct1869 (Entrez Gene)
H2AFXGeneProduct3014 (Entrez Gene)
RAD52GeneProduct5893 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
c-MycGeneProduct4609 (Entrez Gene)
hsa-let-7a-1/7d clusterGeneProduct
hsa-let-7a-2/100 clusterGeneProduct
hsa-let-7a-3/7b clusterGeneProduct
hsa-let-7aGeneProductENSG00000199165 (Ensembl)
hsa-let-7bGeneProductENSG00000284520 (Ensembl)
hsa-let-7dGeneProductENSG00000199133 (Ensembl)
hsa-let-7fGeneProductENSG00000199072 (Ensembl)
hsa-miR-106b/25 clusterGeneProduct
hsa-miR-17/92a-1 clusterGeneProduct
hsa-miR-195/497 clusterGeneProduct
hsa-miR-203 geneGeneProduct
hsa-miR-210 geneGeneProduct
hsa-miR-21geneGeneProduct
hsa-miR-222/221 clusterGeneProduct
hsa-miR-223 geneGeneProduct
hsa-miR-29b-1/29a clusterGeneProduct
hsa-miR-29b-2/29c clusterGeneProduct
hsa-miR-330 geneGeneProduct
hsa-miR-424/450b clusterGeneProduct
hsa-miR-449c/449a clusterGeneProduct
hsa-mir-100GeneProductENSG00000207994 (Ensembl)
hsa-mir-106bGeneProductENSG00000208036 (Ensembl)
hsa-mir-143/145 clusterGeneProduct
hsa-mir-143GeneProductENSG00000284182 (Ensembl)
hsa-mir-145GeneProductENSG00000276365 (Ensembl)
hsa-mir-15a/16-1 clusterGeneProduct
hsa-mir-15aGeneProductENSG00000283785 (Ensembl)
hsa-mir-15b/16-2 clusterGeneProduct
hsa-mir-15bGeneProductENSG00000207779 (Ensembl)
hsa-mir-16GeneProductENSG00000208006 (Ensembl)
hsa-mir-17GeneProductENSG00000284536 (Ensembl)
hsa-mir-181a-1/181b-1 clusterGeneProduct
hsa-mir-181a-2/181b-2 clusterGeneProduct
hsa-mir-181aGeneProductENSG00000207759 (Ensembl)
hsa-mir-181bGeneProductENSG00000207975 (Ensembl)
hsa-mir-18aGeneProductENSG00000283815 (Ensembl)
hsa-mir-195GeneProductENSG00000284112 (Ensembl)
hsa-mir-19aGeneProductENSG00000284204 (Ensembl)
hsa-mir-19b-1 GeneProductENSG00000284375 (Ensembl)
hsa-mir-203GeneProductENSG00000207568 (Ensembl)
hsa-mir-20aGeneProductENSG00000283762 (Ensembl)
hsa-mir-210GeneProductENSG00000199038 (Ensembl)
hsa-mir-21GeneProductENSG00000284190 (Ensembl)
hsa-mir-221GeneProductENSG00000207870 (Ensembl)
hsa-mir-222GeneProductENSG00000207725 (Ensembl)
hsa-mir-223GeneProductENSG00000284567 (Ensembl)
hsa-mir-23a/24-2 clusterGeneProduct
hsa-mir-23aGeneProductENSG00000207980 (Ensembl)
hsa-mir-23b/24-1 clusterGeneProduct
hsa-mir-23bGeneProductENSG00000207563 (Ensembl)
hsa-mir-24GeneProductENSG00000207617 (Ensembl)
hsa-mir-25GeneProductENSG00000207547 (Ensembl)
hsa-mir-27aGeneProductENSG00000207808 (Ensembl)
hsa-mir-27bGeneProductENSG00000207864 (Ensembl)
hsa-mir-29aGeneProductENSG00000284032 (Ensembl)
hsa-mir-29b-1GeneProductENSG00000283797 (Ensembl)
hsa-mir-29cGeneProductENSG00000284214 (Ensembl)
hsa-mir-3074GeneProductMI0014181 (miRBase Sequence)
hsa-mir-330GeneProductENSG00000284544 (Ensembl)
hsa-mir-34b/34c clusterGeneProduct
hsa-mir-34bGeneProductENSG00000207811 (Ensembl)
hsa-mir-34cGeneProductENSG00000207562 (Ensembl)
hsa-mir-371/373 clusterGeneProduct
hsa-mir-371GeneProductENSG00000199031 (Ensembl)
hsa-mir-372GeneProductENSG00000199095 (Ensembl)
hsa-mir-373GeneProductENSG00000199143 (Ensembl)
hsa-mir-374b/421 clusterGeneProduct
hsa-mir-374bGeneProductENSG00000212027 (Ensembl)
hsa-mir-421GeneProductENSG00000202566 (Ensembl)
hsa-mir-424GeneProductENSG00000284231 (Ensembl)
hsa-mir-449aGeneProductENSG00000198983 (Ensembl)
hsa-mir-449bGeneProductENSG00000207728 (Ensembl)
hsa-mir-449cGeneProductMI0003823 (miRBase Sequence)
hsa-mir-450aGeneProductENSG00000207755 (Ensembl)
hsa-mir-450bGeneProductENSG00000216001 (Ensembl)
hsa-mir-497GeneProductENSG00000284027 (Ensembl)
hsa-mir-503GeneProductENSG00000208005 (Ensembl)
hsa-mir-542GeneProductENSG00000207784 (Ensembl)
hsa-mir-92a-1GeneProductENSG00000283705 (Ensembl)
hsa-mir-93GeneProductENSG00000207757 (Ensembl)

Annotated Interactions

No annotated interactions
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