miRNA Regulation of DNA Damage Response (Homo sapiens)

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112345123, 19, 26, 35, 41304715303, 8, 14, 29, 34...3124136224225302530274611453025, 47392745425, 4745252111231748363017163, 8, 14, 29, 34...27393, 8, 14, 29, 34...25, 471040306303072825, 47273, 8, 14, 29, 34...3636313, 8, 14, 29, 34...301825, 47172330303, 8, 14, 29, 34...3, 8, 14, 29, 34...7, 32725303620, 22ROSG1/S transitionInhibitionGene productTextExogenous: Cigarette Smoke Caffeine Radiation (UV) Clastogenes Hypoxia Genotoxic drugsEndogenous: Collapsed replication forks Single stranded DNA replication breaks Free radicals (ROS) G2/M CheckpointActivationCell survivalDouble-strand breaksCaption:Pathway LinkG2/M checkpointTextTextDNA adductROSExtral cellular SpaceBulky DNA lesionDNA damage sourceDNA repair and damage preventionBlocked transcriptionChange in the Cell conditionSpecialized: Somatic hypermutaion V(D)J recombination Class switchingChromatin remodellingDifferent pathwayAlkylating agentsG2/M transitionCellChromatin alterationmiR polycistronmicroRNABlocked replicationDNA repairMitochondrial membraneDNA damage ATM dependentCell membraneMetaboliteReplication stressCell-cycle progressionBAXSFNRRM2BMIR20ARAD1hsa-mir-122hsa-let-7a-1/7dCREB1FASCCNB2PMLATRIPRAD51CASP9hsa-mir-34b/34cRB1hsa-miR-106b/25CCNG1CCNE1CDK4E2F1CCNB1CCNB3CYCSPIDDGADD45ABBC3Cell CycleCASP8FANCD2MIR15a/16-1NBNMIR29cRAD9AMIR29B1TLK1DDB2hsa-mir-181aEstradiolSESN1TP53TP53AIP1CDC25ARB1hsa-mir-449aMIR195H2AFXTNFRSF10BMIR29b-1/29aCaffeineRAD52hsa-mir-106bCDC25Cc-Mychsa-mir-15b/16-2CDK6GADD45BMDM2MIR223hsa-mir-143/145SMC1AMIR424CDKN1BGADD45BRAD17hsa-mir-16hsa-mir-449bE2F1RAD50GADD45Ghsa-mir-21MRE11ATMCDK2APAF1hsa-mir-16hsa-mir-222Senescencehsa-mir-15b/16-2miR-143/145 polycistronTLK2ATRhsa-mir-34bHUS1MIR195/497BID7-hydroxystaurosporineCCNE2hsa-mir-24-1MIR330GADD45ACCND1PMAIP1CDK5hsa-mir-16MIR29AABL1MIR17MIR15AMIR145GADD45GMIR17hsa-mir-421RPA2hsa-miR-449c/449aCHEK1CDKN1Ahsa-mir-210hsa-mir-203CASP3PRKDChsa-mir-449aCCND2Apoptosishsa-mir-373hsa-mir-221CHEK2BRCA1MIR17/92a-1CCND3CDK1RFC


Description

This is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The two central genes can both be divides into their most important genes. For the ATM pathway these are TP53 and CHEK2, while CHEK1 is most important for the ATR pathway.

The goal of this first pathway is to provide an overview of the most important gene products, processes and changes in cell condition elicited by the DNA damage response while keeping it clear and understandable. Also some microRNAs are implemented to visualize the possible effects they can induce. By doing so a better understanding of the role microRNA play in the DNA damage response might arise.

All processes take place in the cytoplasm, except when mentioned differently.

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Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
103023view15:52, 31 January 2019Mkutmonupdated ensembl ids
102986view12:46, 31 January 2019SusanRe-annotated microRNAs
98336view13:26, 23 August 2018EgonwUpdated the MIR21 identifier.
94738view15:05, 5 October 2017Ryanmillerconnected lines
84694view21:01, 15 March 2016KhanspersQuick edit to datanode annotation or property
79564view17:47, 25 March 2015Zarichanged ID for PRKDC
78503view10:29, 7 January 2015MaintBotadded missing graphIds
75268view21:48, 13 May 2014Khanspersupdated miRNAs and lines
71711view20:03, 17 October 2013MaintBotremoved data source from nodes without identifier
70992view21:04, 21 September 2013EgonwAdded the missing DB names.
70112view19:09, 12 July 2013MaintBotupdated to 2013 schema
70023view01:52, 12 July 2013AlexanderPicoModified title
68400view08:12, 5 July 2013EgonwConverted the "alkylating agent" label into a DataNode with ChEBI identifier.
59081view21:57, 21 February 2013MaintBotUpdated Ensembl data source
45379view21:45, 7 October 2011KhanspersOntology Term : 'DNA repair pathway' added !
44908view10:26, 6 October 2011MartijnVanIerselOntology Term : 'miRNA pathway' added !
41096view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
40043view15:20, 1 February 2011AndraPeriodical save, work in progress
39801view15:52, 20 January 2011Stan.gaj
39800view15:51, 20 January 2011Stan.gaj
39799view15:48, 20 January 2011Stan.gaj
39717view11:00, 14 January 2011Stan.gaj
38644view12:16, 23 September 2010Mkutmonadded some pathway links
38435view08:40, 13 September 2010Stan.gajAdded miRNA-122/Cyclin G1/MDM2/p53 regulatory network
38434view08:10, 13 September 2010Stan.gajSpecify description
38432view08:00, 13 September 2010Stan.gajPeriodical save, work in progress
37425view15:16, 1 June 2010J.krumeichSpecify description
37424view15:14, 1 June 2010J.krumeichSpecify description
37423view15:04, 1 June 2010J.krumeichPeriodical save, work in progress
37422view14:34, 1 June 2010J.krumeichPeriodical save, work in progress
37296view09:18, 25 May 2010J.krumeichPeriodical save, work in progress
37195view09:25, 21 May 2010J.krumeichPeriodical save, work in progress
37189view11:30, 20 May 2010J.krumeichModified description
37188view11:23, 20 May 2010J.krumeichPeriodical save, work in progress
37187view11:12, 20 May 2010J.krumeichPeriodical save, work in progress
37186view10:02, 20 May 2010J.krumeichSpecify description
37185view09:59, 20 May 2010J.krumeichPeriodical save, work in progress
37184view09:49, 20 May 2010J.krumeichPeriodical save, work in progress
37183view09:39, 20 May 2010J.krumeichPeriodical save, work in progress
37182view09:23, 20 May 2010J.krumeichSpecify description
37181view09:22, 20 May 2010J.krumeichSpecify description
37180view09:18, 20 May 2010J.krumeichPeriodical save, work in progress
37179view09:08, 20 May 2010J.krumeichPeriodical save, work in progress
37178view08:57, 20 May 2010J.krumeichPeriodical save, work in progress
37177view08:47, 20 May 2010J.krumeichPeriodical save, work in progress
37176view08:42, 20 May 2010J.krumeichSpecify description
37171view08:20, 20 May 2010J.krumeichPeriodical save, work in progress
37170view08:09, 20 May 2010J.krumeichPeriodical save, work in progress
37161view13:38, 19 May 2010J.krumeichwork in progress
37160view11:30, 19 May 2010J.krumeichPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
7-hydroxystaurosporineMetabolite65225 (Chemspider)
ABL1GeneProductENSG00000097007 (Ensembl)
APAF1GeneProductENSG00000120868 (Ensembl)
ATMGeneProductENSG00000149311 (Ensembl)
ATRGeneProductENSG00000175054 (Ensembl)
ATRIPGeneProduct84126 (Entrez Gene)
Alkylating agentsMetaboliteCHEBI:22333 (ChEBI)
ApoptosisPathwayWP254 (WikiPathways)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductENSG00000105327 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
BRCA1GeneProductENSG00000012048 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CCNB1GeneProductENSG00000134057 (Ensembl)
CCNB2GeneProductENSG00000157456 (Ensembl)
CCNB3GeneProductENSG00000147082 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CCND2GeneProductENSG00000118971 (Ensembl)
CCND3GeneProductENSG00000112576 (Ensembl)
CCNE1GeneProductENSG00000105173 (Ensembl)
CCNE2GeneProductENSG00000175305 (Ensembl)
CCNG1GeneProductENSG00000113328 (Ensembl)
CDC25AGeneProductENSG00000164045 (Ensembl)
CDC25CGeneProductENSG00000158402 (Ensembl)
CDK1GeneProductENSG00000170312 (Ensembl)
CDK2GeneProductENSG00000123374 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDK5GeneProductENSG00000164885 (Ensembl)
CDK6GeneProductENSG00000105810 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CHEK1GeneProductENSG00000149554 (Ensembl)
CHEK2GeneProductENSG00000183765 (Ensembl)
CREB1GeneProduct1385 (Entrez Gene)
CYCSGeneProductENSG00000172115 (Ensembl)
CaffeineMetabolite2424 (Chemspider)
Cell CyclePathwayWP179 (WikiPathways)
DDB2GeneProductENSG00000134574 (Ensembl)
E2F1GeneProductENSG00000101412 (Ensembl)
EstradiolMetabolite16469 (ChEBI)
FANCD2GeneProductENSG00000144554 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
GADD45AGeneProductENSG00000116717 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
H2AFXGeneProductENSG00000188486 (Ensembl)
HUS1GeneProductENSG00000188996 (Ensembl)
MDM2GeneProductENSG00000135679 (Ensembl)
MIR145GeneProductENSG00000276365 (Ensembl)
MIR15AGeneProductENSG00000283785 (Ensembl)
MIR15a/16-1Rna
MIR17/92a-1RnaENSG00000215417 (Ensembl)
MIR17RnaENSG00000284536 (Ensembl)
MIR195/497Rna
MIR195RnaENSG00000284112 (Ensembl)
MIR20AGeneProductENSG00000283762 (Ensembl)
MIR223RnaENSG00000284567 (Ensembl)
MIR29ARnaENSG00000284032 (Ensembl)
MIR29B1RnaENSG00000283797 (Ensembl)
MIR29b-1/29aRna
MIR29cRnaENSG00000284214 (Ensembl)
MIR330RnaENSG00000284544 (Ensembl)
MIR424RnaENSG00000284231 (Ensembl)
MRE11GeneProduct4361 (Entrez Gene)
NBNGeneProduct4683 (Entrez Gene)
PIDDGeneProduct55367 (Entrez Gene)
PMAIP1GeneProductENSG00000141682 (Ensembl)
PMLGeneProductENSG00000140464 (Ensembl)
PRKDCGeneProductENSG00000253729 (Ensembl)
RAD17GeneProductENSG00000152942 (Ensembl)
RAD1GeneProductENSG00000113456 (Ensembl)
RAD50GeneProductENSG00000113522 (Ensembl)
RAD51GeneProductENSG00000051180 (Ensembl)
RAD52GeneProductENSG00000002016 (Ensembl)
RAD9AGeneProductENSG00000172613 (Ensembl)
RB1GeneProductENSG00000139687 (Ensembl)
RFCGeneProduct5981 (Entrez Gene)
RPA2GeneProductENSG00000117748 (Ensembl)
RRM2BGeneProductENSG00000048392 (Ensembl)
SESN1GeneProductENSG00000080546 (Ensembl)
SFNGeneProductENSG00000175793 (Ensembl)
SMC1AGeneProductENSG00000072501 (Ensembl)
SenescencePathwayWP615 (WikiPathways)
TLK1GeneProductENSG00000198586 (Ensembl)
TLK2GeneProductENSG00000146872 (Ensembl)
TNFRSF10BGeneProductENSG00000120889 (Ensembl)
TP53AIP1GeneProductENSG00000120471 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
c-MycGeneProduct4609 (Entrez Gene)
hsa-let-7a-1/7dRna
hsa-miR-106b/25Rna4176 (Entrez Gene)
hsa-miR-449c/449aRna166979 (Entrez Gene)
hsa-mir-106bRnaENSG00000208036 (Ensembl)
hsa-mir-122RnaENSG00000207778 (Ensembl)
hsa-mir-143/145Rna
hsa-mir-15b/16-2Rna
hsa-mir-16RnaENSG00000208006 (Ensembl)
hsa-mir-181aRnaENSG00000207759 (Ensembl)
hsa-mir-203RnaENSG00000207568 (Ensembl)
hsa-mir-210RnaENSG00000199038 (Ensembl)
hsa-mir-21RnaENSG00000284190 (Ensembl)
hsa-mir-221RnaENSG00000207870 (Ensembl)
hsa-mir-222RnaENSG00000207725 (Ensembl)
hsa-mir-24-1GeneProductENSG00000284459 (Ensembl)
hsa-mir-34b/34cRna
hsa-mir-34bRnaENSG00000207811 (Ensembl)
hsa-mir-373RnaENSG00000199143 (Ensembl)
hsa-mir-421RnaENSG00000202566 (Ensembl)
hsa-mir-449aRnaENSG00000198983 (Ensembl)
hsa-mir-449bRnaENSG00000207728 (Ensembl)
miR-143/145 polycistronRna

Annotated Interactions

No annotated interactions

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