Selenium Micronutrient Network (Homo sapiens)

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21118741, 224109, 16, 26, 32, 70...9110, 195, 235, 26321127, 109, 211, 24010766, 8361, 64, 256159, 20021225117, 15018, 29, 65, 240133117130MetabolitesProcess or metabolism involved in Se PathwayBiomarker forEnzymesNegative EffectStatusTryptophan metabolismGlycogenesisFrom intracellular part to the plasmaNecessary stimulationInflammation and immune responseMicronutrientsOxidative stressBindingTranscription factorMetabolic stressConversionProtein tyrosine nitrationReactionOther proteinsCleavageLeukotriene metabolismCa++ metabolismLipid peroxidationSelenoproteinsSelenium statusCofactor conversionOverarching processLEGENDProstaglandins metabolismCofactorsInhibitionis composed ofLipoprotein melabolismStimulationCatalysisIntracellularNAD+ metabolismER protein foldingGlutathione metabolismFolate metabolismDNA oxidationPlasmaa-Tocopherol8-Isoprostaglandin F2aPGI2ALAALAPGG2Thromboxane B2Lipoxin A4DGLAPGD28-Isoprostaglandin F2aLinoleic acidMDARELANFkB2PGD2DPAEPAPGH2COX2PGH3Linoleic acidEPAPGI2Lipoxin B4PGE2Thromboxane A2PGE1a-TocopherolLipoxin B4F2-IsoprostanePGF2aDPACOX1PGE3Thromboxane B2MDAPGF2aDHAArachidonic acidPGE1NFkB1DHAArachidonic acidF2-IsoprostaneLipoxin A4PGE28092, 102, 146, 197, 199...80182, 191, 196, 20617246, 14187, 11573, 1451593515, 73, 15292, 146, 197, 199, 23635, 24424487, 11515219138, 73803535, 244737346, 1417321920680, 87, 115, 172, 1822442191824, 206732198020616, 80, 114, 141, 146...73, 2372192061591527346, 141Kynurenine150MTR91, 106TRXR1CBS36, 106IodineIodine113113KMO150Triiodothyronine (T3)5-HETE15-HETE15-HETEThyroxine (T4)Thyroxine (T4)Triiodothyronine (T3)R-Triiodothyronine (rT3)5-HPETE5-HETER-Triiodothyronine (rT3)5,6-Epoxytetraene17232, 162, 172172, 219105, 170105, 113105, 113105, 113219105, 17032, 162, 172105, 17032, 162, 172NADP+MPOMPOCatalase27, 67, 88, 2232740, 211Uric acid41, 180CysteineFactor VIIPAI-1PLGPLGPAI-1ThrombinFactor VIIThrombintPAtPAGGT174148, 2277474747474148, 227148, 155188148, 155GPX 4TRXR2Xantine oxidase49, 180PRDX5H2O2ALOX5ALOX15B114, 151, 194, 199, 219158, 172CopperUric acid41, 180Vitamin B1289, 1165,10-Methylene-THFSelR109, 121Tryptophan117, 1505-methyl-THFSOD3PRDX1RFK93H2OGPX 3NiacinamideCTH106PNPO135Heme15, 36, 40, 211, 212NADPHLipoic acid235ManganeseFAD78Methionine sulfoxide109Dehydroascorbic acid17, 195Leukotriene A4144, 186NADPHFAD78THFHydroxykynurenine150Folic acid91NADP+NADPHSeleniumSelenium118118SelKSep1514718, 225, 240GPX 6GSH198Nicotinamidase117Calcium186Methionine109ManganeseNADPHFolic acid91FMN78SelenophosphateSelenocysteineSelenide105, 263105, 263105, 263CysteineLeukotriene C4Leukotriene C4186, 188GPX 326Dehydroascorbic acid195GPX 2SelP209Trx-S210, 195, 235Ascorbic acid17Lipoic acid235PRDX4GPX 1NADP+HomocysteineRNSROS17, 29, 49, 55, 56, 64...107, 211NADPHVitamin B1289, 116MTHFR91Homocysteine227SelVSPS2SelOSelNSelHDIO1SelMSelTSelIDIO2DIO3SelSSelP105, 11355, 65, 12029, 216, 226105, 11364, 203105, 220203203133, 221105, 113, 26661, 203, 25690, 111, 201, 209203SOD1Pyridoxal 5'-phosphate150SerineIron186HypoxanthinePRDX3GSR103LDLFMNLDLRSAA1SAA4APOBVLDLLDLHDL/APOA1SRB1VLDL-TAGVLDL/APOBSAA3HDL-CCholesterolAPOA1-NO2TyrTAGoxLDLAPOA1CholesterolHDLTAGHDL/SAAHDLSAA2ACTHDL-CAPOA1ACTABCA1APOBVLDL-TAGVLDLoxLDL9, 66, 200, 22310183, 18183101838378101, 253101101, 25322283, 18148, 85, 234481019, 66, 102, 200, 223838383, 22283, 1818348, 85, 23410183, 181, 2229, 66, 200, 2239, 66, 102, 200, 22310183838383, 1818101O2159Pyridoxal 5'-phosphate1508-OHdG8-OHdGFAD13013078PRDX2ADPLeukotriene D4Leukotriene D4188ChlorineChlorineCopperCystathionineFAD78SOD2Dihydrolipoate204, 235SerineNADP+ATPZincNADP+GSSGNADPHZincNiacinLeukotriene B4Leukotriene B4144144, 186Quinolinic Acid117, 150PMPHNO2O3NOHOClNONO267, 8867, 88NADP+GSH133, 144, 198D-dimersICAM-1CCL2HbA1cINSRIFNgINSHBA1D-dimerHbA1cIL10ALBIL1BsICAM-1FibrinogenIL6TNFaINSIL6TNFaIL10ALBFibrinCRPIL1BHBBFibrinogenFLAPIFNgCCL2Fibrin20110468, 90, 26656, 68, 120, 1491245, 42, 102, 20056, 20115174, 15512025, 72, 129, 208, 25312442, 68, 14272, 20874, 1555, 33, 26610420110425, 72, 129, 20842, 68, 14258, 7458, 7410412026656, 2012663390, 120, 14933SelW137, 198, 257Riboflavin143SOD3224TRXR110Ascorbate17, 195O2-“XanthineCalcium186Kynureninase150Methionine109ADPTrx-(SH)210, 235NitrotyrosineONOO-/ONOOHNitrotyrosine107107ATPLeukotriene E4Leukotriene E4188GlucoseFructosamineFructosamineLeukotriene F4124168, 18812425, 104Iron186HypoxanthineTRXR3FLAD193, 110Ascorbic acid17, 92, 236