Selenium Micronutrient Network (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Folate metabolismMetabolic stressCofactor conversionNecessary stimulationMicronutrientsOxidative stressSelenoproteinsTranscription factorLeukotriene metabolismOther proteinsReactionOverarching processFrom intracellular part to the plasmaLipoprotein melabolismProstaglandins metabolismProtein tyrosine nitrationProcess or metabolism involved in Se PathwayInhibitionEnzymesStatusCleavageCofactorsGlycogenesisInflammation and immune responseBindingCatalysisNegative EffectConversionMetabolitesStimulationCa++ metabolismLipid peroxidationLEGENDTryptophan metabolismBiomarker forSelenium statusis composed ofIntracellularNAD+ metabolismER protein foldingGlutathione metabolismDNA oxidationPlasmaLipoxin A4PGD2Arachidonic acidPGE1Thromboxane B2Lipoxin B4Thromboxane A2Linoleic acida-TocopherolArachidonic acidLipoxin A4F2-IsoprostaneDHA8-Isoprostaglandin F2aPGI2PGE2Thromboxane B2MDAPGE2a-TocopherolPGI2PGF2aDHACOX2COX1ALAPGF2aEPAPGD2Linoleic acidPGE1DGLAF2-IsoprostaneDPALipoxin B4PGH3PGG28-Isoprostaglandin F2aDPAEPAALAMDAPGH2PGE3RELANFkB1NFkB2KynurenineMTRTRXR1TRXR2TRXR3CBSIodineIodineKMOR-Triiodothyronine (rT3)Triiodothyronine (T3)15-HETEThyroxine (T4)5-HPETE5,6-EpoxytetraeneR-Triiodothyronine (rT3)15-HETETriiodothyronine (T3)5-HETEThyroxine (T4)5-HETENADP+MPOCatalaseMPOUric acidCysteineFactor VIIThrombintPAtPAPAI-1PLGThrombinFactor VIIPLGPAI-1GGT1GPX 4GPX 3GPX 6GPX 2GPX 1Xantine oxidasePRDX5PRDX1PRDX4PRDX3PRDX2H2O2ALOX5ALOX15BCopperUric acidVitamin B125,10-Methylene-THFSelRTryptophan5-methyl-THFSOD3SOD1SOD2RFKH2ONiacinamideCTHPNPOHemeNADPHLipoic acidManganeseFADMethionine sulfoxideDehydroascorbic acidLeukotriene A4NADPHFADTHFHydroxykynurenineFolic acidNADP+NADPHSeleniumSeleniumSelKSep15GSHNicotinamidaseCalciumMethionineManganeseNADPHFolic acidFMNSelenocysteineSelenideSelenophosphateCysteineLeukotriene C4Leukotriene C4GPX 3Dehydroascorbic acidSelPTrx-S2Ascorbic acidLipoic acidNADP+HomocysteineROSRNSNADPHVitamin B12MTHFRHomocysteineSelHSPS2SelOSelNDIO2SelTSelMSelPDIO3DIO1SelVSelISelSPyridoxal 5'-phosphateSerineIronHypoxanthineGSRAPOA1APOBLDLRVLDLLDLSAA4SRB1ABCA1CholesterolAPOA1-NO2TyrACTHDLVLDL-TAGFMNSAA2HDL-CTAGACTAPOA1HDLHDL-CSAA1SAA3APOBVLDLoxLDLHDL/APOA1HDL/SAACholesteroloxLDLTAGLDLVLDL-TAGVLDL/APOBO2Pyridoxal 5'-phosphate8-OHdG8-OHdGFADADP