Selenium Micronutrient Network (Homo sapiens)

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18765, 75, 83, 88, 111...16518, 20, 24, 25020130, 267595364, 160, 187, 215187969, 88126, 210207, 21319, 152, 268212167126100, 160, 161, 19317762ReactionBiomarker forBindingNecessary stimulationTryptophan metabolismInflammation and immune responseStimulationCofactorsInhibitionProcess or metabolism involved in Se PathwayMetabolic stressLeukotriene metabolismOxidative stressNegative EffectCleavageMicronutrientsFrom intracellular part to the plasmaOverarching processStatusLipid peroxidationEnzymesLEGENDSelenoproteinsConversionProstaglandins metabolismProtein tyrosine nitrationLipoprotein melabolismGlycogenesisCa++ metabolismCatalysisSelenium statusTranscription factorMetabolitesOther proteinsis composed ofCofactor conversionIntracellularER protein foldingNAD+ metabolismGlutathione metabolismFolate metabolismDNA oxidationPlasmaCOX1FGADPAPGH3Lipoxin A4Thromboxane B2Linoleic acidPGF2aLipoxin A4PGE2PGE1MDAa-TocopherolPGI2DGLADPAPGE1NFkB1ALAF2-IsoprostaneRELAa-TocopherolPGE3PGD2EPALipoxin B4Thromboxane B2PGD2Lipoxin B4F2-IsoprostaneNFkB28-Isoprostaglandin F2aALAEPACOX2Arachidonic acidDHAMDAThromboxane A2PGF2aPGI28-Isoprostaglandin F2aPGH2Arachidonic acidLinoleic acidPGE2DHAPGG238, 226147, 26031, 96, 102, 117, 150...226146, 202, 22622611220214789, 112, 147, 228140105, 226140736922614031, 45, 89, 112, 140...6998, 17518022883, 98, 112, 140, 175147134, 2261041042268318073, 1041401477331, 102, 117, 150, 22718098, 17545, 21118022673, 10420245, 21145, 211Kynurenine210MTR53, 243TRXR1CBS133, 243IodineIodine9999KMO2105-HPETE5,6-Epoxytetraene5-HETE15-HETEThyroxine (T4)Triiodothyronine (T3)R-Triiodothyronine (rT3)R-Triiodothyronine (rT3)Triiodothyronine (T3)15-HETE5-HETEThyroxine (T4)7, 801807, 80837, 807, 9975, 83, 2147, 9975, 83, 21475, 83, 21483, 1807, 99NADP+MPOMPOCatalase64, 76, 93, 2196433, 187Uric acid130, 249CysteinetPAGGT1Factor VIIThrombinPLGPLGThrombinPAI-1PAI-1Factor VIItPA12112112112147, 4812112147, 19247, 4847, 192263GPX 4TRXR2Xantine oxidase145, 249PRDX5H2O2ALOX15BALOX565, 86, 144, 180, 22783, 196CopperUric acid130, 249Vitamin B1240, 1185,10-Methylene-THFSelR51, 215Tryptophan126, 2105-methyl-THFSOD3PRDX1RFK222H2OGPX 3NiacinamideCTH243PNPO66Heme33, 133, 146, 187, 212NADPHLipoic acid18ManganeseFAD185Methionine sulfoxide215Dehydroascorbic acid153, 250Leukotriene A455, 158NADPHFAD185THFHydroxykynurenine210Folic acid53NADP+NADPHSeleniumSelenium265265SelKSep1591, 160, 1932GPX 6GSH41Nicotinamidase126Calcium55Methionine215ManganeseNADPHFolic acid53FMN185SelenocysteineSelenideSelenophosphate7, 247, 247, 24CysteineLeukotriene C4Leukotriene C455, 263GPX 3111Dehydroascorbic acid250GPX 2SelP233Trx-S218, 20, 250Ascorbic acid153Lipoic acid18PRDX4GPX 1NADP+HomocysteineRNSROS2, 12, 25, 36, 100...9, 187NADPHVitamin B1240, 118MTHFR53Homocysteine48SelPSelVSPS2DIO2SelOSelHSelISelSSelTSelMDIO3DIO1SelN100, 123, 23019, 152, 2187, 997, 2577, 99, 1907, 9921836, 17721812, 161, 235218, 268106, 166, 233, 251218SOD1Pyridoxal 5'-phosphate210SerineIron55HypoxanthinePRDX3GSR35APOBVLDL-TAGLDLRHDL-CHDLCholesterolABCA1LDLAPOA1SRB1VLDL/APOBLDLVLDL-TAGVLDLSAA1HDLACTFMNHDL/APOA1HDL/SAASAA2oxLDLVLDLTAGSAA4CholesteroloxLDLSAA3APOA1-NO2TyrACTTAGHDL-CAPOBAPOA156, 15515521394, 21360, 115, 16415523776, 88, 122, 20715521321394, 21318521376, 88, 96, 122, 207213213213213, 23721315594, 21315521319776, 88, 122, 20711515556, 15594, 213, 23794, 21360, 115, 16415576, 88, 96, 122, 207O269Pyridoxal 5'-phosphate2108-OHdG8-OHdGFAD6218562PRDX2ADPLeukotriene D4Leukotriene D4263ChlorineCopperChlorineCystathionineFAD185SOD2Dihydrolipoate18, 157SerineNADP+ATPZincNADP+GSSGNADPHZincNiacinLeukotriene B4Leukotriene B455, 158158Quinolinic Acid126, 210PMPNO2HOClNOO3HNO2NO93, 21993, 219NADP+GSH41, 158, 177INSHbA1cFibrinALBINSHBBIL10IL6TNFaINSRIFNgCRPIL10FibrinCCL2D-dimerHbA1csICAM-1IL1BFLAPIFNgFibrinogenIL6HBA1TNFaALBIL1BD-dimersICAM-1CCL2Fibrinogen2597923559, 190, 2017963, 190, 2517979151, 235, 2518614, 49, 56, 167, 23937, 1215910623510663, 240, 255121, 192106, 17163, 240, 25563, 151, 171, 23514, 49, 167, 239121, 19219019025988, 96, 201, 255106, 17114, 4937, 121SelW25, 41, 43Riboflavin208SOD3267TRXR120Ascorbate153, 250O2-“XanthineCalcium55Kynureninase210Methionine215ADPTrx-(SH)218, 20NitrotyrosineONOO-/ONOOHNitrotyrosine99ATPLeukotriene E4Leukotriene E4263Leukotriene F4FructosamineGlucoseFructosamine25979, 167194, 263259Iron55HypoxanthineTRXR3FLAD1131, 222Ascorbic acid102, 117, 153FGBFGG