Oxidative Damage (Mus musculus)

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Adaptive response in liverC5aCell lysis and clearanceC3aMitochondrial pathwayMuscle contraction,Chemotaxis,Phagocyte recruitment,Inflammation etcInduction of antioxidant genesInhibitor of Cell DeathGSHFormation of apoptotic bodiesC3bStressC4a(classical pathway)Activator of Cell DeathROSC4b/2aLiver regenerationProteasomeCell survivalNf-kB pathwayComplement activationC3-convertaseROSMembrane lysis complexC3b/4b, C3b, C3dC5r1Bak1C1qgCdkn1aMapk12TnfMapk14C4Bag4C1qbMap3k1Casp3C1sTraf6Mapk13Cr2ApoptosisBcl2TtrapC1qaCdc42Cdkn1bNfkb1Gadd45aDNA ReplicationBadC2CyctMap2k6Map3k9Apaf1Traf1Traf2C1rTnk2Oxidative stressTraf3Tnfrsf1bHcCdkn1cCycsPcnaCasp9C3ar1


Description

This pathway shows how tissue is damaged when oxygen levels are not balanced and become too high.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
90720view20:45, 13 December 2016KhanspersModified description
90169view14:17, 20 October 2016Mkutmonfix unconnected lines
79337view12:13, 21 March 2015EgonwReplaced a batch of gene names with their Entrez gene IDs.
78428view10:26, 7 January 2015MaintBotadded missing graphIds
75225view18:12, 12 May 2014Khanspersadded pathway nodes
75223view17:54, 12 May 2014Khanspersfixed label and most xrefs
69181view18:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
67560view11:26, 26 June 2013DdiglesOntology Term : 'oxidative stress response pathways' added !
43789view21:45, 27 July 2011Samuel SklarModified description
43788view21:41, 27 July 2011Samuel SklarSpecify description
41370view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
36318view17:55, 19 March 2010MaintBotModified categories
36313view22:19, 18 March 2010MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Apaf1GeneProduct11783 (Entrez Gene)
ApoptosisPathwayWP1254 (WikiPathways)
BadGeneProduct12015 (Entrez Gene)
Bag4GeneProduct67384 (Entrez Gene)
Bak1GeneProduct12018 (Entrez Gene)
Bcl2GeneProduct12043 (Entrez Gene)
C1qaGeneProduct12259 (Entrez Gene)
C1qbGeneProduct12260 (Entrez Gene)
C1qgGeneProduct12262 (Entrez Gene)
C1rGeneProduct50909 (Entrez Gene)
C1sGeneProduct50908 (Entrez Gene)
C2GeneProduct12263 (Entrez Gene)
C3ar1GeneProduct12267 (Entrez Gene)
C4GeneProduct12268 (Entrez Gene)
C5r1GeneProduct12273 (Entrez Gene)
Casp3GeneProduct12367 (Entrez Gene)
Casp9GeneProduct12371 (Entrez Gene)
Cdc42GeneProduct12540 (Entrez Gene)
Cdkn1aGeneProduct12575 (Entrez Gene)
Cdkn1bGeneProduct12576 (Entrez Gene)
Cdkn1cGeneProduct12577 (Entrez Gene)
Cr2GeneProduct12902 (Entrez Gene)
CycsGeneProduct13063 (Entrez Gene) Rel,Nup93,Nrf1,Them2,Syap1,Zfp259,2700059L22Rik,,Cotl1
CyctGeneProduct13067 (Entrez Gene)
DNA ReplicationPathwayWP150 (WikiPathways)
Gadd45aGeneProduct13197 (Entrez Gene)
HcGeneProduct15139 (Entrez Gene)
Map2k6GeneProduct26398 (Entrez Gene) Xbp1,Mapk10,Klhl8,Mapk10
Map3k1GeneProduct26401 (Entrez Gene)
Map3k9GeneProduct338372 (Entrez Gene)
Mapk12GeneProduct18037 (Entrez Gene)
Mapk13GeneProduct26415 (Entrez Gene)
Mapk14GeneProduct26414 (Entrez Gene) Map2k4,Nlk,Fos,Fzd7,Jund1,ORF19,Map2k4,Dhodh,Map3k7,Dvl3,Eda,Rac1,Jup,Mllt4,Mink1,Myef2,Dusp10,Rala,Etv6,Frk,Wee1,Rexo1
Nfkb1GeneProduct18033 (Entrez Gene)
Oxidative stressPathwayWP412 (WikiPathways)
PcnaGeneProduct18538 (Entrez Gene)
TnfGeneProduct21926 (Entrez Gene)
Tnfrsf1bGeneProduct21938 (Entrez Gene)
Tnk2GeneProduct51789 (Entrez Gene)
Traf1GeneProduct22029 (Entrez Gene)
Traf2GeneProduct22030 (Entrez Gene)
Traf3GeneProduct22031 (Entrez Gene)
Traf6GeneProduct22034 (Entrez Gene)
TtrapGeneProduct56196 (Entrez Gene)

Annotated Interactions

No annotated interactions

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