Glycine Metabolism (Homo sapiens)

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SerineGlucogenic AANH3FADH2OPyruvateH2O2a-KetoglutarateGlutamateSpontaneousO2FADH2Glycine TransaminaseSHMT1Glutathionea-IminoacetateGlyoxalatePurinesGlycine OxidaseBile SaltsGlycineHemeSHMT2MTHFRMTHFCreatineOxalate


Glycine is degraded via three pathways. The predominant pathway in animals and plants is the reverse of the glycine synthase pathway. In this context, the enzyme system involved is usually called the glycine cleavage system.

In the second pathway, glycine is degraded in two steps. The first step is the reverse of glycine biosynthesis from serine with serine hydroxymethyl transferase. Serine is then converted to pyruvate by serine dehydratase. In the third pathway of glycine degradation, glycine is converted to glyoxylate by D-amino acid oxidase. Glyoxylate is then oxidized by hepatic lactate dehydrogenase to oxalate in an NAD+-dependent reaction.

Description source: Wikipedia

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108231view14:14, 30 November 2019EgonwBetter ChEBI identifier.
106693view13:04, 17 September 2019MaintBotHMDB identifier normalization
96064view17:56, 15 February 2018KhanspersModified description
94187view14:06, 25 August 2017Mkutmonadded missing identifier
85086view22:54, 12 April 2016EgonwAdded a few metabolite identifiers.
82220view02:46, 16 September 2015AlexanderPicofixed reaction model for biopax conversion
70639view10:07, 20 August 2013EgonwAdded a ChEBI id for 'Purines'.
70637view10:01, 20 August 2013EgonwConverted a IUPAC-named Label into a Chemspider-backed Metabolite DataNode.
63200view20:54, 8 May 2013MaintBotUpdating gpml version
62369view00:37, 28 April 2013AlexanderPicoFixed annotations and biochemistry
45321view20:10, 7 October 2011AlexanderPicoOntology Term : 'glycine metabolic pathway' added !
41169view23:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
38926view21:31, 24 September 2010AlexanderPicoconnected DAO
38924view21:29, 24 September 2010AlexanderPicooverhaul
37213view20:52, 21 May 2010KhanspersModified categories
36309view14:02, 18 March 2010Essam SharafPeriodical save, work in progress
36306view13:52, 18 March 2010Essam SharafPeriodical save, work in progress
36305view13:42, 18 March 2010Essam SharafPeriodical save, work in progress
36304view13:41, 18 March 2010Essam SharafNew pathway

External references


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NameTypeDatabase referenceComment
Bile SaltsMetaboliteCHEBI:36277 (ChEBI)
CreatineMetabolite586 (PubChem-compound)
GlutamateMetabolite4302384 (Chemspider)
GlutathioneMetabolite124886 (PubChem-compound)
Glycine OxidaseGeneProduct1.4.3.19 (Enzyme Nomenclature)
Glycine TransaminaseGeneProduct2.6.1.4 (Enzyme Nomenclature)
GlycineMetaboliteHMDB0000123 (HMDB)
GlyoxalateMetabolite760 (PubChem-compound)
HemeMetaboliteCHEBI:30413 (ChEBI)
MTHFMetabolite97272 (Chemspider)
MTHFRGeneProductENSG00000177000 (Ensembl)
OxalateMetabolite971 (PubChem-compound)
PurinesMetaboliteCHEBI:26401 (ChEBI)
PyruvateMetabolite96901 (Chemspider)
SHMT1GeneProduct6470 (Entrez Gene)
SHMT2GeneProduct6472 (Entrez Gene)
SerineMetabolite597 (Chemspider)
a-IminoacetateMetaboliteCHEBI:53664 (ChEBI)

Annotated Interactions

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