TOR signaling (Caenorhabditis elegans)

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67life span extentionEnergy stressHigh AMP:ATPamino acidsTOR complex 2Amino acid transporterTOR complex 1sgk-1rheb-1let-363akt-2daf-15C10H11.8hif-1rict-1mRNA translationInsulin signalingdaf-16aak-2sinh-1par-4C10H11.8Autophagyrps-6akt-1let-363rsks-1unc-51


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  1. Corradetti MN, Guan KL; ''Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?''; Oncogene, 2006 PubMed Europe PMC
  2. Sancak Y, Sabatini DM; ''Rag proteins regulate amino-acid-induced mTORC1 signalling.''; Biochem Soc Trans, 2009 PubMed Europe PMC
  3. Yang Q, Guan KL; ''Expanding mTOR signaling.''; Cell Res, 2007 PubMed Europe PMC
  4. Wullschleger S, Loewith R, Hall MN; ''TOR signaling in growth and metabolism.''; Cell, 2006 PubMed Europe PMC
  5. Inoki K, Guan KL; ''Complexity of the TOR signaling network.''; Trends Cell Biol, 2006 PubMed Europe PMC
  6. Jia, K., Chen, D., Riddle, D.L.; ''The TOR pathway interacts with the insulin sugnaling pathway to regulate C. elegans larval development, metabolisma and lifespan ''; Development, 2004 PubMed Europe PMC
  7. Chen D, Thomas EL, Kapahi P; ''HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans.''; PLoS Genet, 2009 PubMed Europe PMC


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84466view19:14, 25 February 2016AlexanderPicoQuick edit to datanode annotation or property
68484view20:49, 5 July 2013MaintBotUpdated to 2013 gpml schema
67705view11:52, 26 June 2013DdiglesOntology Term : 'mTOR signaling pathway' added !
58835view23:31, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40637view19:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
39745view03:46, 16 January 2011Webber51daf-16 inhibits DAF-15
39744view03:34, 16 January 2011Webber51Periodical save, work in progress
38696view19:05, 23 September 2010AlexanderPicoadded pathway nodes; altered phenotype and condition labels
37216view21:22, 21 May 2010KhanspersModified categories
36172view14:59, 4 March 2010Pieter GiesbertzSpecify description
36171view14:42, 4 March 2010Pieter GiesbertzSpecify description
36169view12:34, 4 March 2010Pieter GiesbertzSpecify description
36168view12:28, 4 March 2010Pieter GiesbertzSpecify description
36167view12:22, 4 March 2010Pieter GiesbertzSpecify description
36166view12:14, 4 March 2010Pieter GiesbertzPeriodical save, work in progress
36165view11:47, 4 March 2010Pieter GiesbertzSpecify description
36164view11:44, 4 March 2010Pieter GiesbertzSpecify description
36163view11:41, 4 March 2010Pieter GiesbertzSpecify description
36162view10:20, 4 March 2010Pieter GiesbertzNew pathway

External references


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NameTypeDatabase referenceComment
C10H11.8GeneProductC10H11.8 (Ensembl)
C10H11.8GeneProductWBGene00015697 (Ensembl)
Insulin signalingPathway
aak-2GeneProductT01C8.1 (WormBase)
akt-1GeneProductC12D8.10 (WormBase)
akt-2GeneProductF28H6.1 (WormBase)
daf-15GeneProductC10C5.6 (WormBase)
hif-1GeneProductF38A6.3 (WormBase)
let-363GeneProductB0261.2 (WormBase)
mRNA translationPathwayWP110 (WikiPathways)
par-4GeneProductY59A8B.14 (WormBase)
rheb-1GeneProductF54C8.5 (WormBase)
rict-1GeneProductF29C12.3 (WormBase)
rps-6GeneProductY71A12B.1 (WormBase)
rsks-1GeneProductY47D3A.16 (WormBase)
sgk-1GeneProductW10G6.2 (WormBase)
sinh-1GeneProductY57A10A.20 (WormBase)
unc-51GeneProductY60A3A.1 (WormBase)

Annotated Interactions

No annotated interactions

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