Intracellular trafficking of CFTR (Rattus norvegicus)

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recycling endosomlate endosomearly endosomrecycling endosomvesikelVesikelActinvesikelLysosombudding ofTGNPlasmamembran (apical)Endocytic PathwayGTPRecycling Pathwaysabiliesing complex desolvesActinActinCftrCftrCftrCftrTc10Rab11aSYN6Cl -CftrCftrSlc9a3r1EzrinMyosin-VICftrCftrCftrCftrCftrCftrRab5aCftrEzrinRab9Rab11aRab7Myo6EzrinCftrCalCftrCftrCftrSlc9a3r1Slc9a3r1Slc9a3r1CftrCalRab7CftrCftrEzrinCftrCalCftrCftrCftrCftr1, 5, 6423


This pathway describes the mechanism of endo- and exocytosis of CFTR channel, based on the article: "New insights into cystic fibrosis: molecular switches that regulate CFTR" by Guggino et al. 2006.

On the left side (in red) the endocytic mechanism is shown. Respectively in green on the right sight the exocytic mechanism. We integrated the functions of PDZ proteins, SNAREs and Rho GTPases.

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  1. Wennerberg K, Rossman KL, Der CJ; ''The Ras superfamily at a glance.''; J Cell Sci, 2005 PubMed Europe PMC
  2. Charest A, Lane K, McMahon K, Housman DE; ''Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6.''; J Biol Chem, 2001 PubMed Europe PMC
  3. Cheng J, Cebotaru V, Cebotaru L, Guggino WB; ''Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator.''; Mol Biol Cell, 2010 PubMed Europe PMC
  4. Swiatecka-Urban A, Duhaime M, Coutermarsh B, Karlson KH, Collawn J, Milewski M, Cutting GR, Guggino WB, Langford G, Stanton BA; ''PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulator.''; J Biol Chem, 2002 PubMed Europe PMC
  5. Picciano JA, Ameen N, Grant BD, Bradbury NA; ''Rme-1 regulates the recycling of the cystic fibrosis transmembrane conductance regulator.''; Am J Physiol Cell Physiol, 2003 PubMed Europe PMC
  6. Gentzsch M, Chang XB, Cui L, Wu Y, Ozols VV, Choudhury A, Pagano RE, Riordan JR; ''Endocytic trafficking routes of wild type and DeltaF508 cystic fibrosis transmembrane conductance regulator.''; Mol Biol Cell, 2004 PubMed Europe PMC


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97314view13:42, 9 May 2018Fehrhartfixed connections
82986view00:31, 17 November 2015Mkutmonadded title and authors to references
82976view23:45, 16 November 2015Mkutmonfixed outdated identifiers
79336view12:07, 21 March 2015EgonwThe "Myosin-VI" identifier is from Entrez Gene.
79335view12:04, 21 March 2015EgonwModified description
78471view10:27, 7 January 2015MaintBotadded missing graphIds
72090view21:27, 24 October 2013Mkutmonadded datasource for "CAL"
71827view19:31, 18 October 2013MaintBotUpdated UniProt/TrEMBL data source
67768view12:56, 26 June 2013DdiglesOntology Term : 'protein transport pathway' added !
58955view18:26, 21 February 2013MaintBotUpdated Ensembl data source
41706view02:37, 2 March 2011MaintBotRemoved redundant pathway information and comments
36247view01:01, 12 March 2010KhanspersModified categories
36148view14:33, 3 March 2010Tom85Modified description
36147view14:25, 3 March 2010Tom85New pathway

External references


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NameTypeDatabase referenceComment
CalGeneProductENSRNOG00000011774 (Ensembl)
CftrGeneProductENSRNOG00000055103 (Ensembl)
Cl -Metabolite
EzrinGeneProductENSRNOG00000018524 (Ensembl)
Myo6GeneProductENSRNOG00000011852 (Ensembl)
Myosin-VIGeneProductENSRNOG00000011852 (Ensembl)
Rab11aGeneProductENSRNOG00000011302 (Ensembl)
Rab5aProteinENSRNOG00000057056 (Ensembl)
Rab7GeneProductENSRNOG00000012247 (Ensembl)
Rab9ProteinENSRNOG00000030443 (Ensembl)
Slc9a3r1GeneProductENSRNOG00000003232 (Ensembl)
Tc10GeneProductENSRNOG00000015415 (Ensembl)

Annotated Interactions

No annotated interactions

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