Interactions between CFTR and other ion channels (Rattus norvegicus)

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1YAPSlc26 familyNHERF1NHERF1Na+ENaCaCftrYAPENaCbClENaCgNHERF1c-YesNHERF1CftrCALCftrCftrCftrNaHCO3ENaCSlc26 familyYAPClNa+ClCftrCALNHERF1c-YesClNaHCO3ENaC


Description

The CFTR receptor (an ion channel, which transports CL- out of the cell) can form a complex with CFTR assiciated protein (CAL), followed by degradation. If NHERF1 is present it will form a complex with the CFTR receptor (by binding the PDZ1 region), inhibiting degradation. This complex will bind to other proteins / ion channels. One of these ion channels is the Slc26 family, which binds to the PDZ2 region of NHERF1. After forming this complex Cl- and NaHCO3 secretion will be performed. The same thing happens with the ENaC (an ion channel, which transports Na+), which consists of 3 subunits (alfa, beta & gamma). This channels binds YES-accosiated protein (YAP), which in his turn binds the PDZ2 region of NHERF1. Also c-YES will bind to NHERF1, which inhibits the ENaC channel. By forming this complex Cl- secretion will be induced, while Na+ absorption will be reduced.

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Bibliography

  1. Guggino WB, Stanton BA; ''New insights into cystic fibrosis: molecular switches that regulate CFTR.''; Nat Rev Mol Cell Biol, 2006 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
82975view23:28, 16 November 2015Mkutmonfixed outdated identifier
80651view07:08, 29 June 2015Mkutmonremoved space from identifier
79330view11:40, 21 March 2015EgonwFixed the data source of a number of Ensembl IDs which were linked to Entrez Gene.
78468view10:27, 7 January 2015MaintBotadded missing graphIds
71775view20:30, 17 October 2013MaintBotAutomated update of data sources
69348view18:52, 8 July 2013MaintBotUpdated to 2013 gpml schema
67769view12:59, 26 June 2013DdiglesOntology Term : 'chloride ion transport pathway' added !
58923view05:10, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41660view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
36246view01:00, 12 March 2010KhanspersModified categories
36146view14:18, 3 March 2010Thomastitle tweak
36145view14:11, 3 March 2010FlipkeModified description
36144view14:01, 3 March 2010FlipkeNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CALGeneProductENSRNOG0000000408 (Ensembl)
CftrGeneProductENSRNOG00000055103 (Ensembl)
ClMetabolite
ENaCGeneProduct
ENaCaGeneProductENSRNOG00000019368; (Ensembl)
ENaCbGeneProductENSRNOG00000030981 (Ensembl)
ENaCgGeneProductENSRNOG00000017842 (Ensembl)
NHERF1GeneProductENSRNOG00000003232 (Ensembl)
Na+Metabolite
NaHCO3Metabolite
Slc26 familyGeneProduct
YAPGeneProductENSRNOG00000005933 (Ensembl)
c-YesGeneProduct292256 (Entrez Gene)

Annotated Interactions

No annotated interactions

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