Kit Receptor Signaling Pathway (Rattus norvegicus)

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MitochondrionMTProteins in a complex interactionControlERGolgi apparatusPlasma MembraneMethylationEndosomeReaction through unknown mechanisms/moleculesCYActivation(Protein-protein interaction)DMolecule in the pathwayECUbiquitinationAutophosphorlationAccession Number: NetPath 6; cellmap:6ExtracellularAcetylationDesumoylationNUDeacetylationENCY->PMGOInhibitionEnzyme complexGene SymbolTranslocationGlycosylationCytoplasmDephosphorylationPhosphorylationMolecular associationReceptorNucleusp85 complexDeubiquitinationRecruitmentPalmitoylationSumoylationLigandPMProteolytic cleavageDemethylationEndoplasmic reticulumDMap2k1Plcg1Ep300MitfPrkcaRaf1FgrMapk1HckFynSrcTecPlce1BadMpdzShc1Socs4Pik3r2Pik3r1LynCblbCltcCrklStat1Stat5aSos1EporGrb7Stat3MatkJak2Csf2rbSh2b2Ptpn6HrasDok1PtpruPtpn11Grb10Yes1Vav2CblAbl1Vav1KitStat5bKitlgAkt1Stap1Socs1CishRps6ka1Spred1Inpp5dRasa1KitlgPik3cgTnfrsf10bCrkSpred2KitSh3kbp1FesSocs5Grb2Socs6GrapBtkDok1Prkcb


Kit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets among others. Binding of Kit receptor to stem cell factor leads to an intracellular cascade of events that includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include leukemias, gastrointestinal stromal tumors and mastocytomas. Source: NetPath


GenMAPP notes 
NetPath 6; cellmap:6 - Kit Receptor Signaling Pathway. The Kit Receptor signaling pathway was kindly reviewed by Imke Ehlers in Peter Besmer’s lab. This cancer signaling pathway is available at Cancer Cell Map ( and NetPath ( and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (, PandeyLab at Johns Hopkins University ( and Institute of Bioinformatics ( If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks;
This pathway was inferred from Homo sapiens pathway WP304(r21319) with a 100% conversion rate.

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Ontology Terms



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69456view19:07, 8 July 2013MaintBotUpdated to 2013 gpml schema
67426view11:00, 26 June 2013DdiglesOntology Term : 'Stem Cell Factor signaling pathway' added !
41787view02:43, 2 March 2011MaintBotRemoved redundant pathway information and comments
35755view00:04, 13 February 2010AlexanderPico
31396view20:47, 13 August 2009MaintBotFixed text labels
30950view00:43, 30 July 2009MaintBotConverted from Homo sapiens
20991view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Kit-Receptor NetPath 6]] moved to [[Pathway:WP147]]: Moved to stable identifier
8234view13:46, 7 January 2008MaintBot[[Pathway:Rat:Kit-Receptor NetPath 6]] moved to [[Pathway:Rattus norvegicus:Kit-Receptor NetPath 6]]: Renaming species
7737view16:14, 18 December 2007MaintBotfixed category names
7273view12:41, 4 November 2007MaintBotAdded categories to GPML
6571view22:20, 22 May 2007A.Pandeygpml file for [[Rat:Kit-Receptor_NetPath_6]]

External references


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NameTypeDatabase referenceComment
Abl1GeneProduct311860 (Entrez Gene)
Akt1GeneProduct24185 (Entrez Gene)
BadGeneProduct64639 (Entrez Gene)
BtkGeneProduct367901 (Entrez Gene)
CblGeneProduct500985 (Entrez Gene)
CblbGeneProduct171136 (Entrez Gene)
CishGeneProduct83681 (Entrez Gene)
CltcGeneProduct54241 (Entrez Gene)
CrkGeneProduct54245 (Entrez Gene)
CrklGeneProduct287942 (Entrez Gene)
Csf2rbGeneProduct171081 (Entrez Gene)
Dok1GeneProduct312477 (Entrez Gene)
Ep300GeneProduct170915 (Entrez Gene)
EporGeneProduct24336 (Entrez Gene)
FesGeneProduct361597 (Entrez Gene)
FgrGeneProduct79113 (Entrez Gene)
FynGeneProduct25150 (Entrez Gene)
GrapGeneProduct363616 (Entrez Gene)
Grb10GeneProduct498416 (Entrez Gene)
Grb2GeneProduct81504 (Entrez Gene)
Grb7GeneProduct84427 (Entrez Gene)
HckGeneProduct25734 (Entrez Gene)
HrasGeneProduct293621 (Entrez Gene)
Inpp5dGeneProduct54259 (Entrez Gene)
Jak2GeneProduct24514 (Entrez Gene)
KitGeneProduct64030 (Entrez Gene)
KitlgGeneProduct60427 (Entrez Gene)
LynGeneProduct81515 (Entrez Gene)
Map2k1GeneProduct170851 (Entrez Gene)
Mapk1GeneProduct116590 (Entrez Gene)
MatkGeneProduct60450 (Entrez Gene)
MitfGeneProduct25094 (Entrez Gene)
MpdzGeneProduct29365 (Entrez Gene)
Pik3cgGeneProduct298947 (Entrez Gene)
Pik3r1GeneProduct25513 (Entrez Gene)
Pik3r2GeneProduct29741 (Entrez Gene)
Plce1GeneProduct114633 (Entrez Gene)
Plcg1GeneProduct25738 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
PrkcbGeneProduct25023 (Entrez Gene)
Ptpn11GeneProduct25622 (Entrez Gene)
Ptpn6GeneProduct116689 (Entrez Gene)
PtpruGeneProduct116680 (Entrez Gene)
Raf1GeneProduct24703 (Entrez Gene)
Rasa1GeneProduct25676 (Entrez Gene)
Rps6ka1GeneProduct81771 (Entrez Gene)
Sh2b2GeneProduct114203 (Entrez Gene)
Sh3kbp1GeneProduct84357 (Entrez Gene)
Shc1GeneProduct85385 (Entrez Gene)
Socs1GeneProduct252971 (Entrez Gene)
Socs4GeneProduct305828 (Entrez Gene)
Socs5GeneProduct500616 (Entrez Gene)
Socs6GeneProduct307200 (Entrez Gene)
Sos1GeneProduct313845 (Entrez Gene)
Spred1GeneProduct296072 (Entrez Gene)
Spred2GeneProduct305539 (Entrez Gene)
SrcGeneProduct83805 (Entrez Gene)
Stap1GeneProduct305269 (Entrez Gene)
Stat1GeneProduct25124 (Entrez Gene)
Stat3GeneProduct25125 (Entrez Gene)
Stat5aGeneProduct24918 (Entrez Gene)
Stat5bGeneProduct25126 (Entrez Gene)
TecGeneProduct84492 (Entrez Gene)
Tnfrsf10bGeneProduct364420 (Entrez Gene)
Vav1GeneProduct25156 (Entrez Gene)
Vav2GeneProduct296603 (Entrez Gene)
Yes1GeneProduct24884 (Entrez Gene)

Annotated Interactions

No annotated interactions
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