Serotonin transporter activity (Homo sapiens)

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231SLC6A4CitalopramTPH2ITGB3Syntaxin 1AMAOAIL1R1IL1BSerotoninHic-5PP2AnNOSSCAMP2L-Tryptophan


Serotonin is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system (CNS) of animals, including humans. It is popularly thought to be a contributor to feelings of well-being and happiness. This pathway summarizes the role of the antidepressant-sensitive serotonin (5-HT) transporter SERT (encoded by the SLC6A4 gene).

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Ontology Terms



  1. Chanrion B, Mannoury la Cour C, Bertaso F, Lerner-Natoli M, Freissmuth M, Millan MJ, Bockaert J, Marin P; ''Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  2. Carneiro AM, Blakely RD; ''Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  3. Carneiro AM, Cook EH, Murphy DL, Blakely RD; ''Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.''; J Clin Invest, 2008 PubMed Europe PMC Scholia


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117827view15:07, 22 May 2021EweitzModified title
106692view13:00, 17 September 2019MaintBotHMDB identifier normalization
101973view18:27, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
96024view15:30, 15 February 2018MkutmonModified description
89635view06:08, 22 September 2016EgonwConnected lines.
87659view08:55, 25 July 2016LindarieswijkOntology Term : 'serotonin signaling pathway' added !
68965view17:40, 8 July 2013MaintBotUpdated to 2013 gpml schema
46053view21:36, 10 December 2011AllanKuchinskyreclassified IL1R1 to Entrez Gene 3554
46052view21:34, 10 December 2011AllanKuchinskyreclassified IL1R1 to HGNC Accession Number
46051view21:27, 10 December 2011AllanKuchinskyreclassified IL1R1 from Entrez Gene to HGNC
46050view21:22, 10 December 2011AllanKuchinskyreclassified IL1R1 as Entre Gene from HUGO
45033view18:48, 6 October 2011ThomasOntology Term : 'neuron' added !
41133view23:38, 1 March 2011MaintBotRemoved redundant pathway information and comments
39770view07:58, 17 January 2011AlexanderPicomore complete title
38744view22:16, 23 September 2010KhanspersChanged arrows and layout
35869view01:07, 19 February 2010KhanspersModified categories
34706view17:10, 12 January 2010VandyConteSpecify description
34705view17:01, 12 January 2010VandyContePeriodical save, work in progress
34704view16:59, 12 January 2010VandyConteSpecify description
34703view05:22, 12 January 2010VandyConteSerotonin Network
34702view05:20, 12 January 2010VandyContePeriodical save, work in progress
34701view05:10, 12 January 2010VandyContePeriodical save, work in progress
34700view04:50, 12 January 2010VandyContePeriodical save, work in progress
34699view04:40, 12 January 2010VandyConteNew pathway

External references


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NameTypeDatabase referenceComment
CitalopramMetaboliteHMDB0005038 (HMDB)
Hic-5GeneProduct7041 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL1R1GeneProduct3554 (Entrez Gene)
ITGB3GeneProduct3690 (Entrez Gene)
L-TryptophanMetaboliteHMDB0000929 (HMDB)
MAOAGeneProduct4128 (Entrez Gene)
PP2AGeneProduct5516 (Entrez Gene)
SCAMP2GeneProduct10066 (Entrez Gene)
SLC6A4GeneProduct6532 (Entrez Gene)
SerotoninMetaboliteHMDB0000259 (HMDB)
Syntaxin 1AGeneProduct6804 (Entrez Gene)
TPH2GeneProduct121278 (Entrez Gene)
nNOSGeneProduct4842 (Entrez Gene)

Annotated Interactions

No annotated interactions

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