Valine, leucine and isoleucine degradation (Caenorhabditis elegans)

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Krebs CycleValine, leucine and isoleucine biosynthesisRed gradient: fold change > 1.5 Green gradient: fold change < 1.5 Left: daf-2 Middle: daf-2;pept-1 Right: daf-2;pept-1;daf-16F53A2.7Acetyl-CoAech-6tag-173ech-2S-(3-Methylbutanoyl)-dihydrolipoamide-Eivd-1ech-6ech-5Acetoacetic acidacdh-10Branched-chain fatty acidK09H11.1Acetoacetyl-CoAhacd-1ech-32-Methylacetoacetyl-CoAacdh-7acdh-10ZK669.4pcca-13-Hydroxy-3-methylglutaryl-CoAPropionyl-CoAech-7S-Methylmalonyl-CoAacdh-8Methylmalonic acid(S)-3-Hydroxyisobutyric acidacdh-3(S)-3-Hydroxyisobutyryl-CoAS-2-Methylbutanoyl-CoAT08B2.73-Methyl-1-hydroxybutyl-ThPPS-Methylmalonic acid semialdehydeacdh-10Isobutyryl-CoAB0303.3bcat-1T02G5.7R-Methylmalonyl-CoAKetoleucineL-LeucineMethacrylyl-CoAacdh-7Isovaleryl-CoAL-Valineacdh-8S-3-Methyl-2-oxopentanoic acidC05C10.3T08B2.7Y39E4A.3Y39E4A.3ech-2K09H11.12-Methyl-1-hydroxybutyl-ThPPSuccinyl-CoAech-8F32B6.2acdh-7acdh-8L-IsoleucineS-(2-Methylpropionyl)-dihydrolipoamide-EK09H11.1pccb-1ard-13-Methylglutaconyl-CoAech-1Tiglyl-CoAY71G12B.10ech-92-Methyl-3-hydroxybutyryl-CoAB0272.33-Hydroxyisovaleryl-CoAacdh-3ech-53-Methylcrotonyl-CoAkat-1F54C8.1T02G5.4ech-3a-Ketoisovaleric acid2-Methyl-1-hydroxypropyl-ThPPtag-173Y44A6D.5ech-7S-(2-Methylbutanoyl)-dihydrolipoamide-Eech-1


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History

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CompareRevisionActionTimeUserComment
106022view11:54, 16 August 2019MaintBotHMDB identifier normalization
87854view11:53, 25 July 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
85047view10:09, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
84465view19:13, 25 February 2016AlexanderPicoQuick edit to datanode annotation or property
78284view08:33, 22 December 2014EgonwAdded a ChEBI identifier.
78283view08:15, 22 December 2014EgonwAdded missing GraphId's.
78282view17:10, 21 December 2014EgonwConnected dots.
68480view20:45, 5 July 2013MaintBotUpdated to 2013 gpml schema
58834view23:31, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
54697view12:34, 7 December 2012AndraRDF Tidy
48303view04:16, 18 May 2012KhanspersUpdating PubChem xrefs
40633view19:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
36249view12:21, 12 March 2010Pieter GiesbertzSpecify description
34885view00:16, 2 February 2010KhanspersModified categories
34485view11:58, 11 December 2009Pieter GiesbertzPeriodical save, work in progress
34484view11:16, 11 December 2009Pieter GiesbertzNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
(S)-3-Hydroxyisobutyric acidMetaboliteHMDB0000023 (HMDB)
(S)-3-Hydroxyisobutyryl-CoAMetaboliteHMDB0001052 (HMDB)
2-Methyl-1-hydroxybutyl-ThPPMetaboliteHMDB0012310 (HMDB)
2-Methyl-1-hydroxypropyl-ThPPMetaboliteHMDB0006866 (HMDB)
2-Methyl-3-hydroxybutyryl-CoAMetaboliteHMDB0001356 (HMDB)
2-Methylacetoacetyl-CoAMetaboliteHMDB0001157 (HMDB)
3-Hydroxy-3-methylglutaryl-CoAMetaboliteHMDB0001375 (HMDB)
3-Hydroxyisovaleryl-CoAMetaboliteHMDB0006870 (HMDB)
3-Methyl-1-hydroxybutyl-ThPPMetaboliteHMDB0006865 (HMDB)
3-Methylcrotonyl-CoAMetaboliteHMDB0001493 (HMDB)
3-Methylglutaconyl-CoAMetabolite25244136 (PubChem-compound)
Acetoacetic acidMetaboliteCHEBI:15344 (ChEBI)
Acetoacetyl-CoAMetaboliteHMDB0001484 (HMDB)
Acetyl-CoAMetaboliteHMDB0001206 (HMDB)
B0272.3GeneProductWBGene00007129 (Ensembl)
B0303.3GeneProductWBGene00015125 (Ensembl)
Branched-chain fatty acidMetaboliteCHEBI:35819 (ChEBI)
C05C10.3GeneProductWBGene00007330 (Ensembl)
F32B6.2GeneProductF32B6.2 (Ensembl)
F53A2.7GeneProductWBGene00009952 (Ensembl)
F54C8.1GeneProduct186222 (Entrez Gene)
Isobutyryl-CoAMetaboliteHMDB0001243 (HMDB)
Isovaleryl-CoAMetaboliteHMDB0001113 (HMDB)
K09H11.1GeneProduct178962 (Entrez Gene)
KetoleucineMetaboliteHMDB0000695 (HMDB)
L-IsoleucineMetaboliteHMDB0000172 (HMDB)
L-LeucineMetaboliteHMDB0000687 (HMDB)
L-ValineMetaboliteHMDB0000883 (HMDB)
Methacrylyl-CoAMetaboliteHMDB0001011 (HMDB)
Methylmalonic acidMetaboliteHMDB0000202 (HMDB)
Propionyl-CoAMetaboliteHMDB0001275 (HMDB)
R-Methylmalonyl-CoAMetaboliteHMDB0002255 (HMDB)
S-(2-Methylbutanoyl)-dihydrolipoamide-EMetaboliteHMDB0006869 (HMDB)
S-(2-Methylpropionyl)-dihydrolipoamide-EMetaboliteHMDB0006868 (HMDB)
S-(3-Methylbutanoyl)-dihydrolipoamide-EMetaboliteHMDB0006867 (HMDB)
S-2-Methylbutanoyl-CoAMetabolite23724628 (PubChem-compound)
S-3-Methyl-2-oxopentanoic acidMetabolite47 (PubChem-compound)
S-Methylmalonic acid semialdehydeMetaboliteHMDB0002217 (HMDB)
S-Methylmalonyl-CoAMetaboliteHMDB0002310 (HMDB)
Succinyl-CoAMetaboliteHMDB0001022 (HMDB)
T02G5.4GeneProductWBGene00020164 (Ensembl)
T02G5.7GeneProductWBGene00020166 (Ensembl)
T08B2.7GeneProductWBGene00020347 (Ensembl)
Tiglyl-CoAMetaboliteHMDB0002054 (HMDB)
Y39E4A.3GeneProductY39E4A.3 (WormBase) Original kegg element: gene;12;cel:F27D4.5 cel:Y39E4A.3
Y44A6D.5GeneProduct180361 (Entrez Gene)
Y71G12B.10GeneProductWBGene00022150 (Ensembl)
ZK669.4GeneProduct174279 (Entrez Gene)
a-Ketoisovaleric acidMetaboliteHMDB0000019 (HMDB)
acdh-10GeneProductT08G2.3 (WormBase) Original kegg element: gene;58;cel:K05F1.3 cel:K09H11.1 cel:T08G2.3 cel:T25G12.5
acdh-3GeneProductK06A5.6 (WormBase) Original kegg element: gene;41;cel:K06A5.6
acdh-7GeneProductT25G12.5 (WormBase) Original kegg element: gene;58;cel:K05F1.3 cel:K09H11.1 cel:T08G2.3 cel:T25G12.5
acdh-8GeneProductK05F1.3 (WormBase)
ard-1GeneProductF01G4.2 (WormBase)
bcat-1GeneProductK02A4.1 (WormBase) Original kegg element: gene;37;cel:K02A4.1 cel:Y44A6D.5
ech-1GeneProductC29F3.1 (WormBase)
ech-2GeneProductF38H4.8 (WormBase) Original kegg element: gene;57;cel:C29F3.1 cel:F38H4.8 cel:F43H9.1 cel:F56B3.5 cel:T05G5.6 cel:T08B2.7 cel:Y105E8A.4
ech-3GeneProductF43H9.1 (WormBase) Original kegg element: gene;57;cel:C29F3.1 cel:F38H4.8 cel:F43H9.1 cel:F56B3.5 cel:T05G5.6 cel:T08B2.7 cel:Y105E8A.4
ech-5GeneProductF56B3.5 (WormBase) Original kegg element: gene;57;cel:C29F3.1 cel:F38H4.8 cel:F43H9.1 cel:F56B3.5 cel:T05G5.6 cel:T08B2.7 cel:Y105E8A.4
ech-6GeneProductT05G5.6 (WormBase) Original kegg element: gene;57;cel:C29F3.1 cel:F38H4.8 cel:F43H9.1 cel:F56B3.5 cel:T05G5.6 cel:T08B2.7 cel:Y105E8A.4
ech-7GeneProductY105E8A.4 (WormBase) Original kegg element: gene;57;cel:C29F3.1 cel:F38H4.8 cel:F43H9.1 cel:F56B3.5 cel:T05G5.6 cel:T08B2.7 cel:Y105E8A.4
ech-8GeneProductF01G10.2 (WormBase)
ech-9GeneProductF01G10.3 (WormBase)
hacd-1GeneProductR09B5.6 (WormBase)
ivd-1GeneProductC02B10.1 (WormBase) Original kegg element: gene;41;cel:K06A5.6
kat-1GeneProductT02G5.8 (WormBase)
pcca-1GeneProductF27D9.5 (WormBase)
pccb-1GeneProductF52E4.1 (WormBase)
tag-173GeneProductF27D4.5 (WormBase) Original kegg element: gene;43;cel:F27D4.5 cel:Y39E4A.3

Annotated Interactions

No annotated interactions
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