Statin Pathway (Rattus norvegicus)

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1CholesterolCholic AcidIDLCholesterolCell MembraneacetylCoATriglyceridesTissuesPhospholipidVLDLLiver cellCholesterol EsterPlasmaStatinSoat1Dgat1Cyp7a1LplLcatLipcLDLApoa4Apoc2PtlpApoc1ApoeApoc3Abca1Scarb1HmgcrLrp1MttpApoa1HDLFree FALdlrCetp


What are statins? See Wikipedia at: More about this pathway and statins:

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Ontology Terms



  1. Chen H, Ikeda U, Shimpo M, Shimada K; ''Direct effects of statins on cells primarily involved in atherosclerosis.''; Hypertens Res, 2000 PubMed Europe PMC Scholia


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109395view16:09, 16 March 2020L DupuisConverted interactions to graphical lines
79447view07:26, 22 March 2015EgonwConnected dots and added a few metabolite identifiers.
79446view07:06, 22 March 2015EgonwRemoved Entrez Gene xref where the 'Cetp' gene name was used (no orthology...) and used the identifier for 'Ptlp'.
77393view11:47, 5 September 2014EgonwConverted a few labels into metabolite DataNodes with an ChEBI identifier.
69350view18:52, 8 July 2013MaintBotUpdated to 2013 gpml schema
67657view11:45, 26 June 2013DdiglesOntology Term : 'statin drug pathway' added !
41661view02:34, 2 March 2011MaintBotRemoved redundant pathway information and comments
38715view19:31, 23 September 2010AlexanderPico
35544view14:20, 12 February 2010Thomasremoved genmapp remark
35543view14:19, 12 February 2010ThomasModified description
35536view14:16, 12 February 2010Thomasadded literature
20987view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Statin Pathway PharmGKB]] moved to [[Pathway:WP145]]: Moved to stable identifier
11891view18:23, 8 May 2008KhanspersChanged contact info
8406view13:46, 7 January 2008MaintBot[[Pathway:Rat:Statin Pathway PharmGKB]] moved to [[Pathway:Rattus norvegicus:Statin Pathway PharmGKB]]: Renaming species
7820view16:20, 18 December 2007MaintBotfixed category names
7397view12:42, 4 November 2007MaintBotAdded categories to GPML
19545view22:20, 22 May 2007BruceConklingpml file for [[Rat:Statin_Pathway_PharmGKB]]
6596view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:Statin_Pathway_PharmGKB]]

External references


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NameTypeDatabase referenceComment
Abca1GeneProduct313210 (Entrez Gene)
Apoa1GeneProduct25081 (Entrez Gene)
Apoa4GeneProduct25080 (Entrez Gene)
Apoc1GeneProduct25292 (Entrez Gene)
Apoc2GeneProduct25384 (Entrez Gene)
Apoc3GeneProduct24207 (Entrez Gene)
ApoeGeneProduct25728 (Entrez Gene)
Cholesterol EsterMetaboliteCHEBI:17002 (ChEBI)
CholesterolMetaboliteCHEBI:16113 (ChEBI)
Cholic AcidMetaboliteCHEBI:16359 (ChEBI)
Cyp7a1GeneProduct25428 (Entrez Gene)
Dgat1GeneProduct84497 (Entrez Gene)
Free FAMetaboliteCHEBI:35366 (ChEBI)
HDLMetaboliteCHEBI:39025 (ChEBI)
HmgcrGeneProduct25675 (Entrez Gene)
LDLMetaboliteCHEBI:39026 (ChEBI)
LcatGeneProduct24530 (Entrez Gene)
LdlrGeneProduct300438 (Entrez Gene)
LipcGeneProduct24538 (Entrez Gene)
LplGeneProduct24539 (Entrez Gene)
Lrp1GeneProduct299858 (Entrez Gene)
MttpGeneProduct310900 (Entrez Gene)
PhospholipidMetaboliteCHEBI:16247 (ChEBI)
PtlpGeneProduct296371 (Entrez Gene)
Scarb1GeneProduct25073 (Entrez Gene)
Soat1GeneProduct81782 (Entrez Gene)
TriglyceridesMetaboliteCHEBI:17855 (ChEBI)
acetylCoAMetaboliteCHEBI:15351 (ChEBI)

Annotated Interactions

No annotated interactions

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