Regulation of toll-like receptor signaling pathway (Homo sapiens)

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1, 2Imidazoquinolin(anti-viral compounds)cytokine receptorinteraction+Ub+LUBAC-UbUnmethylated+p+pEndosome-Ub+pInflammatory cytokinesMyD88-dependent pathway+pNK cell)+p+DNAIKKInflammatory cytokines+p+p+p+p(Neutrophil, immature DC,Autocrine / Paracrine+p+pT cell stimulationAntiviral effectsCostimulatory moleculescoagulation cascadeseffectsFlagellin+pJak-STAT signaling pathway+pDegradationUbiquitin mediated proteolysis+pCpG DNAChemotacticMyD88-independent pathwayeffects+pLPS(G-)+p-Ubeffects+p(T cell)Complement anddsRNA-pCytokine-ssRNA+UbSpecific pathwayin pDCsDownregulatesProinflammatoryChemotacticMAPK signaling pathwayLY96MAPK12RNF31IRAK1hsa-mir-105-1hsa-let-7i (gene)PELI1NFKB1RNF41CD80JUNIFNA10TLR1TIRAPTLR9STAT1IRAK4TLR5PIK3R1NFKB1TICAM1IFNA8MAPK14TRAF6AKT2CCL5PELI2TOLLIPIL12BPIK3CBTLR2sPIK3CGIFNA16TRAF3PELI3TLR6MAPK10IRAK2PIK3R5MBL2IFNA2CHUKCYLDTBK1AKT3MAP3K7IP3NFKBIAIL12AIFNA7SIGIRRIFNA21TRAF6TNFCD40ApoptosisIFNA17IFNB1CD180CUEDC2CASP8TIRAPSYKSPP1CCL3TLR2CXCL10OTUD5TLR4IRAK3SARM1PLK1IFNA14TLR7IFNA4IKBKEhsa-mir-146aIFNA1IRF7MAP2K4IL1Bhsa-let-7eRBCK1MYD88IRAK1TLR8MAP3K7MAP2K6SOCS1CTNNAL1RNF41TICAM2TRAFD1CISHhsa-mir-155IRF3CHUKUSP7BTKIL6CD86MAPK3IRAK4PIK3CDMAPK13IFNA13CD14TNFAIP3Tifahsa-let-7eTICAM2 (TAG)hsa-mir-98NEU1IFNB1MLST8RNF216IFNAR1MYD88sMYD88MAPK8RIPK1SMAD6LBPMYD88IRF5MAP3K7IP2MAP3K7IP1IL8MAPK1SQSTM1MAP2K1SFTPA1PTPN6FADDIFNB1MAP2K2IFNAR2TRAF6IFNA5PIK3R3MYD88MAP3K8RAC1TLR2PIK3R2Trim30MAP2K7CXCL9SFTPDTLR3IFNA6AKT1MAPK11MAP2K3TREM1TLR4sZMYND11RELACCL4IKBKGNFKB2IKBKBFOSPIK3CACXCL11MAPK9FBXW5Peptidoglycan(G+)Zymosan (Yeast)LipoproteinLipoarabinomannan(Mycobacteria)


Description

Toll-like receptors (TLRs) are critical pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs), which are conserved and specific molecular "signatures" expressed by pathogens. TLR ligation triggers distinct but shared signaling pathways that lead to effector mechanisms in innate immune responses. TLR specificity and activation are strictly and finely tuned at multiple levels of various signal transduction pathways, resulting in complex signaling platforms. Many molecules, ranging from membrane and cytosol to nuclear, contribute to TLR ligand discrimination or receptor signaling and play different roles in the regulation of TLR responses via different mechanisms, such as cross-regulation, protein modification, helper cofactors, and posttranscriptional and epigenetic regulation. [1]

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Ontology Terms

 

Bibliography

  1. Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S; ''Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.''; Nat Immunol, 2002 PubMed
  2. Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H, Lipford G, Bauer S; ''Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.''; Nat Immunol, 2002 PubMed

History

View all...
CompareRevisionActionTimeUserComment
96021view15:24, 15 February 2018DeSlConnected more lines, according to original PW
96017view15:07, 15 February 2018DeSlModified description
96016view15:07, 15 February 2018DeSlModified description
94748view15:17, 5 October 2017DeSlConnected as many lines as possible...
81172view13:07, 31 July 2015EgonwReplaced the ChemSpider ID for a specific compound to a ChEBI identifier for the compound class (following the two papers I just added and the Wikipedia article on imidazoquinolin).
81171view13:06, 31 July 2015EgonwAdded two papers describing the interaction of imisazoquonilines with TLR7/TLR8.
80070view18:32, 4 May 2015Khanspersremoved mouse identifier
79976view12:37, 29 April 2015Zaricorrected Id for hsa-mir-98
79550view11:15, 25 March 2015Zari
79549view11:13, 25 March 2015Zarichanged Id for tifa
77378view10:57, 1 September 2014EgonwUpdated layout, grouped noded, and fixed link to TLR7/TLR8.
77377view10:51, 1 September 2014Egonw"Anti-viral compound" has a ChEBI ID too.
77376view10:49, 1 September 2014EgonwConverted a label into a metabolite DataNode with a Chemspider identifier.
72114view23:00, 24 October 2013AlexanderPicoupdate mmu-let-7e to hsa-let-7e
72113view22:58, 24 October 2013AlexanderPicoadded missing database to xref
71388view18:42, 17 October 2013MaintBotAutomated update of data sources
70945view12:38, 17 September 2013Cloris816Periodical save, work in progress
69023view17:49, 8 July 2013MaintBotUpdated to 2013 gpml schema
59207view19:50, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
57636view08:08, 31 January 2013MaintBotReverted to version '19:11, 6 October 2011' by MaintBot
57633view04:05, 31 January 2013MaiyuPeriodical save, work in progress
45049view19:11, 6 October 2011ThomasOntology Term : 'Toll-like receptor signaling pathway' added !
41202view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
38854view18:05, 24 September 2010Khanspers
38853view18:05, 24 September 2010KhanspersChanged line types and added pathway link
36215view16:17, 9 March 2010Khansperschanged title
34714view19:03, 12 January 2010Khansperschanged pathway title
34459view18:26, 10 December 2009MaintBotAutomatic update of empty xrefs
33706view22:18, 4 December 2009MisbahNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(anti-viral compounds)MetaboliteCHEBI:22587 (ChEBI)
AKT1GeneProduct207 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT2GeneProduct208 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
AKT3GeneProduct10000 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
ApoptosisPathwayWP254 (WikiPathways)
BTKGeneProductENSG00000010671 (Ensembl)
CASP8GeneProduct841 (Entrez Gene) Original kegg element: gene;87;hsa:841
CCL3GeneProduct6348 (Entrez Gene) Original kegg element: gene;44;hsa:6348
CCL4GeneProduct6351 (Entrez Gene) Original kegg element: gene;38;hsa:6351
CCL5GeneProduct6352 (Entrez Gene) Original kegg element: gene;58;hsa:6352
CD14GeneProduct929 (Entrez Gene) Original kegg element: gene;84;hsa:929
CD180GeneProductENSG00000134061 (Ensembl)
CD40GeneProduct958 (Entrez Gene) Original kegg element: gene;29;hsa:958
CD80GeneProduct941 (Entrez Gene) Original kegg element: gene;69;hsa:941
CD86GeneProduct942 (Entrez Gene) Original kegg element: gene;28;hsa:942
CHUKGeneProduct1147 (Entrez Gene) Original kegg element: gene;42;hsa:1147
CISHGeneProductENSG00000114737 (Ensembl)
CTNNAL1GeneProductENSG00000119326 (Ensembl)
CUEDC2GeneProductENSG00000107874 (Ensembl)
CXCL10GeneProduct3627 (Entrez Gene) Original kegg element: gene;25;hsa:3627
CXCL11GeneProduct6373 (Entrez Gene) Original kegg element: gene;23;hsa:6373
CXCL9GeneProduct4283 (Entrez Gene) Original kegg element: gene;24;hsa:4283
CYLDGeneProductENSG00000083799 (Ensembl)
FADDGeneProduct8772 (Entrez Gene) Original kegg element: gene;56;hsa:8772
FBXW5GeneProductENSG00000159069 (Ensembl)
FOSGeneProduct2353 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
IFNA10GeneProduct3446 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13GeneProduct3447 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA1GeneProduct3439 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA14GeneProduct3448 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA16GeneProduct3449 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA17GeneProduct3451 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21GeneProduct3452 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA2GeneProduct3440 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4GeneProduct3441 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5GeneProduct3442 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6GeneProduct3443 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7GeneProduct3444 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8GeneProduct3445 (Entrez Gene) Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNAR1GeneProduct3454 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNAR2GeneProduct3455 (Entrez Gene) Original kegg element: gene;49;hsa:3454 hsa:3455
IFNB1GeneProduct3456 (Entrez Gene) Original kegg element: gene;1;hsa:3456
IKBKBGeneProduct3551 (Entrez Gene) Original kegg element: gene;36;hsa:3551
IKBKEGeneProduct9641 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IKBKGGeneProduct8517 (Entrez Gene) Original kegg element: gene;85;hsa:8517
IL12AGeneProduct3592 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL12BGeneProduct3593 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL1BGeneProduct3553 (Entrez Gene) Original kegg element: gene;51;hsa:3553
IL6GeneProduct3569 (Entrez Gene) Original kegg element: gene;57;hsa:3569
IL8GeneProduct3576 (Entrez Gene) Original kegg element: gene;43;hsa:3576
IRAK1GeneProduct3654 (Entrez Gene) Original kegg element: gene;41;hsa:3654
IRAK2GeneProductENSG00000134070 (Ensembl)
IRAK3GeneProductENSG00000090376 (Ensembl)
IRAK4GeneProduct51135 (Entrez Gene) Original kegg element: gene;86;hsa:51135
IRF3GeneProduct3661 (Entrez Gene) Original kegg element: gene;67;hsa:3661
IRF5GeneProduct3663 (Entrez Gene) Original kegg element: gene;21;hsa:3663
IRF7GeneProduct3665 (Entrez Gene) Original kegg element: gene;20;hsa:3665
ImidazoquinolinMetaboliteCHEBI:38776 (ChEBI)
JUNGeneProduct3725 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
LBPGeneProduct3929 (Entrez Gene) Original kegg element: gene;77;hsa:3929
LY96GeneProduct23643 (Entrez Gene) Original kegg element: gene;71;hsa:23643
MAP2K1GeneProduct5604 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K2GeneProduct5605 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
MAP2K3GeneProduct5606 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K4GeneProduct6416 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP2K6GeneProduct5608 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
MAP2K7GeneProduct5609 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
MAP3K7GeneProduct6885 (Entrez Gene) Original kegg element: gene;37;hsa:6885
MAP3K7IP1GeneProduct10454 (Entrez Gene) Original kegg element: gene;59;hsa:10454
MAP3K7IP2GeneProductENSG00000055208 (Ensembl) Original kegg element: gene;59;hsa:10454
MAP3K7IP3GeneProductENSG00000157625 (Ensembl) Original kegg element: gene;61;hsa:23118
MAP3K8GeneProduct1326 (Entrez Gene) Original kegg element: gene;13;hsa:1326
MAPK10GeneProduct5602 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK11GeneProduct5600 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK12GeneProduct6300 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK13GeneProduct5603 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK14GeneProduct1432 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
MAPK1GeneProduct5594 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK3GeneProduct5595 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
MAPK8GeneProduct5599 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK9GeneProduct5601 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MBL2GeneProductENSG00000165471 (Ensembl)
MLST8GeneProduct64223 (Entrez Gene)
MYD88GeneProduct4615 (Entrez Gene) Original kegg element: gene;47;hsa:4615
MYD88sGeneProductENSG00000172936 (Ensembl)
NEU1GeneProductENSG00000184494 (Ensembl)
NFKB1GeneProduct4790 (Entrez Gene) Original kegg element: gene;14;hsa:4790
NFKB2GeneProduct4791 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NFKBIAGeneProduct4792 (Entrez Gene) Original kegg element: gene;64;hsa:4792
OTUD5GeneProductENSG00000068308 (Ensembl)
PELI1GeneProductENSG00000197329 (Ensembl)
PELI2GeneProductENSG00000139946 (Ensembl)
PELI3GeneProductENSG00000174516 (Ensembl)
PIK3CAGeneProduct5290 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CBGeneProduct5291 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CDGeneProduct5293 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3CGGeneProduct5294 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R1GeneProduct5295 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R2GeneProduct5296 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R3GeneProduct8503 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PIK3R5GeneProduct23533 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
PLK1GeneProductENSG00000166851 (Ensembl)
PTPN6GeneProductENSG00000111679 (Ensembl)
RAC1GeneProduct5879 (Entrez Gene) Original kegg element: gene;48;hsa:5879
RBCK1GeneProductENSG00000125826 (Ensembl)
RELAGeneProduct5970 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
RIPK1GeneProduct8737 (Entrez Gene) Original kegg element: gene;17;hsa:8737
RNF216GeneProductENSG00000011275 (Ensembl)
RNF31GeneProductENSG00000092098 (Ensembl)
RNF41GeneProductENSG00000181852 (Ensembl)
SARM1GeneProductENSG00000004139 (Ensembl)
SFTPA1GeneProductENSG00000185303 (Ensembl)
SFTPDGeneProductENSG00000133661 (Ensembl)
SIGIRRGeneProductENSG00000185187 (Ensembl)
SMAD6GeneProductENSG00000137834 (Ensembl)
SOCS1GeneProductENSG00000185338 (Ensembl)
SPP1GeneProduct6696 (Entrez Gene) Original kegg element: gene;15;hsa:6696
SQSTM1GeneProductENSG00000161011 (Ensembl)
STAT1GeneProduct6772 (Entrez Gene) Original kegg element: gene;62;hsa:6772
SYKGeneProductENSG00000165025 (Ensembl)
TBK1GeneProduct29110 (Entrez Gene) Original kegg element: gene;52;hsa:29110
TICAM1GeneProduct148022 (Entrez Gene) Original kegg element: gene;82;hsa:148022
TICAM2 (TAG)GeneProductENSG00000134970 (Ensembl)
TICAM2GeneProduct353376 (Entrez Gene) Original kegg element: gene;80;hsa:353376
TIRAPGeneProduct114609 (Entrez Gene) Original kegg element: gene;46;hsa:114609
TLR1GeneProduct7096 (Entrez Gene) Original kegg element: gene;75;hsa:7096
TLR2GeneProduct7097 (Entrez Gene) Original kegg element: gene;74;hsa:7097
TLR2sGeneProductENSG00000137462 (Ensembl)
TLR3GeneProduct7098 (Entrez Gene) Original kegg element: gene;73;hsa:7098
TLR4GeneProduct7099 (Entrez Gene) Original kegg element: gene;79;hsa:7099
TLR4sGeneProductENSG00000136869 (Ensembl)
TLR5GeneProduct7100 (Entrez Gene) Original kegg element: gene;72;hsa:7100
TLR6GeneProduct10333 (Entrez Gene) Original kegg element: gene;76;hsa:10333
TLR7GeneProduct51284 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR8GeneProduct51311 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
TLR9GeneProduct54106 (Entrez Gene) Original kegg element: gene;78;hsa:54106
TNFGeneProduct7124 (Entrez Gene) Original kegg element: gene;66;hsa:7124
TNFAIP3GeneProductENSG00000118503 (Ensembl)
TOLLIPGeneProduct54472 (Entrez Gene) Original kegg element: gene;81;hsa:54472
TRAF3GeneProduct7187 (Entrez Gene) Original kegg element: gene;16;hsa:7187
TRAF6GeneProduct7189 (Entrez Gene) Original kegg element: gene;9;hsa:7189
TRAFD1GeneProductENSG00000135148 (Ensembl)
TREM1GeneProductENSG00000124731 (Ensembl)
TifaGeneProductENSG00000145365 (Ensembl)
Trim30GeneProduct
USP7GeneProductENSG00000187555 (Ensembl)
ZMYND11GeneProductENSG00000015171 (Ensembl)
hsa-let-7eGeneProduct
hsa-let-7eGeneProductENSG00000198972 (Ensembl)
hsa-let-7i (gene)GeneProductENSG00000199179 (Ensembl)
hsa-mir-105-1GeneProductENSG00000207957 (Ensembl)
hsa-mir-146aGeneProductENSG00000207936 (Ensembl)
hsa-mir-155GeneProductENSG00000207795 (Ensembl)
hsa-mir-98GeneProduct407054 (Entrez Gene)

Annotated Interactions

No annotated interactions

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