Osteopontin signaling (Homo sapiens)

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Study of regulation of promatrix metalloproteinase-9 (MMP-9) by osteopontin (OPN) through IKK signaling pathway.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms



  1. Das R, Philip S, Mahabeleshwar GH, Bulbule A, Kundu GC; ''Osteopontin: it's role in regulation of cell motility and nuclear factor kappa B-mediated urokinase type plasminogen activator expression.''; IUBMB Life, 2005 PubMed Europe PMC Scholia


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117813view14:46, 22 May 2021EweitzModified title
106571view21:16, 6 September 2019KhanspersModified description
105768view19:38, 15 August 2019KhanspersModified description
94913view00:09, 13 October 2017Khanspersconverted interaction to line
94742view15:09, 5 October 2017EgonwConverted to decorative interactions to graphical lines.
78545view10:30, 7 January 2015MaintBotadded missing graphIds
72145view10:09, 25 October 2013Mkutmonadded datasource for ITGB3 and ITGAV
68956view17:38, 8 July 2013MaintBotUpdated to 2013 gpml schema
67558view11:25, 26 June 2013DdiglesOntology Term : 'signaling pathway pertinent to development' added !
45316view20:08, 7 October 2011KhanspersOntology Term : 'signaling pathway' added !
41120view23:37, 1 March 2011MaintBotRemoved redundant pathway information and comments
39762view07:35, 17 January 2011AlexanderPicomore specific title
38779view00:09, 24 September 2010KhanspersAdded complex
38778view00:08, 24 September 2010KhanspersChanged graphics
35194view15:26, 11 February 2010Thomasadded literature and made cosmetic changes
33714view19:56, 7 December 2009MaintBotModified categories
33375view14:36, 30 November 2009MaintBotRemoved group label
33270view07:17, 14 November 2009UomoamareDef
33269view07:06, 14 November 2009UomoamareModified description
33268view02:18, 14 November 2009UomoamareOPN
33267view01:47, 14 November 2009UomoamarePeriodical save, work in progress
33226view13:18, 8 November 2009UomoamareSpecify description
33225view12:17, 8 November 2009UomoamareOPN (pathway in progress)
33224view11:50, 8 November 2009UomoamareNew pathway

External references


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NameTypeDatabase referenceComment
ERK1GeneProduct5595 (Entrez Gene)
ERK2GeneProduct5594 (Entrez Gene)
IKK-alphaGeneProduct1147 (Entrez Gene)
IKK-betaGeneProduct3551 (Entrez Gene)
ITGAVGeneProduct3685 (Entrez Gene)
ITGB3GeneProduct3690 (Entrez Gene)
MEK1GeneProduct5604 (Entrez Gene)
MMP-9GeneProduct4318 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NIKGeneProduct9020 (Entrez Gene)
PLAUGeneProduct5328 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
SPP1GeneProduct6696 (Entrez Gene)

Annotated Interactions

No annotated interactions

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