Nucleotide-binding Oligomerization Domain (NOD) pathway (Homo sapiens)

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1Muramyl Dipeptidee.g. Bacillus anthracis transcriptional reg./cleavageRestriction of L. pneumophila infectionInhibitorStimulantdownregulatesInflammasomeMuramyl Dipeptide &ATP induce Oligomerization cleavesdirect bindingNigericin, Maitotoxin, Aerolysin(pore forming toxins)Asbestos, Silica Gram +ve L. monocytogenesS. aureus, M. marinum, ATPCleavescleavesMeso-DAP UpregulatescleavesActivated by Flagellin from L. pneumophila,S. typhimurium, Shigella flexneri, or P. aeruginosaCARD9CASP1CHUKNLRP4PYCARDCASP5NAIPIKBKGNLRP10NLRC4CARD6NLRP1DUOX2MEFVRIPK2NOD1COPS6PRDM1AAMPCASP8RELAERBB2IPIKBKBNOD2NLRP7IL1BCASP9XIAPNLRP3CASP7SUGT1NFKBIANLRP2CARD8RAC1Nf-kappa B signalingCENTB1NLRP12NDUFA13IL18AIM2HSP90AA2


Description

The NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importance of these molecules is underscored by the fact that mutations in the gene that encodes NOD2 occur in a subpopulation of patients with Crohn's disease, and NOD1 has also been shown to participate in host defence against infection with Helicobacter pylori.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms

 

Bibliography

  1. Strober W, Murray PJ, Kitani A, Watanabe T; ''Signalling pathways and molecular interactions of NOD1 and NOD2.''; Nat Rev Immunol, 2006 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106666view21:27, 12 September 2019KhanspersModified description
105761view19:33, 15 August 2019KhanspersModified description
86035view12:30, 28 June 2016EveloModified title
86034view12:30, 28 June 2016EveloModified title
83527view16:44, 20 November 2015JmeliusCorrect outdated id
80018view17:37, 30 April 2015Zaricorrected ID for NDUFA13, NAIP
68991view17:43, 8 July 2013MaintBotUpdated to 2013 gpml schema
59191view19:07, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45352view20:29, 7 October 2011KhanspersModified description
45351view20:27, 7 October 2011KhanspersOntology Term : 'NOD-like receptor signaling pathway' added !
41168view23:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
38800view07:16, 24 September 2010Thomaslinked to NF-kB signaling
35545view14:20, 12 February 2010MichielModified description
35541view14:18, 12 February 2010MichielModified description
35538view14:17, 12 February 2010MichielAdded refs
34887view00:28, 2 February 2010KhanspersModified categories
33214view22:38, 5 November 2009MisbahPeriodical save, work in progress
33213view22:04, 5 November 2009MisbahPeriodical save, work in progress
33212view21:39, 5 November 2009MisbahPeriodical save, work in progress
33211view21:29, 5 November 2009MisbahPeriodical save, work in progress
33210view20:57, 5 November 2009MisbahNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AAMPGeneProductENSG00000127837 (Ensembl)
AIM2GeneProductENSG00000163568 (Ensembl)
CARD6GeneProductENSG00000132357 (Ensembl)
CARD8GeneProductENSG00000105483 (Ensembl)
CARD9GeneProductENSG00000187796 (Ensembl)
CASP1GeneProductENSG00000137752 (Ensembl)
CASP5GeneProductENSG00000137757 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CENTB1GeneProductENSG00000072818 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
COPS6GeneProductENSG00000168090 (Ensembl)
DUOX2GeneProductENSG00000140279 (Ensembl)
ERBB2IPGeneProductENSG00000112851 (Ensembl)
HSP90AA2GeneProductENSG00000080824 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
IL18GeneProductENSG00000150782 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
MEFVGeneProductENSG00000103313 (Ensembl)
NAIPGeneProduct4671 (Entrez Gene)
NDUFA13GeneProduct51079 (Entrez Gene)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NLRC4GeneProductENSG00000091106 (Ensembl)
NLRP10GeneProductENSG00000182261 (Ensembl)
NLRP12GeneProductENSG00000142405 (Ensembl)
NLRP1GeneProductENSG00000091592 (Ensembl)
NLRP2GeneProductENSG00000022556 (Ensembl)
NLRP3GeneProductENSG00000162711 (Ensembl)
NLRP4GeneProductENSG00000160505 (Ensembl)
NLRP7GeneProductENSG00000167634 (Ensembl)
NOD1GeneProductENSG00000106100 (Ensembl)
NOD2GeneProductENSG00000167207 (Ensembl)
Nf-kappa B signalingPathwayWP231 (WikiPathways)
PRDM1GeneProductENSG00000057657 (Ensembl)
PYCARDGeneProductENSG00000103490 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl)
RIPK2GeneProductENSG00000104312 (Ensembl)
SUGT1GeneProductENSG00000165416 (Ensembl)
XIAPGeneProductENSG00000101966 (Ensembl)

Annotated Interactions

No annotated interactions

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