Myometrial Relaxation and Contraction Pathways (Rattus norvegicus)

From WikiPathways

Jump to: navigation, search
1-3Na+IGFBPPKC inhibitor 1Myometrial RelaxationCa2+Ca2+Pathways of Myometrial RelaxationTranscription FactorsPAdenylyl CyclasesDAGPge2Calcium MobilizationNa+PKC inhibitor 1Calcium InfluxGbgPKCNORegulators of G-proteinsignaling (RGS)Predicted OT-RPip2SRRGSIP3PKCMyometrial ContractionMg2+Activation via CRH and cAMPAdenylyl CyclasesIGFBPAP-1 complexPathways of Myometrial ContractionCamk2LPACell GrowthMAPKTRPi + TR GbgTranscriptional RegulationPhospholipase-CNucleusGbgPhospholipase-CPredicted Cxn43Camk2TREts complexATPGrk6Gabpb1lNfkb1YwhaeRyr2PrkczIgfbp5Sp1Rgs20Creb3Rgs19Adcy3Rgs9GUCY2ERgs4PrkcqRyr3Adcy5Gnb2Atf5OxtGng2Arrb2Adcy8AABR07013776.1Adcy1LOC100361457CorinAdcy7OxtrGrk4Rgs6Rgs2Rgs10Rgs16Slc8a1Prkar1bMylk2Gng5YWHAZGnb1Grk5Igfbp2YwhahGnb4AdmGrk4Ackr3ATPGucy1a3Gng4PkibRln1Rgs7Cyclic AMPCamk2bPrkar1aGsto1Gpr182Cald1Rxfp2JunGabpaPlcd1Atf6bACTA2Atp2a3Gnb5ActbPlcg1Camk2aRgs5Igfbp3Adcy4PrkcgMyl4GNASCamk2gMyl2Gng8Ramp1GnaqActc1Gngt1Arrb1Creb1Gng12Igfbp4YwhabRGS11Cnn2AABR07062512.1Rgs3FosPlcg2Gng7Guca2aSfnIgfbp6CrhPrkacbGng11Rgs17Gng13CALM3Lpar1Prkar2bMaffGrk6Atf3Prkar2aPde4dCnn1Atf2Rgs18YwhagAtf4Atf1Adcy2Gng3Adcy9PrkchCrcpCALM2Adcy6Prkd1Plcb3Cyclic GMPPde4bRgs14Ramp3Mylk2Il6OxtrPrkcbPRKACAYwhaqPrkcaGja1Cacnb3PrkceCamk2dIl1bEts2Ryr1CalcaRgs1PkigNos1Igfbp1Grk5Nos3Crhr1PkiaADPGuca2bDgkzRamp2Cyclic AMPArrb1ADPGnb3Acta1Itpr3PrkcdAtp2a2Arrb2Rxfp1Itpr1


Description

This pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile activity is the myometrium. Genes in this pathway are either transcribed in myometrial muscle cells or act upon the myometrium to regulate contraction. The left half of this pathway illustrates pathways of myometrial relaxation that are active throughout normal gestation. These signaling events act to suppress coordinated contractions to prevent the early onset of labor at term, largely via activation of the adenylyl-cyclase thrhough G-protein coupled receptors. On the right side of this pathway are signaling componets involved in the activation of uterine contractions at labor, in particular, activation of calcium mobilization via Oxytocin mediated binding to the Oxytocin G-protein coupled receptor. Additional genes implicated in this pathway, based on microarray expression profiling of gestation, term and postpartum of term mice are also included (e.g., Guca2b, Rdc1, Edg2) have also been included. For a detailed description of this pathway see: http://genomebiology.com/2005/6/2/R12.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP289 (r89548) with a 95.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Méhats C, Tanguy G, Dallot E, Cabrol D, Ferré F, Leroy MJ; ''Is up-regulation of phosphodiesterase 4 activity by PGE2 involved in the desensitization of beta-mimetics in late pregnancy human myometrium?''; J Clin Endocrinol Metab, 2001 PubMed Europe PMC
  2. Aggelidou E, Hillhouse EW, Grammatopoulos DK; ''Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC
  3. Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, Dolganov G, Conklin BR; ''Identifying genetic networks underlying myometrial transition to labor.''; Genome Biol, 2005 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106965view13:42, 17 September 2019MaintBotHMDB identifier normalization
95805view14:53, 19 January 2018MkutmonHomology conversion update
87895view12:52, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
71831view19:37, 18 October 2013MaintBotremoved data source from nodes without identifier
71285view05:02, 17 October 2013MaintBot
69919view19:43, 11 July 2013MaintBotupdated to 2013 schema
69918view19:42, 11 July 2013MaintBotModified description
47773view05:37, 6 April 2012Khanspersupdated xref
41734view02:39, 2 March 2011MaintBotRemoved redundant pathway information and comments
35261view20:17, 11 February 2010Thomasmoved references from comment to bibliography
34109view19:22, 9 December 2009MaintBotAutomatic update of empty xrefs
32347view13:36, 15 August 2009MaintBotFixed text labels
31970view13:08, 14 August 2009MaintBotFixed group labels
31394view20:47, 13 August 2009MaintBotFixed text labels
30924view00:35, 30 July 2009MaintBotConverted from Homo sapiens
20977view11:30, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Smooth muscle contraction]] moved to [[Pathway:WP140]]: Moved to stable identifier
8400view13:46, 7 January 2008MaintBot[[Pathway:Rat:Smooth muscle contraction]] moved to [[Pathway:Rattus norvegicus:Smooth muscle contraction]]: Renaming species
7817view16:19, 18 December 2007MaintBotfixed category names
7490view12:42, 4 November 2007MaintBotAdded categories to GPML
6595view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:Smooth_muscle_contraction]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AABR07013776.1GeneProductENSRNOG00000048082 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:801
AABR07062512.1GeneProductENSRNOG00000053339 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3709
ACTA2GeneProductNo homologues found for original id L:59
ADPMetabolite58-64-0 (CAS)
ATPMetabolite1927-31-7 (CAS)
Ackr3GeneProductENSRNOG00000019622 (Ensembl)
  • PMID: 10614663
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:57007
Acta1GeneProductENSRNOG00000017786 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:58
ActbGeneProductENSRNOG00000034254 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:60
Actc1GeneProductENSRNOG00000008536 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:70
Adcy1GeneProductENSRNOG00000059479 (Ensembl)
  • CYA1 HUMAN
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:107
Adcy2GeneProductENSRNOG00000032150 (Ensembl)
  • There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:108
Adcy3GeneProductENSRNOG00000003999 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:109
Adcy4GeneProductENSRNOG00000020401 (Ensembl)
  • There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:196883
Adcy5GeneProductENSRNOG00000002229 (Ensembl)
  • There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:111
Adcy6GeneProductENSRNOG00000054757 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:112
Adcy7GeneProductENSRNOG00000014776 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:113
Adcy8GeneProductENSRNOG00000004890 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:114
Adcy9GeneProductENSRNOG00000049768 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:115
AdmGeneProductENSRNOG00000027030 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:133
Arrb1GeneProductENSRNOG00000030404 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:408
Arrb2GeneProductENSRNOG00000019308 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:409
Atf1GeneProductENSRNOG00000061088 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:466
Atf2GeneProductENSRNOG00000001597 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1386
Atf3GeneProductENSRNOG00000003745 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:467
Atf4GeneProductENSRNOG00000017801 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:468
Atf5GeneProductENSRNOG00000020060 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:22809
Atf6bGeneProductENSRNOG00000000431 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1388
Atp2a2GeneProductENSRNOG00000001285 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:488
Atp2a3GeneProductENSRNOG00000017912 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:489
CALM2GeneProductMultiple homologues found: En:ENSRNOG00000004060;En:ENSRNOG00000048082;En:ENSRNOG00000004060;
CALM3GeneProductMultiple homologues found: En:ENSRNOG00000004060;En:ENSRNOG00000048082;
Cacnb3GeneProductENSRNOG00000054274 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:784
CalcaGeneProductENSRNOG00000011130 (Ensembl)
  • CRF HUMAN PMID: 11854458
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:796
Cald1GeneProductENSRNOG00000010233 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:800
Camk2aGeneProductENSRNOG00000018712 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:815
Camk2bGeneProductENSRNOG00000052080 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:816
Camk2dGeneProductENSRNOG00000011589 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:817
Camk2gGeneProductENSRNOG00000009783 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:818
Cnn1GeneProductENSRNOG00000027736 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1264
Cnn2GeneProductENSRNOG00000043044 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1265
CorinGeneProductENSRNOG00000002302 (Ensembl)
  • MGI:97367
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10699
CrcpGeneProductENSRNOG00000000901 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:27297
Creb1GeneProductENSRNOG00000013412 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1385
Creb3GeneProductENSRNOG00000016452 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10488
CrhGeneProductENSRNOG00000012703 (Ensembl)
  • CRF HUMAN PMID: 11854458
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1392
Crhr1GeneProductENSRNOG00000004900 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1394
Cyclic AMPMetaboliteHMDB0000058 (HMDB)
Cyclic GMPMetaboliteHMDB0001314 (HMDB)
DgkzGeneProductENSRNOG00000017737 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8525
Ets2GeneProductENSRNOG00000001647 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2114
FosGeneProductENSRNOG00000008015 (Ensembl)
  • PMID: 10218980 PMID: 7628395 [
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2353
GNASGeneProduct
  • No homologues found for original id L:2778
GUCY2EGeneProductPMID: 11854458
GabpaGeneProductENSRNOG00000053205 (Ensembl)
  • Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun.

    Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS.

    PMID: 10218980
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2551
Gabpb1lGeneProductENSRNOG00000053439 (Ensembl)
  • Identification of a GABP alpha/beta binding site involved in the induction of oxytocin receptor gene expression in human breast cells, potentiation by c-Fos/c-Jun.

    Hoare S, Copland JA, Wood TG, Jeng YJ, Izban MG, Soloff MS.

    PMID: 10218980
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2553
Gja1GeneProductENSRNOG00000000805 (Ensembl)
  • Endogenous nitric oxide suppresses rat myometrial connexin 43 gap junction protein expression during pregnancy.

    Sladek SM, Westerhausen-Larson A, Roberts JM.

    PMID: 10377025
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2697
GnaqGeneProductENSRNOG00000014183 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2776
Gnb1GeneProductENSRNOG00000016638 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2782
Gnb2GeneProductENSRNOG00000001409 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2783
Gnb3GeneProductENSRNOG00000015541 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2784
Gnb4GeneProductENSRNOG00000011070 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:59345
Gnb5GeneProductENSRNOG00000047799 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10681
Gng11GeneProductENSRNOG00000047914 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2791
Gng12GeneProductENSRNOG00000050231 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:55970
Gng13GeneProductENSRNOG00000039350 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:51764
Gng2GeneProductENSRNOG00000048980 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:54331
Gng3GeneProductENSRNOG00000019570 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2785
Gng4GeneProductENSRNOG00000047080 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2786
Gng5GeneProductENSRNOG00000038205 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2787
Gng7GeneProductENSRNOG00000019857 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2788
Gng8GeneProductENSRNOG00000016701 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:94235
Gngt1GeneProductENSRNOG00000010546 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2792
Gpr182GeneProductENSRNOG00000004311 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11318
Grk4GeneProductENSRNOG00000011847 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2868
Grk5GeneProductENSRNOG00000011439 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2869
Grk6GeneProductENSRNOG00000014615 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2870
Gsto1GeneProductENSRNOG00000028746 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9446
Guca2aGeneProductENSRNOG00000008849 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2980
Guca2bGeneProductENSRNOG00000008979 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2981
Gucy1a3GeneProductENSRNOG00000012302 (Ensembl)
  • PMID: 11854458
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2982
Igfbp1GeneProductENSRNOG00000058780 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3484
Igfbp2GeneProductENSRNOG00000016957 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3485
Igfbp3GeneProductENSRNOG00000061910 (Ensembl)
  • Relaxin is a member of the Insulin Growth Factor family of proteins. IGFBP-3 binds IGFII preferentially. (SwissProt).
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3486
Igfbp4GeneProductENSRNOG00000010635 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3487
Igfbp5GeneProductENSRNOG00000017206 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3488
Igfbp6GeneProductENSRNOG00000010977 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3489
Il1bGeneProductENSRNOG00000004649 (Ensembl)
  • Structure, characterization, and expression of the rat oxytocin receptor gene.

    Rozen F, Russo C, Banville D, Zingg HH PMID: 7816817 quote: The presence of APREs in the OTR gene promoter suggests that the acute induction of OTR expression at the onset of parturition may be a phenomenon mechanistically similar to the fast induction of acute phase response genes. This notion is strengthened by the observation that the uterus is populated by macrophages and other specific lymphocytes (19,20). Specifically, at term, nearly half of the decidual cells are of bone marrow origin (20). IL-1beta released from macrophages stimulates the production and release of IL-6 by uterine stromal cells (21,22). Moreover, IL- is a central pathophysiological mediator of infection-induced premature delivery (23), and preterm delivery can be prevented by an IL-1 antagonist in mice (24). We speculate that under physiological as well as phathophysiological conditions, inflammatory cytokines are important inducers of labor and that this mechanism involves the cytokine-induced transcriptional activation of the OTR gene. :end quote

    19. Hunt, J.S. (1994) Biol. Reprod. 50, 461-466 20. Vince, G.S., et al. (1990) J. Immunol. Methods 132, 181-189. 21. Tabibzadeh, S. (1991) Endocr. Rev, 12, 272-290. 22. Dudley, D.Jl, et. Al. (1992) J. Clin. Endocrinol. Metab. 74, 884-889

    23. Romero, R., et. Al, Am. J. Obstet. Gynecol. 167, 863-872.
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3553
Il6GeneProductENSRNOG00000010278 (Ensembl)
  • Structure, characterization, and expression of the rat oxytocin receptor gene.

    Rozen F, Russo C, Banville D, Zingg HH PMID: 7816817 quote: The presence of APREs in the OTR gene promoter suggests that the acute induction of OTR expression at the onset of parturition may be a phenomenon mechanistically similar to the fast induction of acute phase response genes. This notion is strengthened by the observation that the uterus is populated by macrophages and other specific lymphocytes (19,20). Specifically, at term, nearly half of the decidual cells are of bone marrow origin (20). IL-1beta released from macrophages stimulates the production and release of IL-6 by uterine stromal cells (21,22). Moreover, IL- is a central pathophysiological mediator of infection-induced premature delivery (23), and preterm delivery can be prevented by an IL-1 antagonist in mice (24). We speculate that under physiological as well as phathophysiological conditions, inflammatory cytokines are important inducers of labor and that this mechanism involves the cytokine-induced transcriptional activation of the OTR gene. :end quote

    19. Hunt, J.S. (1994) Biol. Reprod. 50, 461-466 20. Vince, G.S., et al. (1990) J. Immunol. Methods 132, 181-189. 21. Tabibzadeh, S. (1991) Endocr. Rev, 12, 272-290. 22. Dudley, D.Jl, et. Al. (1992) J. Clin. Endocrinol. Metab. 74, 884-889

    23. Romero, R., et. Al, Am. J. Obstet. Gynecol. 167, 863-872.
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3569
Itpr1GeneProductENSRNOG00000007104 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3708
Itpr3GeneProductENSRNOG00000052795 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3710
JunGeneProductENSRNOG00000026293 (Ensembl)
  • PMID: 10218980
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3725
LOC100361457GeneProductENSRNOG00000036701 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:71
Lpar1GeneProductENSRNOG00000013656 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1902
MaffGeneProductENSRNOG00000012886 (Ensembl)
  • OMIM: Inoue et al. (1994) demonstrated that the US-2 element in the promoter of the human oxytocin receptor gene (OXTR; 167055) binds specifically nuclear proteins from human myometrium at parturition. Using the US-2 element in a yeast 1-hybrid system to screen a human myometrium cDNA library, Kimura et al. (1999) isolated a full-length cDNA encoding the homolog of chicken MafF. Human MAFF encodes a deduced 164-amino acid protein with a predicted molecular mass of 17.8 kD. Like other small MAF proteins (e.g., MAFG, 602020), it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. Northern blot analysis showed a strong 2.6-kb signal in mRNA from term myometrium and from kidney, but not from nonpregnant myometrium. The MAFF protein is also preferentially expressed in term myometrium. The authors concluded that MAFF plays a role in OXTR gene upregulation at term.
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:23764
Myl2GeneProductENSRNOG00000030848 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4633
Myl4GeneProductENSRNOG00000050675 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4635
Mylk2GeneProductENSRNOG00000008235 (Ensembl)
  • KML2 MOUSE
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:85366
Nfkb1GeneProductENSRNOG00000023258 (Ensembl)
  • Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene. Echetebu CO, Ali M, Izban MG, MacKay L, Garfield RE. PMID: 10421804
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4790
Nos1GeneProductENSRNOG00000001130 (Ensembl)
  • PMID: 11854458
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4842
Nos3GeneProductENSRNOG00000009348 (Ensembl)
  • PMID: 11854458
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4846
OxtGeneProductENSRNOG00000021225 (Ensembl)
  • MGI:97453
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5020
OxtrGeneProductENSRNOG00000005806 (Ensembl)
  • Sladek SM, Westerhausen-Larson A, Roberts JM. PMID: 10377025
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5021
PRKACAGeneProductNo homologues found for original id L:5566
Pde4bGeneProductENSRNOG00000005905 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5142
Pde4dGeneProductENSRNOG00000042536 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5144
PkiaGeneProductENSRNOG00000012095 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5569
PkibGeneProductENSRNOG00000000811 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5570
PkigGeneProductENSRNOG00000010235 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11142
Plcb3GeneProductENSRNOG00000021150 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5331
Plcd1GeneProductENSRNOG00000032238 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5333
Plcg1GeneProductENSRNOG00000051490 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5335
Plcg2GeneProductENSRNOG00000051986 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5336
PrkacbGeneProductENSRNOG00000004978 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5567
Prkar1aGeneProductENSRNOG00000049876 (Ensembl)
  • KAP0 HUMAN
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5573
Prkar1bGeneProductENSRNOG00000028733 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5575
Prkar2aGeneProductENSRNOG00000020284 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5576
Prkar2bGeneProductENSRNOG00000009079 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5577
PrkcaGeneProductENSRNOG00000003491 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5578
PrkcbGeneProductENSRNOG00000012061 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5579
PrkcdGeneProductENSRNOG00000016346 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5580
PrkceGeneProductENSRNOG00000015603 (Ensembl)
  • This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5581
PrkcgGeneProductENSRNOG00000054371 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5582
PrkchGeneProductENSRNOG00000004873 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5583
PrkcqGeneProductENSRNOG00000019057 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5588
PrkczGeneProductENSRNOG00000015480 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5590
Prkd1GeneProductENSRNOG00000004165 (Ensembl)
  • KPCM HUMAN
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5587
RGS11GeneProductNo homologues found for original id L:8786
Ramp1GeneProductENSRNOG00000019926 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10267
Ramp2GeneProductENSRNOG00000020415 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10266
Ramp3GeneProductENSRNOG00000053766 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10268
Rgs10GeneProductENSRNOG00000042592 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6001
Rgs14GeneProductENSRNOG00000015616 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10636
Rgs16GeneProductENSRNOG00000027024 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6004
Rgs17GeneProductENSRNOG00000018690 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:26575
Rgs18GeneProductENSRNOG00000003959 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:64407
Rgs19GeneProductENSRNOG00000016547 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10287
Rgs1GeneProductENSRNOG00000003895 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5996
Rgs20GeneProductENSRNOG00000008100 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8601
Rgs2GeneProductENSRNOG00000003687 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5997
Rgs3GeneProductENSRNOG00000024501 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5998
Rgs4GeneProductENSRNOG00000002773 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5999
Rgs5GeneProductENSRNOG00000002730 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8490
Rgs6GeneProductENSRNOG00000008082 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9628
Rgs7GeneProductENSRNOG00000021984 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6000
Rgs9GeneProductENSRNOG00000003800 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:8787
Rln1GeneProductENSRNOG00000060867 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6013
Rxfp1GeneProductENSRNOG00000024120 (Ensembl)
  • PMID: 11809971
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:59350
Rxfp2GeneProductENSRNOG00000000897 (Ensembl)
  • PMID: 11809971 LGR8 MOUSE
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:122042
Ryr1GeneProductENSRNOG00000020557 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6261
Ryr2GeneProductENSRNOG00000017060 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6262
Ryr3GeneProductENSRNOG00000006645 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6263
SfnGeneProductENSRNOG00000033153 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:2810
Slc8a1GeneProductENSRNOG00000008479 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6546
Sp1GeneProductENSRNOG00000014084 (Ensembl)
  • Promoter activity of the rat connexin 43 gene in NRK cells.

    Fernandez-Cobo M, Stewart D, Drujan D, De Maio A.

    Division of Pediatric Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

    PMID: 11255234
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6667
YWHAZGeneProduct
  • PMID: 9861170 PMID: 1317796
  • No homologues found for original id L:7534
YwhabGeneProductENSRNOG00000010945 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7529
YwhaeGeneProductENSRNOG00000005290 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7531
YwhagGeneProductENSRNOG00000001436 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7532
YwhahGeneProductENSRNOG00000055471 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7533
YwhaqGeneProductENSRNOG00000051650 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10971

Annotated Interactions

No annotated interactions
Personal tools