Cell cycle (Danio rerio)

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1+uGrowth FactoreApoptosisMG2proteolysis+p+pDNA damage checkpointTranscription Factor E2FGrowth Factor withdrawal+pHDACSecurin-p-p+p+p(Start)+uMAPKsignaling+u+p+p+p+ueSeparinDNAp21p27,57+pe+p+pDNASORC (OriginRecognition complex)G1+pmediatedp16,15,18,19epathwayR-point+p+pUbiquitinDNA biosynthesisMCM (Mini-ChromosomeMaintenance) complex+pS-phase proteinseHistone Deacetylases+p+p+uCondensinccna2hdac1orc5zgc:153369GeneProductrbl1orc3APC/Cwee1espl1pcnachek2ccna2skp2UBE2Fhdac3mcm6ccna1zgc:174506rbl1ep300aabl1tp53mcm5hdac8cdk4cdc25bbub3gsk3bPTTG2orc1mdm2mad1l1atrLOC557486cdkn1bLOC559111cdc20cdk2e2f1tfdp1aMPEG1ccnd2aCDH1cdc2hdac4ASKsmc1accnhrb1ywhag1ARFrb1mcm2ccnepttg1ccne2ORCccnb1smad3bCDKN1Abub1cdc45lhdac6zgc:101602MCMcdk2e2f2orc2zgc:163016e2f314-3-3HDAC2CCND3DKEY-168J9.1CDC25Crb1cdc2cdkn2a/bcdc14bmcm3mad2l2atmmad2l1orc6lccnb2tbc1d8TGFB1si:ch211-195d17.2E2Fe2f4GADD45Acdk2mcm4ccna1e2f5HDAC7AMENzgc:85772cdc25cdk6APC/Cmcm7kitlgbbub1bbwu:fa96e12PTTG3chek1plk1kitlgakitlgbskp2kitlgaywhag2


(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.


GenMAPP notes 
Adapted from: http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html
This pathway was inferred from Homo sapiens pathway WP179(r30295) with a 68% conversion rate.

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Ontology Terms



  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia


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111031view21:40, 1 July 2020L DupuisConverted interactions to graphical lines in outlines
91983view09:20, 11 April 2017LWackersUpdated annotations.
86992view14:38, 15 July 2016MkutmonOntology Term : 'cell cycle pathway' added !
71498view19:20, 17 October 2013MaintBotAutomated update of data sources
68614view03:56, 6 July 2013MaintBotUpdated to 2013 gpml schema
62730view03:21, 2 May 2013MaintBotUpdated UniProt data source
40775view22:14, 1 March 2011MaintBotRemoved redundant pathway information and comments
35388view09:30, 12 February 2010MartijnVanIerselModified description
34167view21:16, 9 December 2009MaintBotAutomatic update of empty xrefs
32346view13:36, 15 August 2009MaintBotFixed text labels
31969view13:07, 14 August 2009MaintBotFixed group labels
31393view20:46, 13 August 2009MaintBotFixed text labels
31105view01:43, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
14-3-3GeneProductWhat is this supposed to represent?
APC/CGeneProductAnaphase promoting complex
ASKGeneProductASK; activator of S phase kinas
CCND3GeneProductENSDARG00000027391 (Ensembl) CCND3; cyclin D3
CDC25CGeneProductCDC25C; cell division cycle 25C [EC:]
CDH1GeneProduct114424 (Entrez Gene)
CDKN1AGeneProduct100151416 (Entrez Gene)
DKEY-168J9.1GeneProduct565969 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
GADD45AGeneProduct431763 (Entrez Gene)
HDAC2GeneProductHDAC2; histone deacetylase 2
HDAC7AGeneProductENSDARG00000105179 (Ensembl) HDAC7A; histone deacetylase 7
LOC557486GeneProduct557486 (Entrez Gene) HDAC5; histone deacetylase 5
LOC559111GeneProduct559111 (Entrez Gene) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
MENGeneProductENSDARG00000000568 (Ensembl)
MPEG1GeneProduct335407 (Entrez Gene)
PTTG2GeneProductPTTG2; pituitary tumor-transforming
PTTG3GeneProductPTTG3; pituitary tumor-transforming
TGFB1GeneProduct359834 (Entrez Gene)
UBE2FGeneProductENSDARG00000025754 (Ensembl) UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
abl1GeneProduct100000720 (Entrez Gene) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:
atmGeneProductENSDARG00000002385 (Ensembl) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:]
atrGeneProductENSDARG00000079625 (Ensembl) ATR; ataxia telangiectasia and Rad3 related
bub1GeneProductENSDARG00000077029 (Ensembl) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
bub1bbGeneProduct567006 (Entrez Gene) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
bub3GeneProduct403012 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
ccna1GeneProduct404206 (Entrez Gene) CCNA1; cyclin A1
ccna2GeneProduct192295 (Entrez Gene) CCNA2; cyclin A2
ccnb1GeneProduct58025 (Entrez Gene) CCNB1; cyclin B1
ccnb2GeneProduct368316 (Entrez Gene) CCNB2; cyclin B2
ccnd2aGeneProduct799608 (Entrez Gene) CCND2; cyclin D2
ccne2GeneProduct415165 (Entrez Gene) CCNE2; cyclin E
ccneGeneProduct30188 (Entrez Gene) CCNE1; cyclin E
ccnhGeneProduct541325 (Entrez Gene) CCNH; cyclin H
cdc14bGeneProduct393148 (Entrez Gene) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
cdc20GeneProduct406353 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
cdc25GeneProduct57925 (Entrez Gene) CDC25B; cell division cycle 25B [EC:]
cdc25bGeneProductENSDARG00000010792 (Ensembl)
  • CDC25A; cell division cycle 25A [EC:]
  • cdc25b is zebrafish ortholog of human CDC25A
cdc2GeneProduct80973 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
cdc45lGeneProduct406695 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
cdk2GeneProduct406715 (Entrez Gene) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
cdk4GeneProduct777730 (Entrez Gene) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
cdk6GeneProduct100034507 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
cdkn1bGeneProduct368329 (Entrez Gene) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
cdkn2a/bGeneProductENSDARG00000037262 (Ensembl)
chek1GeneProduct393162 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
chek2GeneProduct336998 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
e2f1GeneProductENSDARG00000103868 (Ensembl) E2F1; E2F transcription factor 1
e2f2GeneProductENSDARG00000079233 (Ensembl) E2F2; E2F transcription factor 2
e2f3GeneProductENSDARG00000070463 (Ensembl) E2F3; E2F transcription factor 3
e2f4GeneProduct406741 (Entrez Gene) E2F4; E2F transcription factor 4 p107/p130-binding
e2f5GeneProduct402908 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
ep300aGeneProduct559273 (Entrez Gene) EP300; E1A binding protein p300
espl1GeneProduct797406 (Entrez Gene) ESPL1; extra spindle poles like 1 (S. cerevisiae
gsk3bGeneProduct30654 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:]
hdac1GeneProduct192302 (Entrez Gene) HDAC1; histone deacetylase 1
hdac3GeneProduct393965 (Entrez Gene) HDAC3; histone deacetylase 3
hdac4GeneProduct568877 (Entrez Gene) HDAC4; histone deacetylase 4
hdac6GeneProduct565482 (Entrez Gene) HDAC6; histone deacetylase 6
hdac8GeneProduct406740 (Entrez Gene) HDAC8; histone deacetylase
kitlgaGeneProductENSDARG00000070917 (Ensembl)
kitlgbGeneProductENSDARG00000058042 (Ensembl)
mad1l1GeneProduct393886 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
mad2l1GeneProduct550434 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
mad2l2GeneProductENSDARG00000042456 (Ensembl) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
mcm2GeneProduct192338 (Entrez Gene) MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
mcm3GeneProduct192323 (Entrez Gene) MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
mcm4GeneProduct337598 (Entrez Gene) MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
mcm5GeneProduct286747 (Entrez Gene) MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
mcm6GeneProduct566409 (Entrez Gene) MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
mcm7GeneProductENSDARG00000101180 (Ensembl) MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
mdm2GeneProduct30637 (Entrez Gene) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
orc1GeneProduct554509 (Entrez Gene) ORC1L; origin recognition complex subunit 1-like (yeast)
orc2GeneProductENSDARG00000101465 (Ensembl) ORC2L; origin recognition complex subunit 2-like (yeast)
orc3GeneProduct334315 (Entrez Gene) ORC3L; origin recognition complex subunit 3-like (yeast)
orc5GeneProduct406479 (Entrez Gene) ORC5L; origin recognition complex subunit 5-like (yeast)
orc6lGeneProduct324256 (Entrez Gene) ORC6L; origin recognition complex subunit 6-like (yeast)
pcnaGeneProduct30678 (Entrez Gene) PCNA; proliferating cell nuclear antigen
plk1GeneProduct280649 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
pttg1GeneProductENSDARG00000075421 (Ensembl) PTTG1; pituitary tumor-transforming
rb1GeneProduct777733 (Entrez Gene) RB1; retinoblastoma 1 (including osteosarcoma)
rbl1GeneProduct795522 (Entrez Gene) RBL1; retinoblastoma-like 1 (p107)
si:ch211-195d17.2GeneProduct560495 (Entrez Gene) E2F6; E2F transcription factor 6
skp2GeneProduct563708 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
smad3bGeneProduct326283 (Entrez Gene) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
smc1aGeneProduct559665 (Entrez Gene) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
tbc1d8GeneProductENSDARG00000104493 (Ensembl)
tfdp1aGeneProduct406813 (Entrez Gene) TFDP1; transcription factor Dp-1
tp53GeneProduct30590 (Entrez Gene)
wee1GeneProduct327060 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:]
wu:fa96e12GeneProduct562283 (Entrez Gene) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:]
ywhag1GeneProductENSDARG00000067626 (Ensembl) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
ywhag2GeneProductENSDARG00000071658 (Ensembl) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
zgc:101602GeneProduct492768 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
zgc:153369GeneProduct767751 (Entrez Gene) CCNB3; cyclin B
zgc:163016GeneProduct100049158 (Entrez Gene) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
zgc:174506GeneProduct402825 (Entrez Gene) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
zgc:85772GeneProduct406462 (Entrez Gene) ORC4L; origin recognition complex subunit 4-like (yeast)

Annotated Interactions

No annotated interactions
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