Signal Transduction of S1P Receptor (Danio rerio)

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1GPCRs similar to S1Ps1pr2akt3bmapk7smpd2amapk4racgap1pik3c2basah1bgnai1s1pr3bCABZ01072157.1akt2mapk1gnai3s1pr5bs1pr1mapk12bgnai2bmapk3PLCB1plcb3akt1sphk2mapk6SPHK1


Description

Metabolism of sphingomyelin by the sphingomyelinase, ceramidase (Cer'ase) and the sphingosine kinase (SK) enzymes results in formation of S1P and receptor activation. Autocrine and paracrine modes of receptor activation have been implied but have yet to be rigorously proven. Critical signaling molecules, such as phospholipase C (PLC), ERK, PI3K, and Akt are activated. Active Akt binds to the receptor and phosphorylates the third intracellular loop, which is essential for Rac activation.

Comments

GenMAPP notes 
Representation of Figure 2. from T. Hla, et al. 2001, Science, 294, pg. 1877
HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP26 (r79950) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Hla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ; ''Lysophospholipids--receptor revelations.''; Science, 2001 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
95804view14:52, 19 January 2018MkutmonHomology conversion update
87663view08:55, 25 July 2016LindarieswijkOntology Term : 'sphingosine 1-phosphate signaling pathway' added !
68691view05:53, 6 July 2013MaintBotUpdated to 2013 gpml schema
40867view22:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
34247view21:43, 9 December 2009MaintBotAutomatic update of empty xrefs
31967view13:06, 14 August 2009MaintBotFixed group labels
31103view01:42, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CABZ01072157.1GeneProductENSDARG00000090381 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5330
PLCB1GeneProductNo homologues found for original id L:23236
SPHK1GeneProductENSDARG00000100290 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8877
akt1GeneProductENSDARG00000099657 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:207
akt2GeneProductENSDARG00000011219 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:208
akt3bGeneProductENSDARG00000087205 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10000
asah1bGeneProductENSDARG00000034817 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:427
gnai1GeneProductENSDARG00000021647 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2770
gnai2bGeneProductENSDARG00000017294 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2771
gnai3GeneProductENSDARG00000030644 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2773
mapk12bGeneProductENSDARG00000006409 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6300
mapk1GeneProductENSDARG00000027552 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5594
mapk3GeneProductENSDARG00000070573 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5595
mapk4GeneProductENSDARG00000017681 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5596
mapk6GeneProductENSDARG00000032103 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5597
mapk7GeneProductENSDARG00000023110 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5598
pik3c2bGeneProductENSDARG00000086927 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5287
plcb3GeneProductENSDARG00000068246 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5331
racgap1GeneProductENSDARG00000015460 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:29127
s1pr1GeneProductENSDARG00000042690 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1901
s1pr2GeneProductENSDARG00000036548 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9294
s1pr3bGeneProductENSDARG00000098253 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1903
s1pr5bGeneProductENSDARG00000052192 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:53637
smpd2aGeneProductENSDARG00000040523 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6610
sphk2GeneProductENSDARG00000069893 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:56848

Annotated Interactions

No annotated interactions
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