Integrin-mediated cell adhesion (Danio rerio)

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1cell maintenancesignaling systemPhosphatidylinositiolcell motilityF-actincell maintenanceF-actinIntegrin betaC3GCAPNCAPNECMPAKcell proliferationERKp130 CasPI3KPAKIntegrin alphaMEKITGBITGARAFROCK1PI5KLOC100151619itgb3bmap2k6raf1zgc:172250ITGA4mapk7grb2MAP2K3ITGAXRAC3LOC100007176ITGA7ITGAEzgc:162320wu:fk86g11LOC563639LOC557797MAPK12pxncapn7itga6LOC560549itgb8fynbbrafLOC797491CAPN11zgc:92074zgc:175192CH211-127H20.2pak2azgc:92014CSKilkVAV2cdc42lmapk1MYO-Pzgc:63474LOC572348ARHGEF7LOC407685CAPN6HRASakt2itga5LOC100002756mapk4mapk6capn3vclsrcpik3r2LOC570868tln1rhoitga2bmapk10cav2ITGALTNS1ptk2.1SOS1pak1LOC570311PAK6dock1rock2aITGA8rac2zgc:172137itgavrap1asepp1aLOC792354map2k1capn9srcptk2.1LOC571984ITGB4crkITGAMLOC557935cav1capn2lrap1bitgb5DKEY-234H16.4PAK3zgc:171680MYLK2p110zgc:153787cav3ITGB1ITGA11MYOACTNCAPN1rac1CAPNS1CAPN5


Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP185(r21067) with a 68% conversion rate.

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Ontology Terms



  1. Sepulveda JL, Gkretsi V, Wu C; ''Assembly and signaling of adhesion complexes.''; Curr Top Dev Biol, 2005 PubMed Europe PMC Scholia


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71515view19:22, 17 October 2013MaintBotAutomated update of data sources
68647view05:01, 6 July 2013MaintBotUpdated to 2013 gpml schema
67401view10:56, 26 June 2013DdiglesOntology Term : 'integrin mediated signaling pathway' added !
62788view16:32, 2 May 2013MaintBotUpdated UniProt data source
40815view22:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
35599view15:45, 12 February 2010ThomasModified description
35592view15:41, 12 February 2010Thomasadded literature
34203view21:29, 9 December 2009MaintBotAutomatic update of empty xrefs
31961view13:05, 14 August 2009MaintBotFixed group labels
31098view01:40, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ARHGEF7GeneProductARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
CAPN11GeneProductCAPN11; calpain 11 [EC:]
CAPN1GeneProduct553353 (Entrez Gene) CAPN1; calpain 1 (mu/I) large subunit [EC:]
CAPN5GeneProductCAPN5; calpain
CAPN6GeneProductCAPN6; calpain 6 [EC:]
CAPNS1GeneProductCAPNS1; calpain small subunit 1 [EC:]
CH211-127H20.2GeneProduct558635 (Entrez Gene) GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
CSKGeneProduct556454 (Entrez Gene) CSK; c-src tyrosine kinase [EC:]
DKEY-234H16.4GeneProduct793882 (Entrez Gene) GIT2; G protein-coupled receptor kinase-interactor 2
HRASGeneProduct550286 (Entrez Gene)
ITGA7GeneProduct100006255 (Entrez Gene)
ITGB4GeneProduct335269 (Entrez Gene)
LOC100002756GeneProduct100002756 (Entrez Gene) SH3D5; SH3-domain protein 5 (ponsin
LOC100007176GeneProduct100007176 (Entrez Gene) SHC3; neuronal Sh
LOC100151619GeneProduct100151619 (Entrez Gene)
LOC407685GeneProduct407685 (Entrez Gene)
LOC557797GeneProduct557797 (Entrez Gene)
LOC557935GeneProduct557935 (Entrez Gene)
LOC560549GeneProduct560549 (Entrez Gene) AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
LOC563639GeneProduct563639 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
LOC570311GeneProduct570311 (Entrez Gene) CAPN10; calpain 10 [EC:
LOC570868GeneProduct570868 (Entrez Gene)
LOC571984GeneProduct571984 (Entrez Gene)
LOC572348GeneProduct572348 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene) AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
LOC797491GeneProduct797491 (Entrez Gene)
MAP2K3GeneProductMAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAPK12GeneProduct30681 (Entrez Gene) MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
MYLK2GeneProduct100169950 (Entrez Gene) MYLK2; myosin light chain kinase 2 skeletal muscle [EC:
PAK3GeneProductPAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
PAK6GeneProductPAK6; p21(CDKN1A)-activated kinase
RAC3GeneProduct437027 (Entrez Gene) RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
ROCK1GeneProductROCK1; Rho-associated coiled-coil containing protein kinase
SOS1GeneProductSOS1; son of sevenless homolog 1 (Drosophila)
TNS1GeneProductTNS; tensi
VAV2GeneProductVAV2; vav 2 oncogene
akt2GeneProduct378972 (Entrez Gene) AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
brafGeneProduct403065 (Entrez Gene) BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
capn2lGeneProduct550505 (Entrez Gene) CAPN2; calpain 2 (m/II) large subunit [EC:]
capn3GeneProduct447832 (Entrez Gene) CAPN3; calpain 3 (p94) [EC:]
capn7GeneProduct556792 (Entrez Gene) CAPN7; calpain 7 [EC:
capn9GeneProduct445107 (Entrez Gene) CAPN9; calpain 9 (nCL-4) [EC:
cav1GeneProduct323695 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
cav2GeneProduct415240 (Entrez Gene) CAV2; caveolin 2
cav3GeneProduct449679 (Entrez Gene) CAV3; caveolin 3
cdc42lGeneProduct793158 (Entrez Gene) CDC42; cell division cycle 42 (GTP binding protein 25kD)
crkGeneProduct445234 (Entrez Gene) CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
dock1GeneProduct572187 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
fynbGeneProduct574422 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:]
grb2GeneProduct406308 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
ilkGeneProduct393543 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
itga2bGeneProduct445380 (Entrez Gene)
itga5GeneProduct386787 (Entrez Gene)
itga6GeneProduct503893 (Entrez Gene)
itgavGeneProduct100151255 (Entrez Gene)
itgb3bGeneProduct100001836 (Entrez Gene)
itgb5GeneProduct563556 (Entrez Gene)
itgb8GeneProduct556752 (Entrez Gene)
map2k1GeneProduct406728 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
map2k6GeneProduct65239 (Entrez Gene) MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
mapk10GeneProduct569698 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
mapk4GeneProduct406782 (Entrez Gene) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
mapk6GeneProduct565830 (Entrez Gene) MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
mapk7GeneProduct541323 (Entrez Gene) MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
pak1GeneProduct373103 (Entrez Gene) PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
pak2aGeneProduct266749 (Entrez Gene) PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
pik3r2GeneProduct404211 (Entrez Gene) PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
ptk2.1GeneProduct142986 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:
pxnGeneProduct399546 (Entrez Gene) PXN; paxillin
rac1GeneProduct327204 (Entrez Gene) RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
rac2GeneProduct415151 (Entrez Gene) RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
raf1GeneProduct30716 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
rap1aGeneProduct415242 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
rap1bGeneProduct321107 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
rhoGeneProduct30295 (Entrez Gene) RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
rock2aGeneProduct317747 (Entrez Gene) ROCK2; Rho-associated coiled-coil containing protein kinase
sepp1aGeneProduct352931 (Entrez Gene) SEPP1; selenoprotein P plasma
srcGeneProduct325084 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
tln1GeneProduct494453 (Entrez Gene) TLN1; talin 1
vclGeneProduct552980 (Entrez Gene) VCL; vinculin
wu:fk86g11GeneProduct559145 (Entrez Gene) VAV3; vav 3 oncogene
zgc:153787GeneProduct768202 (Entrez Gene) PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:]
zgc:162320GeneProduct555805 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
zgc:171680GeneProduct564246 (Entrez Gene) ZYX; zyxin
zgc:172137GeneProduct100007679 (Entrez Gene) MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
zgc:172250GeneProduct100002225 (Entrez Gene) MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
zgc:175192GeneProduct568309 (Entrez Gene) BCAR1; breast cancer anti-estrogen resistance 1
zgc:63474GeneProduct394012 (Entrez Gene)
zgc:92014GeneProduct431769 (Entrez Gene) PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
zgc:92074GeneProduct403063 (Entrez Gene) ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]

Annotated Interactions

No annotated interactions
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