Toll-like receptor signaling pathway (Danio rerio)

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Lipoprotein+pChemotactic+pEndosome+p+pInflammatory cytokinesFlagellar assembly+pLipoarabinomannanProinflammatory(T cell)NK cell)MAPK signaling pathwayImidazoquinolinFlagellinT cell stimulation(Neutrophil, immature DC,Costimulatory moleculesAutocrine / Paracrine+p+pChemotacticcytokine receptorCytokine-MyD88-dependent pathwayZymosan (Yeast)+p+LPS(G-)effectseffectsCpG DNAMyD88-independent pathwayLipopolysaccharidessRNA+pbiosynthesis+pUbiquitin mediated proteolysisIKK(anti-viral compounds)+pApoptosis+pAntiviral effectsinteractionComplement andSpecific pathwayin pDCscoagulation cascadesJak-STAT signaling pathway+pDegradationPeptidoglycan(G+)dsRNAeffectsDNA(Mycobacteria)+pUnmethylatedInflammatory cytokines+p+rac1IFNA6IFNA5myd88TLR5atlr2IFNA4pik3cdzgc:86905irf3faddLOC557176chukmapk14atraf6CCL4irak4IFNA16casp8pik3r3traf6IRF5tirapLOC560549TLR4SPP1NFKBIAmyd88ticam1map3k7ip1IL12Birak1myd88LY96IFNA10junLOC100004036TLR3MAPK12tlr2IFNB1mapk3wu:fb92a07CXCL9irak4MAP3K7IP2mapk1pik3r2IL1Bim:7136778IFNA13IFNA7tlr7CXCL10NFKB1CCL5IFNAR2zgc:194486stat1aTICAM2IKBKErelaMAP2K3LOC563727LOC100149273ripk1ltollipCCL3IFNA8irf7CXCL11IFNB1IL12ACD86zgc:172250IL8IFNA14LBPmap3k7IFNA21irak1tlr8atiraptraf3IFNB1nfkb2zgc:172209TLR1NFKB1akt2IFNA1CD80LOC561737tlr1IFNA2mapk10LOC560913CD14chukikbkbzgc:77033map2k6map2k1IFNA17myd88CD40traf6tbk1LOC792354tlr9ikbkgIFNAR1fosIL6TNFLepbtnfatnfbTLR5b


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP75(r30264) with a 56% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
87796view11:16, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
77485view11:40, 16 September 2014VenemanEnsembl annotation updated
77484view11:30, 16 September 2014VenemanSpecify description
77483view09:58, 16 September 2014Venemantnfa and tnfb added
77479view14:51, 15 September 2014VenemanLepb added
68667view05:25, 6 July 2013MaintBotUpdated to 2013 gpml schema
40839view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
34222view21:35, 9 December 2009MaintBotAutomatic update of empty xrefs
32343view13:35, 15 August 2009MaintBotFixed text labels
31959view13:04, 14 August 2009MaintBotFixed group labels
31390view20:45, 13 August 2009MaintBotFixed text labels
31096view01:39, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CCL3GeneProductOriginal kegg element: gene;44;hsa:6348
CCL4GeneProductOriginal kegg element: gene;38;hsa:6351
CCL5GeneProductOriginal kegg element: gene;58;hsa:6352
CD14GeneProductOriginal kegg element: gene;84;hsa:929
CD40GeneProductENSDARG00000054968 (Ensembl) Original kegg element: gene;29;hsa:958
CD80GeneProductOriginal kegg element: gene;69;hsa:941
CD86GeneProductOriginal kegg element: gene;28;hsa:942
CXCL10GeneProductOriginal kegg element: gene;25;hsa:3627
CXCL11GeneProductOriginal kegg element: gene;23;hsa:6373
CXCL9GeneProductOriginal kegg element: gene;24;hsa:4283
IFNA1GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA10GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA14GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA16GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA17GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA2GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNAR1GeneProductOriginal kegg element: gene;49;hsa:3454 hsa:3455
IFNAR2GeneProductOriginal kegg element: gene;49;hsa:3454 hsa:3455
IFNB1GeneProductOriginal kegg element: gene;1;hsa:3456
IKBKEGeneProduct437024 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IL12AGeneProduct445410 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL12BGeneProductOriginal kegg element: gene;45;hsa:3592 hsa:3593
IL1BGeneProduct405770 (Entrez Gene) Original kegg element: gene;51;hsa:3553
IL6GeneProductOriginal kegg element: gene;57;hsa:3569
IL8GeneProductOriginal kegg element: gene;43;hsa:3576
IRF5GeneProduct405811 (Entrez Gene) Original kegg element: gene;21;hsa:3663
LBPGeneProductOriginal kegg element: gene;77;hsa:3929
LOC100004036GeneProduct100004036 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
LOC100149273GeneProduct100149273 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
LOC557176GeneProduct557176 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
LOC560549GeneProduct560549 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
LOC560913GeneProduct560913 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
LOC561737GeneProduct561737 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
LOC563727GeneProduct563727 (Entrez Gene) Original kegg element: gene;13;hsa:1326
LOC792354GeneProduct792354 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
LY96GeneProductOriginal kegg element: gene;71;hsa:23643
LepbGeneProductENSDARG00000045548 (Ensembl) Original kegg element: gene;57;hsa:3569
MAP2K3GeneProductOriginal kegg element: gene;65;hsa:5606 hsa:5608
MAP3K7IP2GeneProduct494163 (Entrez Gene) Original kegg element: gene;61;hsa:23118
MAPK12GeneProduct30681 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
NFKB1GeneProduct565756 (Entrez Gene) Original kegg element: gene;14;hsa:4790
NFKBIAGeneProductOriginal kegg element: gene;64;hsa:4792
SPP1GeneProductENSDARG00000044276 (Ensembl) Original kegg element: gene;15;hsa:6696
TICAM2GeneProductOriginal kegg element: gene;80;hsa:353376
TLR1GeneProduct403127 (Entrez Gene) Original kegg element: gene;75;hsa:7096
TLR3GeneProduct403126 (Entrez Gene) Original kegg element: gene;73;hsa:7098
TLR4GeneProductOriginal kegg element: gene;79;hsa:7099
TLR5aGeneProductENSDARG00000044415 (Ensembl) Original kegg element: gene;72;hsa:7100
TLR5bGeneProductENSDARG00000052322 (Ensembl) Original kegg element: gene;72;hsa:7100
TNFGeneProductOriginal kegg element: gene;66;hsa:7124
akt2GeneProduct378972 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
casp8GeneProduct58022 (Entrez Gene) Original kegg element: gene;87;hsa:841
chukGeneProduct393287 (Entrez Gene) Original kegg element: gene;42;hsa:1147
faddGeneProduct562317 (Entrez Gene) Original kegg element: gene;56;hsa:8772
fosGeneProduct394198 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
ikbkbGeneProduct563560 (Entrez Gene) Original kegg element: gene;36;hsa:3551
ikbkgGeneProduct541530 (Entrez Gene) Original kegg element: gene;85;hsa:8517
im:7136778GeneProduct100002318 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
irak1GeneProduct569226 (Entrez Gene) Original kegg element: gene;41;hsa:3654
irak4GeneProduct393132 (Entrez Gene) Original kegg element: gene;86;hsa:51135
irf3GeneProduct564854 (Entrez Gene) Original kegg element: gene;67;hsa:3661
irf7GeneProduct393650 (Entrez Gene) Original kegg element: gene;20;hsa:3665
junGeneProduct335916 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
map2k1GeneProduct406728 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
map2k6GeneProduct65239 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
map3k7GeneProduct553788 (Entrez Gene) Original kegg element: gene;37;hsa:6885
map3k7ip1GeneProduct403084 (Entrez Gene) Original kegg element: gene;59;hsa:10454
mapk10GeneProduct569698 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
mapk1GeneProduct360144 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
mapk14aGeneProduct65237 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
mapk3GeneProduct399480 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
myd88GeneProduct403145 (Entrez Gene) Original kegg element: gene;47;hsa:4615
nfkb2GeneProduct415100 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
pik3cdGeneProduct394174 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
pik3r2GeneProduct404211 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
pik3r3GeneProduct100000252 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
rac1GeneProduct327204 (Entrez Gene) Original kegg element: gene;48;hsa:5879
relaGeneProduct415099 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
ripk1lGeneProduct567460 (Entrez Gene) Original kegg element: gene;17;hsa:8737
stat1aGeneProduct30768 (Entrez Gene) Original kegg element: gene;62;hsa:6772
tbk1GeneProduct692289 (Entrez Gene) Original kegg element: gene;52;hsa:29110
ticam1GeneProduct403147 (Entrez Gene) Original kegg element: gene;82;hsa:148022
tirapGeneProduct403148 (Entrez Gene) Original kegg element: gene;83;hsa:114609
tlr1GeneProduct403127 (Entrez Gene) Original kegg element: gene;76;hsa:10333
tlr2GeneProduct403125 (Entrez Gene) Original kegg element: gene;74;hsa:7097
tlr7GeneProduct403129 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
tlr8aGeneProduct403137 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
tlr9GeneProduct403128 (Entrez Gene) Original kegg element: gene;78;hsa:54106
tnfaGeneProductENSDARG00000009511 (Ensembl)
tnfbGeneProductENSDARG00000013598 (Ensembl)
tollipGeneProduct336876 (Entrez Gene) Original kegg element: gene;81;hsa:54472
traf3GeneProduct445119 (Entrez Gene) Original kegg element: gene;16;hsa:7187
traf6GeneProduct554561 (Entrez Gene) Original kegg element: gene;53;hsa:7189
wu:fb92a07GeneProduct100002263 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
zgc:172209GeneProduct562720 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
zgc:172250GeneProduct100002225 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
zgc:194486GeneProduct568951 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
zgc:77033GeneProduct406598 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
zgc:86905GeneProduct415185 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300

Annotated Interactions

No annotated interactions
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