Endochondral Ossification (Danio rerio)

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1, 2DyingCathepsinsand CalpainsCartilage?Removal of extracellular matrixand invasion by bone cellsBoneChondrocyte (pre)hypertrophyHypertrophyFull differentiationMineralisationBMPsChondrocyte deathWNT signalingcanonical / non-canonicalintegrinsGsProliferationChondrocyte proliferationRemoval of cartilage matrixVascular invastionOsteoblasticdifferentiationAggrecankif3acdkn1cfgfr3STAT5col2a1apth1raadamts1zgc:158799runx3sox9aLOC100149108LOC792354hdac4frzbLOC564254TNAPmef2cbnkx3.2cAMPsox6COL10A1IGF1RLOC565053vegfabgli3Thyroid hormonehmgcs1tgfb2PTCH1pthlhBMPR1Arunx2aIHHTGFBIghraOxygencab39PTCHigf1OsteopontinCarminerinFGF18bmp7bfgfr1aift88sox5mmp9TIMP3SERPINH1Thyroid hormoneLOC566764THRAstat1asi:ch211-142e24.2PLAUFGF2TGFB1LOC556380runx2achst11si:ch211-132p20.4MGPTHRActsl1aPTHCALM1bmp6IGF2wu:fi36g12runx2aADAMTS4Growth hormoneTriiodothyronine


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP474(r29737) with a 62% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC
  2. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
107099view14:18, 17 September 2019MaintBotChEBI identifier normalization
106081view11:59, 16 August 2019MaintBotHMDB identifier normalization
87976view13:18, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
72213view12:52, 27 October 2013Egonw
72173view22:16, 25 October 2013AlexanderPicoAdded missing metabolite identifiers.
68643view04:57, 6 July 2013MaintBotUpdated to 2013 gpml schema
40811view22:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
34199view21:28, 9 December 2009MaintBotAutomatic update of empty xrefs
32342view13:34, 15 August 2009MaintBotFixed text labels
31958view13:04, 14 August 2009MaintBotFixed group labels
31389view20:45, 13 August 2009MaintBotFixed text labels
31095view01:39, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADAMTS4GeneProduct
AggrecanGeneProduct
BMPR1AGeneProduct58145 (Entrez Gene)
CALM1GeneProduct
COL10A1GeneProduct558919 (Entrez Gene)
CarminerinGeneProduct
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
FGF18GeneProduct
FGF2GeneProduct404231 (Entrez Gene)
Growth hormoneGeneProduct
IGF1RGeneProduct
IGF2GeneProduct
IHHGeneProduct
LOC100149108GeneProduct100149108 (Entrez Gene)
LOC556380GeneProduct556380 (Entrez Gene)
LOC564254GeneProduct564254 (Entrez Gene)
LOC565053GeneProduct565053 (Entrez Gene)
LOC566764GeneProduct566764 (Entrez Gene) PMID: 17097081
LOC792354GeneProduct792354 (Entrez Gene)
MGPGeneProduct402937 (Entrez Gene)
OsteopontinGeneProduct
OxygenMetaboliteHMDB0001377 (HMDB)
PLAUGeneProduct
PTCHGeneProduct
PTCH1GeneProduct
PTHGeneProduct
SERPINH1GeneProduct
STAT5GeneProduct
TGFB1GeneProduct359834 (Entrez Gene)
TGFBIGeneProduct321421 (Entrez Gene)
THRAGeneProduct
TIMP3GeneProduct
TNAPGeneProduct
Thyroid hormoneMetaboliteCHEBI:60311 (ChEBI)
Thyroid hormoneMetaboliteT4
TriiodothyronineMetaboliteCHEBI:24864 (ChEBI)
adamts1GeneProduct565145 (Entrez Gene)
bmp6GeneProduct503761 (Entrez Gene)
bmp7bGeneProduct557567 (Entrez Gene)
cAMPMetaboliteHMDB0000058 (HMDB)
cab39GeneProduct415235 (Entrez Gene)
cdkn1cGeneProduct399483 (Entrez Gene)
chst11GeneProduct404232 (Entrez Gene)
col2a1aGeneProduct562496 (Entrez Gene)
ctsl1aGeneProduct321453 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
fgfr1aGeneProduct30705 (Entrez Gene)
fgfr3GeneProduct58129 (Entrez Gene)
frzbGeneProduct30119 (Entrez Gene)
ghraGeneProduct100001424 (Entrez Gene)
gli3GeneProduct403042 (Entrez Gene)
hdac4GeneProduct568877 (Entrez Gene)
hmgcs1GeneProduct394060 (Entrez Gene)
ift88GeneProduct321855 (Entrez Gene)
igf1GeneProduct114433 (Entrez Gene)
kif3aGeneProduct550267 (Entrez Gene)
mef2cbGeneProduct798771 (Entrez Gene)
mmp9GeneProduct406397 (Entrez Gene)
nkx3.2GeneProduct337865 (Entrez Gene)
pth1raGeneProduct30629 (Entrez Gene)
pthlhGeneProduct554221 (Entrez Gene)
runx2aGeneProduct405784 (Entrez Gene)
runx3GeneProduct58127 (Entrez Gene)
si:ch211-132p20.4GeneProduct566537 (Entrez Gene)
si:ch211-142e24.2GeneProduct562399 (Entrez Gene)
sox5GeneProduct567413 (Entrez Gene)
sox6GeneProduct567154 (Entrez Gene)
sox9aGeneProduct60641 (Entrez Gene)
stat1aGeneProduct30768 (Entrez Gene)
tgfb2GeneProduct369194 (Entrez Gene)
vegfabGeneProduct558154 (Entrez Gene)
wu:fi36g12GeneProduct100006896 (Entrez Gene)
zgc:158799GeneProduct564064 (Entrez Gene)

Annotated Interactions

No annotated interactions
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