Regulation of Actin Cytoskeleton (Danio rerio)

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Growth Factor (GF)Actin polymerizationRTKActomyosinassembly contractionStabilizationof actinChemotatic factorRTKRAS?Actin polymerizationstress fiberFocal adhesionassemblyLamellipodiaFilipodiaGene ExpressionGPCRGFFocal complexassembly+pChemotactic factorstress fiberRASPI3KActin polymerizationPI3K-pGPCRdock1im:7150469myl1pik3cbRAC1P4pik3r2pdgfrbpak1fgfr4PIP2FGF1fgf3CFL1zgc:86903pdgfraMAP2K2crkWASF2msnaRAC3chrm2avil1lLOC792708mospip5k1bbrras2ARPC5raf1bzgc:153663ACTG1myh10fgf8amapk1ACTBLOC568935pik3r3fgfr2cyfip2pip5k1abfgf10aiqgap1PDGFBFGF15chrm4asos2zgc:153713FGF22PAK3wu:fc03h05chrm3aDIAP1cdc42lPDGFAzgc:114164pik3c3apcpik3r4egfmylkblimk1PIK3CABAIAP2cskFGF2CD14rrasbcar1LOC555920TMSB4Xfgf23ENAHFGF21C11orf13arhgef7aLPSzgc:92014LOC557176map2k1gsnarock2aApc2ACTBgna12LOC100149843DIAP3vclbdkrb1mapk3VIL2PIK3C2GegfraPIP5K2Cppp1r12afgd1si:dkey-24l11.7itga1krasACTBwasbbrafFGF6LOC558288ROCK1SSH2Focal Adhesionpathwayf2Adherens junctionpathwayFGF11SSH3actn1fgfr1aINS2ACTG1msnbLOC558288pip4k2aapak2aPFN1FGF9pik3cdACTG1PFN1fgf7FGF13chrm5aLOC442775f2rsi:ch211-197g15.13fgf4nrasINS1slc9a1Focal AdhesionpathwayLOC565130BAIAP2pik3cgrac2BradykininVAV1PAK6fgf5mapk4MAPK Signalingpathwayfn1nckap1si:dkey-74f15.3ssh1bLOC100536317ARPC5fgf12amapk6WASF1vclpip4k2aafgfr3PIP3ptk2.1PIP2GRLF1FGF18fgf16AcetylcholineLOC100330960pak7gna13acfl2SOS1ARHGEF1FGF20fgf17fgf14GNG12rac1


Description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP51(r45278) with a 66% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
72128view07:53, 25 October 2013Mkutmonadded datasource to pathway data nodes
71535view19:23, 17 October 2013MaintBotAutomated update of data sources
68684view05:44, 6 July 2013MaintBotUpdated to 2013 gpml schema
47916view21:38, 18 April 2012KhanspersRemoved redundant information
47915view21:37, 18 April 2012KhanspersUpdating from human to fix xref duplication
40858view22:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
34239view21:40, 9 December 2009MaintBotAutomatic update of empty xrefs
32340view13:34, 15 August 2009MaintBotFixed text labels
31956view13:03, 14 August 2009MaintBotFixed group labels
31386view20:44, 13 August 2009MaintBotFixed text labels
31092view01:38, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTBGeneProduct
ACTG1GeneProduct
ARHGEF1GeneProduct
ARPC5GeneProduct
AcetylcholineMetabolite51-84-3 (CAS)
Adherens junction pathwayPathway
Apc2GeneProduct
BAIAP2GeneProduct
BradykininMetabolite58-82-2 (CAS)
C11orf13GeneProduct
CD14GeneProduct
CFL1GeneProduct
DIAP1GeneProduct
DIAP3GeneProduct
ENAHGeneProduct
FGF1GeneProduct
FGF11GeneProduct
FGF13GeneProduct
FGF15GeneProduct
FGF18GeneProduct
FGF2GeneProduct
FGF20GeneProduct
FGF21GeneProduct
FGF22GeneProduct
FGF6GeneProduct
FGF9GeneProduct
Focal Adhesion pathwayPathwayWP306 (WikiPathways)
GNG12GeneProduct
GRLF1GeneProduct
INS1GeneProduct
INS2GeneProduct
LOC100149843GeneProduct100149843 (Entrez Gene)
LOC100330960GeneProduct100330960 (Entrez Gene)
LOC100536317GeneProduct100536317 (Entrez Gene)
LOC442775GeneProduct
LOC555920GeneProduct555920 (Entrez Gene)
LOC557176GeneProduct557176 (Entrez Gene)
LOC558288GeneProduct558288 (Entrez Gene)
LOC565130GeneProduct565130 (Entrez Gene)
LOC568935GeneProduct568935 (Entrez Gene)
LOC792708GeneProduct792708 (Entrez Gene)
LPSMetaboliteC00338 (KEGG Compound)
MAP2K2GeneProduct
MAPK Signaling pathwayPathwayWP382 (WikiPathways)
PAK3GeneProduct
PAK6GeneProduct
PDGFAGeneProduct
PDGFBGeneProduct
PFN1GeneProduct
PIK3C2GGeneProduct
PIK3CAGeneProduct
PIP2MetaboliteC04637 (KEGG Compound)
PIP3MetaboliteC05981 (KEGG Compound)
PIP5K2CGeneProduct
RAC1P4GeneProduct
RAC3GeneProduct
ROCK1GeneProduct
SOS1GeneProduct
SSH2GeneProduct
SSH3GeneProduct
TMSB4XGeneProduct
VAV1GeneProduct
VIL2GeneProduct
WASF1GeneProduct
WASF2GeneProduct
actn1GeneProduct560400 (Entrez Gene)
apcGeneProduct386762 (Entrez Gene)
arhgef7aGeneProduct553493 (Entrez Gene)
bcar1GeneProduct568309 (Entrez Gene)
bdkrb1GeneProduct368199 (Entrez Gene)
brafGeneProduct403065 (Entrez Gene)
cdc42lGeneProduct793158 (Entrez Gene)
cfl2GeneProduct403001 (Entrez Gene)
chrm2aGeneProduct352938 (Entrez Gene)
chrm3aGeneProduct571679 (Entrez Gene)
chrm4aGeneProduct100150701 (Entrez Gene)
chrm5aGeneProduct553978 (Entrez Gene)
crkGeneProduct445234 (Entrez Gene)
cskGeneProduct556454 (Entrez Gene)
cyfip2GeneProduct100002872 (Entrez Gene)
dock1GeneProduct572187 (Entrez Gene)
egfGeneProduct403045 (Entrez Gene)
egfraGeneProduct378478 (Entrez Gene)
f2GeneProduct325881 (Entrez Gene)
f2rGeneProduct558477 (Entrez Gene)
fgd1GeneProduct560305 (Entrez Gene)
fgf10aGeneProduct359830 (Entrez Gene)
fgf12aGeneProduct777735 (Entrez Gene)
fgf14GeneProduct497642 (Entrez Gene)
fgf16GeneProduct692065 (Entrez Gene)
fgf17GeneProduct407737 (Entrez Gene)
fgf23GeneProduct494456 (Entrez Gene)
fgf3GeneProduct30549 (Entrez Gene)
fgf4GeneProduct570435 (Entrez Gene)
fgf5GeneProduct494454 (Entrez Gene)
fgf7GeneProduct493181 (Entrez Gene)
fgf8aGeneProduct30538 (Entrez Gene)
fgfr1aGeneProduct30705 (Entrez Gene)
fgfr2GeneProduct352940 (Entrez Gene)
fgfr3GeneProduct58129 (Entrez Gene)
fgfr4GeneProduct100000160 (Entrez Gene)
fn1GeneProduct100005469 (Entrez Gene)
gna12GeneProduct503589 (Entrez Gene)
gna13aGeneProduct326825 (Entrez Gene)
gsnaGeneProduct321099 (Entrez Gene)
im:7150469GeneProduct567938 (Entrez Gene)
iqgap1GeneProduct100002928 (Entrez Gene)
itga1GeneProduct570868 (Entrez Gene)
krasGeneProduct445289 (Entrez Gene)
limk1GeneProduct735292 (Entrez Gene)
map2k1GeneProduct406728 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
mapk3GeneProduct399480 (Entrez Gene)
mapk4GeneProduct406782 (Entrez Gene)
mapk6GeneProduct565830 (Entrez Gene)
mosGeneProduct795517 (Entrez Gene)
msnaGeneProduct286739 (Entrez Gene)
msnbGeneProduct553434 (Entrez Gene)
myh10GeneProduct555454 (Entrez Gene)
myl1GeneProduct336165 (Entrez Gene)
mylkbGeneProduct492576 (Entrez Gene)
nckap1GeneProduct561894 (Entrez Gene)
nrasGeneProduct30380 (Entrez Gene)
pak1GeneProduct373103 (Entrez Gene)
pak2aGeneProduct266749 (Entrez Gene)
pak7GeneProduct405898 (Entrez Gene)
pdgfraGeneProduct30745 (Entrez Gene)
pdgfrbGeneProduct559529 (Entrez Gene)
pik3c3GeneProduct548346 (Entrez Gene)
pik3cbGeneProduct100002263 (Entrez Gene)
pik3cdGeneProduct394174 (Entrez Gene)
pik3cgGeneProduct406598 (Entrez Gene)
pik3r2GeneProduct404211 (Entrez Gene)
pik3r3GeneProduct100000252 (Entrez Gene)
pik3r4GeneProduct564088 (Entrez Gene)
pip4k2aaGeneProduct560360 (Entrez Gene)
pip5k1abGeneProduct492549 (Entrez Gene)
pip5k1bbGeneProduct447840 (Entrez Gene)
ppp1r12aGeneProduct445393 (Entrez Gene)
ptk2.1GeneProduct142986 (Entrez Gene)
rac1GeneProduct327204 (Entrez Gene)
rac2GeneProduct415151 (Entrez Gene)
raf1bGeneProduct557109 (Entrez Gene)
rock2aGeneProduct317747 (Entrez Gene)
rras2GeneProduct550513 (Entrez Gene)
rrasGeneProduct449660 (Entrez Gene)
si:ch211-197g15.13GeneProduct798876 (Entrez Gene)
si:dkey-24l11.7GeneProduct571356 (Entrez Gene)
si:dkey-74f15.3GeneProduct559017 (Entrez Gene)
slc9a1GeneProduct795135 (Entrez Gene)
sos2GeneProduct561670 (Entrez Gene)
ssh1bGeneProduct567479 (Entrez Gene)
vclGeneProduct552980 (Entrez Gene)
vil1lGeneProduct393207 (Entrez Gene)
wasbGeneProduct335158 (Entrez Gene)
wu:fc03h05GeneProduct323588 (Entrez Gene)
zgc:114164GeneProduct574004 (Entrez Gene)
zgc:153663GeneProduct767646 (Entrez Gene)
zgc:153713GeneProduct751630 (Entrez Gene)
zgc:86903GeneProduct415187 (Entrez Gene)
zgc:92014GeneProduct431769 (Entrez Gene)

Annotated Interactions

No annotated interactions
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