Polyol pathway (Danio rerio)

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1-3glycolysisglycolysiskhkD-Glyceraldehyde 3-phosphateFructose 1-phosphateSorbitolD-FructosesordD-GlucosealdobDihydroxyacetone phosphateakr1b1Glyceraldehyde


Description

When glucose is unused, it is metabolized via the polyol pathway. This pathway consists of two main enzymatic steps. First, glucose is reduced to sorbitol by aldose reductase. In this step, NADPH is oxidized to NADP+. The next step is the oxidation of sorbitol to D-fructose by sorbitol dehydrogenase.

Fructose can then be phosphorylated by fructokinase and subsequently be metabolized via dihydroxyacetone phosphate or glyceraldehyde to D-glyceraldehyde 3-phosphate, which can be used as a substrate in the process of glycolysis.

The sorbitol pathway plays a role in diabetic renal complications because aldose reductase metabolizes the excess of glucose to toxic metabolites that induce hyperfiltration and glomerular dysfunction.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP690(r29659) with a 100% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Dunlop M; ''Aldose reductase and the role of the polyol pathway in diabetic nephropathy.''; Kidney Int Suppl, 2000 PubMed Europe PMC
  2. Brownlee M; ''Biochemistry and molecular cell biology of diabetic complications.''; Nature, 2001 PubMed Europe PMC
  3. Tolan DR; ''Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene.''; Hum Mutat, 1995 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106080view11:59, 16 August 2019MaintBotHMDB identifier normalization
88338view15:57, 1 August 2016FehrhartOntology Term : 'polyol pathway' added !
68664view05:21, 6 July 2013MaintBotUpdated to 2013 gpml schema
58794view22:45, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40835view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
32763view23:42, 3 September 2009MaintBotModified categories
31087view01:35, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
D-FructoseMetaboliteHMDB0000660 (HMDB)
D-GlucoseMetaboliteHMDB0000122 (HMDB)
D-Glyceraldehyde 3-phosphateMetaboliteHMDB0001112 (HMDB)
Dihydroxyacetone phosphateMetaboliteHMDB0001473 (HMDB)
Fructose 1-phosphateMetaboliteHMDB0001076 (HMDB)
GlyceraldehydeMetaboliteHMDB0001051 (HMDB)
SorbitolMetaboliteHMDB0000247 (HMDB)
akr1b1GeneProduct415138 (Entrez Gene)
aldobGeneProductENSDARG00000053684 (Ensembl)
khkGeneProductENSDARG00000029874 (Ensembl)
sordGeneProductENSDARG00000053405 (Ensembl)

Annotated Interactions

No annotated interactions
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