Id Signaling Pathway (Danio rerio)

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PhosphorylationRecruitmentActivationProteolytic cleavageID Gene RegulationGlycosylationDDPNUEnzyme complexNucleusCytoplasmENDTranslocationAcetylationDephosphorylationProteins in a complex interactionAutophosphorylationGolgi apparatusMitochondriaMolecule in the PathwayControlMethylationPMExtracellularDDeubiquitinationLigandUbiquitinationERMolecular associationEndosomeDSumoylationPalmitoylationInhibitionGOReceptorDesumoylationPCY(Protein-protein interaction)Reaction through unknown mechanisms/moleculesPAccession Number: NetPath 5; cellmap:5DeacetylationMTECCY -> NUDemethylationEndoplasmic reticulumPlasma membranemyf5tertatf3pax8CD40LGLOC559111smad3bid2asmad5NFKB1ELK4bmpr2bid1elk3PI3Krb1myod1id2azgc:123214vegfabegfccneRASmyf6myogctnnb1LOC559111LOC559281zgc:86833LOC557385LOC556396kdrbmp6pax5smad1IFI16smad1igf1MAPKtgif1IGF1RID3tcf12bmp2bPAX2ERKccna2smad5atf3acvrl1TCRsrebf1tcf7l2LOC567895NGFBsmad3bLCKcdk2rbl1zgc:113045her6Gene Symbolflt1rela


Inhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA binding capacity. This family of proteins is comprised of IDs 1, 2, 3 and 4. They can be stimulated by ligands such as the Vascular Endothelial Growth Factor (VEGF), TGF beta and the T cell receptor. Source: NetPath


GenMAPP notes 
NetPath 5; cellmap:5 - Id Signaling Pathway

The Id Signaling Pathway was kindly reviewed by Jonathan Perk and other members of Robert Benezra’s lab. This cancer signaling pathway is available at Cancer Cell Map ( and NetPath ( and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (, PandeyLab at Johns Hopkins University ( and Institute of Bioinformatics ( If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks;
This pathway was inferred from Homo sapiens pathway WP53(r20789) with a 76% conversion rate.

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Ontology Terms



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68686view05:47, 6 July 2013MaintBotUpdated to 2013 gpml schema
67357view10:41, 26 June 2013Christine ChichesterOntology Term : 'Inhibitor of DNA binding signaling pathway' added !
40861view22:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
35753view23:59, 12 February 2010AlexanderPico
34241view21:41, 9 December 2009MaintBotAutomatic update of empty xrefs
31383view20:42, 13 August 2009MaintBotFixed text labels
31086view01:35, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
ELK4GeneProduct30093 (Entrez Gene)
Gene SymbolGeneProduct
ID3GeneProduct246093 (Entrez Gene)
LCKGeneProduct414333 (Entrez Gene)
LOC556396GeneProduct556396 (Entrez Gene)
LOC557385GeneProduct557385 (Entrez Gene)
LOC559111GeneProduct559111 (Entrez Gene)
LOC559281GeneProduct559281 (Entrez Gene)
LOC567895GeneProduct567895 (Entrez Gene)
NFKB1GeneProduct565756 (Entrez Gene)
acvrl1GeneProduct266753 (Entrez Gene)
atf3GeneProduct393939 (Entrez Gene)
bmp2bGeneProduct30632 (Entrez Gene)
bmp6GeneProduct503761 (Entrez Gene)
bmpr2bGeneProduct555655 (Entrez Gene)
ccna2GeneProduct192295 (Entrez Gene)
ccneGeneProduct30188 (Entrez Gene)
cdk2GeneProduct406715 (Entrez Gene)
ctnnb1GeneProduct30265 (Entrez Gene)
egfGeneProduct403045 (Entrez Gene)
elk3GeneProduct557074 (Entrez Gene)
flt1GeneProduct544667 (Entrez Gene)
her6GeneProduct30288 (Entrez Gene)
id1GeneProduct30493 (Entrez Gene)
id2aGeneProduct266599 (Entrez Gene)
igf1GeneProduct114433 (Entrez Gene)
kdrGeneProduct554230 (Entrez Gene)
myf5GeneProduct58097 (Entrez Gene)
myf6GeneProduct404208 (Entrez Gene)
myod1GeneProduct30513 (Entrez Gene)
myogGeneProduct30200 (Entrez Gene)
pax5GeneProduct60636 (Entrez Gene)
pax8GeneProduct60637 (Entrez Gene)
rb1GeneProduct777733 (Entrez Gene)
rbl1GeneProduct795522 (Entrez Gene)
relaGeneProduct415099 (Entrez Gene)
smad1GeneProduct30628 (Entrez Gene)
smad3bGeneProduct326283 (Entrez Gene)
smad5GeneProduct30641 (Entrez Gene)
srebf1GeneProduct793274 (Entrez Gene)
tcf12GeneProduct407985 (Entrez Gene)
tcf7l2GeneProduct30510 (Entrez Gene)
tertGeneProduct796551 (Entrez Gene)
tgif1GeneProduct321756 (Entrez Gene)
vegfabGeneProduct558154 (Entrez Gene)
zgc:113045GeneProduct664768 (Entrez Gene)
zgc:123214GeneProduct664761 (Entrez Gene)
zgc:86833GeneProduct415202 (Entrez Gene)

Annotated Interactions

No annotated interactions
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