Oxidative Stress (Danio rerio)

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Inhibition of oxidasesRepression of ROS-producing systemsRepressionActivationTF activationInduction ofantioxidant genesStress-regulated MAP kinaseAdaptive responseTF inhibitionImmediate-earlygene inductionReactive Oxygen SpeciesJUNBhmox1nqo1gclcMGST1si:dkey-117m1.6GSTT1bGPX3cybaTXNRD1zgc:110010GPX1aNFKB1cyp1amapk10fossp1mapk14axdhsod1TXNRD2LOC555669MAOAsod2MT1XcatNrf2UGT1A6txn2GPX1bGSTT1a


No description


GenMAPP notes 
Adapted from Biochem J 1999 Sep 15;342 Pt 3:481-96 Morel Y, Barouki R. Repression of gene expression by oxidative stress. Biochem J 1999 Sep 15;342 Pt 3:481-96
GenMAPP remarks 
Adapted from rat by GenMAPP.org
This pathway was inferred from Homo sapiens pathway WP408(r21540) with a 58% conversion rate.

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91955view13:58, 6 April 2017LWackersUpdated annotations. Split GSTT2 into its zebrafish orthologues.
88284view14:42, 1 August 2016FehrhartOntology Term : 'oxidative stress response pathway' added !
71514view19:22, 17 October 2013MaintBotAutomated update of data sources
68644view04:58, 6 July 2013MaintBotUpdated to 2013 gpml schema
40812view22:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
34200view21:28, 9 December 2009MaintBotAutomatic update of empty xrefs
32338view13:32, 15 August 2009MaintBotFixed text labels
31951view13:01, 14 August 2009MaintBotFixed group labels
31382view20:41, 13 August 2009MaintBotFixed text labels
31084view01:34, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
GPX1aGeneProductENSDARG00000018146 (Ensembl)
GPX1bGeneProductNM_001004634 (RefSeq)
GPX3GeneProduct798788 (Entrez Gene)
GSTT1aGeneProductENSDARG00000042428 (Ensembl)
GSTT1bGeneProductENSDARG00000017388 (Ensembl)
JUNBGeneProduct407086 (Entrez Gene)
LOC555669GeneProduct555669 (Entrez Gene)
MAOAGeneProductENSDARG00000023712 (Ensembl)
MGST1GeneProduct449784 (Entrez Gene)
NFKB1GeneProduct565756 (Entrez Gene)
TXNRD1GeneProduct352924 (Entrez Gene)
TXNRD2GeneProductENSDARG00000075923 (Ensembl)
catGeneProduct30068 (Entrez Gene)
cybaGeneProduct393551 (Entrez Gene) Probe set ID: u18729
cyp1aGeneProduct140634 (Entrez Gene)
fosGeneProduct394198 (Entrez Gene)
gclcGeneProduct326857 (Entrez Gene)
hmox1GeneProduct791518 (Entrez Gene)
mapk10GeneProduct569698 (Entrez Gene)
mapk14aGeneProduct65237 (Entrez Gene)
nqo1GeneProduct322506 (Entrez Gene)
si:dkey-117m1.6GeneProduct794006 (Entrez Gene)
sod1GeneProduct30553 (Entrez Gene)
sod2GeneProduct335799 (Entrez Gene)
sp1GeneProduct324109 (Entrez Gene)
txn2GeneProduct402938 (Entrez Gene)
xdhGeneProduct560486 (Entrez Gene)
zgc:110010GeneProduct553575 (Entrez Gene)

Annotated Interactions

No annotated interactions
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