G Protein Signaling Pathways (Danio rerio)

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1, 2CellResponseCytoskeletalChangesProtein Kinase CCellResponseTranscriptionTranscriptionG betaGqGiGscAMPPhosphodiesterasesProtein Kinase AAdenylate CyclasesAKAPsPhosphatase 2BG gammaG12/13zgc:92392LOC558595LOC556160zgc:158458PDE7BLOC564915gnai3Ca2+gnao1aLOC571011PPP3CALOC100000320IP3GNB1DAGLOC796780gnb2cAMPPDE1Bzgc:153713rrasprkcb1gngt2LOC565706krasCALM1ADCY4AKAP8LOC792687ADCY6LOC100149388gng12LOC557337si:dkey-197m14.4gnb5prkacbakap1bzgc:92704gng5AKAP7AKAP3zgc:112145gna12AKAP4GNG11LOC557123AKAP2AKAP9gngt1zgc:101761adcy2bPPP3CCPPP3CCprkceprkar2aaslc9a1LOC100002625DKEYP-60A7.2PRKCQLOC572061LOC100006640LOC568726LOC100149498CH211-220F13.4PRKCDnrasGNB3gnao1aLOC564465LOC569499wu:fi40d09LOC100148685akap12gnai1LOC557353gnai1PRKAR2Bgnai2GNA15gna13aLOC795659prkcizgc:153624CH73-270F14.2ARHGEF1zgc:91856zgc:158799gng3ADCY9AKAP5zgc:172124HRASLOC571825LOC100003514LOC100151215plcb3DKEY-190G11.2prkczgng7


Description

G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades.

G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes.

Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP35(r20751) with a 73% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC
  2. Stryer L, Bourne HR; ''G proteins: a family of signal transducers.''; Annu Rev Cell Biol, 1986 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106079view11:59, 16 August 2019MaintBotHMDB identifier normalization
71520view19:22, 17 October 2013MaintBotAutomated update of data sources
68654view05:09, 6 July 2013MaintBotUpdated to 2013 gpml schema
67260view10:28, 26 June 2013Christine ChichesterOntology Term : 'G protein mediated signaling pathway' added !
40823view22:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
35325view08:24, 12 February 2010ThomasModified description
35324view08:23, 12 February 2010Thomasadded literature
34209view21:31, 9 December 2009MaintBotAutomatic update of empty xrefs
32337view13:31, 15 August 2009MaintBotFixed text labels
31950view13:01, 14 August 2009MaintBotFixed group labels
31381view20:41, 13 August 2009MaintBotFixed text labels
31083view01:34, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY4GeneProduct
ADCY6GeneProduct
ADCY9GeneProduct
AKAP2GeneProduct
AKAP3GeneProduct
AKAP4GeneProduct
AKAP5GeneProduct
AKAP7GeneProduct
AKAP8GeneProduct
AKAP9GeneProduct565037 (Entrez Gene)
ARHGEF1GeneProduct368266 (Entrez Gene)
CALM1GeneProduct
CH211-220F13.4GeneProduct100148976 (Entrez Gene)
CH73-270F14.2GeneProduct570108 (Entrez Gene)
Ca2+MetaboliteHMDB0000464 (HMDB)
DAGMetaboliteC00165 (KEGG Compound)
DKEY-190G11.2GeneProduct566998 (Entrez Gene)
DKEYP-60A7.2GeneProduct562619 (Entrez Gene)
GNA15GeneProduct
GNB1GeneProduct322104 (Entrez Gene)
GNB3GeneProduct406483 (Entrez Gene)
GNG11GeneProduct
HRASGeneProduct550286 (Entrez Gene)
IP3MetaboliteHMDB0001143 (HMDB)
LOC100000320GeneProduct100000320 (Entrez Gene)
LOC100002625GeneProduct100002625 (Entrez Gene)
LOC100003514GeneProduct100003514 (Entrez Gene)
LOC100006640GeneProduct100006640 (Entrez Gene)
LOC100148685GeneProduct100148685 (Entrez Gene)
LOC100149388GeneProduct100149388 (Entrez Gene)
LOC100149498GeneProduct100149498 (Entrez Gene)
LOC100151215GeneProduct100151215 (Entrez Gene)
LOC556160GeneProduct556160 (Entrez Gene)
LOC557123GeneProduct557123 (Entrez Gene)
LOC557337GeneProduct557337 (Entrez Gene)
LOC557353GeneProduct557353 (Entrez Gene)
LOC558595GeneProduct558595 (Entrez Gene)
LOC564465GeneProduct564465 (Entrez Gene)
LOC564915GeneProduct564915 (Entrez Gene)
LOC565706GeneProduct565706 (Entrez Gene)
LOC568726GeneProduct568726 (Entrez Gene)
LOC569499GeneProduct569499 (Entrez Gene)
LOC571011GeneProduct571011 (Entrez Gene)
LOC571825GeneProduct571825 (Entrez Gene)
LOC572061GeneProduct572061 (Entrez Gene)
LOC792687GeneProduct792687 (Entrez Gene)
LOC795659GeneProduct795659 (Entrez Gene)
LOC796780GeneProduct796780 (Entrez Gene)
PDE1BGeneProduct
PDE7BGeneProduct
PPP3CAGeneProduct
PPP3CCGeneProduct
PRKAR2BGeneProduct
PRKCDGeneProduct334571 (Entrez Gene)
PRKCQGeneProduct555521 (Entrez Gene)
adcy2bGeneProduct557902 (Entrez Gene)
akap12GeneProduct567365 (Entrez Gene)
akap1bGeneProduct556208 (Entrez Gene)
cAMPMetaboliteHMDB0000058 (HMDB)
gna12GeneProduct503589 (Entrez Gene)
gna13aGeneProduct326825 (Entrez Gene)
gnai1GeneProduct393946 (Entrez Gene)
gnai2GeneProduct327650 (Entrez Gene)
gnai3GeneProduct100006888 (Entrez Gene)
gnao1aGeneProduct393760 (Entrez Gene)
gnb2GeneProduct541370 (Entrez Gene)
gnb5GeneProduct393719 (Entrez Gene)
gng12GeneProduct406604 (Entrez Gene)
gng3GeneProduct114462 (Entrez Gene)
gng5GeneProduct337838 (Entrez Gene)
gng7GeneProduct436670 (Entrez Gene)
gngt1GeneProduct335656 (Entrez Gene)
gngt2GeneProduct335655 (Entrez Gene)
krasGeneProduct445289 (Entrez Gene)
nrasGeneProduct30380 (Entrez Gene)
plcb3GeneProduct100001532 (Entrez Gene)
prkacbGeneProduct563147 (Entrez Gene)
prkar2aaGeneProduct556042 (Entrez Gene)
prkcb1GeneProduct393953 (Entrez Gene)
prkceGeneProduct100005075 (Entrez Gene)
prkciGeneProduct117507 (Entrez Gene)
prkczGeneProduct555737 (Entrez Gene)
rrasGeneProduct449660 (Entrez Gene)
si:dkey-197m14.4GeneProduct566920 (Entrez Gene)
slc9a1GeneProduct795135 (Entrez Gene)
wu:fi40d09GeneProduct556620 (Entrez Gene)
zgc:101761GeneProduct493613 (Entrez Gene)
zgc:112145GeneProduct550427 (Entrez Gene)
zgc:153624GeneProduct767685 (Entrez Gene)
zgc:153713GeneProduct751630 (Entrez Gene)
zgc:158458GeneProduct791145 (Entrez Gene)
zgc:158799GeneProduct564064 (Entrez Gene)
zgc:172124GeneProduct100144561 (Entrez Gene)
zgc:91856GeneProduct445076 (Entrez Gene)
zgc:92392GeneProduct407724 (Entrez Gene)
zgc:92704GeneProduct436673 (Entrez Gene)

Annotated Interactions

No annotated interactions
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