Transforming growth factor (TGF) beta signaling pathway (Danio rerio)

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1, 2CofactorsTGFbRepressorsAccessory receptors:RsmadsCo-smadsR-SmadsCo-SmadsCofactorligands:ENGrunx2aTGFB1LIFLOC571984INHBANFKB1thbs1tgfbr2LOC562180zeb2ajak1ctnnb1serpine1smad2fstabmp4TFE3NOGsmad1stat3IFNGFKBP1Awnt1si:ch211-216l23.1LOC100149273LOC559111junSPP1tgfbr1bfoxh1stat1amapk3lef1tgfbr2bmp4skiatgif1LOC556403smad2smad7smad5HRASegfcrebbpbTNFLOC558054tgfbr1bep300afosLOC564395TGFB1smad1smad3bsmad9TNFrunx3bambiCH211-57G18.2


The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: WikiPedia). Also see: TGF-beta receptor signaling at the NCI-Nature pathway interaction database.


GenMAPP remarks 
edited by: Nathan Salomonis
This pathway was inferred from Homo sapiens pathway WP560(r30273) with a 76% conversion rate.

Quality Tags

Ontology Terms



  1. Massague J; ''How cells read TGF-beta signals.''; Nat Rev Mol Cell Biol, 2000 PubMed Europe PMC Scholia
  2. Massague J, Blain SW, Lo RS; ''TGFbeta signaling in growth control, cancer, and heritable disorders.''; Cell, 2000 PubMed Europe PMC Scholia


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118030view11:44, 23 May 2021EweitzModified title
87738view09:44, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
87736view09:43, 25 July 2016MirellaKalafatiModified title
68675view05:33, 6 July 2013MaintBotUpdated to 2013 gpml schema
40848view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
34229view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
31949view13:01, 14 August 2009MaintBotFixed group labels
31082view01:34, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
CH211-57G18.2GeneProduct100005449 (Entrez Gene)
HRASGeneProduct550286 (Entrez Gene)
LOC100149273GeneProduct100149273 (Entrez Gene)
LOC556403GeneProduct556403 (Entrez Gene)
LOC558054GeneProduct558054 (Entrez Gene)
LOC559111GeneProduct559111 (Entrez Gene)
LOC562180GeneProduct562180 (Entrez Gene)
LOC564395GeneProduct564395 (Entrez Gene)
LOC571984GeneProduct571984 (Entrez Gene)
NFKB1GeneProduct565756 (Entrez Gene)
TGFB1GeneProduct359834 (Entrez Gene)
bambiGeneProduct83496 (Entrez Gene)
bmp4GeneProduct30612 (Entrez Gene)
crebbpbGeneProduct503776 (Entrez Gene)
ctnnb1GeneProduct30265 (Entrez Gene)
egfGeneProduct403045 (Entrez Gene)
ep300aGeneProduct559273 (Entrez Gene)
fosGeneProduct394198 (Entrez Gene)
foxh1GeneProduct57930 (Entrez Gene)
fstaGeneProduct100004116 (Entrez Gene)
jak1GeneProduct30280 (Entrez Gene)
junGeneProduct335916 (Entrez Gene)
lef1GeneProduct30701 (Entrez Gene)
mapk3GeneProduct399480 (Entrez Gene)
runx2aGeneProduct405784 (Entrez Gene)
runx3GeneProduct58127 (Entrez Gene)
serpine1GeneProduct100136840 (Entrez Gene)
si:ch211-216l23.1GeneProduct566696 (Entrez Gene)
skiaGeneProduct30101 (Entrez Gene)
smad1GeneProduct30628 (Entrez Gene)
smad2GeneProduct30639 (Entrez Gene)
smad3bGeneProduct326283 (Entrez Gene)
smad5GeneProduct30641 (Entrez Gene)
smad7GeneProduct326282 (Entrez Gene)
smad9GeneProduct445564 (Entrez Gene)
stat1aGeneProduct30768 (Entrez Gene)
stat3GeneProduct30767 (Entrez Gene)
tgfbr1bGeneProduct792928 (Entrez Gene)
tgfbr2GeneProduct30739 (Entrez Gene)
tgif1GeneProduct321756 (Entrez Gene)
thbs1GeneProduct561901 (Entrez Gene) there are 5 types of tsp
wnt1GeneProduct30128 (Entrez Gene)
zeb2aGeneProduct100003889 (Entrez Gene)

Annotated Interactions

No annotated interactions
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