ErbB Signaling Pathway (Danio rerio)

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+pAdhesionDNA+p+p+pProliferationSurvival+pReceptor ubiquitylationCellular targetsER+pCa+2+p(EGFR)mTor signaling pathway+pPancreaticCancer+pDegradationDNA+pCell cycleDifferentiationIP3Migration / Invasion+p(HER2/Neu)+p+pAdhesionMigration+pERBB SIGNALING PATHWAYProteinsynthesisCellular targetsCell cycleprogressionDNAActivation by ErbB2overexpression (cancers)DNACell survival+p+pPIP3DGEndometrialcancer+p+pNon-smallcell lungcancerGliomaMAPK signalingpathwayNo signalingCalcium signaling pathway+pAngiogenesisMetabolismLOC100000720ERBB4zgc:92014zgc:92074STAT5zgc:172209MycjunTGFAmapk1ERBB3NRG4HRASNRG3LOC100149498crkptk2.1gab1LOC560913ERBB3rps6kb1erbb2nrg1frap1LOC100004036ERBB3grb2egfrcdkn1bzgc:64137map2k1erbb2erbb2SOSgrb2erbb2LOC560549HBEGFegfrcamk2aBADERBB4si:dkey-94n12.3plcg1AREGEREGLOC567895erbb2p21egfERBB4CBLBTCNCKSTAT5LOC558866egfrgsk3bsrcLOC567895


Description

The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. In mice loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the lungs, skin, heart and brain. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors.

The ErbB protein family consists of 4 members

   * ErbB-1, also named epidermal growth factor receptor (EGFR)
   * ErbB-2, also named HER2 in humans and neu in rodents
   * ErbB-3, also named HER3 and
   * ErbB-4, also named HER4

The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher order oligomers upon activation by a subset of potential growth factor ligands.


Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP673(r29836) with a 63% conversion rate.

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Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
108184view10:54, 29 November 2019FehrhartOntology Term : 'cancer' added !
108183view10:53, 29 November 2019FehrhartOntology Term : 'Alzheimer's disease' added !
108182view10:53, 29 November 2019FehrhartOntology Term : 'multiple sclerosis' added !
87996view13:25, 25 July 2016SusanOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
70185view01:49, 13 July 2013AlexanderPicoModified title
68650view05:04, 6 July 2013MaintBotUpdated to 2013 gpml schema
40818view22:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
34206view21:30, 9 December 2009MaintBotAutomatic update of empty xrefs
31378view20:39, 13 August 2009MaintBotFixed text labels
31077view01:32, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AREGGeneProduct
BADGeneProduct58100 (Entrez Gene)
BTCGeneProduct503869 (Entrez Gene)
CBLGeneProduct492364 (Entrez Gene)
ERBB3GeneProduct
ERBB4GeneProduct100007677 (Entrez Gene)
EREGGeneProduct
HBEGFGeneProduct407664 (Entrez Gene)
HRASGeneProduct550286 (Entrez Gene)
LOC100000720GeneProduct100000720 (Entrez Gene)
LOC100004036GeneProduct100004036 (Entrez Gene)
LOC100149498GeneProduct100149498 (Entrez Gene)
LOC558866GeneProduct558866 (Entrez Gene)
LOC560549GeneProduct560549 (Entrez Gene)
LOC560913GeneProduct560913 (Entrez Gene)
LOC567895GeneProduct567895 (Entrez Gene)
MycGeneProduct
NCKGeneProduct
NRG3GeneProduct
NRG4GeneProduct
SOSGeneProduct
STAT5GeneProduct
TGFAGeneProduct
camk2aGeneProduct550436 (Entrez Gene)
cdkn1bGeneProduct368329 (Entrez Gene)
crkGeneProduct445234 (Entrez Gene)
egfGeneProduct403045 (Entrez Gene)
egfrGeneProduct378478 (Entrez Gene)
erbb2GeneProduct386966 (Entrez Gene)
frap1GeneProduct324254 (Entrez Gene)
gab1GeneProduct406666 (Entrez Gene)
grb2GeneProduct406308 (Entrez Gene)
gsk3bGeneProduct30654 (Entrez Gene)
junGeneProduct335916 (Entrez Gene)
map2k1GeneProduct406728 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
nrg1GeneProduct796461 (Entrez Gene)
p21GeneProduct
plcg1GeneProduct373867 (Entrez Gene)
ptk2.1GeneProduct142986 (Entrez Gene)
rps6kb1GeneProduct406349 (Entrez Gene)
si:dkey-94n12.3GeneProduct562011 (Entrez Gene)
srcGeneProduct325084 (Entrez Gene)
zgc:172209GeneProduct562720 (Entrez Gene)
zgc:64137GeneProduct799566 (Entrez Gene)
zgc:92014GeneProduct431769 (Entrez Gene)
zgc:92074GeneProduct403063 (Entrez Gene)

Annotated Interactions

No annotated interactions
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