p38 MAPK Signaling Pathway (Danio rerio)

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1-8DNA transcription???TranslationStress: Osmotic shockg-radiation, AnisomycinFASL, InflammatoryCytokines, UV, etc.Cytokines Production,Apoptosis, etc.Growth Factors, UVTrophic Factors, etc.??creb1bmef2dpla2g4aashc1Apoptosisstat1addit3hrasarps6ka5ripk1lmapkapk2acdc42l2grb2aunm_sa808mycaelk1map2k4atraddhspb1mapk14amap3k9maxHMGN1RASGRF1mapkapk2adaxxtgfbr1amapk14amap3k7map3k5rac1bmap2k6mknk1atf2mapkapk5tgfb2map3k1Transcription factors


Description

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP400 (r95117) with a 97.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia
  2. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  3. Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.''; Biochem Soc Symp, 1999 PubMed Europe PMC Scholia
  4. Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  5. Ichijo H; ''From receptors to stress-activated MAP kinases.''; Oncogene, 1999 PubMed Europe PMC Scholia
  6. Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.''; Cell Mol Life Sci, 1999 PubMed Europe PMC Scholia
  7. Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.''; Mol Med Today, 1999 PubMed Europe PMC Scholia
  8. Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.''; Toxicol Appl Pharmacol, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
95742view13:41, 19 January 2018Mkutmonupdated homology conversion
95212view12:04, 24 November 2017Mkutmonadded homology converter comment source
84629view19:30, 10 March 2016KhanspersQuick edit to datanode annotation or property
84628view19:28, 10 March 2016KhanspersQuick edit to datanode annotation or property
68695view05:57, 6 July 2013MaintBotUpdated to 2013 gpml schema
67568view11:27, 26 June 2013DdiglesOntology Term : 'p38 MAPK signaling pathway' added !
40871view22:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
38711view19:30, 23 September 2010AlexanderPico
38231view21:11, 27 August 2010KhanspersRemoved receptor and protein complex graphics
38230view21:10, 27 August 2010Khanspers
35724view23:34, 12 February 2010KhanspersDescription and bibliography
34251view21:44, 9 December 2009MaintBotAutomatic update of empty xrefs
32334view13:30, 15 August 2009MaintBotFixed text labels
31945view12:59, 14 August 2009MaintBotFixed group labels
31376view20:38, 13 August 2009MaintBotFixed text labels
31074view01:30, 30 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ApoptosisPathwayWP254 (WikiPathways)
HMGN1GeneProductNo homologues found for original id L:3150
RASGRF1GeneProductENSDARG00000073824 (Ensembl)
  • PDZ domain containing guanine nucleotide exchange
  • Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5923
atf2GeneProductENSDARG00000023903 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1386
cdc42l2GeneProductENSDARG00000057869 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:998
creb1bGeneProductENSDARG00000093420 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1385
daxxGeneProductENSDARG00000000729 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1616
ddit3GeneProductENSDARG00000059836 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1649
elk1GeneProductENSDARG00000078066 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2002
grb2aGeneProductENSDARG00000105276 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2885
hrasaGeneProductENSDARG00000098497 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3265
hspb1GeneProductENSDARG00000041065 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3315
map2k4aGeneProductENSDARG00000063583 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6416
map2k6GeneProductENSDARG00000099184 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5608
map3k1GeneProductENSDARG00000098405 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4214
map3k5GeneProductENSDARG00000005416 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4217
map3k7GeneProductENSDARG00000020469 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6885
map3k9GeneProductENSDARG00000013491 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4293
mapk14aGeneProductENSDARG00000000857 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1432
mapkapk2aGeneProductENSDARG00000002552 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9261
mapkapk5GeneProductENSDARG00000028082 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8550
maxGeneProductENSDARG00000024844 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4149
mef2dGeneProductENSDARG00000040237 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4209
mknk1GeneProductENSDARG00000018411 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8569
mycaGeneProductENSDARG00000045695 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4609
pla2g4aaGeneProductENSDARG00000024546 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5321
rac1bGeneProductENSDARG00000087954 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5879
ripk1lGeneProductENSDARG00000006677 (Ensembl)
  • receptor (TNFRSF)-interacting serine-threonine kinase 1
  • Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8737
rps6ka5GeneProductENSDARG00000060551 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9252
shc1GeneProductENSDARG00000075437 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6464
stat1aGeneProductENSDARG00000006266 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6772
tgfb2GeneProductENSDARG00000027087 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7042
tgfbr1aGeneProductENSDARG00000017494 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7046
traddGeneProductENSDARG00000036057 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8717
unm_sa808GeneProductENSDARG00000078378 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7186

Annotated Interactions

No annotated interactions
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