Wnt Signaling Pathway (Danio rerio)

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1Apoptosis26S Proteasome DegredationRecruitment to UnknownTranscriptional ActivationUbiquitin TaggedB - CateninBNucleusFrizzled LigandsPhosphorylatedUbiquitin Conjugating EnzymeP-CateninCytoskeletonwnt7bbgsk3bLOC100003514axin1ctnnb1wnt3LOC100149082junPRKCDFZD7pafah1b1bprkcewnt2bbSFRP4wnt10bLOC557123LOC100149273zgc:153713wnt10appp2r5ebFZD1ccnd1zgc:162280APCfzd3WNT4wnt16fbxw2ppp2r5cFZD9wnt11rdvl2wnt7afosl1wnt1LOC100149498wnt5bfzd8crac1prkciMYCprkcb1PRKCQwnt3lwnt16FRAT1zgc:65879wnt5azgc:172124PLAUldlrFZD10prkczmapk10DKEY-31M21.2wnt2bCCND3fzd2LOC560032csnk1daTCF-1/LEFFZD8


Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. Source: KEGG.


This pathway was inferred from Homo sapiens pathway WP428(r28695) with a 75% conversion rate.

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Ontology Terms



  1. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC


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82353view10:22, 27 September 2015EgonwAdded a missing gene identifier.
68625view04:36, 6 July 2013MaintBotUpdated to 2013 gpml schema
67749view11:58, 26 June 2013DdiglesOntology Term : 'Wnt signaling pathway' added !
40790view22:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
35130view13:41, 11 February 2010Thomasconnected line
35123view13:25, 11 February 2010ThomasSpecify description
35112view13:17, 11 February 2010ThomasModified description
34180view21:21, 9 December 2009MaintBotAutomatic update of empty xrefs
32328view13:28, 15 August 2009MaintBotFixed text labels
31934view12:56, 14 August 2009MaintBotFixed group labels
31365view20:35, 13 August 2009MaintBotFixed text labels
31059view01:25, 30 July 2009MaintBotNew pathway

External references


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NameTypeDatabase referenceComment
APCGeneProduct386762 (Entrez Gene)
DKEY-31M21.2GeneProduct561831 (Entrez Gene)
FZD10GeneProduct30366 (Entrez Gene)
FZD1GeneProduct30365 (Entrez Gene)
FZD9GeneProduct58023 (Entrez Gene)
LOC100003514GeneProduct100003514 (Entrez Gene)
LOC100149082GeneProduct100149082 (Entrez Gene)
LOC100149273GeneProduct100149273 (Entrez Gene)
LOC100149498GeneProduct100149498 (Entrez Gene)
LOC557123GeneProduct557123 (Entrez Gene)
LOC560032GeneProduct560032 (Entrez Gene)
PRKCDGeneProduct334571 (Entrez Gene)
PRKCQGeneProduct555521 (Entrez Gene)
TCF-1/LEFGeneProductENSDARG00000031894 (Ensembl)
axin1GeneProduct57931 (Entrez Gene)
ccnd1GeneProduct30222 (Entrez Gene)
csnk1daGeneProduct322106 (Entrez Gene)
ctnnb1GeneProduct30265 (Entrez Gene)
dvl2GeneProduct323630 (Entrez Gene)
fbxw2GeneProduct553942 (Entrez Gene)
fosl1GeneProduct564241 (Entrez Gene)
fzd2GeneProduct30370 (Entrez Gene)
fzd3GeneProduct565921 (Entrez Gene)
fzd8cGeneProduct30364 (Entrez Gene)
gsk3bGeneProduct30654 (Entrez Gene) MOUSE:KG38 MOUSE
junGeneProduct335916 (Entrez Gene)
ldlrGeneProduct387529 (Entrez Gene)
mapk10GeneProduct569698 (Entrez Gene)
pafah1b1bGeneProduct394247 (Entrez Gene)
ppp2r5cGeneProduct557208 (Entrez Gene)
ppp2r5ebGeneProduct373878 (Entrez Gene)
prkcb1GeneProduct393953 (Entrez Gene)
prkceGeneProduct100005075 (Entrez Gene)
prkciGeneProduct117507 (Entrez Gene)
prkczGeneProduct555737 (Entrez Gene)
rac1GeneProduct327204 (Entrez Gene)
wnt10aGeneProduct30171 (Entrez Gene)
wnt10bGeneProduct30308 (Entrez Gene)
wnt11rGeneProduct30283 (Entrez Gene)
wnt1GeneProduct30128 (Entrez Gene)
wnt16GeneProduct791563 (Entrez Gene)
wnt2bGeneProduct359837 (Entrez Gene)
wnt2bbGeneProduct556087 (Entrez Gene)
wnt3GeneProduct569420 (Entrez Gene)
wnt3lGeneProduct60632 (Entrez Gene)
wnt5aGeneProduct568191 (Entrez Gene)
wnt5bGeneProduct30105 (Entrez Gene)
wnt7aGeneProduct565714 (Entrez Gene)
wnt7bbGeneProduct100148840 (Entrez Gene)
zgc:153713GeneProduct751630 (Entrez Gene)
zgc:162280GeneProduct799608 (Entrez Gene)
zgc:172124GeneProduct100144561 (Entrez Gene)
zgc:65879GeneProduct393533 (Entrez Gene)

Annotated Interactions

No annotated interactions
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