Kit Receptor Signaling Pathway (Danio rerio)

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TranslocationMitochondrionEnzyme complexECEndoplasmic reticulumMTCytoplasmDemethylationERAcetylationNUInhibitionDPM(Protein-protein interaction)ExtracellularDeubiquitinationDephosphorylationProteins in a complex interactionENDeacetylationDGlycosylationEndosomeAccession Number: NetPath 6; cellmap:6Golgi apparatusAutophosphorlationReceptorMolecule in the pathwayDesumoylationMethylationNucleusPlasma MembraneActivationPhosphorylationLigandCY->PMMolecular associationRecruitmentControlp85 complexProteolytic cleavageUbiquitinationGene SymbolCYSumoylationPalmitoylationGOReaction through unknown mechanisms/moleculesstat3stat1afynbmapk1plcg1spred2LOC569951LOC100000720yes1prkcb1plce1zgc:92124jak2bSOS1dok1bCSF2RBSOCS5LOC563639pik3r2dok1bTRAILR1crkcblSTAT5ASTAT5Bep300arps6ka3aMPDZBADGRAPgrb2LOC562032ptpn11GRB7raf1STAP1eporLOC792354rasa1CH211-63J24.2socs1LOC559103VAV2LOC557176KITLGzgc:77033map2k1zgc:175287LOC100149498VAV1CLTCmitfbSH3KBP1LOC792089FESKITLOC560525btksrcspred1KITLGcblbcrklcishLOC558703SOCS4ptpruKITptpn6HRAS


Description

Kit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets among others. Binding of Kit receptor to stem cell factor leads to an intracellular cascade of events that includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include leukemias, gastrointestinal stromal tumors and mastocytomas. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_6

Comments

GenMAPP notes 
NetPath 6; cellmap:6 - Kit Receptor Signaling Pathway. The Kit Receptor signaling pathway was kindly reviewed by Imke Ehlers in Peter Besmer’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP304(r21319) with a 68% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
68692view05:54, 6 July 2013MaintBotUpdated to 2013 gpml schema
67425view10:59, 26 June 2013DdiglesOntology Term : 'Stem Cell Factor signaling pathway' added !
40868view22:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
35760view00:05, 13 February 2010AlexanderPico
34248view21:43, 9 December 2009MaintBotAutomatic update of empty xrefs
31359view20:33, 13 August 2009MaintBotFixed text labels
31051view01:22, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BADGeneProduct58100 (Entrez Gene)
CH211-63J24.2GeneProduct567405 (Entrez Gene)
CLTCGeneProduct
CSF2RBGeneProduct100135062 (Entrez Gene)
FESGeneProduct
GRAPGeneProduct553596 (Entrez Gene)
GRB7GeneProduct
HRASGeneProduct550286 (Entrez Gene)
KITGeneProduct
KITLGGeneProduct
LOC100000720GeneProduct100000720 (Entrez Gene)
LOC100149498GeneProduct100149498 (Entrez Gene)
LOC557176GeneProduct557176 (Entrez Gene)
LOC558703GeneProduct558703 (Entrez Gene)
LOC559103GeneProduct559103 (Entrez Gene)
LOC560525GeneProduct560525 (Entrez Gene)
LOC562032GeneProduct562032 (Entrez Gene)
LOC563639GeneProduct563639 (Entrez Gene)
LOC569951GeneProduct569951 (Entrez Gene)
LOC792089GeneProduct792089 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene)
MPDZGeneProduct
SH3KBP1GeneProduct
SOCS4GeneProduct797891 (Entrez Gene)
SOCS5GeneProduct
SOS1GeneProduct
STAP1GeneProduct
STAT5AGeneProduct
STAT5BGeneProduct
TRAILR1GeneProduct
VAV1GeneProduct
VAV2GeneProduct
btkGeneProduct568653 (Entrez Gene)
cblGeneProduct492364 (Entrez Gene)
cblbGeneProduct556277 (Entrez Gene)
cishGeneProduct767678 (Entrez Gene)
crkGeneProduct445234 (Entrez Gene)
crklGeneProduct556443 (Entrez Gene)
dok1bGeneProduct406361 (Entrez Gene)
ep300aGeneProduct559273 (Entrez Gene)
eporGeneProduct751109 (Entrez Gene)
fynbGeneProduct574422 (Entrez Gene)
grb2GeneProduct406308 (Entrez Gene)
jak2bGeneProduct30298 (Entrez Gene)
map2k1GeneProduct406728 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
mitfbGeneProduct114833 (Entrez Gene)
pik3r2GeneProduct404211 (Entrez Gene)
plce1GeneProduct568288 (Entrez Gene)
plcg1GeneProduct373867 (Entrez Gene)
prkcb1GeneProduct393953 (Entrez Gene)
ptpn11GeneProduct333979 (Entrez Gene)
ptpn6GeneProduct335573 (Entrez Gene)
ptpruGeneProduct335096 (Entrez Gene)
raf1GeneProduct30716 (Entrez Gene)
rasa1GeneProduct100002155 (Entrez Gene)
rps6ka3aGeneProduct338219 (Entrez Gene)
socs1GeneProduct445073 (Entrez Gene)
spred1GeneProduct406513 (Entrez Gene)
spred2GeneProduct793290 (Entrez Gene)
srcGeneProduct325084 (Entrez Gene)
stat1aGeneProduct30768 (Entrez Gene)
stat3GeneProduct30767 (Entrez Gene)
yes1GeneProduct407620 (Entrez Gene)
zgc:175287GeneProduct571588 (Entrez Gene)
zgc:77033GeneProduct406598 (Entrez Gene)
zgc:92124GeneProduct447804 (Entrez Gene)

Annotated Interactions

No annotated interactions
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