MAPK Signaling Pathway (Danio rerio)

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Scaffold1-3, 5-10411LegendActivating mutationCalcium channelsHeteromeric G-proteinCalcium channelsProliferation, differentiationJNK & p38 MAP kinase pathwayERK5 pathwayClassical MAP kinase PathwayMKPProliferation, differentiation,inflammationSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressProliferation, inflammation, anti-apoptosisp38Proliferation, differentiationSerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamDNA damagePTPJNKtraf6mef2caPsrfaRPS6KA3PMAP2K3Pelk4Prap1aaPcrkIL1Apdgfbaakt3becsitMAP3K13rasgrp4map3k7Pmapk9Pgrb2amknk1Pdusp1stmn1aPelk1PPPegfraPPP3CBppp3ccaMAP4K1nfatc1Parrb2bmaptbPRASGRP1rap1bPCD14ikbkgbdnfdaxxmapk10PtnfbmosSTK4mapk14aPikbkbPParrb1lrrk2casp3bflnaprkacabmapkapk2aPtnfrsf1amap3k14ahspb1Pzakgna12atgfb1amap3k1Pmap3k2PmaxPdusp10rasgrf2aMAP4K4PDGFRBtab1map3k4gadd45aaWnt signaling pathwaymap2k5cdc25bPCU855885.1rac2prkcdbppp5cmap2k1PPrac1bPTPN7CABZ01078737.1tab2tgfbr1amapk1PPCABZ01062511.1ptpn5pla2g4f.1Pbrafntrk1atf2Pmap2k4aPLPSfosabprkcgmycasos2tgfb2elk1Pmapk7Pdusp4cacng3aApoptosishspa8mapk12bPmapk8ip1aIP3ppm1abCa2+il1belk4Punm_sa808mapk13Ptaok1bmap2k6Pdusp8bakt2mapkapk5PRASA2dusp7PPP3R2fgfr1btgfb3PPP3CAegfddit3PMAP3K6map3k8ngfbcrkltaok2bcAMPmapk3PPmapk8aPnr4a1PCell cyclePRKCAatf4aPNTF4pdgfabatf4aPntrk2bfaslgPDGFRBppm1bbfgfr2cdc42l2fgfr3lamtor3fgfr4junPPjundsos1PhrasarrasPPrps6ka5Pmap3k12tp53Prras2Pnfkb1GNG12CABZ01068093.1Pnf1arasgrp2akt1p53 signaling pathwayrasgrp3rasgrp4rasa1bRASGRF1hsc70Ca2+ntf3rapgef2Phosphatidylinositolsignaling systemprkacbahsc70prkacabstk3dusp3amap4k3bchukPtgfbr2bnfkb2map4k6relamap2k7Prelbppp3r1aDUSP9nlk2Pdusp2DAGdusp16fasmknk2bPpla2g4aaPnfatc3aPmap3k5PMAP3K11Ptaok3bdusp6map2k2aPPPPP5D1mapk11Prps6ka4Pmapkapk3Prac3bmapk8ip2mapk8ip3flnblflncahsc70hsc70hsc70MRASPnrasPKRASPraf1aPPLA2G4FPpla2g4f.1pla2g4f.1PPcacng2acacng5bcacng4bCACNA2D3cacng8acacng7bcacng6acacna1aacacna1bbcacna1ccfap74cacna1eacacna1fbcacna1sbcacna2d1acacnb1cacnb2acacnb3bcacnb4acacng1bcacna1icacna1hacacna1gcacna2d2bcacna2d4bfgf4FGF1fgf2fgf3fgf4fgf5fgf6afgf7fgf8aFGF9fgf10afgf11bfgf12bfgf13bfgf14fgf20afgf21fgf22fgf23fgf18afgf17fgf16fgf19Fibroblast growth factorsFibroblast growthfactorspak2aPAK1


Description

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP382 (r95114) with a 92.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH; ''MAP kinases.''; Chem Rev, 2001 PubMed Europe PMC
  2. Takeda K, Ichijo H; ''Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.''; Genes Cells, 2002 PubMed Europe PMC
  3. Harper SJ, LoGrasso P; ''Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.''; Cell Signal, 2001 PubMed Europe PMC
  4. Abell AN, Granger DA, Johnson GL; ''MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.''; J Biol Chem, 2007 PubMed Europe PMC
  5. Zhu X, Lee HG, Raina AK, Perry G, Smith MA; ''The role of mitogen-activated protein kinase pathways in Alzheimer's disease.''; Neurosignals, 2002 PubMed Europe PMC
  6. Huang EJ, Reichardt LF; ''Trk receptors: roles in neuronal signal transduction.''; Annu Rev Biochem, 2003 PubMed Europe PMC
  7. Yang SH, Sharrocks AD, Whitmarsh AJ; ''Transcriptional regulation by the MAP kinase signaling cascades.''; Gene, 2003 PubMed Europe PMC
  8. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y; ''Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.''; Toxicol Lett, 2003 PubMed Europe PMC
  9. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S; ''MAPK pathways in radiation responses.''; Oncogene, 2003 PubMed Europe PMC
  10. Tanoue T, Nishida E; ''Docking interactions in the mitogen-activated protein kinase cascades.''; Pharmacol Ther, 2002 PubMed Europe PMC
  11. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106072view11:58, 16 August 2019MaintBotHMDB identifier normalization
105686view20:56, 13 August 2019Khanspersremoved human-specific drug targeting and mutation
96395view09:58, 12 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95779view14:33, 19 January 2018MkutmonHomology conversion update
95122view15:06, 16 November 2017Mkutmonadded missing homology converter comment source
84627view19:26, 10 March 2016KhanspersQuick edit to datanode annotation or property
84626view19:15, 10 March 2016KhanspersQuick edit to datanode annotation or property
84625view19:14, 10 March 2016KhanspersQuick edit to datanode annotation or property
84624view19:12, 10 March 2016KhanspersQuick edit to datanode annotation or property
84623view19:02, 10 March 2016KhanspersQuick edit to datanode annotation or property
84622view19:01, 10 March 2016KhanspersQuick edit to datanode annotation or property
78354view09:42, 7 January 2015MaintBotadded missing graphIds
77428view09:11, 8 September 2014Mkutmonudpated gene labels and added some references
68657view05:13, 6 July 2013MaintBotUpdated to 2013 gpml schema
67441view11:02, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
47927view22:33, 18 April 2012Khanspersupdated xref
40826view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
35664view22:28, 12 February 2010KhanspersDescription and lit refs
34212view21:32, 9 December 2009MaintBotAutomatic update of empty xrefs
32321view13:25, 15 August 2009MaintBotFixed text labels
31926view12:54, 14 August 2009MaintBotFixed group labels
31356view20:32, 13 August 2009MaintBotFixed text labels
31047view01:20, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ApoptosisPathwayWP254 (WikiPathways)
CABZ01062511.1GeneProductENSDARG00000105744 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5801
CABZ01068093.1GeneProductENSDARG00000101721 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000105499
CABZ01078737.1GeneProductENSDARG00000100461 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7850
CACNA2D3GeneProductENSDARG00000106018 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000157445
CD14GeneProductNo homologues found for original id L:929
CU855885.1GeneProductENSDARG00000101527 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3554
Ca2+MetaboliteHMDB0000464 (HMDB)
Cell cyclePathwayWP179 (WikiPathways)
DAGMetaboliteCHEBI:18035 (ChEBI)
DUSP9GeneProductNo homologues found for original id En:ENSG00000130829
FGF1GeneProductNo homologues found for original id En:ENSG00000113578
FGF9GeneProductNo homologues found for original id En:ENSG00000102678
GNG12GeneProductENSDARG00000098123 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000172380
IL1AGeneProductNo homologues found for original id L:3552
IP3MetaboliteCHEBI:16595 (ChEBI)
KRASGeneProductNo homologues found for original id L:3845
LPSMetaboliteCHEBI:16412 (ChEBI)
MAP2K3GeneProductNo homologues found for original id L:5606
MAP3K11GeneProductENSDARG00000091521 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4296
MAP3K13GeneProductENSDARG00000009493 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9175
MAP3K6GeneProductENSDARG00000104760 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9064
MAP4K1GeneProductNo homologues found for original id L:11184
MAP4K4GeneProductNo homologues found for original id L:9448
MRASGeneProductENSDARG00000075285 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:22808
NTF4GeneProductNo homologues found for original id En:ENSG00000225950
PAK1GeneProductNo homologues found for original id L:5058
PDGFRBGeneProductENSDARG00000100897 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000113721
PLA2G4FGeneProductNo homologues found for original id En:ENSG00000168907
PPP3CAGeneProductNo homologues found for original id L:5530
PPP3CBGeneProductNo homologues found for original id L:5532
PPP3R2GeneProductNo homologues found for original id L:5535
PPP5D1GeneProductNo homologues found for original id En:ENSG00000230510
PRKCAGeneProductENSDARG00000099841 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000154229
PTPN7GeneProductNo homologues found for original id L:5778
Phosphatidylinositol signaling systemPathway
RASA2GeneProductENSDARG00000078775 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5922
RASGRF1GeneProductENSDARG00000073824 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000058335
RASGRP1GeneProductNo homologues found for original id L:10125
RPS6KA3GeneProductNo homologues found for original id L:6197
STK4GeneProductNo homologues found for original id En:ENSG00000101109
Wnt signaling pathwayPathwayWP428 (WikiPathways)
akt1GeneProductENSDARG00000099657 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:207
akt2GeneProductENSDARG00000011219 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:208
akt3bGeneProductENSDARG00000087205 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10000
arrb1GeneProductENSDARG00000043241 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:408
arrb2bGeneProductENSDARG00000011545 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:409
atf2GeneProductENSDARG00000023903 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1386
atf4aGeneProductENSDARG00000039515 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:468
bdnfGeneProductENSDARG00000018817 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:627
brafGeneProductENSDARG00000017661 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:673
cAMPMetaboliteHMDB0000058 (HMDB)
cacna1aaGeneProductENSDARG00000037905 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000141837
cacna1bbGeneProductENSDARG00000079295 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000148408
cacna1cGeneProductENSDARG00000008398 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000151067
cacna1eaGeneProductENSDARG00000062346 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000198216
cacna1fbGeneProductENSDARG00000023683 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000102001
cacna1gGeneProductENSDARG00000089913 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000006283
cacna1haGeneProductENSDARG00000060496 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000196557
cacna1iGeneProductENSDARG00000070522 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000100346
cacna1sbGeneProductENSDARG00000042552 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000081248
cacna2d1aGeneProductENSDARG00000014804 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000153956
cacna2d2bGeneProductENSDARG00000078169 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000007402
cacna2d4bGeneProductENSDARG00000023886 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000151062
cacnb1GeneProductENSDARG00000002167 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000067191
cacnb2aGeneProductENSDARG00000099045 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000165995
cacnb3bGeneProductENSDARG00000076030 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000167535
cacnb4aGeneProductENSDARG00000009738 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000182389
cacng1bGeneProductENSDARG00000052360 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000108878
cacng2aGeneProductENSDARG00000032565 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000166862
cacng3aGeneProductENSDARG00000058460 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = H:CACNG3
cacng4bGeneProductENSDARG00000074669 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000075461
cacng5bGeneProductENSDARG00000039240 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000075429
cacng6aGeneProductENSDARG00000036457 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000130433
cacng7bGeneProductENSDARG00000070624 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000105605
cacng8aGeneProductENSDARG00000020450 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000142408
casp3bGeneProductENSDARG00000055045 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:836
cdc25bGeneProductENSDARG00000010792 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:994
cdc42l2GeneProductENSDARG00000057869 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:998
cfap74GeneProductENSDARG00000075917 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000157388
chukGeneProductENSDARG00000011662 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000213341
crkGeneProductENSDARG00000055635 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1398
crklGeneProductENSDARG00000028699 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1399
daxxGeneProductENSDARG00000000729 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1616
ddit3GeneProductENSDARG00000059836 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1649
dusp10GeneProductENSDARG00000052465 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:11221
dusp16GeneProductENSDARG00000102474 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000111266
dusp1GeneProductENSDARG00000100515 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1843
dusp2GeneProductENSDARG00000098108 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000158050
dusp3aGeneProductENSDARG00000061255 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000108861
dusp4GeneProductENSDARG00000044688 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1846
dusp6GeneProductENSDARG00000070914 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1848
dusp7GeneProductENSDARG00000101413 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1849
dusp8bGeneProductENSDARG00000039232 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000184545
ecsitGeneProductENSDARG00000062834 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:51295
egfGeneProductENSDARG00000052739 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1950
egfraGeneProductENSDARG00000013847 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1956
elk1GeneProductENSDARG00000078066 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2002
elk4GeneProductENSDARG00000077092 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000158711
fasGeneProductENSDARG00000043586 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:355
faslgGeneProductENSDARG00000098913 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:356
fgf10aGeneProductENSDARG00000030932 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000070193
fgf11bGeneProductENSDARG00000043907 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000161958
fgf12bGeneProductENSDARG00000062542 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000114279
fgf13bGeneProductENSDARG00000056633 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000129682
fgf14GeneProductENSDARG00000040982 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000102466
fgf16GeneProductENSDARG00000042233 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000196468
fgf17GeneProductENSDARG00000102778 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000158815
fgf18aGeneProductENSDARG00000088048 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000156427
fgf19GeneProductENSDARG00000098663 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000162344
fgf20aGeneProductENSDARG00000007356 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000078579
fgf21GeneProductENSDARG00000100846 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000105550
fgf22GeneProductENSDARG00000076510 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000070388
fgf23GeneProductENSDARG00000045854 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000118972
fgf2GeneProductENSDARG00000104348 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000138685
fgf3GeneProductENSDARG00000101540 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000186895
fgf4GeneProductENSDARG00000105230 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000075388
fgf5GeneProductENSDARG00000035377 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000138675
fgf6aGeneProductENSDARG00000009351 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000111241
fgf7GeneProductENSDARG00000059387 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000140285
fgf8aGeneProductENSDARG00000003399 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000107831
fgfr1bGeneProductENSDARG00000011190 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2260
fgfr2GeneProductENSDARG00000058115 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000066468
fgfr3GeneProductENSDARG00000004782 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000068078
fgfr4GeneProductENSDARG00000069105 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000160867
flnaGeneProductENSDARG00000074201 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2316
flnblGeneProductENSDARG00000097351 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000136068
flncaGeneProductENSDARG00000018566 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000128591
fosabGeneProductENSDARG00000031683 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2353
gadd45aaGeneProductENSDARG00000043581 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1647
gna12aGeneProductENSDARG00000025826 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2768
grb2aGeneProductENSDARG00000105276 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2885
hrasaGeneProductENSDARG00000098497 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000174775
hsc70GeneProductENSDARG00000012381 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000126803
hspa8GeneProductENSDARG00000068992 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3312
hspb1GeneProductENSDARG00000041065 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3315
ikbkbGeneProductENSDARG00000079123 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3551
ikbkgGeneProductENSDARG00000017037 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8517
il1bGeneProductENSDARG00000098700 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3553
junGeneProductENSDARG00000043531 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3725
jundGeneProductENSDARG00000067850 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3727
lamtor3GeneProductENSDARG00000057075 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8649
lrrk2GeneProductENSDARG00000006169 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000188906
map2k1GeneProductENSDARG00000007825 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5604
map2k2aGeneProductENSDARG00000006609 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5605
map2k4aGeneProductENSDARG00000063583 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6416
map2k5GeneProductENSDARG00000011851 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5607
map2k6GeneProductENSDARG00000099184 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5608
map2k7GeneProductENSDARG00000008279 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5609
map3k12GeneProductENSDARG00000103651 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7786
map3k14aGeneProductENSDARG00000074060 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000006062
map3k1GeneProductENSDARG00000098405 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4214
map3k2GeneProductENSDARG00000062884 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10746
map3k4GeneProductENSDARG00000104835 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4216
map3k5GeneProductENSDARG00000005416 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4217
map3k7GeneProductENSDARG00000020469 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6885
map3k8GeneProductENSDARG00000061710 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1326
map4k3bGeneProductENSDARG00000071357 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8491
map4k6GeneProductENSDARG00000033444 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000168067
mapk10GeneProductENSDARG00000102730 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5602
mapk11GeneProductENSDARG00000045836 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000185386
mapk12bGeneProductENSDARG00000006409 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6300
mapk13GeneProductENSDARG00000058470 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5603
mapk14aGeneProductENSDARG00000000857 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1432
mapk1GeneProductENSDARG00000027552 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5594
mapk3GeneProductENSDARG00000070573 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5595
mapk7GeneProductENSDARG00000023110 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5598
mapk8aGeneProductENSDARG00000031888 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5599
mapk8ip1aGeneProductENSDARG00000102229 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000121653
mapk8ip2GeneProductENSDARG00000063157 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000008735
mapk8ip3GeneProductENSDARG00000062531 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000138834
mapk9GeneProductENSDARG00000077364 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5601
mapkapk2aGeneProductENSDARG00000002552 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9261
mapkapk3GeneProductENSDARG00000089016 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000114738
mapkapk5GeneProductENSDARG00000028082 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8550
maptbGeneProductENSDARG00000087616 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4137
maxGeneProductENSDARG00000024844 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4149
mef2caGeneProductENSDARG00000029764 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4208
mknk1GeneProductENSDARG00000018411 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8569
mknk2bGeneProductENSDARG00000015164 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000099875
mosGeneProductENSDARG00000069744 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4342
mycaGeneProductENSDARG00000045695 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4609
nf1aGeneProductENSDARG00000012982 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000196712
nfatc1GeneProductENSDARG00000036168 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4772
nfatc3aGeneProductENSDARG00000076297 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000072736
nfkb1GeneProductENSDARG00000105261 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4790
nfkb2GeneProductENSDARG00000038687 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000077150
ngfbGeneProductENSDARG00000014050 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000134259
nlk2GeneProductENSDARG00000028793 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:51701
nr4a1GeneProductENSDARG00000000796 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3164
nrasGeneProductENSDARG00000038225 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4893
ntf3GeneProductENSDARG00000059043 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000185652
ntrk1GeneProductENSDARG00000004586 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4914
ntrk2bGeneProductENSDARG00000098511 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000148053
p53 signaling pathwayPathway
pak2aGeneProductENSDARG00000068177 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5062
pdgfabGeneProductENSDARG00000098578 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000197461
pdgfbaGeneProductENSDARG00000086778 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5155
pla2g4aaGeneProductENSDARG00000024546 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000116711
pla2g4f.1GeneProductENSDARG00000056535 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000188089
ppm1abGeneProductENSDARG00000043250 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5494
ppm1bbGeneProductENSDARG00000011496 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5495
ppp3ccaGeneProductENSDARG00000014962 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5533
ppp3r1aGeneProductENSDARG00000092659 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5534
ppp5cGeneProductENSDARG00000034313 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5536
prkacabGeneProductENSDARG00000016809 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000165059
prkacbaGeneProductENSDARG00000001782 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000142875
prkcdbGeneProductENSDARG00000070651 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5580
prkcgGeneProductENSDARG00000004561 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5582
ptpn5GeneProductENSDARG00000074866 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:84867
rac1bGeneProductENSDARG00000087954 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5879
rac2GeneProductENSDARG00000038010 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5880
rac3bGeneProductENSDARG00000020795 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000169750
raf1aGeneProductENSDARG00000096415 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5894
rap1aaGeneProductENSDARG00000012553 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5906
rap1bGeneProductENSDARG00000008867 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5908
rapgef2GeneProductENSDARG00000005482 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000109756
rasa1bGeneProductENSDARG00000073665 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5921
rasgrf2aGeneProductENSDARG00000075054 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5924
rasgrp2GeneProductENSDARG00000062328 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000068831
rasgrp3GeneProductENSDARG00000077864 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000152689
rasgrp4GeneProductENSDARG00000061796 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000171777
relaGeneProductENSDARG00000098696 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000173039
relbGeneProductENSDARG00000086173 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000104856
rps6ka4GeneProductENSDARG00000044436 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000162302
rps6ka5GeneProductENSDARG00000060551 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9252
rras2GeneProductENSDARG00000036252 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000133818
rrasGeneProductENSDARG00000006553 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000126458
sos1GeneProductENSDARG00000100503 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000115904
sos2GeneProductENSDARG00000060506 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6655
srfaGeneProductENSDARG00000053918 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6722
stk3GeneProductENSDARG00000011312 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6788
stmn1aGeneProductENSDARG00000004169 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3925
tab1GeneProductENSDARG00000036613 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10454
tab2GeneProductENSDARG00000021509 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:23118
taok1bGeneProductENSDARG00000098304 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:57551
taok2bGeneProductENSDARG00000100620 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9344
taok3bGeneProductENSDARG00000094052 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000135090
tgfb1aGeneProductENSDARG00000041502 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7040
tgfb2GeneProductENSDARG00000027087 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7042
tgfb3GeneProductENSDARG00000019367 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7043
tgfbr1aGeneProductENSDARG00000017494 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7046
tgfbr2bGeneProductENSDARG00000034541 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7048
tnfbGeneProductENSDARG00000013598 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7124
tnfrsf1aGeneProductENSDARG00000018569 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000067182
tp53GeneProductENSDARG00000035559 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7157
traf6GeneProductENSDARG00000028058 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7189
unm_sa808GeneProductENSDARG00000078378 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7186
zakGeneProductENSDARG00000044615 (Ensembl) Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:51776

Annotated Interactions

No annotated interactions
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