Hypothetical Network for Drug Addiction (Danio rerio)

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1Gap junctionNMDARGnRH Signal pathwayAMPARGonadotropins gene expression & secretionStrong depolarizationMAPK signaling pathwayLocal TranslationLong-term potentiationRegulation of actin cytoskeletonRegulation of gap junctionmGluRNeuroactive ligand-receptorinteractioncamk4Cyclic AMPzgc:158799prkceI-1zgc:172250mapk1zgc:158799GRIN2Ddrd1CH211-220F13.4Ca++LOC569499GRIA4GRIA2GRIA3GRIN2CGsLOC569499D-Glutamatekrit1cx28.8DRD2DRD4grin1bcreb1LOC798222LOC568406acta1bLOC407707CH211-13C14.1GRIA1map2k1Gisi:ch211-51a19.1zhx2ppa1mapk3CH211-243A20.1cx28.8


Description

Adapted from figure 2 in Li et al..

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP666(r29740) with a 70% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107095view14:17, 17 September 2019MaintBotChEBI identifier normalization
102280view08:38, 17 December 2018EgonwReplaced the ChEBI idea of Ca(0) with that of Ca2++
88657view15:14, 12 August 2016JmeliusOntology Term : 'substance dependence disease pathway' added !
68646view05:00, 6 July 2013MaintBotUpdated to 2013 gpml schema
40814view22:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
34202view21:29, 9 December 2009MaintBotAutomatic update of empty xrefs
32320view13:25, 15 August 2009MaintBotFixed text labels
31922view12:53, 14 August 2009MaintBotFixed group labels
31355view20:32, 13 August 2009MaintBotFixed text labels
31043view01:19, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CH211-13C14.1GeneProduct563297 (Entrez Gene)
CH211-220F13.4GeneProduct100148976 (Entrez Gene)
CH211-243A20.1GeneProduct559976 (Entrez Gene)
Ca++MetaboliteCHEBI:29108 (ChEBI)
Cyclic AMPMetaboliteCHEBI:17489 (ChEBI)
D-GlutamateMetaboliteCHEBI:15966 (ChEBI)
DRD2GeneProduct
DRD4GeneProduct
GRIA1GeneProduct
GRIA2GeneProduct
GRIA3GeneProduct
GRIA4GeneProduct
GRIN2CGeneProduct100003342 (Entrez Gene)
GRIN2DGeneProduct
GiGeneProduct
GsGeneProduct
I-1GeneProduct
LOC407707GeneProduct407707 (Entrez Gene)
LOC568406GeneProduct568406 (Entrez Gene)
LOC569499GeneProduct569499 (Entrez Gene)
LOC798222GeneProduct798222 (Entrez Gene)
acta1bGeneProduct407658 (Entrez Gene)
camk4GeneProduct550270 (Entrez Gene)
creb1GeneProduct573207 (Entrez Gene)
cx28.8GeneProduct566668 (Entrez Gene)
drd1GeneProduct568126 (Entrez Gene)
grin1bGeneProduct100005675 (Entrez Gene)
krit1GeneProduct321836 (Entrez Gene)
map2k1GeneProduct406728 (Entrez Gene)
mapk1GeneProduct360144 (Entrez Gene)
mapk3GeneProduct399480 (Entrez Gene)
ppa1GeneProduct550531 (Entrez Gene)
prkceGeneProduct100005075 (Entrez Gene)
si:ch211-51a19.1GeneProduct555576 (Entrez Gene)
zgc:158799GeneProduct564064 (Entrez Gene)
zgc:172250GeneProduct100002225 (Entrez Gene)
zhx2GeneProduct386660 (Entrez Gene)

Annotated Interactions

No annotated interactions
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